A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors

British Journal of Pharmacology

Volumn 157, Issue 6, 2009, Pages 974-983

  King, A R ^a   Lodola, A ^b   Carmi, C ^b   Fu, J ^a   Mor, M ^b   Piomelli, D ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PARMA   (Italy)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

2 arachidonoylglycerol; Endocannabinoids; Monoacylglycerol lipase

Indexed keywords

2 METHYL 4 ISOTHIAZOLIN 3 ONE; 2 OLEOYL 4 ISOTHIAZOLINE 3 ONE; ACYLGLYCEROL LIPASE; CYSTEINE; ENZYME INHIBITOR; GLYCINE; MALEIMIDE DERIVATIVE; N ARACHIDONYLMALEIMIDE; OCTHILINONE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; RAT; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CYSTEINE; DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; GLYCINE; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MONOACYLGLYCEROL LIPASES; MUTAGENESIS, SITE-DIRECTED; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIAZOLES;

EID: 70350339817     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00276.x     Document Type: Article

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