Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors

ACS Chemical Neuroscience

Volumn 4, Issue 9, 2013, Pages 1322-1332

  Niphakis, Micah J ^a   Cognetta, Armand B ^a   Chang, Jae Won ^a   Buczynski, Matthew W ^a   Parsons, Loren H ^a   Byrne, Frederika ^b   Burston, James J ^b   Chapman, Victoria ^b   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

2 arachidonoyl glycerol; activity based protein profiling; carbamate; click chemistry; endocannabinoid; inhibitor; monoacylglycerol lipase

Indexed keywords

CARBAMIC ACID DERIVATIVE; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; HYDROLASE; HYDROLASE INHIBITOR; MJN 110; N HYDROXYSUCCINIMIDYL CARBAMATE DERIVATIVE; PREGABALIN; PROTEOME; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN HOMOGENATE; CONTROLLED STUDY; CROSS REACTION; DIABETIC NEUROPATHY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROLYSIS; IN VIVO STUDY; LIVER; MOUSE; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; RAT;

AMIDOHYDROLASES; ANIMALS; BLOOD GLUCOSE; BRAIN; CARBAMATES; DIABETES MELLITUS, TYPE 2; DIABETIC NEUROPATHIES; DRUG EVALUATION, PRECLINICAL; ENDOCANNABINOIDS; HEK293 CELLS; HUMANS; HYPERALGESIA; INSULIN; LIVER; MALE; MICE; MOLECULAR STRUCTURE; MONOACYLGLYCEROL LIPASES; NOCICEPTION; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINIMIDES;

EID: 84884396218     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn400116z     Document Type: Article

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