In vivo imaging of microglial activation by positron emission tomography with [11C]PBR28 in the 5XFAD model of Alzheimer's disease

GLIA

Volumn 64, Issue 6, 2016, Pages 993-1006

  Mirzaei, Nazanin ^a   Tang, Sac Pham ^b   Ashworth, Sharon ^b   Coello, Christopher ^b   Plisson, Christophe ^b   Passchier, Jan ^b   Selvaraj, Vimal ^c   Tyacke, Robin J ^a   Nutt, David J ^a   Sastre, Magdalena ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Imanova Ltd   (United Kingdom)

^c Department of Obstetrics Gynecology   (United States)

Author keywords

Alzheimer's disease; Animal model; Autoradiography; In vivo imaging; Microglia; PET; TSPO

Indexed keywords

AMYLOID; ANTIBODY; IONIZED CALCIUM BINDING ADAPTER MOLECULE 1; MITOCHONDRIAL PROTEIN; PBR 28 C 11; PROTEIN; RADIOLIGAND; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR;

5XFAD MOUSE; AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASTROCYTE; AUTORADIOGRAPHY; BRAIN CORTEX; BRAIN REGION; CELL ACTIVATION; CONTROLLED STUDY; DRUG BINDING; DRUG SCREENING; DRUG UPTAKE; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MICROGLIA; MITOCHONDRION; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; VALIDATION STUDY; WESTERN BLOTTING; ANIMAL; BRAIN; DISEASE MODEL; METABOLISM; PATHOLOGY; PROCEDURES; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; ASTROCYTES; BRAIN; DISEASE MODELS, ANIMAL; MICE; MICE, TRANSGENIC; MICROGLIA; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, GABA;

EID: 84960359914     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22978     Document Type: Article

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