Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors

Chemistry and Biology

Volumn 16, Issue 10, 2009, Pages 1045-1052

  King, Alvin R ^a   Dotsey, Emmanuel Y ^a   Lodola, Alessio ^b   Jung, Kwang Mook ^a   Ghomian, Azar ^a   Qiu, Yan ^c   Fu, Jin ^a   Mor, Marco ^b   Piomelli, Daniele ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PARMA   (Italy)

^c XIAMEN UNIVERSITY   (China)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

CHEMBIO; MOLNEURO

Indexed keywords

ACYLGLYCEROL LIPASE; ARACHIDONIC ACID DERIVATIVE; DRUG DERIVATIVE; ENDOCANNABINOID 2 ARACHIDONOYL GLYCEROL; ENDOCANNABINOID 2-ARACHIDONOYL GLYCEROL; ENZYME INHIBITOR; EUPHOL; GLYCEROL; LANOSTEROL; PRISTIMERIN; TRITERPENE;

ANIMAL; ARTICLE; BINDING SITE; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; HELA CELL; HUMAN; METABOLISM; MOLECULAR DYNAMICS; NERVE CELL; PROTEIN TERTIARY STRUCTURE; RAT; WISTAR RAT;

ANIMALS; ARACHIDONIC ACIDS; BINDING SITES; CELLS, CULTURED; DRUG DESIGN; ENZYME INHIBITORS; GLYCEROL; HELA CELLS; HUMANS; LANOSTEROL; MOLECULAR DYNAMICS SIMULATION; MONOACYLGLYCEROL LIPASES; NEURONS; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, WISTAR; TRITERPENES;

EID: 71149108705     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2009.09.012     Document Type: Article

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