Differences in the Mode of Phagocytosis of Bacteria between Macrophages and Testicular Sertoli Cells

drug discoveries & therapeutics

Volumn 7, Issue 2, 2013, Pages 73-77

  Shiratsuchi, Akiko ^a   Osada, Yoichi ^a,b   Nakanishi, Yoshinobu ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

Author keywords

Bacterial infection; innate immunity; macrophage; phagocytosis; Sertoli cell

Indexed keywords

EID: 85008726033     PISSN: 18817831     EISSN: 1881784x     Source Type: Journal    
DOI: 10.5582/ddt.2013.v7.2.73     Document Type: Article

References (33)

1. Russell LD, Peterson RN. Sertoli cell junctions: Morphological and functional correlates. Int Rev Cytol. 1985; 94:177-211.
2. Russell LD. Morphological and functional evidence for Sertoli-germ cell relationships. In: The Sertoli cell (Russell D, Griswold MD, eds.). Cache River Press, Clearwater, USA, 1993; pp. 365-390.
3. Kierszenbaum AL. Mammalian spermatogenesis in vivo and in vitro: A partnership of spermatogenic and somatic cell linages. Endocr Rev. 1994; 15:116-134.
4. Enders GC. Sertoli-Sertoli and Sertoli-germ cell communications. In: The Sertoli cell (Russell LD, Griswold MD, eds.). Cache River Press, Clearwater, USA, 1993; pp. 447-460.
5. Sharpe RM. Experimental evidence for Sertoli-germ cell and Sertoli-Leydig cell interactions. In: The Sertoli cell (Russell LD, Griswold MD, eds.). Cache River Press, Clearwater, USA, 1993; pp. 391-417.
6. Byers S, Pelletier RM, Suáerz-Quian C. Sertoli-Sertoli cell junctions and the seminiferous epithelium barrier. In: The Sertoli cell (Russell LD, Griswold MD, eds.). Cache River Press, Clearwater, USA, 1993; pp. 431-446.
7. Nagaosa K, Nakashima C, Kishimoto A, Nakanishi, Y. Immune response to bacteria in seminiferous epithelium. Reproduction. 2009; 137:879-888.
8. Nakanishi Y, Shiratsuchi A. Phagocytic removal of apoptotic spermatogenic cells by Sertoli cells: Mechanisms and consequences. Biol Pharm Bull. 2004; 27:13-16.
9. Sang Y, Ortega MT, Blecha F, Prakash O, Melgarejo T. Molecular cloning and characterization of three β-defensins from canine testes. Infect Immun. 2005; 73:2611-2620.
10. Lennartsson A, Pieters K. Vidovic K, Gullberg U. A murine antibacterial ortholog to human bactericidal/permeability-increasing protein (BPI) is expressed in testis, epididymis, and bone marrow. J Leukoc Biol. 2005; 77:369-377.
11. Avellar MC, Honda L, Hamil KG, Yenugu S, Grossman G, Petrusz P, French FS, Hall SH. Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta). Biol Reprod. 2004; 71:1453-1460.
12. Com E, Bourgeon F, Evrard B, Ganz T, Colleu D, Jégou B, Pineau C. Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans. Biol Reprod. 2003; 68:95-104.
13. Grandjean V, Vincent S, Martin L, Rassoulzadegan M, Cuzin F. Antimicrobial protection of the mouse testis: Synthesis of defensins of the cryptdin family. Biol Reprod. 1997; 57:1115-1122.
14. Bhushan S, Tchatalbachev S, Klug J, Fijak M, Pineau C, Chakraborty T, Meinhardt A. Uropathogenic Escherichia coli block MyD88-dependent and activate MyD88-independent signaling pathways in rat testicular cells. J Immunol. 2008; 180:5537-5547.
15. Bhushan S, Schuppe HC, Fijak M, Meinhardt A. Testicular infection: Microorganisms, clinical implications and host-pathogen interaction. J Reprod Immunol. 2009; 83:164-167.
16. Bhushan S, Schuppe HC, Tchatalbachev S, Fijak M, Weidner W, Chakraborty T, Meinhardt A. Testicular innate immune defense against bacteria. Mol Cell Endocrinol. 2009; 306:37-44.
17. Riccioli A, Starace D, Galli R, Fuso A, Scarpa S, Palombi F, De Cesaris P, Ziparo E, Filippini A. Sertoli cells initiate testicular innate immune responses through TLR activation. J Immunol. 2006; 77:7122-7130.
18. Shiratsuchi A, Umeda M, Ohba Y, Nakanishi Y. Recognition of phosphatidylserine on the surface of apoptotic spermatogenic cells and subsequent phagocytosis by Sertoli cells of the rat. J Biol Chem. 1997; 272:2354-2358.
19. Shiratsuchi A, Kawasaki Y, Ikemoto M, Arai H, Nakanishi, Y. Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells. J Biol Chem. 1999; 274:5901-5908.
20. Kawasaki Y, Nakagawa A, Nagaosa K, Shiratsuchi A, Nakanishi, Y. Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular Sertoli cells. J Biol Chem. 2002; 277:27559-27566.
21. Areschoug T, Gordon S. Scavenger receptors: Role in innate immunity and microbial pathogenesis. Cell Microbiol. 2009; 11:1160-1169.
22. Baranova IN, Vishnyakova TG, Bocharov AV, Leelahavanichkul A, Kurlander R, Chen Z, Souza AC, Yuen PS, Star RA, Csako G, Patterson AP, Eggerman TL. Class B scavenger receptor types I and II and CD36 mediate bacterial recognition and proinflammatory signaling induced by Escherichia coli, lipopolysaccharide, and cytosolic chaperonin 60. J Immunol. 2012; 188:1371-1380.
23. Leelahavanichkul A, Bocharov AV, Kurlander R, et al. Class B scavenger receptor types I and II and CD36 targeting improves sepsis survival and acute outcomes in mice. J Immunol. 2012; 188:2749-2758.
24. Philips JA, Rubin EJ, Perrimon N. Drosophila RNAi screen reveals CD36 family member required for mycrobacterial infection. Science. 2005; 309:1251-1253.
25. Rämet M, Pearson A, Manfruelli P, Li X, Koziel H, Guöbel V, Chung E, Krieger M, Ezekowitz RAB. Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria. Immunity. 2001; 15:1027-1038.
26. Stuart LM, Deng J, Silver JM, Takahashi K, Tseng AA, Hennessy EJ, Ezekowitz RAB, Moore KJ. Response to Staphylococcus aureus required CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol. 2005; 170:477-485.
27. Nakagawa A, Nagaosa K, Hirose T, Tsuda K, Hasegawa K, Shiratsuchi A, Nakanishi Y. Expression and function of class B scavenger receptor type I on both apical and basolateral sides of the plasma membrane of polarized testicular Sertoli cells of the rat. Develop Growth Differ. 2004; 46:283-298.
28. Shiratsuchi A, Nakanishi Y. Phosphatidylserine-mediated phagocytosis of anticancer drug-treated cells by macrophages. J Biochem. 1999; 26:1101-1106.
29. Watanabe I, Ichiki M, Shiratsuchi A, Nakankshi Y. TLR2-mediated survival of Staphylococcus aureus in macrophages: A novel bacterial strategy against host innate immunity. J Immunol. 2007; 178:4917-4925.
30. Zhou CX, Zhang YL, Xiao L, Zheng M, Leung KM, Chan MY, Lo PS, Tsang LL, Wong HY, Ho LS, Chung YW, Chan HC. An epididymis-specific b-defensin is important for the initiation of sperm maturation. Nat Cell Biol. 2004; 6:458-464.
31. Maeda Y, Shiratsuchi A, Namiki M, Nakanishi Y Inhibition of sperm production in mice by annexin V microinjected into seminiferous tubules: Possible etiology of phagocytic clearance of apoptotic spermatogenic cells and male infertility. Cell Death Differ. 2002; 9:742-749.
32. Nakagawa A, Shiratsuchi A, Nakanishi Y. In vivo analysis of phagocytosis of apoptotic cells by testicular Sertoli cells. Mol Reprod Dev. 2005; 71:166-177.
33. Fijak M, Meinhardt A. The testis in immune privilege. Immunol Rev. 2006; 213:66-81.