-
1
-
-
0004244867
-
-
2nd edn. London: Academic Press
-
Barclay AN, Brown MH, Law SKA, McKnight AJ, Tomlinson MG, van der Merwe PA. The Leukocyte Antigen Factsbook. 2nd edn. London: Academic Press, 1997.
-
(1997)
The Leukocyte Antigen Factsbook
-
-
Barclay, A.N.1
Brown, M.H.2
Law, S.K.A.3
McKnight, A.J.4
Tomlinson, M.G.5
van der Merwe, P.A.6
-
2
-
-
0042932789
-
The T cell surface - how well do we know it?
-
Evans EJ, et al. The T cell surface - how well do we know it? Immunity 2003;19:213-223.
-
(2003)
Immunity
, vol.19
, pp. 213-223
-
-
Evans, E.J.1
-
3
-
-
0025182959
-
Adhesion receptors of the immune system
-
Springer TA. Adhesion receptors of the immune system. Nature 1990;346:425-434.
-
(1990)
Nature
, vol.346
, pp. 425-434
-
-
Springer, T.A.1
-
4
-
-
44349161113
-
A mechanism for Src kinase-dependent signaling by noncatalytic receptors
-
Cooper JA, Qian H. A mechanism for Src kinase-dependent signaling by noncatalytic receptors. Biochemistry 2008;47:5681-5688.
-
(2008)
Biochemistry
, vol.47
, pp. 5681-5688
-
-
Cooper, J.A.1
Qian, H.2
-
5
-
-
77952887713
-
The SYK tyrosine kinase: a crucial player in diverse biological functions
-
Mócsai A, Ruland J, Tybulewicz VLJ. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol 2010;10:387-402.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 387-402
-
-
Mócsai, A.1
Ruland, J.2
Tybulewicz, V.L.J.3
-
6
-
-
44649088312
-
Paired receptor systems of the innate immune system
-
Chapter 1: Appendix 1X.
-
Yamada E, et al. Paired receptor systems of the innate immune system. Curr Protoc Immunol 2008;81:A.1X.1-A.1X.25. Chapter 1: Appendix 1X.
-
(2008)
Curr Protoc Immunol
, vol.81
-
-
Yamada, E.1
-
7
-
-
58049200736
-
DAP10- and DAP12-associated receptors in innate immunity
-
Lanier LL. DAP10- and DAP12-associated receptors in innate immunity. Immunol Rev 2008;227:150-160.
-
(2008)
Immunol Rev
, vol.227
, pp. 150-160
-
-
Lanier, L.L.1
-
8
-
-
33947173844
-
Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling
-
Kuhns MS, Davis MM. Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling. Immunity 2007;26:357-369.
-
(2007)
Immunity
, vol.26
, pp. 357-369
-
-
Kuhns, M.S.1
Davis, M.M.2
-
9
-
-
77955501085
-
Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor
-
Radaev S, et al. Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor. Structure 2010;18:934-943.
-
(2010)
Structure
, vol.18
, pp. 934-943
-
-
Radaev, S.1
-
10
-
-
35548988341
-
Common themes in the assembly and architecture of activating immune receptors
-
Call ME, Wucherpfennig KW. Common themes in the assembly and architecture of activating immune receptors. Nat Rev Immunol 2007;7:841-850.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 841-850
-
-
Call, M.E.1
Wucherpfennig, K.W.2
-
11
-
-
84857040883
-
Role of ITAM signaling module in signal integration
-
Bezbradica JS, Medzhitov R. Role of ITAM signaling module in signal integration. Curr Opin Immunol 2012;24:58-66.
-
(2012)
Curr Opin Immunol
, vol.24
, pp. 58-66
-
-
Bezbradica, J.S.1
Medzhitov, R.2
-
12
-
-
79956292569
-
Myeloid C-type lectin receptors in pathogen recognition and host defense
-
Osorio F, Reis e Sousa C. Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity 2011;34:651-664.
-
(2011)
Immunity
, vol.34
, pp. 651-664
-
-
Osorio, F.1
Reis e Sousa, C.2
-
13
-
-
1242269763
-
Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells
-
Xie Q, et al. Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells. DNA Cell Biol 2004;23:111-117.
-
(2004)
DNA Cell Biol
, vol.23
, pp. 111-117
-
-
Xie, Q.1
-
14
-
-
77951062027
-
CLEC-2 activates Syk through dimerization
-
Hughes CE, et al. CLEC-2 activates Syk through dimerization. Blood 2010;115:2947-2955.
-
(2010)
Blood
, vol.115
, pp. 2947-2955
-
-
Hughes, C.E.1
-
15
-
-
84859993076
-
The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments
-
Zhang J-G, et al. The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity 2012;36:646-657.
-
(2012)
Immunity
, vol.36
, pp. 646-657
-
-
Zhang, J.-G.1
-
16
-
-
79251564072
-
Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity
-
Dennehy KM, Klimosch SN, Steinle A. Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity. J Immunol 2011;186:657-661.
-
(2011)
J Immunol
, vol.186
, pp. 657-661
-
-
Dennehy, K.M.1
Klimosch, S.N.2
Steinle, A.3
-
18
-
-
70350367120
-
Importance and mechanism of "switch" function of SAP family adapters
-
Veillette A, Dong Z, Pérez-Quintero L-A, Zhong M-C, Cruz-Munoz M-E. Importance and mechanism of "switch" function of SAP family adapters. Immunol Rev 2009;232:229-239.
-
(2009)
Immunol Rev
, vol.232
, pp. 229-239
-
-
Veillette, A.1
Dong, Z.2
Pérez-Quintero, L.-A.3
Zhong, M.-C.4
Cruz-Munoz, M.-E.5
-
20
-
-
84862983486
-
SAP signaling: a dual mechanism of action
-
Le Borgne M, Shaw AS. SAP signaling: a dual mechanism of action. Immunity 2012;36:899-901.
-
(2012)
Immunity
, vol.36
, pp. 899-901
-
-
Le Borgne, M.1
Shaw, A.S.2
-
21
-
-
77951529848
-
Therapeutic antibodies for autoimmunity and inflammation
-
Chan AC, Carter PJ. Therapeutic antibodies for autoimmunity and inflammation. Nat Rev Immunol 2010;10:301-316.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 301-316
-
-
Chan, A.C.1
Carter, P.J.2
-
22
-
-
84863736362
-
Immunology: actin' dangerously
-
Brown GD. Immunology: actin' dangerously. Nature 2012;485:589-590.
-
(2012)
Nature
, vol.485
, pp. 589-590
-
-
Brown, G.D.1
-
23
-
-
77953896432
-
Cell signaling by receptor tyrosine kinases
-
Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2010;141:1117-1134.
-
(2010)
Cell
, vol.141
, pp. 1117-1134
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
24
-
-
0032863261
-
The Janus kinase family of protein tyrosine kinases and their role in signaling
-
Yeh TC, Pellegrini S. The Janus kinase family of protein tyrosine kinases and their role in signaling. Cell Mol Life Sci 1999;55:1523-1534.
-
(1999)
Cell Mol Life Sci
, vol.55
, pp. 1523-1534
-
-
Yeh, T.C.1
Pellegrini, S.2
-
25
-
-
34247891506
-
Structural basis of integrin regulation and signaling
-
Luo B-H, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu Rev Immunol 2007;25:619-647.
-
(2007)
Annu Rev Immunol
, vol.25
, pp. 619-647
-
-
Luo, B.-H.1
Carman, C.V.2
Springer, T.A.3
-
26
-
-
79957621253
-
The insider's guide to leukocyte integrin signaling and function
-
Hogg N, Patzak I, Willenbrock F. The insider's guide to leukocyte integrin signaling and function. Nat Rev Immunol 2011;11:416-426.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 416-426
-
-
Hogg, N.1
Patzak, I.2
Willenbrock, F.3
-
27
-
-
33749057463
-
An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway
-
Vatinel S, et al. An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway. Biochim Biophys Acta 2006;1763:1098-1107.
-
(2006)
Biochim Biophys Acta
, vol.1763
, pp. 1098-1107
-
-
Vatinel, S.1
-
28
-
-
72749110288
-
Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis
-
El Firar A, Voisin T, Rouyer-Fessard C, Ostuni MA, Couvineau A, Laburthe M. Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis. FASEB J 2009;23:4069-4080.
-
(2009)
FASEB J
, vol.23
, pp. 4069-4080
-
-
El Firar, A.1
Voisin, T.2
Rouyer-Fessard, C.3
Ostuni, M.A.4
Couvineau, A.5
Laburthe, M.6
-
29
-
-
77953911933
-
Constitutively active Lck kinase in T cells drives antigen receptor signal transduction
-
Nika K, et al. Constitutively active Lck kinase in T cells drives antigen receptor signal transduction. Immunity 2010;32:766-777.
-
(2010)
Immunity
, vol.32
, pp. 766-777
-
-
Nika, K.1
-
30
-
-
3042615397
-
Src-family kinases: rheostats of immune cell signaling
-
Lowell CA. Src-family kinases: rheostats of immune cell signaling. Mol Immunol 2004;41:631-643.
-
(2004)
Mol Immunol
, vol.41
, pp. 631-643
-
-
Lowell, C.A.1
-
31
-
-
38349014380
-
Src family kinases: regulation of their activities, levels and identification of new pathways
-
Ingley E. Src family kinases: regulation of their activities, levels and identification of new pathways. Biochim Biophys Acta 2008;1784:56-65.
-
(2008)
Biochim Biophys Acta
, vol.1784
, pp. 56-65
-
-
Ingley, E.1
-
32
-
-
0041976988
-
The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
-
Lin J, Weiss A. The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J Cell Biol 2003;162:673-682.
-
(2003)
J Cell Biol
, vol.162
, pp. 673-682
-
-
Lin, J.1
Weiss, A.2
-
33
-
-
34548683241
-
Why is there so much CD45 on T cells?
-
Zamoyska R. Why is there so much CD45 on T cells? Immunity 2007;27:421-423.
-
(2007)
Immunity
, vol.27
, pp. 421-423
-
-
Zamoyska, R.1
-
34
-
-
61849136595
-
CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
-
Hermiston ML, Zikherman J, Zhu JW. CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Immunol Rev 2009;228:288-311.
-
(2009)
Immunol Rev
, vol.228
, pp. 288-311
-
-
Hermiston, M.L.1
Zikherman, J.2
Zhu, J.W.3
-
35
-
-
79959358205
-
Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148
-
Stepanek O, et al. Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148. J Biol Chem 2011;286:22101-22112.
-
(2011)
J Biol Chem
, vol.286
, pp. 22101-22112
-
-
Stepanek, O.1
-
36
-
-
44049086837
-
SRC family kinases and receptors: analysis of three activation mechanisms by dynamic systems modeling
-
Fuß H, Dubitzky W, Downes CS, Kurth MJ. SRC family kinases and receptors: analysis of three activation mechanisms by dynamic systems modeling. Biophys J 2008;94:1995-2006.
-
(2008)
Biophys J
, vol.94
, pp. 1995-2006
-
-
Fuß, H.1
Dubitzky, W.2
Downes, C.S.3
Kurth, M.J.4
-
37
-
-
0038815306
-
CD45: a critical regulator of signaling thresholds in immune cells
-
Hermiston ML, Xu Z, Weiss A. CD45: a critical regulator of signaling thresholds in immune cells. Annu Rev Immunol 2003;21:107-137.
-
(2003)
Annu Rev Immunol
, vol.21
, pp. 107-137
-
-
Hermiston, M.L.1
Xu, Z.2
Weiss, A.3
-
38
-
-
58249138122
-
Large-scale structural analysis of the classical human protein tyrosine phosphatome
-
Barr AJ, et al. Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell 2009;136:352-363.
-
(2009)
Cell
, vol.136
, pp. 352-363
-
-
Barr, A.J.1
-
39
-
-
84858759719
-
Mechanical modulation of receptor-ligand interactions at cell-cell interfaces
-
Allard JF, Dushek O, Coombs D, van der Merwe PA. Mechanical modulation of receptor-ligand interactions at cell-cell interfaces. Biophys J 2012;102:1265-1273.
-
(2012)
Biophys J
, vol.102
, pp. 1265-1273
-
-
Allard, J.F.1
Dushek, O.2
Coombs, D.3
van der Merwe, P.A.4
-
41
-
-
0036789459
-
Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse
-
Burroughs NJ, Wulfing C. Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse. Biophys J 2002;83:1784-1796.
-
(2002)
Biophys J
, vol.83
, pp. 1784-1796
-
-
Burroughs, N.J.1
Wulfing, C.2
-
42
-
-
10044247245
-
Pattern formation during T-cell adhesion
-
Weikl TR, Lipowsky R. Pattern formation during T-cell adhesion. Biophys J 2004;87:3665-3678.
-
(2004)
Biophys J
, vol.87
, pp. 3665-3678
-
-
Weikl, T.R.1
Lipowsky, R.2
-
43
-
-
1542375362
-
Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs
-
Coombs D, Dembo M, Wofsy C, Goldstein B. Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs. Biophys J 2004;86:1408-1423.
-
(2004)
Biophys J
, vol.86
, pp. 1408-1423
-
-
Coombs, D.1
Dembo, M.2
Wofsy, C.3
Goldstein, B.4
-
44
-
-
84856020544
-
Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands
-
Robert P, Aleksic M, Dushek O, Cerundolo V, Bongrand P, van der Merwe PA. Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands. Biophys J 2012;102:248-257.
-
(2012)
Biophys J
, vol.102
, pp. 248-257
-
-
Robert, P.1
Aleksic, M.2
Dushek, O.3
Cerundolo, V.4
Bongrand, P.5
van der Merwe, P.A.6
-
45
-
-
0030061494
-
Visualization of the CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area
-
Dustin ML, Ferguson L, Chan P, Springer T, Golan DE. Visualization of the CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area. J Cell Biol 1996;132:465-474.
-
(1996)
J Cell Biol
, vol.132
, pp. 465-474
-
-
Dustin, M.L.1
Ferguson, L.2
Chan, P.3
Springer, T.4
Golan, D.E.5
-
46
-
-
33846818557
-
Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules
-
Zhu D-M, Dustin ML, Cairo CW, Golan DE. Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules. Biophys J 2007;92:1022-1034.
-
(2007)
Biophys J
, vol.92
, pp. 1022-1034
-
-
Zhu, D.-M.1
Dustin, M.L.2
Cairo, C.W.3
Golan, D.E.4
-
47
-
-
47749135219
-
Measuring diffusion and binding kinetics by contact area FRAP
-
Tolentino TP, Wu J, Zarnitsyna VI, Fang Y, Dustin ML, Zhu C. Measuring diffusion and binding kinetics by contact area FRAP. Biophys J 2008;95:920-930.
-
(2008)
Biophys J
, vol.95
, pp. 920-930
-
-
Tolentino, T.P.1
Wu, J.2
Zarnitsyna, V.I.3
Fang, Y.4
Dustin, M.L.5
Zhu, C.6
-
48
-
-
77249114784
-
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity
-
Huppa JB, et al. TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature 2010;463:963-967.
-
(2010)
Nature
, vol.463
, pp. 963-967
-
-
Huppa, J.B.1
-
49
-
-
77950809538
-
The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness
-
Huang J, et al. The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness. Nature 2010;464:932-936.
-
(2010)
Nature
, vol.464
, pp. 932-936
-
-
Huang, J.1
-
50
-
-
73449105773
-
A role for rebinding in rapid and reliable T cell responses to antigen
-
Dushek O, Das R, Coombs D. A role for rebinding in rapid and reliable T cell responses to antigen. PLoS Comput Biol 2009;5:e1000578.
-
(2009)
PLoS Comput Biol
, vol.5
-
-
Dushek, O.1
Das, R.2
Coombs, D.3
-
51
-
-
76949085272
-
Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time
-
Aleksic M, et al. Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time. Immunity 2010;32:163-174.
-
(2010)
Immunity
, vol.32
, pp. 163-174
-
-
Aleksic, M.1
-
53
-
-
79958213129
-
Antigen potency and maximal efficacy reveal a mechanism of efficient T Cell activation
-
Dushek O, et al. Antigen potency and maximal efficacy reveal a mechanism of efficient T Cell activation. Sci Signal 2011;4:ra39-ra39.
-
(2011)
Sci Signal
, vol.4
-
-
Dushek, O.1
-
54
-
-
0001424903
-
An amplified sensitivity arising from covalent modification in biological systems
-
Goldbeter A, Koshland DE. An amplified sensitivity arising from covalent modification in biological systems. Proc Natl Acad Sci USA 1981;78:6840-6844.
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 6840-6844
-
-
Goldbeter, A.1
Koshland, D.E.2
-
55
-
-
79953897645
-
Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins
-
Dushek O, van der Merwe PA, Shahrezaei V. Ultrasensitivity in multisite phosphorylation of membrane-anchored proteins. Biophys J 2011;100:1189-1197.
-
(2011)
Biophys J
, vol.100
, pp. 1189-1197
-
-
Dushek, O.1
van der Merwe, P.A.2
Shahrezaei, V.3
-
56
-
-
26844571282
-
Multisite protein phosphorylation makes a good threshold but can be a poor switch
-
Gunawardena J. Multisite protein phosphorylation makes a good threshold but can be a poor switch. Proc Natl Acad Sci USA 2005;102:14617-14622.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 14617-14622
-
-
Gunawardena, J.1
-
57
-
-
67650360968
-
Unlimited multistability in multisite phosphorylation systems
-
Thomson M, Gunawardena J. Unlimited multistability in multisite phosphorylation systems. Nature 2009;460:274-277.
-
(2009)
Nature
, vol.460
, pp. 274-277
-
-
Thomson, M.1
Gunawardena, J.2
-
58
-
-
66249102308
-
Multisite protein phosphorylation - from molecular mechanisms to kinetic models
-
Salazar C, Höfer T. Multisite protein phosphorylation - from molecular mechanisms to kinetic models. FEBS J 2009;276:3177-3198.
-
(2009)
FEBS J
, vol.276
, pp. 3177-3198
-
-
Salazar, C.1
Höfer, T.2
-
59
-
-
78650599246
-
Mechanisms for T cell receptor triggering
-
van der Merwe PA, Dushek O. Mechanisms for T cell receptor triggering. Nat Rev Immunol 2011;11:47-55.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 47-55
-
-
van der Merwe, P.A.1
Dushek, O.2
-
60
-
-
78049287668
-
The tipping points in the initiation of B cell signaling: how small changes make big differences
-
Pierce SK, Liu W. The tipping points in the initiation of B cell signaling: how small changes make big differences. Nat Rev Immunol 2010;10:767-777.
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 767-777
-
-
Pierce, S.K.1
Liu, W.2
-
61
-
-
0036795530
-
Activated TCRs remain marked for internalization after dissociation from pMHC
-
Coombs D, Kalergis AM, Nathenson SG, Wofsy C, Goldstein B. Activated TCRs remain marked for internalization after dissociation from pMHC. Nat Immunol 2002;3:926-931.
-
(2002)
Nat Immunol
, vol.3
, pp. 926-931
-
-
Coombs, D.1
Kalergis, A.M.2
Nathenson, S.G.3
Wofsy, C.4
Goldstein, B.5
-
62
-
-
27844541328
-
Modeling T cell antigen discrimination based on feedback control of digital ERK responses
-
Altan-Bonnet G, Germain R. Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol 2005;3:e356.
-
(2005)
PLoS Biol
, vol.3
-
-
Altan-Bonnet, G.1
Germain, R.2
-
63
-
-
43649103144
-
Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters
-
Dushek O, Coombs D. Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters. Biophys J 2008;94:3447--3460.
-
(2008)
Biophys J
, vol.94
, pp. 3447-3460
-
-
Dushek, O.1
Coombs, D.2
-
64
-
-
58249092059
-
Digital signaling and hysteresis characterize Ras activation in lymphoid cells
-
Das J, et al. Digital signaling and hysteresis characterize Ras activation in lymphoid cells. Cell 2009;136:337-351.
-
(2009)
Cell
, vol.136
, pp. 337-351
-
-
Das, J.1
-
65
-
-
0033762433
-
Phosphorylation of T cell receptor ζ is regulated by a lipid dependent folding transition
-
Aivazian D, Stern LJ. Phosphorylation of T cell receptor ζ is regulated by a lipid dependent folding transition. Nat Struct Biol 2000;7:1023-1026.
-
(2000)
Nat Struct Biol
, vol.7
, pp. 1023-1026
-
-
Aivazian, D.1
Stern, L.J.2
-
66
-
-
55449138409
-
Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif
-
Xu C, et al. Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell 2008;135:702-713.
-
(2008)
Cell
, vol.135
, pp. 702-713
-
-
Xu, C.1
-
67
-
-
77956167214
-
What controls T cell receptor phosphorylation?
-
Fernandes RA, Yu C, Carmo AM, Evans EJ, van der Merwe PA, Davis SJ. What controls T cell receptor phosphorylation? Cell 2010;142:668-669.
-
(2010)
Cell
, vol.142
, pp. 668-669
-
-
Fernandes, R.A.1
Yu, C.2
Carmo, A.M.3
Evans, E.J.4
van der Merwe, P.A.5
Davis, S.J.6
-
68
-
-
82755165363
-
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
-
Zhang H, Cordoba S-P, Dushek O, van der Merwe AP. Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling. Proc Nat Acad Sci USA 2011;108:19323-19328.
-
(2011)
Proc Nat Acad Sci USA
, vol.108
, pp. 19323-19328
-
-
Zhang, H.1
Cordoba, S.-P.2
Dushek, O.3
van der Merwe, A.P.4
-
69
-
-
84867435523
-
Mechanical force in T cell receptor signal initiation
-
Ma Z, Discher DE, Finkel TH. Mechanical force in T cell receptor signal initiation. Front Immunol 2012;3:217.
-
(2012)
Front Immunol
, vol.3
, pp. 217
-
-
Ma, Z.1
Discher, D.E.2
Finkel, T.H.3
-
70
-
-
0344585437
-
Lipid rafts: elusive or illusive?
-
Munro S. Lipid rafts: elusive or illusive? Cell 2003;115:377-388.
-
(2003)
Cell
, vol.115
, pp. 377-388
-
-
Munro, S.1
-
71
-
-
77957167810
-
Revitalizing membrane rafts: new tools and insights
-
Simons K, Gerl MJ. Revitalizing membrane rafts: new tools and insights. Nat Rev Mol Cell Biol 2010;11:688-699.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 688-699
-
-
Simons, K.1
Gerl, M.J.2
-
72
-
-
34548012864
-
Plasma membrane segregation during T cell activation: probing the order of domains
-
Harder T, Rentero C, Zech T, Gaus K. Plasma membrane segregation during T cell activation: probing the order of domains. Curr Opin Immunol 2007;19:470-475.
-
(2007)
Curr Opin Immunol
, vol.19
, pp. 470-475
-
-
Harder, T.1
Rentero, C.2
Zech, T.3
Gaus, K.4
-
73
-
-
74849118341
-
Lipid rafts as a membrane-organizing principle
-
Lingwood D, Simons K. Lipid rafts as a membrane-organizing principle. Science 2009;327:46-50.
-
(2009)
Science
, vol.327
, pp. 46-50
-
-
Lingwood, D.1
Simons, K.2
-
74
-
-
77954380512
-
T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering
-
Hashimoto-Tane A, Yokosuka T, Ishihara C, Sakuma M, Kobayashi W, Saito T. T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering. Mol Cell Biol 2010;30:3421-3429.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 3421-3429
-
-
Hashimoto-Tane, A.1
Yokosuka, T.2
Ishihara, C.3
Sakuma, M.4
Kobayashi, W.5
Saito, T.6
-
75
-
-
61349094652
-
Direct observation of the nanoscale dynamics of membrane lipids in a living cell
-
Eggeling C, et al. Direct observation of the nanoscale dynamics of membrane lipids in a living cell. Nature 2009;457:1159-1162.
-
(2009)
Nature
, vol.457
, pp. 1159-1162
-
-
Eggeling, C.1
-
76
-
-
0029930984
-
The structure and ligand interactions of CD2: implications for T-cell function
-
Davis SJ, van der Merwe PA. The structure and ligand interactions of CD2: implications for T-cell function. Immunol Today 1996;17:177-187.
-
(1996)
Immunol Today
, vol.17
, pp. 177-187
-
-
Davis, S.J.1
van der Merwe, P.A.2
-
77
-
-
0034005120
-
Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition
-
van der Merwe PA, Davis SJ, Shaw AS, Dustin ML. Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition. Semin Immunol 2000;12:5-21.
-
(2000)
Semin Immunol
, vol.12
, pp. 5-21
-
-
van der Merwe, P.A.1
Davis, S.J.2
Shaw, A.S.3
Dustin, M.L.4
-
78
-
-
33746114879
-
The kinetic-segregation model: TCR triggering and beyond
-
Davis SJ, van der Merwe PA. The kinetic-segregation model: TCR triggering and beyond. Nat Immunol 2006;7:803-809.
-
(2006)
Nat Immunol
, vol.7
, pp. 803-809
-
-
Davis, S.J.1
van der Merwe, P.A.2
-
79
-
-
33746153912
-
Ligand detection and discrimination by spatial relocalization: a kinase-phosphatase segregation model of TCR activation
-
Burroughs NJ, Lazic Z, van der Merwe PA. Ligand detection and discrimination by spatial relocalization: a kinase-phosphatase segregation model of TCR activation. Biophys J 2006;91:1619-1629.
-
(2006)
Biophys J
, vol.91
, pp. 1619-1629
-
-
Burroughs, N.J.1
Lazic, Z.2
van der Merwe, P.A.3
-
80
-
-
0037144842
-
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
-
Bunnell SC, et al. T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol 2002;158:1263-1275.
-
(2002)
J Cell Biol
, vol.158
, pp. 1263-1275
-
-
Bunnell, S.C.1
-
81
-
-
33746011209
-
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
-
Varma R, Campi G, Yokosuka T, Saito T, Dustin ML. T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 2006;25:117-127.
-
(2006)
Immunity
, vol.25
, pp. 117-127
-
-
Varma, R.1
Campi, G.2
Yokosuka, T.3
Saito, T.4
Dustin, M.L.5
-
82
-
-
84863482471
-
Biophysical mechanism of T-cell receptor triggering in a reconstituted system
-
James JR, Vale RD. Biophysical mechanism of T-cell receptor triggering in a reconstituted system. Nature 2012;487:64-69.
-
(2012)
Nature
, vol.487
, pp. 64-69
-
-
James, J.R.1
Vale, R.D.2
-
83
-
-
0034730188
-
A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation
-
Johnson KG, Bromley SK, Dustin ML, Thomas ML. A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. Proc Natl Acad Sci USA 2000;97:10138-10143.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10138-10143
-
-
Johnson, K.G.1
Bromley, S.K.2
Dustin, M.L.3
Thomas, M.L.4
-
84
-
-
0034624809
-
Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes
-
Leupin O, Zaru R, Laroche T, Muller S, Valitutti S. Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes. Curr Biol 2000;10:277-280.
-
(2000)
Curr Biol
, vol.10
, pp. 277-280
-
-
Leupin, O.1
Zaru, R.2
Laroche, T.3
Muller, S.4
Valitutti, S.5
-
85
-
-
0036737124
-
Targeting of CD45 protein tyrosine phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling
-
He X, Woodford-Thomas TA, Johnson KG, Shah DD, Thomas ML. Targeting of CD45 protein tyrosine phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling. Eur J Immunol 2002;32:2578-2587.
-
(2002)
Eur J Immunol
, vol.32
, pp. 2578-2587
-
-
He, X.1
Woodford-Thomas, T.A.2
Johnson, K.G.3
Shah, D.D.4
Thomas, M.L.5
-
86
-
-
0037318863
-
CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling
-
Irles C, Symons A, Michel F, Bakker TR, van der Merwe PA, Acuto O. CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling. Nat Immunol 2003;4:189-197.
-
(2003)
Nat Immunol
, vol.4
, pp. 189-197
-
-
Irles, C.1
Symons, A.2
Michel, F.3
Bakker, T.R.4
van der Merwe, P.A.5
Acuto, O.6
-
87
-
-
23144455728
-
T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand
-
Choudhuri K, Wiseman D, Brown MH, Gould K, van der Merwe PA. T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand. Nature 2005;436:578-582.
-
(2005)
Nature
, vol.436
, pp. 578-582
-
-
Choudhuri, K.1
Wiseman, D.2
Brown, M.H.3
Gould, K.4
van der Merwe, P.A.5
-
88
-
-
70350035998
-
Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation
-
Choudhuri K, et al. Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation. J Biol Chem 2009;284:26096-26105.
-
(2009)
J Biol Chem
, vol.284
, pp. 26096-26105
-
-
Choudhuri, K.1
-
89
-
-
45549093089
-
Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane
-
James SE, et al. Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane. J Immunol 2008;180:7028-7038.
-
(2008)
J Immunol
, vol.180
, pp. 7028-7038
-
-
James, S.E.1
-
90
-
-
33947633597
-
T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells
-
Hombach AA, Schildgen V, Heuser C, Finnern R, Gilham DE, Abken H. T cell activation by antibody-like immunoreceptors: the position of the binding epitope within the target molecule determines the efficiency of activation of redirected T cells. J Immunol 2007;178:4650-4657.
-
(2007)
J Immunol
, vol.178
, pp. 4650-4657
-
-
Hombach, A.A.1
Schildgen, V.2
Heuser, C.3
Finnern, R.4
Gilham, D.E.5
Abken, H.6
-
91
-
-
84856291875
-
αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities
-
Tikhonova AN, et al αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities. Immunity 2012;36:79-91.
-
(2012)
Immunity
, vol.36
, pp. 79-91
-
-
Tikhonova, A.N.1
-
92
-
-
84862628815
-
Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be "preferentially" transported to the cSMAC
-
Xie J, et al. Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be "preferentially" transported to the cSMAC. Nat Immunol 2012;13:674-680.
-
(2012)
Nat Immunol
, vol.13
, pp. 674-680
-
-
Xie, J.1
-
93
-
-
77954112215
-
Ligand dimensions are important in controlling NK-cell responses
-
Brzostek J, et al. Ligand dimensions are important in controlling NK-cell responses. Eur J Immunol 2010;40:2050-2059.
-
(2010)
Eur J Immunol
, vol.40
, pp. 2050-2059
-
-
Brzostek, J.1
-
94
-
-
78149489327
-
Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells
-
Köhler K, et al. Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells. PLoS ONE 2010;5:e15374.
-
(2010)
PLoS ONE
, vol.5
-
-
Köhler, K.1
-
95
-
-
54949103906
-
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation
-
Yokosuka T, et al. Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity 2008;29:589-601.
-
(2008)
Immunity
, vol.29
, pp. 589-601
-
-
Yokosuka, T.1
-
96
-
-
77957099358
-
Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation
-
Yokosuka T, et al. Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation. Immunity 2010;33:326-339.
-
(2010)
Immunity
, vol.33
, pp. 326-339
-
-
Yokosuka, T.1
-
97
-
-
84864324543
-
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
-
Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, Hashimoto-Tane A, Azuma M, Saito T. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med 2012;209:1201-1217.
-
(2012)
J Exp Med
, vol.209
, pp. 1201-1217
-
-
Yokosuka, T.1
Takamatsu, M.2
Kobayashi-Imanishi, W.3
Hashimoto-Tane, A.4
Azuma, M.5
Saito, T.6
-
98
-
-
20144376352
-
Crystal structure of a soluble CD28-Fab complex
-
Evans EJ, et al. Crystal structure of a soluble CD28-Fab complex. Nat Immunol 2005;6:271-279.
-
(2005)
Nat Immunol
, vol.6
, pp. 271-279
-
-
Evans, E.J.1
-
99
-
-
33244497571
-
Dectin-1: a signaling non-TLR pattern-recognition receptor
-
Brown GD. Dectin-1: a signaling non-TLR pattern-recognition receptor. Nat Rev Immunol 2006;6:33-43.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 33-43
-
-
Brown, G.D.1
-
100
-
-
79955537225
-
Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'
-
Goodridge HS, et al. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature 2011;472:471-475.
-
(2011)
Nature
, vol.472
, pp. 471-475
-
-
Goodridge, H.S.1
-
101
-
-
0037044326
-
Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48
-
Zhu B, Davies EA, van der Merwe PA, Calvert T, Leckband DE. Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48. Biochemistry 2002;41:12163-12170.
-
(2002)
Biochemistry
, vol.41
, pp. 12163-12170
-
-
Zhu, B.1
Davies, E.A.2
van der Merwe, P.A.3
Calvert, T.4
Leckband, D.E.5
-
102
-
-
34247158241
-
Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58
-
Bayas MV, Kearney A, Avramovic A, van der Merwe PA, Leckband DE. Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58. J Biol Chem 2007;282:5589-5596.
-
(2007)
J Biol Chem
, vol.282
, pp. 5589-5596
-
-
Bayas, M.V.1
Kearney, A.2
Avramovic, A.3
van der Merwe, P.A.4
Leckband, D.E.5
-
103
-
-
84867414653
-
Elementary steps in T cell receptor triggering
-
Dushek O. Elementary steps in T cell receptor triggering. Front Immunol 2011;2:91.
-
(2011)
Front Immunol
, vol.2
, pp. 91
-
-
Dushek, O.1
|