Pet visualization of microglia in multiple sclerosis patients using [11C]PK11195

European Journal of Neurology

Volumn 10, Issue 3, 2003, Pages 257-264

  Debruyne, Jan C ^a   Versijpt, J ^a   Van Laere, K J ^a   De Vos, F ^b   Keppens, J ^a   Strijckmans, K ^c   Achten, E ^a   Slegers, G ^b   Dierckx, R A ^a   Korf, J ^d   De Reuck, J L ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Inflammation; Microglia; Multiple sclerosis; Peripheral benzodiazepine receptor; PK11195; Positron emission tomography

Indexed keywords

CARBON 11; GADOLINIUM; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE;

ADULT; APPARATUS; ARTICLE; BELGIUM; CLINICAL ARTICLE; DOWN REGULATION; DRUG UPTAKE; FEMALE; GRAY MATTER; HUMAN; IMAGING SYSTEM; IMMUNOPATHOLOGY; INFLAMMATION; INTERMETHOD COMPARISON; MALE; MICROGLIA; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WHITE MATTER;

ADULT; AGE FACTORS; ANTINEOPLASTIC AGENTS; BRAIN MAPPING; COHORT STUDIES; FEMALE; HUMANS; ISOQUINOLINES; MAGNETIC RESONANCE IMAGING; MALE; MICROGLIA; MIDDLE AGED; MULTIPLE SCLEROSIS; PARIETAL LOBE; RADIOLIGAND ASSAY; RECURRENCE; THALAMUS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0038293470     PISSN: 13515101     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-1331.2003.00571.x     Document Type: Article

References (29)

1. Andersson PB, Waubant E, Gee L, Goodkin DE (1999). Multiple sclerosis that is progressive from the time of onset: clinical characteristics and progression of disability. Arch Neurol 56:1138-1142.
2. 3H]PK11195 binding to activated microglia. J Neurocytol 26:77-82.
3. Banati RB, Newcombe J, Gunn RN et al. (2000). The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain 123:2321-2337.
4. Barkhof F, van Walderveen M (1999). Characterization of tissue damage in multiple sclerosis by nuclear magnetic resonance. Philos Trans R Soc Lond B Biol Sci 354:1675-1686.
5. 3 site radioligand. Ann Neurol 24:708-712.
6. Benveniste EN (1997). Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med 75:165-173.
7. Camsonne R, Crouzel C, Comar D et al. (1984). Synthesis of n-(C-11) methyl, n-(methyl-1 propyl),·(chloro-2 phenyl)-1 isoquinoleine carboxamide-3 (PK-11195) - a new ligand for peripheral benzodiazepine receptors. J Labelled Compd Rad 21:985-991.
8. Confavreux C, Vukusic S, Moreau T, Adeleine P (2000). Relapses and progression of disability in multiple sclerosis. N Engl J Med 343:1430-1438.
9. Dangond F, Windhagen A, Groves CJ, Hafler DA (1997). Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity. J Neuroimmunol 76:132-138.
10. 11C]PK11195 in normal human brain and application in multiple sclerosis patients. Acta Neurol Belg 102:127-135.
11. 3H]PK 11195: anatomical and subcellular distribution. Brain Res Bull 18:49-61.
12. 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr 4:727-736.
13. Friston KJ, Frith CD, Liddle PF, Frackowiak RS (1991). Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab 11:690-699.
14. 11C](R)-PK11195 positron emission tomography. Am J Roentgenol 176:1016-1018.
15. Hayes GM, Woodroofe MN, Cuzner ML (1987). Microglia are the major cell type expressing MHC class II in human white matter. J Neurol Sci 80:25-37.
16. 3H]Ro5-4864 binding sites after exposure to peripheral-type benzodiazepines in vitro. J Pharmacol Exp Ther 238:855-859.
17. Kesselring J (1990). The pathogenesis of multiple sclerosis. Schweiz Med Wochenschr 120:1083-1090.
18. Lawson LJ, Perry VH, Dri P, Gordon S (1990). Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39:151-170.
19. Mikolajczyk K, Szabatin M, Rudnicki P, Grodzki M, Burger C (1998). A JAVA environment for medical image data analysis: initial application for brain PET quantitation. Med Inform (Lond) 23:207-214.
20. Miller SD, McRae BL, Vanderlugt CL et al. (1995). Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases. Immunol Rev 144:225-244.
21. Nesbit GM, Forbes GS, Scheithauer BW, Okazaki H, Rodriguez M (1991). Multiple sclerosis: histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy. Radiology 180:467-474.
22. Nijeholt GJ, van Walderveen MA, Castelijns JA et al. (1998). Brain and spinal cord abnormalities in multiple sclerosis. Correlation between MRI parameters, clinical subtypes and symptoms. Brain 121:687-697.
23. Poser CM, Paty DW, Scheinberg L et al. (1983). New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227-231.
24. Ramsay SC, Weiller C, Myers R et al. (1992). Monitoring by PET of macrophage accumulation in brain after ischaemic stroke. Lancet 339:1054-1055.
25. Schlumpf M, Parmar R, Lichtensteiger W (1993). Prenatal diazepam induced persisting downregulation of peripheral (omega 3) benzodiazepine receptors on rat splenic macrophages. Life Sci 52:927-934.
26. Sorensen JC, Dalmau I, Zimmer J, Finsen B (1996). Microglial reactions to retrograde degeneration of tracer-identified thalamic neurons after frontal sensorimotor cortex lesions in adult rats. Exp Brain Res 112:203-212.
27. Sriram S, Rodriguez M (1997). Indictment of the microglia as the villain in multiple sclerosis. Neurology 48:464-470.
28. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L (1998). Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338:278-285.
29. Vowinckel E, Reutens D, Becher B et al. (1997). PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci Res 50:345-353.