메뉴 건너뛰기




Volumn 212, Issue 5, 2016, Pages 545-560

Elevated p62/SQS TM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 16L1; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; PROTEIN; PROTEIN P62; SEQUESTOME 1 PROTEIN; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; HEAT SHOCK PROTEIN; SEQUESTOSOME 1; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, MOUSE;

EID: 84960389624     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201507023     Document Type: Article
Times cited : (48)

References (65)
  • 1
    • 3242715114 scopus 로고    scopus 로고
    • Reactive oxygen species: metabolism, oxidative stress, and signal transduction
    • Apel, K., and H. Hirt. 2004. Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Annu. Rev. Plant Biol. 55:373-399. http://dx.doi.org/10.1146/annurev.arplant.55.031903.141701
    • (2004) Annu. Rev. Plant Biol. , vol.55 , pp. 373-399
    • Apel, K.1    Hirt, H.2
  • 2
    • 27944504351 scopus 로고    scopus 로고
    • p62/SQS TM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjørkøy, G., T. Lamark, A. Brech, H. Outzen, M. Perander, A. Overvatn, H. Stenmark, and T. Johansen. 2005. p62/SQS TM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 171:603-614. http://dx.doi.org/10.1083/jcb.200507002
    • (2005) J. Cell Biol. , vol.171 , pp. 603-614
    • Bjørkøy, G.1    Lamark, T.2    Brech, A.3    Outzen, H.4    Perander, M.5    Overvatn, A.6    Stenmark, H.7    Johansen, T.8
  • 3
    • 84880376355 scopus 로고    scopus 로고
    • Emerging regulation and functions of autophagy
    • Boya, P., F. Reggiori, and P. Codogno. 2013. Emerging regulation and functions of autophagy. Nat. Cell Biol. 15:713-720. http://dx.doi.org/10.1038/ncb2788
    • (2013) Nat. Cell Biol. , vol.15 , pp. 713-720
    • Boya, P.1    Reggiori, F.2    Codogno, P.3
  • 5
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Dröge, W. 2002. Free radicals in the physiological control of cell function. Physiol. Rev. 82:47-95. http://dx.doi.org/10.1152/physrev.00018.2001
    • (2002) Physiol. Rev. , vol.82 , pp. 47-95
    • Dröge, W.1
  • 6
    • 58149290220 scopus 로고    scopus 로고
    • An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure
    • Fujita, N., M. Hayashi-Nishino, H. Fukumoto, H. Omori, A. Yamamoto, T. Noda, and T. Yoshimori. 2008. An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol. Biol. Cell. 19:4651-4659. http://dx.doi.org/10.1091/mbc.E08-03-0312
    • (2008) Mol. Biol. Cell. , vol.19 , pp. 4651-4659
    • Fujita, N.1    Hayashi-Nishino, M.2    Fukumoto, H.3    Omori, H.4    Yamamoto, A.5    Noda, T.6    Yoshimori, T.7
  • 7
    • 39749119904 scopus 로고    scopus 로고
    • FIP200, a key signaling node to coordinately regulate various cellular processes
    • Gan, B., and J.L. Guan. 2008. FIP200, a key signaling node to coordinately regulate various cellular processes. Cell. Signal. 20:787-794. http://dx.doi.org/10.1016/j.cellsig.2007.10.021
    • (2008) Cell. Signal. , vol.20 , pp. 787-794
    • Gan, B.1    Guan, J.L.2
  • 8
    • 33749562122 scopus 로고    scopus 로고
    • Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways
    • Gan, B., X. Peng, T. Nagy, A. Alcaraz, H. Gu, and J.L. Guan. 2006. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J. Cell Biol. 175:121-133. http://dx.doi.org/10.1083/jcb.200604129
    • (2006) J. Cell Biol. , vol.175 , pp. 121-133
    • Gan, B.1    Peng, X.2    Nagy, T.3    Alcaraz, A.4    Gu, H.5    Guan, J.L.6
  • 11
    • 43149090064 scopus 로고    scopus 로고
    • FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
    • Hara, T., A. Takamura, C. Kishi, S. Iemura, T. Natsume, J.L. Guan, and N. Mizushima. 2008. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J. Cell Biol. 181:497-510. http://dx.doi.org/10.1083/jcb.200712064
    • (2008) J. Cell Biol. , vol.181 , pp. 497-510
    • Hara, T.1    Takamura, A.2    Kishi, C.3    Iemura, S.4    Natsume, T.5    Guan, J.L.6    Mizushima, N.7
  • 12
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He, C., and D.J. Klionsky. 2009. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 43:67-93. http://dx.doi.org/10.1146/annurev-genet-102808-114910
    • (2009) Annu. Rev. Genet. , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 13
    • 0035500460 scopus 로고    scopus 로고
    • Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice
    • Huang, T.T., E.J. Carlson, H.M. Kozy, S. Mantha, S.I. Goodman, P.C. Ursell, and C.J. Epstein. 2001. Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice. Free Radic. Biol. Med. 31:1101-1110. http://dx.doi.org/10.1016/S0891-5849(01)00694-3
    • (2001) Free Radic. Biol. Med. , vol.31 , pp. 1101-1110
    • Huang, T.T.1    Carlson, E.J.2    Kozy, H.M.3    Mantha, S.4    Goodman, S.I.5    Ursell, P.C.6    Epstein, C.J.7
  • 14
    • 33645128441 scopus 로고    scopus 로고
    • Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase
    • Huang, T.T., M. Naeemuddin, S. Elchuri, M. Yamaguchi, H.M. Kozy, E.J. Carlson, and C.J. Epstein. 2006. Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase. Hum. Mol. Genet. 15:1187-1194. http://dx.doi.org/10.1093/hmg/ddl034
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1187-1194
    • Huang, T.T.1    Naeemuddin, M.2    Elchuri, S.3    Yamaguchi, M.4    Kozy, H.M.5    Carlson, E.J.6    Epstein, C.J.7
  • 16
    • 0035947221 scopus 로고    scopus 로고
    • Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model
    • Jung, C., Y. Rong, S. Doctrow, M. Baudry, B. Malfroy, and Z. Xu. 2001. Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model. Neurosci. Lett. 304:157-160. http://dx.doi.org/10.1016/S0304-3940(01)01784-0
    • (2001) Neurosci. Lett. , vol.304 , pp. 157-160
    • Jung, C.1    Rong, Y.2    Doctrow, S.3    Baudry, M.4    Malfroy, B.5    Xu, Z.6
  • 18
    • 84918827750 scopus 로고    scopus 로고
    • Cellular and metabolic functions for autophagy in cancer cells
    • Kenific, C.M., and J. Debnath. 2015. Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol. 25:37-45. http://dx.doi.org/10.1016/j.tcb.2014.09.001
    • (2015) Trends Cell Biol. , vol.25 , pp. 37-45
    • Kenific, C.M.1    Debnath, J.2
  • 20
    • 84907042842 scopus 로고    scopus 로고
    • Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells
    • Kishi-Itakura, C., I. Koyama-Honda, E. Itakura, and N. Mizushima. 2014. Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells. J. Cell Sci. 127:4089-4102. http://dx.doi.org/10.1242/jcs.156034
    • (2014) J. Cell Sci. , vol.127 , pp. 4089-4102
    • Kishi-Itakura, C.1    Koyama-Honda, I.2    Itakura, E.3    Mizushima, N.4
  • 23
    • 36849089101 scopus 로고    scopus 로고
    • Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
    • Komatsu, M., S. Waguri, M. Koike, Y.S. Sou, T. Ueno, T. Hara, N. Mizushima, J. Iwata, J. Ezaki, S. Murata, et al. 2007a. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell. 131:1149-1163. http://dx.doi.org/10.1016/j.cell.2007.10.035
    • (2007) Cell. , vol.131 , pp. 1149-1163
    • Komatsu, M.1    Waguri, S.2    Koike, M.3    Sou, Y.S.4    Ueno, T.5    Hara, T.6    Mizushima, N.7    Iwata, J.8    Ezaki, J.9    Murata, S.10
  • 24
    • 35448938087 scopus 로고    scopus 로고
    • Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration
    • Komatsu, M., Q.J. Wang, G.R. Holstein, V.L. Friedrich Jr., J. Iwata, E. Kominami, B.T. Chait, K. Tanaka, and Z. Yue. 2007b. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc. Natl. Acad. Sci. USA. 104:14489-14494. http://dx.doi.org/10.1073/pnas.0701311104
    • (2007) Proc. Natl. Acad. Sci. USA. , vol.104 , pp. 14489-14494
    • Komatsu, M.1    Wang, Q.J.2    Holstein, G.R.3    Friedrich, V.L.4    Iwata, J.5    Kominami, E.6    Chait, B.T.7    Tanaka, K.8    Yue, Z.9
  • 27
    • 84859639962 scopus 로고    scopus 로고
    • Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress
    • Lee, I.H., Y. Kawai, M.M. Fergusson, I.I. Rovira, A.J. Bishop, N. Motoyama, L. Cao, and T. Finkel. 2012. Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. Science. 336:225-228. http://dx.doi.org/10.1126/science.1218395
    • (2012) Science. , vol.336 , pp. 225-228
    • Lee, I.H.1    Kawai, Y.2    Fergusson, M.M.3    Rovira, I.I.4    Bishop, A.J.5    Motoyama, N.6    Cao, L.7    Finkel, T.8
  • 29
    • 77449094358 scopus 로고    scopus 로고
    • Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration
    • Liang, C.C., C. Wang, X. Peng, B. Gan, and J.L. Guan. 2010. Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J. Biol. Chem. 285:3499-3509. http://dx.doi.org/10.1074/jbc.M109.072389
    • (2010) J. Biol. Chem. , vol.285 , pp. 3499-3509
    • Liang, C.C.1    Wang, C.2    Peng, X.3    Gan, B.4    Guan, J.L.5
  • 30
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang, X.H., S. Jackson, M. Seaman, K. Brown, B. Kempkes, H. Hibshoosh, and B. Levine. 1999. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 402:672-676. http://dx.doi.org/10.1038/45257
    • (1999) Nature. , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3    Brown, K.4    Kempkes, B.5    Hibshoosh, H.6    Levine, B.7
  • 31
    • 84876339267 scopus 로고    scopus 로고
    • The scaffold protein EPG-7 links cargo-receptor complexes with the autophagic assembly machinery
    • Lin, L., P. Yang, X. Huang, H. Zhang, Q. Lu, and H. Zhang. 2013. The scaffold protein EPG-7 links cargo-receptor complexes with the autophagic assembly machinery. J. Cell Biol. 201:113-129. http://dx.doi.org/10.1083/jcb.201209098
    • (2013) J. Cell Biol. , vol.201 , pp. 113-129
    • Lin, L.1    Yang, P.2    Huang, X.3    Zhang, H.4    Lu, Q.5    Zhang, H.6
  • 32
    • 80053501671 scopus 로고    scopus 로고
    • Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
    • Liu, J., H. Xia, M. Kim, L. Xu, Y. Li, L. Zhang, Y. Cai, H.V. Norberg, T. Zhang, T. Furuya, et al. 2011. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell. 147:223-234. http://dx.doi.org/10.1016/j.cell.2011.08.037
    • (2011) Cell. , vol.147 , pp. 223-234
    • Liu, J.1    Xia, H.2    Kim, M.3    Xu, L.4    Li, Y.5    Zhang, L.6    Cai, Y.7    Norberg, H.V.8    Zhang, T.9    Furuya, T.10
  • 34
    • 84905907209 scopus 로고    scopus 로고
    • The crucial role of Atg5 in cortical neurogenesis during early brain development
    • Lv, X., H. Jiang, B. Li, Q. Liang, S. Wang, Q. Zhao, and J. Jiao. 2014. The crucial role of Atg5 in cortical neurogenesis during early brain development. Sci. Rep. 4:6010. http://dx.doi.org/10.1038/srep06010
    • (2014) Sci. Rep. , vol.4 , pp. 6010
    • Lv, X.1    Jiang, H.2    Li, B.3    Liang, Q.4    Wang, S.5    Zhao, Q.6    Jiao, J.7
  • 35
    • 0034676493 scopus 로고    scopus 로고
    • Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology
    • Matés, J.M. 2000. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology. 153:83-104. http://dx.doi.org/10.1016/S0300-483X(00)00306-1
    • (2000) Toxicology. , vol.153 , pp. 83-104
    • Matés, J.M.1
  • 37
    • 0035503501 scopus 로고    scopus 로고
    • Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics
    • Melov, S., S.R. Doctrow, J.A. Schneider, J. Haberson, M. Patel, P.E. Coskun, K. Huffman, D.C. Wallace, and B. Malfroy. 2001. Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J. Neurosci. 21:8348-8353.
    • (2001) J. Neurosci. , vol.21 , pp. 8348-8353
    • Melov, S.1    Doctrow, S.R.2    Schneider, J.A.3    Haberson, J.4    Patel, M.5    Coskun, P.E.6    Huffman, K.7    Wallace, D.C.8    Malfroy, B.9
  • 38
    • 84876567161 scopus 로고    scopus 로고
    • Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
    • Misawa, T., M. Takahama, T. Kozaki, H. Lee, J. Zou, T. Saitoh, and S. Akira. 2013. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat. Immunol. 14:454-460. http://dx.doi.org/10.1038/ni.2550
    • (2013) Nat. Immunol. , vol.14 , pp. 454-460
    • Misawa, T.1    Takahama, M.2    Kozaki, T.3    Lee, H.4    Zou, J.5    Saitoh, T.6    Akira, S.7
  • 39
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: renovation of cells and tissues
    • Mizushima, N., and M. Komatsu. 2011. Autophagy: renovation of cells and tissues. Cell. 147:728-741. http://dx.doi.org/10.1016/j.cell.2011.10.026
    • (2011) Cell. , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 40
    • 77956416339 scopus 로고    scopus 로고
    • Autophagy in mammalian development and differentiation
    • Mizushima, N., and B. Levine. 2010. Autophagy in mammalian development and differentiation. Nat. Cell Biol. 12:823-830. http://dx.doi.org/10.1038/ncb0910-823
    • (2010) Nat. Cell Biol. , vol.12 , pp. 823-830
    • Mizushima, N.1    Levine, B.2
  • 41
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy, M.P. 2009. How mitochondria produce reactive oxygen species. Biochem. J. 417:1-13. http://dx.doi.org/10.1042/BJ20081386
    • (2009) Biochem. J. , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 42
    • 51349120502 scopus 로고    scopus 로고
    • Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells
    • Naka, K., T. Muraguchi, T. Hoshii, and A. Hirao. 2008. Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells. Antioxid. Redox Signal. 10:1883-1894. http://dx.doi.org/10.1089/ars.2008.2114
    • (2008) Antioxid. Redox Signal. , vol.10 , pp. 1883-1894
    • Naka, K.1    Muraguchi, T.2    Hoshii, T.3    Hirao, A.4
  • 43
    • 84870527124 scopus 로고    scopus 로고
    • TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling
    • Newman, A.C., C.L. Scholefield, A.J. Kemp, M. Newman, E.G. McIver, A. Kamal, and S. Wilkinson. 2012. TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS One. 7:e50672. http://dx.doi.org/10.1371/journal.pone.0050672
    • (2012) PLoS One. , vol.7
    • Newman, A.C.1    Scholefield, C.L.2    Kemp, A.J.3    Newman, M.4    McIver, E.G.5    Kamal, A.6    Wilkinson, S.7
  • 45
    • 67549132527 scopus 로고    scopus 로고
    • The late stages of autophagy: how does the end begin?
    • Noda, T., N. Fujita, and T. Yoshimori. 2009. The late stages of autophagy: how does the end begin? Cell Death Differ. 16:984-990. http://dx.doi.org/10.1038/cdd.2009.54
    • (2009) Cell Death Differ , vol.16 , pp. 984-990
    • Noda, T.1    Fujita, N.2    Yoshimori, T.3
  • 46
    • 65449133190 scopus 로고    scopus 로고
    • The alpha-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice
    • Okada, K., T. Yanagawa, E. Warabi, K. Yamastu, J. Uwayama, K. Takeda, H. Utsunomiya, H. Yoshida, J. Shoda, and T. Ishii. 2009. The alpha-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice. Hepatol. Res. 39:490-500. http://dx.doi.org/10.1111/j.1872-034X.2008.00478.x
    • (2009) Hepatol. Res. , vol.39 , pp. 490-500
    • Okada, K.1    Yanagawa, T.2    Warabi, E.3    Yamastu, K.4    Uwayama, J.5    Takeda, K.6    Utsunomiya, H.7    Yoshida, H.8    Shoda, J.9    Ishii, T.10
  • 47
    • 34548259958 scopus 로고    scopus 로고
    • p62/SQS TM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • Pankiv, S., T.H. Clausen, T. Lamark, A. Brech, J.A. Bruun, H. Outzen, A. Øvervatn, G. Bjørkøy, and T. Johansen. 2007. p62/SQS TM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282:24131-24145. http://dx.doi.org/10.1074/jbc.M702824200
    • (2007) J. Biol. Chem. , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5    Outzen, H.6    Øvervatn, A.7    Bjørkøy, G.8    Johansen, T.9
  • 49
    • 17644390613 scopus 로고    scopus 로고
    • 2: regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification
    • 2: regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification. Antioxid. Redox Signal. 7:619-626. http://dx.doi.org/10.1089/ars.2005.7.619
    • (2005) Antioxid. Redox Signal. , vol.7 , pp. 619-626
    • Rhee, S.G.1    Yang, K.S.2    Kang, S.W.3    Woo, H.A.4    Chang, T.S.5
  • 50
    • 80052303130 scopus 로고    scopus 로고
    • Autophagy and aging
    • Rubinsztein, D.C., G. Mariño, and G. Kroemer. 2011. Autophagy and aging. Cell. 146:682-695. http://dx.doi.org/10.1016/j.cell.2011.07.030
    • (2011) Cell. , vol.146 , pp. 682-695
    • Rubinsztein, D.C.1    Mariño, G.2    Kroemer, G.3
  • 52
    • 57549094368 scopus 로고    scopus 로고
    • The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice
    • Sou, Y.S., S. Waguri, J. Iwata, T. Ueno, T. Fujimura, T. Hara, N. Sawada, A. Yamada, N. Mizushima, Y. Uchiyama, et al. 2008. The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol. Biol. Cell. 19:4762-4775. http://dx.doi.org/10.1091/mbc.E08-03-0309
    • (2008) Mol. Biol. Cell. , vol.19 , pp. 4762-4775
    • Sou, Y.S.1    Waguri, S.2    Iwata, J.3    Ueno, T.4    Fujimura, T.5    Hara, T.6    Sawada, N.7    Yamada, A.8    Mizushima, N.9    Uchiyama, Y.10
  • 54
    • 84920508024 scopus 로고    scopus 로고
    • Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance
    • Tsang, C.K., Y. Liu, J. Thomas, Y. Zhang, and X.F. Zheng. 2014. Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance. Nat. Commun. 5:3446. http://dx.doi.org/10.1038/ncomms4446
    • (2014) Nat. Commun. , vol.5 , pp. 3446
    • Tsang, C.K.1    Liu, Y.2    Thomas, J.3    Zhang, Y.4    Zheng, X.F.5
  • 55
    • 84857345898 scopus 로고    scopus 로고
    • Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells
    • Vázquez, P., A.I. Arroba, F. Cecconi, E.J. de la Rosa, P. Boya, and F. de Pablo. 2012. Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells. Autophagy. 8:187-199. http://dx.doi.org/10.4161/auto.8.2.18535
    • (2012) Autophagy. , vol.8 , pp. 187-199
    • Vázquez, P.1    Arroba, A.I.2    Cecconi, F.3    de la Rosa, E.J.4    Boya, P.5    de Pablo, F.6
  • 56
    • 84876893671 scopus 로고    scopus 로고
    • FIP200 is required for maintenance and differentiation of postnatal neural stem cells
    • Wang, C., C.C. Liang, Z.C. Bian, Y. Zhu, and J.L. Guan. 2013. FIP200 is required for maintenance and differentiation of postnatal neural stem cells. Nat. Neurosci. 16:532-542. http://dx.doi.org/10.1038/nn.3365
    • (2013) Nat. Neurosci. , vol.16 , pp. 532-542
    • Wang, C.1    Liang, C.C.2    Bian, Z.C.3    Zhu, Y.4    Guan, J.L.5
  • 57
    • 79960401862 scopus 로고    scopus 로고
    • Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
    • Wei, H., S. Wei, B. Gan, X. Peng, W. Zou, and J.L. Guan. 2011. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev. 25:1510-1527. http://dx.doi.org/10.1101/gad.2051011
    • (2011) Genes Dev. , vol.25 , pp. 1510-1527
    • Wei, H.1    Wei, S.2    Gan, B.3    Peng, X.4    Zou, W.5    Guan, J.L.6
  • 58
    • 84925539360 scopus 로고    scopus 로고
    • Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis
    • Wen, J., S. Yeo, C. Wang, S. Chen, S. Sun, M.A. Haas, W. Tu, F. Jin, and J.L. Guan. 2015. Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis. Breast Cancer Res. Treat. 149:619-629. http://dx.doi.org/10.1007/s10549-015-3283-9
    • (2015) Breast Cancer Res. Treat. , vol.149 , pp. 619-629
    • Wen, J.1    Yeo, S.2    Wang, C.3    Chen, S.4    Sun, S.5    Haas, M.A.6    Tu, W.7    Jin, F.8    Guan, J.L.9
  • 59
    • 84861526009 scopus 로고    scopus 로고
    • Deconvoluting the context-dependent role for autophagy in cancer
    • White, E. 2012. Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer. 12:401-410. http://dx.doi.org/10.1038/nrc3262
    • (2012) Nat. Rev. Cancer. , vol.12 , pp. 401-410
    • White, E.1
  • 61
    • 84921792662 scopus 로고    scopus 로고
    • The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone
    • Yazdankhah, M., S. Farioli-Vecchioli, A.B. Tonchev, A. Stoykova, and F. Cecconi. 2014. The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone. Cell Death Dis. 5:e1403. http://dx.doi.org/10.1038/cddis.2014.358
    • (2014) Cell Death Dis. , vol.5
    • Yazdankhah, M.1    Farioli-Vecchioli, S.2    Tonchev, A.B.3    Stoykova, A.4    Cecconi, F.5
  • 62
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue, Z., S. Jin, C. Yang, A.J. Levine, and N. Heintz. 2003. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. USA. 100:15077-15082. http://dx.doi.org/10.1073/pnas.2436255100
    • (2003) Proc. Natl. Acad. Sci. USA. , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 63
    • 0036667555 scopus 로고    scopus 로고
    • Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and ECSOD (SOD3) gene structures, evolution, and expression
    • Zelko, I.N., T.J. Mariani, and R.J. Folz. 2002. Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and ECSOD (SOD3) gene structures, evolution, and expression. Free Radic. Biol. Med. 33:337-349. http://dx.doi.org/10.1016/S0891-5849(02)00905-X
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 337-349
    • Zelko, I.N.1    Mariani, T.J.2    Folz, R.J.3
  • 64
    • 39149111914 scopus 로고    scopus 로고
    • Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells
    • Zeng, M., and J.N. Zhou. 2008. Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells. Cell. Signal. 20:659-665. http://dx.doi.org/10.1016/j.cellsig.2007.11.015
    • (2008) Cell. Signal. , vol.20 , pp. 659-665
    • Zeng, M.1    Zhou, J.N.2
  • 65
    • 23644443053 scopus 로고    scopus 로고
    • Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    • Zhu, Y., F. Guignard, D. Zhao, L. Liu, D.K. Burns, R.P. Mason, A. Messing, and L.F. Parada. 2005. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell. 8:119-130. http://dx.doi.org/10.1016/j.ccr.2005.07.004
    • (2005) Cancer Cell. , vol.8 , pp. 119-130
    • Zhu, Y.1    Guignard, F.2    Zhao, D.3    Liu, L.4    Burns, D.K.5    Mason, R.P.6    Messing, A.7    Parada, L.F.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.