Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity

Journal of Neurochemistry

Volumn 74, Issue 4, 2000, Pages 1694-1704

  Kuhlmann, Anthony C ^a   Guilarte, Tomás R ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Astrocyte; Glial fibrillary acidic protein; Lectin; Microglia; Peripheral benzodiazepine receptor; PK11195; Trimethyltin

Indexed keywords

BENZODIAZEPINE RECEPTOR; TRIMETHYLTIN;

ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN INJURY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; ASTROCYTES; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; ISOQUINOLINES; MALE; MICROGLIA; NERVE DEGENERATION; NEUROTOXINS; RADIOLIGAND ASSAY; RATS; RATS, LONG-EVANS; RECEPTORS, GABA-A; TRIMETHYLTIN COMPOUNDS; TRITIUM;

ANIMALIA; GRIFFONIA SIMPLICIFOLIA;

EID: 0034063730     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0741694.x     Document Type: Article

References (43)

1. Alho H., Varga V., and Krueger K. E. (1994) Expression of mitochondrial benzodiazepine receptor and its putative endogenous ligand diazepam binding inhibitor in cultured primary astrocytes and C-6 cells: relation to cell growth. Cell Growth Differ. 5, 1005-1014.
2. 3H]PK11195 autoradiography. Exp. Neurol. 109, 333-341.
3. Amri H., Ogwuegbu S. O., Boujard N., Drieu K., and Papadopoulos V. (1996) In vivo regulation of peripheral-type benzodiazepine receptor and glucocorticoid synthesis by Ginkgo biloba extract Egb 761 and isolated ginkgolides. Endocrinology 137, 5707-5718.
4. Anholt R. R. H., Pedersen P. L., DeSouza E. B., and Snyder S. H. (1986) The peripheral-type benzodiazepine receptor: localization to the mitochondrial outer membrane. J. Biol. Chem. 261, 576-583.
5. Balaban C. D., O'Callaghan J. P., and Billingsley M. L. (1988) Trimethyltin-induced neuronal damage in the rat brain: comparative studies using silver degeneration stains, immunocytochemistry and immunoassay for neurotypic and gliotypic proteins. Neuroscience 26, 337-361.
6. 3H]-PK11195 binding to activated microglia. J. Neurocytol. 26, 77-82.
7. Baulieu E. E. (1998) Neurosteroids: a novel function of the brain. Psychoneuroendocrinology 23, 963-987.
8. Benavides J., Gage D., Carter D., and Scatton B. (1987) Peripheral type benzodiazepine binding sites are a sensitive indirect index of neuronal damage. Brain Res. 421, 167-172.
9. 3H]-PK14105. Neurosci. Lett. 114, 32-38.
10. Brock T. O. and O'Callaghan J. P. (1987) Quantitative changes in the synaptic vesicle proteins, synapsin I and p38 and the astrocytic protein, glial fibrillary acidic protein, are associated with chemical-induced injury to the rat nervous system. J. Neurosci. 7, 931-942.
11. Canat X., Carayon P., Bouaboula M., Cahard D., Shire D., Roque C., LeFur G., and Casellas P. (1992) Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells. Life Sci. 52, 107-118.
12. Chang L. W. (1986) Neuropathology of trimelhyltin: a proposed pathogenetic mechanism. Fundam. Appl. Toxicol. 6, 217-232.
13. Chang L. W. and Dyer R. S. (1985) Early effects of trimethyltin in the dentate gyrus basket cells: a morphological study. J. Toxicol. Environ. Health 16, 641-653.
14. Del Cerro S., Garcia-Estrada J., and Garcia-Segura L. (1995) Neuroactive steroids regulate astroglia morphology in hippocampal cultures from adult rats. Glia 14, 65-71.
15. Demerlé-Pallardy C., Duverger D., Spinnewyn B., Pirotzky E., and Braquet P. (1991) Peripheral type benzodiazepine binding sites following transient forebrain ischemia in the rat: effect of neuroprotective drugs. Brain Res. 565, 312-320.
16. Gallyas F., Wolff J. R., Bottcher H., and Zaborszky L. (1980) A reliable method for demonstrating axonal degeneration shortly after axotomy. Stain Technol. 55, 291-297.
17. Gehlert D. R., Stephenson D. T., Schober D. A., Rash D., and Clemens J. A. (1997) Increased expression of peripheral benzodiazepine receptors in the facial nucleus following motor neuron axotomy. Neurochem. Int. 31, 705-713.
18. Guilarte T. R., Kuhlmann A. C., O'Callaghan J. P., and Miceli R. C. (1995) Enhanced expression of peripheral benzodiazepine receptors in trimethyltin-exposed rat brain: a biomarker of neurotoxicity. Neurotoxicology 16, 441-450.
19. Hardwick M., Fertikh D., Culty M., Li H., Vidic B., and Papadopoulos V. (1999) Peripheral-type benzodiazepine receptor (PBR) in human breast tissue: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization and PBR-mediated cell proliferation and nuclear transport of cholesterol. Cancer Res. 59, 831-842.
20. Jung-Testas I., Renoir M., Bugnard H., Greene G. L., and Baulieu E. E. (1992) Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cells. J. Steroid Biochem. Mol. Biol. 41, 621-631.
21. Kreutzberg G. W. (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19, 312-318.
22. Krueger K. E. and Papadopoulos V. (1990) Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells. J. Biol. Chem. 265, 15015-15022.
23. Kuhlmann A. C. and Guilarte T. R. (1997) The peripheral benzodiazepine receptor is a sensitive indicator of domoic acid neurotoxicity. Brain Res. 751, 281-288.
24. Kuhlmann A. C. and Guilarte T. R. (1999) Regional and temporal expression of the peripheral benzodiazepine receptor in MPTP neurotoxicity. Toxicol. Sci. 48, 107-116.
25. Lacor P., Gandolfo P., Tonon M. C., Brault E., Dalibert I., Schumacher M., Benavides J., and Ferzaz B. (1999) Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis. Brain Res. 815, 70-80.
26. Li H. and Papadopoulos V. (1998) Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology 139, 4991-4997.
27. McCann M. J., O'Callaghan J. P., Martin P. M., Bertram T., and Streit W. J. (1996) Differential activation of microglia and astrocytes following trimethyltin-induced neurodegeneration. Neuroscience 72, 273-281.
28. McEnery M. W., Snowman A. M., Trifiletti R. R., and Snyder S. H. (1992) Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc. Natl. Acad. Sci. USA 89, 3170-3174.
29. McLean I. W. and Nakane P. K. (1974) Periodate-lysate-paraformaldehyde fixative: a new fixative for immunoelectron microscopy. J. Histochem. Cytochem. 22, 1077-1083.
30. Meßmer K. and Reynolds G. P. (1998) Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease. Neurosci. Lett. 241, 53-56.
31. 3H]PK-111195 as a marker for gliosis. Acta Neurochir. (Wien) 137, 207-216.
32. Monnet-Tschudi F., Zurich M. G., Pithon E., van Melle G., and Honegger P. (1995) Microglial responsiveness as a sensitive marker for trimethyltin (TMT) neurotoxicity. Brain Res. 690, 8-14.
33. 3H]PK11195 binding to rat cerebral cortex following a local ischaemic lesion. J. Cereb. Blood Flow Metab. 11, 314-322.
34. Norton W. T., Aquino D. A., Hozumi I., Chiu F. C., and Brosnan C. F. (1992) Quantitative aspects of reactive gliosis: a review. Neurochem. Res. 17, 877-885.
35. Papadopoulos V., Amri H., Boujrad N., Vidic B., and Garnier M. (1997) Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line. J. Biol. Chem. 272, 32129-32135.
36. Park C. H., Carboni E., Wood P. L., and Gee K. W. (1996) Characterization of peripheral benzodiazepine type sites in a cultured murine BV-2 microglial cell line. Glia 16, 65-70.
37. Ramsay S. C., Weiller C., Myers R., Cremer J. E., Luthra S. K., Lammertsma A. A., and Frackowiak R. S. J. (1992) Monitoring by PET of macrophage accumulation in brain after ischaemic stroke. Lancet 339, 1054-1055.
38. Richards J. G. and Möhler H. (1984) Benzodiazepine receptors. Neuropharmacology 23, 233-242.
39. Riva-Depaty I., Fardeau C., Mariani J., Bouchaud C., and Delhaye-Bouchaud N. (1994) Contribution of peripheral macrophages after mechanical or neurotoxin-induced lesions of the rat brain. Exp. Neurol. 128, 77-87.
40. Stephenson D. T., Schober D. A., Smalstig E. B., Mincy R. E., Gehlert D. R., and Clemens J. A. (1995) Peripheral benzodiazepine receptors are colocalized with activated microglia following global forebrain ischaemia in the rat. J. Neurosci. 15, 5263-5274.
41. 4). J. Histochem. Cytochem. 38, 1683-1686.
42. Streit W. J., Graeber M. B., and Kreutzberg G. W. (1988) Functional plasticity of microglia: a review. Glia 1, 301-307.
43. Vowinckel E., Reutens D., Becher B., Verge G., Evans A., Owens T., and Antel J. P. ( 1997) PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. J. Neurosci. Res. 50, 345-353.