What Is wrong with granulocytes in inflammatory bowel diseases

Digestive Diseases

Volumn 31, Issue 3-4, 2013, Pages 321-327

  Levine, Adam P ^a   Segal, Anthony W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Acute inflammatory response; Chronic granulomatous disease; Crohn's disease; Inflammatory bowel disease; Neutrophil

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; COLONY STIMULATING FACTOR 1; INTEGRIN; LEVAMISOLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SELECTIN; CYTOKINE; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; BACTERICIDAL ACTIVITY; CELL FUNCTION; CELL PHAGOCYTOSIS; CHRONIC GRANULOMATOUS DISEASE; CHRONIC INFLAMMATION; CONFERENCE PAPER; CROHN DISEASE; ELECTRON TRANSPORT; GENE MUTATION; GRANULOCYTE; HUMAN; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; INNATE IMMUNITY; MACROPHAGE ACTIVATION; NEUTROPENIA; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PHAGOCYTE; PRIORITY JOURNAL; REMISSION; RESPIRATORY BURST; CYTOKINE RELEASE; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; LEUKOCYTE FUNCTION; MACROPHAGE; ANIMAL; BIOLOGICAL MODEL; IMMUNOLOGY; PATHOLOGY; SECRETION (PROCESS);

ANIMALS; CROHN DISEASE; CYTOKINES; HUMANS; INFLAMMATORY BOWEL DISEASES; MACROPHAGES; MODELS, IMMUNOLOGICAL; NEUTROPHILS;

EID: 84888232565     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000354686     Document Type: Conference Paper

References (42)

1. Xavier RJ, Podolsky DK: Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448: 427-434.
2. Segal AW, Loewi G: Neutrophil dysfunction in Crohn's disease. Lancet 1976; 2: 219-221.
3. Ament ME, Ochs HD: Gastrointestinal manifestations of chronic granulomatous disease. N Engl J Med 1973; 288: 382-387.
4. Marks DJB, Harbord MWN, MacAllister R, Rahman FZ, Young J, Al-Lazikani B, Lees W, Novelli M, Bloom S, Segal AW: Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet 2006; 367: 668-678.
5. Smith AM, Rahman FZ, Hayee BH, Graham SJ, Marks DJB, Sewell GW, Palmer CD, Wilde J, Foxwell BMJ, Gloger IS, Sweeting T, Marsh M, Walker AP, Bloom SL, Segal AW: Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med 2009; 206: 1883-1897.
6. Delves PJ, Roitt IM: The immune system. First of two parts. N Engl J Med 2000; 343: 37-49.
7. Segal AW: How neutrophils kill microbes. Annu Rev Immunol 2005; 23: 197-223.
8. Li Y, Karlin A, Loike JD, Silverstein SC: Determination of the critical concentration of neutrophils required to block bacterial growth in tissues. J Exp Med 2004; 200: 613-622.
9. Reeves EP, Lu H, Jacobs HL, Messina CGM, Bolsover S, Gabella G, Potma EO, Warley A, Roes J, Segal AW: Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 2002; 416: 291-297.
10. Belaaouaj A, McCarthy R, Baumann M, Gao Z, Ley TJ, Abraham SN, Shapiro SD: Mice lacking neutrophil elastase reveal impaired host defense against Gram-negative bacterial sepsis. Nat Med 1998; 4: 615-618.
11. Farthing MJG: Bugs and the gut: an unstable marriage. Best Pract Res Clinical Gastroenterol 2004; 18: 233-239.
12. Segal AW, Ensell J, Munro JM, Sarner M: Indium-111 tagged leucocytes in the diagnosis of inflammatory bowel disease. Lancet 1981; 230-232.
13. Roseth AG, Schmidt PN, Fagerhol MK: Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease. Scand J Gastroenterol 1999; 34: 50-54.
14. Burman JH, Williams JA, Thompson H, Cooke WT: The effect of diversion of intestinal contents on the progress of Crohn's disease of the large bowel. Gut 1969; 10: 1054.
15. Rutgeerts P, Goboes K, Peeters M, Hiele M, Penninckx F, Aerts R, Kerremans R, Vantrappen G: Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Lancet 1991; 338: 771-774.
16. Rahman FZ, Marks DJB, Hayee BH, Smith AM, Bloom SL, Segal AW: Phagocyte dysfunction and inflammatory bowel disease. Inflamm Bowel Dis 2008; 14: 1443-1452.
17. Thrasher AJ, Keep NH, Wientjes F, Segal AW: Chronic granulomatous disease. Biochim Biophys Acta 1994; 1227: 1-24.
18. Quie PG, White JG, Holmes B, Good RA: In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood. J Clin Invest 1967; 46: 668-679.
19. Marks DJB, Miyagi K, Rahman FZ, Novelli M, Bloom SL, Segal AW: Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease. Am J Gastroenterol 2009; 104: 117-124.
20. Sewell GW, Marks DJ, Segal AW: The immunopathogenesis of Crohn's disease: a threestage model. Curr Opin Immunol 2009; 21: 506-513.
21. Freudenberg F, Wintergerst U, Roesen-Wolff A, Albert MH, Prell C, Strahm B, Koletzko S, Ehl S, Roos D, Tommasini A, Ventura A, Belohradsky BH, Seger R, Roesler J, Gungor T: Therapeutic strategy in p47-phox deficient chronic granulomatous disease presenting as inflammatory bowel disease. J Allergy Clin Immunol 2010; 125: 943-946.e1.
22. Hermanowicz A, Gibson PR, Jewell DP: The role of phagocytes in inflammatory bowel disease. Clin Sci (Lond) 1985; 69: 241-249.
23. Hayee BH, Rahman FZ, Sewell GW, Smith AM, Segal AW: Crohn's disease as an immunodeficiency. Expert Rev Clin Immunol 2010; 6: 585-596.
24. Hayee BH, Rahman FZ, Tempero J, McCartney S, Bloom SL, Segal AW, Smith AM: The neutrophil respiratory burst and bacterial digestion in Crohn's disease. Dig Dis Sci 2011; 56: 1482-1488.
25. Hayee BH, Antonopoulos A, Murphy EJ, Rahman FZ, Sewell GW, Smith BN, McCartney S, Furman M, Hall G, Bloom SL, Haslam SM, Morris HR, Boztug K, Klein C, Winchester B, Pick E, Linch DC, Gale RE, Smith AM, Dell A, Segal AW: G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction. Glycobiology 2011; 21: 914-924.
26. Woodman RC, Newburger PE, Anklesaria P, Erickson RW, Rae J, Cohen MS, Curnutte JT: A new X-linked variant of chronic granulomatous disease characterized by the existence of a normal clone of respiratory burst-competent phagocytic cells. Blood 1995; 85: 231-241.
27. O'Morain CA, Segal AW, Walker D, Levi A: Abnormalities of neutrophil function do not cause the migration defect in Crohn's disease. Gut 1981; 22: 817-822.
28. Harbord MWN, Marks DJB, Forbes A, Bloom SL, Day RM, Segal AW: Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony stimulating factor. Aliment Pharmacol Ther 2006; 24: 651-660.
29. Sewell GW, Rahman FZ, Levine AP, Jostins L, Smith PJ, Walker AP, Bloom SL, Segal AW, Smith AM: Defective tumor necrosis factor release from Crohn's disease macrophages in response to toll-like receptor activation: relationship to phenotype and genome-wide association susceptibility loci. Inflamm Bowel Dis 2012; 18: 2120-2127.
30. Harvey RF, Bradshaw JM: A simple index of Crohn's-disease activity. Lancet 1980; 1: 514.
31. Marks DJB, Radulovic M, McCartney S, Bloom SL, Segal AW: Modified skin window technique for the extended characterisation of acute inflammation in humans. Inflamm Res 2007; 56: 168-174.
32. Segal AW, Peters TJ: The nylon column dye test: a possible screening test of phagocyte function. Clin Sci Mol Med 1975; 49: 591-596.
33. Wandall J, Binder V: Leucocyte function in Crohn's disease. Studies on mobilisation using a quantitative skin window technique and on the function of circulating polymorphonuclear leucocytes in vitro. Gut 1982; 23: 173-180.
34. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nunez G, Cho JH: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411: 603-606.
35. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599-603.
36. Van Heel DA, Ghosh S, Butler M, Hunt KA, Lundberg AMC, Ahmad T, McGovern DPB, Onnie C, Negoro K, Goldthorpe S, Foxwell BMJ, Mathew CG, Forbes A, Jewell DP, Playford RJ: Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet 2005; 365: 1794-1796.
37. Finegold SM: Intestinal bacteria. The role they play in normal physiology, pathologic physiology, and infection. Calif Med 1969; 110: 455-459.
38. Rhodes JM: The role of Escherichia coli in inflammatory bowel disease. Gut 2007; 56: 610-612.
39. Vinh DC, Behr MA: Crohn's as an immune deficiency: from apparent paradox to evolving paradigm. Expert Rev Clin Immunol 2013; 9: 17-30.
40. O'Morain CA, Segal AW, Levi AJ: Elemental diet as primary treatment of acute Crohn's disease: a controlled trial. Br Med J (Clin Res Ed) 1984; 288: 1859-1862.
41. Segal AW, Levi AJ, Loewi G: Levamisole in the treatment of Crohn's disease. Lancet 1977; 310: 382-384.
42. Korzenik JR, Dieckgraefe BK, Valentine JF, Hausman DF, Gilbert MJ: Sargramostim for active Crohn's disease. N Engl J Med 2005; 352: 2193-2201.