Phagocytosis: An Immunobiologic Process

Immunity

Volumn 44, Issue 3, 2016, Pages 463-475

  Gordon, Siamon ^a,b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; CELLULAR IMMUNITY; IMMUNE RESPONSE; INFECTION; INFLAMMATION; INJURY; INNATE IMMUNITY; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; PROTEOMICS; REVIEW; ANIMAL; HOMEOSTASIS; HUMAN; IMMUNOLOGY; PHAGOCYTE;

ADAPTIVE IMMUNITY; ANIMALS; HOMEOSTASIS; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, INNATE; INFLAMMATION; PHAGOCYTES; PHAGOCYTOSIS;

EID: 84960419945     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.02.026     Document Type: Review

References (131)

1. Ahrens S., Zelenay S., Sancho D., Hanč P., Kjær S., Feest C., Fletcher G., Durkin C., Postigo A., Skehel M., et al. F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells. Immunity 2012, 36:635-645.
2. Arandjelovic S., Ravichandran K.S. Phagocytosis of apoptotic cells in homeostasis. Nat. Immunol. 2015, 16:907-917.
3. Arredouani M.S., Palecanda A., Koziel H., Huang Y.C., Imrich A., Sulahian T.H., Ning Y.Y., Yang Z., Pikkarainen T., Sankala M., et al. MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. J. Immunol. 2005, 175:6058-6064.
4. Balkwill F., Mantovani A. Inflammation and cancer: back to Virchow?. Lancet 2001, 357:539-545.
5. Baxter A.E., Russell R.A., Duncan C.J., Moore M.D., Willberg C.B., Pablos J.L., Finzi A., Kaufmann D.E., Ochsenbauer C., Kappes J.C., et al. Macrophage infection via selective capture of HIV-1-infected CD4+ T cells. Cell Host Microbe 2014, 16:711-721.
6. Billings E.A., Lee C.S., Owen K.A., D'Souza R.S., Ravichandran K.S., Casanova J.E. The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria. Sci. Signal. 2016, 9:ra14.
7. Bonilla D.L., Bhattacharya A., Sha Y., Xu Y., Xiang Q., Kan A., Jagannath C., Komatsu M., Eissa N.T. Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. Immunity 2013, 39:537-547.
8. Boulais J., Trost M., Landry C.R., Dieckmann R., Levy E.D., Soldati T., Michnick S.W., Thibault P., Desjardins M. Molecular characterization of the evolution of phagosomes. Mol. Syst. Biol. 2010, 6:423.
9. Bowdish D.M., Loffredo M.S., Mukhopadhyay S., Mantovani A., Gordon S. Macrophage receptors implicated in the "adaptive" form of innate immunity. Microbes Infect. 2007, 9:1680-1687.
10. Branzk N., Lubojemska A., Hardison S.E., Wang Q., Gutierrez M.G., Brown G.D., Papayannopoulos V. Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nat. Immunol. 2014, 15:1017-1025.
11. Brown G.C., Vilalta A., Fricker M. Phagoptosis - Cell Death By Phagocytosis - Plays Central Roles in Physiology, Host Defense and Pathology. Curr. Mol. Med. 2015, 15:842-851.
12. Brown H.E., Dougherty T.F. The diurnal variation of blood leucocytes in normal and adrenalectomized mice. Endocrinology 1956, 58:365-375.
13. Buckley C.D., Gilroy D.W., Serhan C.N. Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. Immunity 2014, 40:315-327.
14. Butovsky O., Landa G., Kunis G., Ziv Y., Avidan H., Greenberg N., Schwartz A., Smirnov I., Pollack A., Jung S., Schwartz M. Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J. Clin. Invest. 2006, 116:905-915.
15. Butters T.D., Dwek R.A., Platt F.M. Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses. Glycobiology 2005, 15:43R-52R.
16. Campbell-Valois F.X., Trost M., Chemali M., Dill B.D., Laplante A., Duclos S., Sadeghi S., Rondeau C., Morrow I.C., Bell C., et al. Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome. Mol. Cell. Proteomics 2012, 11:016378.
17. Canton J., Neculai D., Grinstein S. Scavenger receptors in homeostasis and immunity. Nat. Rev. Immunol. 2013, 13:621-634.
18. Caruso R., Warner N., Inohara N., Núñez G. NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity 2014, 41:898-908.
19. Chernyak L., Tauber A.I. The birth of immunology: Metchnikoff, the embryologist. Cell. Immunol. 1988, 117:218-233.
20. Cross A.R., Segal A.W. The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems. Biochim. Biophys. Acta 2004, 1657:1-22.
21. Crotti A., Ransohoff R.M. Fifty Shades of Microglia. Immunity 2016, 44:505-515. this issue.
22. Dambuza I.M., Brown G.D. C-type lectins in immunity: recent developments. Curr. Opin. Immunol. 2015, 32:21-27.
23. Davies J.Q., Lin H.H., Stacey M., Yona S., Chang G.W., Gordon S., Hamann J., Campo L., Han C., Chan P., Fox S.B. Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival. Oncol. Rep. 2011, 25:619-627.
24. Derdeyn C.A., Moore P.L., Morris L. Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection. Curr. Opin. HIV AIDS 2014, 9:210-216.
25. Dill B.D., Gierlinski M., Härtlova A., Arandilla A.G., Guo M., Clarke R.G., Trost M. Quantitative proteome analysis of temporally resolved phagosomes following uptake via key phagocytic receptors. Mol. Cell. Proteomics 2015, 14:1334-1349.
26. Dorhoi A., Desel C., Yeremeev V., Pradl L., Brinkmann V., Mollenkopf H.J., Hanke K., Gross O., Ruland J., Kaufmann S.H. The adaptor molecule CARD9 is essential for tuberculosis control. J. Exp. Med. 2010, 207:777-792.
27. Drummond R.A., Dambuza I.M., Vautier S., Taylor J.A., Reid D.M., Bain C.C., Underhill D.M., Masopust D., Kaplan D.H., Brown G.D. CD4(+) T-cell survival in the GI tract requires dectin-1 during fungal infection. Mucosal Immunol. 2015, 10.1038/mi.2015.79.
28. Dushek O., Goyette J., van der Merwe P.A. Non-catalytic tyrosine-phosphorylated receptors. Immunol. Rev. 2012, 250:258-276.
29. Flannagan R.S., Harrison R.E., Yip C.M., Jaqaman K., Grinstein S. Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets. J. Cell Biol. 2010, 191:1205-1218.
30. Flannagan R.S., Jaumouillé V., Grinstein S. The cell biology of phagocytosis. Annu. Rev. Pathol. 2012, 7:61-98.
31. Fond A.M., Lee C.S., Schulman I.G., Kiss R.S., Ravichandran K.S. Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1. J. Clin. Invest. 2015, 125:2748-2758.
32. Freeman S.A., Goyette J., Furuya W., Woods E.C., Bertozzi C.R., Bergmeier W., Hinz B., van der Merwe P.A., Das R., Grinstein S. Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis. Cell 2016, 164:128-140.
33. Germano G., Frapolli R., Belgiovine C., Anselmo A., Pesce S., Liguori M., Erba E., Uboldi S., Zucchetti M., Pasqualini F., et al. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell 2013, 23:249-262.
34. Ginhoux F., Guilliams M. Tissue-Resident Macrophage Ontogeny and Homeostasis. Immunity 2016, 44:439-449. this issue.
35. Gonzalez S.F., Lukacs-Kornek V., Kuligowski M.P., Pitcher L.A., Degn S.E., Kim Y.A., Cloninger M.J., Martinez-Pomares L., Gordon S., Turley S.J., Carroll M.C. Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. Nat. Immunol. 2010, 11:427-434.
36. Goodridge H.S., Reyes C.N., Becker C.A., Katsumoto T.R., Ma J., Wolf A.J., Bose N., Chan A.S., Magee A.S., Danielson M.E., et al. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature 2011, 472:471-475.
37. Gordon S. Macrophages and phagocytosis. Fundamental Immunology 2012, 448-467. Lippincott, Williams, and Wilkins. W.E. Paul (Ed.).
38. Gordon S., Plüddemann A., Mukhopadhyay S. Sinusoidal immunity: macrophages at the lymphohematopoietic interface. Cold Spring Harb. Perspect. Biol. 2015, 7:a016378.
39. Goren M.B., D'Arcy Hart P., Young M.R., Armstrong J.A. Prevention of phagosome-lysosome fusion in cultured macrophages by sulfatides of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 1976, 73:2510-2514.
40. Griffiths G., Nyström B., Sable S.B., Khuller G.K. Nanobead-based interventions for the treatment and prevention of tuberculosis. Nat. Rev. Microbiol. 2010, 8:827-834.
41. Hanč P., Fujii T., Iborra S., Yamada Y., Huotari J., Schulz O., Ahrens S., Kjær S., Way M., Sancho D., et al. Structure of the Complex of F-Actin and DNGR-1, a C-Type Lectin Receptor Involved in Dendritic Cell Cross-Presentation of Dead Cell-Associated Antigens. Immunity 2015, 42:839-849.
42. Helming L., Winter J., Gordon S. The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion. J. Cell Sci. 2009, 122:453-459.
43. Henson P.M., Bratton D.L. Recognition and removal of apoptotic cells. Phagocyte-pathogen interactions: macrophages and the host response to infection 2009, 341-365. ASM Press. D.G. Russell, S. Gordon (Eds.).
44. Herhaus L., Dikic I. Expanding the ubiquitin code through post-translational modification. EMBO Rep. 2015, 16:1071-1083.
45. Herrmann M., Schäfer C., Heiss A., Gräber S., Kinkeldey A., Büscher A., Schmitt M.M., Bornemann J., Nimmerjahn F., Herrmann M., et al. Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A. Circ. Res. 2012, 111:575-584.
46. Herweg J.A., Hansmeier N., Otto A., Geffken A.C., Subbarayal P., Prusty B.K., Becher D., Hensel M., Schaible U.E., Rudel T., Hilbi H. Purification and proteomics of pathogen-modified vacuoles and membranes. Front. Cell. Infect. Microbiol. 2015, 5:48.
47. Hirsch J.G. Cinemicrophotographic observations on granule lysis in polymorphonuclear leucocytes during phagocytosis. J. Exp. Med. 1962, 116:827-834.
48. Hirsch J.G. Phagocytosis and degranulation 1962, Rockefeller University Press. http://www.rupress.org/site/films/index.xhtml.
49. Hubbard A.L., Wilson G., Ashwell G., Stukenbrok H. An electron microscope autoradiographic study of the carbohydrate recognition systems in rat liver. I. Distribution of 125I-ligands among the liver cell types. J. Cell Biol. 1979, 83:47-64.
50. Iwasaki A., Medzhitov R. Control of adaptive immunity by the innate immune system. Nat. Immunol. 2015, 16:343-353.
51. Janka G.E., Lehmberg K. Hemophagocytic syndromes--an update. Blood Rev. 2014, 28:135-142.
52. Khaminets A., Heinrich T., Mari M., Grumati P., Huebner A.K., Akutsu M., Liebmann L., Stolz A., Nietzsche S., Koch N., et al. Regulation of endoplasmic reticulum turnover by selective autophagy. Nature 2015, 522:354-358.
53. Khaminets A., Behl C., Dikic I. Ubiquitin-Dependent And Independent Signals In Selective Autophagy. Trends Cell Biol. 2016, 26:6-16.
54. Khokha R., Werb Z. Mammary gland reprogramming: metalloproteinases couple form with function. Cold Spring Harb. Perspect. Biol. 2011, 3:3.
55. Klaas M., Crocker P.R. Sialoadhesin in recognition of self and non-self. Semin. Immunopathol. 2012, 34:353-364.
56. Kwong L.S., Brown M.H., Barclay A.N., Hatherley D. Signal-regulatory protein α from the NOD mouse binds human CD47 with an exceptionally high affinity-- implications for engraftment of human cells. Immunology 2014, 143:61-67.
57. Lackey D.E., Olefsky J.M. Regulation of metabolism by the innate immune system. Nat. Rev. Endocrinol. 2016, 12:15-28.
58. Lecube A., Pachón G., Petriz J., Hernández C., Simó R. Phagocytic activity is impaired in type 2 diabetes mellitus and increases after metabolic improvement. PLoS ONE 2011, 6:e23366.
59. Levine A.P., Segal A.W. What is wrong with granulocytes in inflammatory bowel diseases?. Dig. Dis. 2013, 31:321-327.
60. Levine B., Mizushima N., Virgin H.W. Autophagy in immunity and inflammation. Nature 2011, 469:323-335.
61. Lööv C., Mitchell C.H., Simonsson M., Erlandsson A. Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification. Glia 2015, 63:1997-2009.
62. Ma Y., Adjemian S., Mattarollo S.R., Yamazaki T., Aymeric L., Yang H., Portela Catani J.P., Hannani D., Duret H., Steegh K., et al. Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity 2013, 38:729-741.
63. Martinez F.O., Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 2014, 6:13.
64. Martinez J., Malireddi R.K., Lu Q., Cunha L.D., Pelletier S., Gingras S., Orchard R., Guan J.L., Tan H., Peng J., et al. Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nat. Cell Biol. 2015, 17:893-906.
65. McCracken M.N., Cha A.C., Weissman I.L. Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals. Clin. Cancer Res. 2015, 21:3597-3601.
66. Metchnikoff O. Life of Elie Metchnikoff 1845-1916 1921, Houghton Mifflin.
67. Mevorach D., Zuckerman T., Reiner I., Shimoni A., Samuel S., Nagler A., Rowe J.M., Or R. Single infusion of donor mononuclear early apoptotic cells as prophylaxis for graft-versus-host disease in myeloablative HLA-matched allogeneic bone marrow transplantation: a phase I/IIa clinical trial. Biol. Blood Marrow Transplant. 2014, 20:58-65.
68. Michl J., Pieczonka M.M., Unkeless J.C., Silverstein S.C. Effects of immobilized immune complexes on Fc- and complement-receptor function in resident and thioglycollate-elicited mouse peritoneal macrophages. J. Exp. Med. 1979, 150:607-621.
69. Michl J., Pieczonka M.M., Unkeless J.C., Bell G.I., Silverstein S.C. Fc receptor modulation in mononuclear phagocytes maintained on immobilized immune complexes occurs by diffusion of the receptor molecule. J. Exp. Med. 1983, 157:2121-2139.
70. Milde R., Ritter J., Tennent G.A., Loesch A., Martinez F.O., Gordon S., Pepys M.B., Verschoor A., Helming L. Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction. Cell Rep. 2015, 13:1937-1948.
71. Montaner L.J., da Silva R.P., Sun J., Sutterwala S., Hollinshead M., Vaux D., Gordon S. Type 1 and type 2 cytokine regulation of macrophage endocytosis: differential activation by IL-4/IL-13 as opposed to IFN-gamma or IL-10. J. Immunol. 1999, 162:4606-4613.
72. Mortimer G.M., Butcher N.J., Musumeci A.W., Deng Z.J., Martin D.J., Minchin R.F. Cryptic epitopes of albumin determine mononuclear phagocyte system clearance of nanomaterials. ACS Nano 2014, 8:3357-3366.
73. Munn D.H., Bronte V. Immune suppressive mechanisms in the tumor microenvironment. Curr. Opin. Immunol. 2015, 39:1-6.
74. Nair-Gupta P., Baccarini A., Tung N., Seyffer F., Florey O., Huang Y., Banerjee M., Overholtzer M., Roche P.A., Tampé R., et al. TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation. Cell 2014, 158:506-521.
75. Nathan C. Secretory products of macrophages: twenty-five years on. J. Clin. Invest. 2012, 122:1189-1190.
76. Neyen C., Plüddemann A., Roversi P., Thomas B., Cai L., van der Westhuyzen D.R., Sim R.B., Gordon S. Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E. Biochemistry 2009, 48:11858-11871.
77. Neyen C., Pluddemann A., Gordon S. Identification of scavenger receptor ligands. Methods Mol. Biol. 2011, 748:35-50.
78. O'Neill L.A., Pearce E.J. Immunometabolism governs dendritic cell and macrophage function. J. Exp. Med. 2016, 213:15-23.
79. Parinot C., Nandrot E.F. A Comprehensive Review of Mutations in the MERTK Proto-Oncogene. Adv. Exp. Med. Biol. 2016, 854:259-265.
80. Paul D., Achouri S., Yoon Y.Z., Herre J., Bryant C.E., Cicuta P. Phagocytosis dynamics depends on target shape. Biophys. J. 2013, 105:1143-1150.
81. Penberthy K.K., Ravichandran K.S. Apoptotic cell recognition receptors and scavenger receptors. Immunol. Rev. 2016, 269:44-59.
82. Platt N., Suzuki H., Kurihara Y., Kodama T., Gordon S. Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro. Proc. Natl. Acad. Sci. USA 1996, 93:12456-12460.
83. Plüddemann A., Mukhopadhyay S., Gordon S. Innate immunity to intracellular pathogens: macrophage receptors and responses to microbial entry. Immunol. Rev. 2011, 240:11-24.
84. Podinovskaia M., VanderVen B.C., Yates R.M., Glennie S., Fullerton D., Mwandumba H.C., Russell D.G. Dynamic quantitative assays of phagosomal function. Curr. Protoc. Immunol. 2013, 102:34.
85. Pollard J.W. Trophic macrophages in development and disease. Nat. Rev. Immunol. 2009, 9:259-270.
86. Puleston D.J., Simon A.K. Autophagy in the immune system. Immunology 2014, 141:1-8.
87. Rabinovitch M. Professional and non-professional phagocytes: an introduction. Trends Cell Biol. 1995, 5:85-87.
88. Romao S., Münz C. LC3-associated phagocytosis. Autophagy 2014, 10:526-528.
89. Rongvaux A., Willinger T., Martinek J., Strowig T., Gearty S.V., Teichmann L.L., Saito Y., Marches F., Halene S., Palucka A.K., et al. Development and function of human innate immune cells in a humanized mouse model. Nat. Biotechnol. 2014, 32:364-372.
90. Rossi F. The O2- -forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function. Biochim. Biophys. Acta 1986, 853:65-89.
91. Rothlin C.V., Lemke G. TAM receptor signaling and autoimmune disease. Curr. Opin. Immunol. 2010, 22:740-746.
92. Russell D.G. Mycobacterium tuberculosis and the intimate discourse of a chronic infection. Immunol. Rev. 2011, 240:252-268.
93. Sancho D., Joffre O.P., Keller A.M., Rogers N.C., Martínez D., Hernanz-Falcón P., Rosewell I., Reis e Sousa C. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 2009, 458:899-903.
94. Savill J., Dransfield I., Gregory C., Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat. Rev. Immunol. 2002, 2:965-975.
95. Schlam D., Bagshaw R.D., Freeman S.A., Collins R.F., Pawson T., Fairn G.D., Grinstein S. Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins. Nat. Commun. 2015, 6:8623.
96. Segal A.W., Geisow M., Garcia R., Harper A., Miller R. The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH. Nature 1981, 290:406-409.
97. Segawa K., Nagata S. An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure. Trends Cell Biol. 2015, 25:639-650.
98. Shiratsuchi A., Osada Y., Nakanishi Y. Differences in the mode of phagocytosis of bacteria between macrophages and testicular Sertoli cells. Drug Discov. Ther. 2013, 7:73-77.
99. Soares M.P., Hamza I. Macrophages and Iron Metabolism. Immunity 2016, 44:492-504. this issue.
100. Sousa Mda.G., Reid D.M., Schweighoffer E., Tybulewicz V., Ruland J., Langhorne J., Yamasaki S., Taylor P.R., Almeida S.R., Brown G.D. Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin. Cell Host Microbe 2011, 9:436-443.
101. Steinman R.M. Decisions about dendritic cells: past, present, and future. Annu. Rev. Immunol. 2012, 30:1-22.
102. Steinman R.M., Moberg C.L. Zanvil Alexander Cohn 1926-1993. J. Exp. Med. 1994, 179:1-30.
103. Stienstra R., Dijk W., van Beek L., Jansen H., Heemskerk M., Houtkooper R.H., Denis S., van Harmelen V., Willems van Dijk K., Tack C.J., Kersten S. Mannose-binding lectin is required for the effective clearance of apoptotic cells by adipose tissue macrophages during obesity. Diabetes 2014, 63:4143-4153.
104. Stranks A.J., Hansen A.L., Panse I., Mortensen M., Ferguson D.J., Puleston D.J., Shenderov K., Watson A.S., Veldhoen M., Phadwal K., et al. Autophagy Controls Acquisition of Aging Features in Macrophages. J. Innate Immun. 2015, 7:375-391.
105. Stuart L.M., Boulais J., Charriere G.M., Hennessy E.J., Brunet S., Jutras I., Goyette G., Rondeau C., Letarte S., Huang H., et al. A systems biology analysis of the Drosophila phagosome. Nature 2007, 445:95-101.
106. Sung S.S., Silverstein S.C. Role of 2-deoxy-D-glucose in the inhibition of phagocytosis by mouse peritoneal macrophage. Biochim. Biophys. Acta 1985, 845:204-215.
107. Sutterwala F.S., Noel G.J., Salgame P., Mosser D.M. Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I. J. Exp. Med. 1998, 188:217-222.
108. Swanson J.A. Shaping cups into phagosomes and macropinosomes. Nat. Rev. Mol. Cell Biol. 2008, 9:639-649.
109. Tan S., Russell D.G. Trans-species communication in the Mycobacterium tuberculosis-infected macrophage. Immunol. Rev. 2015, 264:233-248.
110. Taylor P.R., Carugati A., Fadok V.A., Cook H.T., Andrews M., Carroll M.C., Savill J.S., Henson P.M., Botto M., Walport M.J. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J. Exp. Med. 2000, 192:359-366.
111. Taylor P.R., Martinez-Pomares L., Stacey M., Lin H.H., Brown G.D., Gordon S. Macrophage receptors and immune recognition. Annu. Rev. Immunol. 2005, 23:901-944.
112. Thurston T.L., Wandel M.P., von Muhlinen N., Foeglein A., Randow F. Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature 2012, 482:414-418.
113. Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 2009, 30:143-154.
114. Underhill D.M., Pearlman E. Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street. Immunity 2015, 43:845-858.
115. van der Meer J.W., Joosten L.A., Riksen N., Netea M.G. Trained immunity: A smart way to enhance innate immune defence. Mol. Immunol. 2015, 68:40-44.
116. van Furth R., Cohn Z.A., Hirsch J.G., Humphrey J.H., Spector W.G., Langevoort H.L. The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells. Bull. World Health Organ. 1972, 46:845-852.
117. van Rooijen N. Liposomes for targeting of antigens and drugs: immunoadjuvant activity and liposome-mediated depletion of macrophages. J. Drug Target. 2008, 16:529-534.
118. Vance R.E., Isberg R.R., Portnoy D.A. Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe 2009, 6:10-21.
119. Varin A., Mukhopadhyay S., Herbein G., Gordon S. Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion. Blood 2010, 115:353-362.
120. Vikhanski L. Immunity: How Elie Metchnikoff changed the course of modern medicine 2016, Chicago Review Press.
121. Wen H., Miao E.A., Ting J.P. Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity 2013, 39:432-441.
122. Williams-Hermann D., Werb Z. Phagocytosis by non-professional phagocytes. Phagocytosis: The Host 1999, 47-67. JAI Press. S. Gordon (Ed.).
123. Wilson G.J., Marakalala M.J., Hoving J.C., van Laarhoven A., Drummond R.A., Kerscher B., Keeton R., van de Vosse E., Ottenhoff T.H., Plantinga T.S., et al. The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. Cell Host Microbe 2015, 17:252-259.
124. Wright S.D., Silverstein S.C. Tumor-promoting phorbol esters stimulate C3b and C3b' receptor-mediated phagocytosis in cultured human monocytes. J. Exp. Med. 1982, 156:1149-1164.
125. Wu J., Chen Z.J. Innate immune sensing and signaling of cytosolic nucleic acids. Annu. Rev. Immunol. 2014, 32:461-488.
126. Wynn T.A., Vannella K.M. Macrophages in Tissue Repair, Regeneration, and Fibrosis. Immunity 2016, 44:450-462. this issue.
127. Yamauchi S., Kawauchi K., Sawada Y. Myosin II-dependent exclusion of CD45 from the site of Fcγ receptor activation during phagocytosis. FEBS Lett. 2012, 586:3229-3235.
128. Yates R.M., Hermetter A., Taylor G.A., Russell D.G. Macrophage activation downregulates the degradative capacity of the phagosome. Traffic 2007, 8:241-250.
129. Yates R.M., Rohde K., Abramovitch R.B., Russell D.G. Functional analysis of the intraphagosomal environment of the macrophage: fluorogenic reporters and the transcriptional responses of Salmonella and Mycobacterium spp. Phagocyte-pathogen interactions: macrophages and the host response to infection 2009, 249-264. ASM Press. D.G. Russell, S. Gordon (Eds.).
130. Zhang J.G., Czabotar P.E., Policheni A.N., Caminschi I., Wan S.S., Kitsoulis S., Tullett K.M., Robin A.Y., Brammananth R., van Delft M.F., et al. The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity 2012, 36:646-657.
131. Zizzo G., Cohen P.L. IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids. J. Immunol. 2013, 190:5237-5246.