Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: Modulation at the N-portion and distal phenyl ring

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 118-132

  Ortar, Giorgio ^a   Morera, Enrico ^a   De Petrocellis, Luciano ^b   Ligresti, Alessia ^c   Schiano Moriello, Aniello ^b   Morera, Ludovica ^a   Nalli, Marianna ^a   Ragno, Rino ^a   Pirolli, Adele ^a   Di Marzo, Vincenzo ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

^c CNR   (Italy)

Author keywords

Biaryl tetrazolyl ureas; Endocannabinoids; Fatty acid amide hydrolase (FAAH); Monoacylglycerol lipase (MAGL); TRPA1 channel; TRPV1 channel

Indexed keywords

(5 (BIPHENYL 4 YLMETHYL) 2H TETRAZOL 2 YL)(PIPERIDIN 1 YL)METHANONE; 5 (BIPHENYL 4 YLMETHYL)N CYCLOHEXYL N METHYL 1H TETRAZOLE 1 CARBOXAMIDE; 5 (BIPHENYL 4 YLMETHYL)N CYCLOHEXYL N METHYL 2H TETRAZOLE 2 CARBOXAMIDE; 5 (BIPHENYL 4 YLMETHYL)N METHYL N(4 PHENYLBUTYL) 1H TETRAZOLE 1 CARBOXAMIDE; 5 (BIPHENYL 4 YLMETHYL)N METHYL N(4 PHENYLBUTYL) 2H TETRAZOLE 2 CARBOXAMIDE; 5 (BIPHENYL 4 YLMETHYL)N METHYL N(NAPHTHALEN 2 YLMETHYL) 1H TETRAZOLE 1 CARBOXAMIDE; 5 (BIPHENYL 4 YLMETHYL)N METHYL N(NAPHTHALEN 2 YLMETHYL) 2H TETRAZOLE 2 CARBOXAMIDE; 5 (NIPHENYL 4 YLMETHYL) 1H TETRAZOL 1 YL)(PIPERIDIN 1 YL)METHANONE; 5 [(3' ACETYLBIPHENYL 4 YL)METHYL] N,N DIMETHYL 1H TETRAZOLE 1 CARBOXAMIDE; 5 [(3' ACETYLBIPHENYL 4 YL)METHYL]N,N DIMETHYL 2H TETRAZOLE 2 CARBOXAMIDE; 5 [(3' CARBAMOYLBIPHENYL 4 YL)METHYL]N,N DIMETHYL 1H TETRAZOLE 1 CARBOXAMIDE; 5 [(3' CARBAMOYLBIPHENYL 4 YL)METHYL]N,N DIMETHYL 2H TETRAZOLE 2 CARBOXAMIDE; 5 [[3' (HYDROXYMETHYL)BIPHENYL 4 YL]METHYL] N,N DIMETHYL 1H TETRAZOLE 1 CARBOXAMIDE; 5 [[3' (HYDROXYMETHYL)BIPHENYL 4 YL]METHYL]N,N DIMETHYL 2H TETRAZOLE 2 CARBOXAMIDE; 5 [[4' (HYDROXYMETHYL)BIPHENYL 4 YL]METHYL]N,N DIMETHYL 1H TETRAZOLE 1 CARBOXAMIDE; 5 [[4'(HYDROXYMETHYL)BIPHENYL 4 YL]METHYL]N,N DIMETHYL 2H TETRAZOLE 2 CARBOXAMIDE; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; ESTERASE INHIBITOR; FATTY ACID AMIDASE INHIBITOR; METHYL 4' [[1 (DIMETHYLCARBAMOYL) 1H TETRAZOL 5 YL]METHYL]BIPHENYL 3 CARBOXYLATE; METHYL 4' [[2 (DIMETHYLCARBAMOYL) 2H TETRAZOL 5 YL]METHYL]BIPHENYL 3 CARBOXYLATE; N,N DIMETHYL 5 [(2' METHYLBIPHENYL 4 YL)METHYL] 1H TETRAZOLE 1 CARBOXAMIDE; N,N DIMETHYL 5 [(2' METHYLBIPHENYL 4 YL)METHYL] 2H TETRAZOLE 2 CARBOXAMIDE; N,N DIMETHYL 5 [(3' METHYLBIPHENYL 4 YL)METHY] 1H TETRAZOLE CARBOXAMIDE; N,N DIMETHYL 5 [(3' METHYLBIPHENYL 4 YL)METHYL] 2H TETRAZOLE 2 CARBOXAMIDE; N,N DIMETHYL 5 [(4' METHYLBIPHENYL 4 YL)METHYL] 1H TETRAZOLE 1 CARBOXAMIDE; N,N DIMETHYL 5 [(4' METHYLBIPHENYL 4 YL)METHYL] 2H TETRAZOLE 2 CARBOXAMIDE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; COVALENT BOND; DRUG PROTEIN BINDING; EMBRYO; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; NONHUMAN;

AMIDOHYDROLASES; ANIMALS; CALCIUM CHANNELS; CERCOPITHECUS AETHIOPS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCANNABINOIDS; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOACYLGLYCEROL LIPASES; NERVE TISSUE PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS; UREA;

EID: 84874543386     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.02.005     Document Type: Article

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