Detection of microglial activation in an acute model of neuroinflammation using PET and radiotracers 11C-(R)-PK11195 and 18F-GE-180

Journal of Nuclear Medicine

Volumn 55, Issue 3, 2014, Pages 466-472

  Dickens, Alex M ^a,b   Vainio, Susanne ^b   Marjamäki, Päivi ^b   Johansson, Jarkko ^b   Lehtiniemi, Paula ^b   Rokka, Johanna ^b   Rinne, Juha ^b   Solin, Olof ^b   Haaparanta Solin, Merja ^b   Jones, Paul A ^c   Trigg, William ^c   Anthony, Daniel C ^d   Airas, Laura ^e  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU PET CENTRE   (Finland)

^c GE HEALTHCARE   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Astrocyte; Brain; Neuroinflammation; Positron emission tomography; Second generation TSPO ligand

Indexed keywords

GE 180; GLIAL FIBRILLARY ACIDIC PROTEIN; LIPOPOLYSACCHARIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; N,N DIETHYL 9 [2 FLUOROETHYL] 5 METHOXY 2,3,4,9 TETRAHYDRO 1H CARBAZOLE 4 CARBOXAMIDE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; (R) (11C)1 (2 CHLOROPHENYL) N METHYL N (1 METHYLPROPYL) 3 ISOQUINOLINECARBOXAMIDE; (R)-(11C)1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE; AMIDE; CARBAZOLE DERIVATIVE; DIAGNOSTIC AGENT; GE-180; ISOQUINOLINE DERIVATIVE; TRACER;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTORADIOGRAPHY; CELL ACTIVATION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG SELECTIVITY; EX VIVO STUDY; GRAY MATTER; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MALE; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; WHITE MATTER; ANIMAL; BRAIN; DISEASE MODEL; INFLAMMATION; SCINTISCANNING; SECOND-GENERATION TSPO LIGAND;

ASTROCYTE; BRAIN; NEUROINFLAMMATION; POSITRON EMISSION TOMOGRAPHY; SECOND-GENERATION TSPO LIGAND;

AMIDES; ANIMALS; ASTROCYTES; CARBAZOLES; DISEASE MODELS, ANIMAL; INFLAMMATION; ISOQUINOLINES; MALE; MICROGLIA; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS; RATS;

EID: 84899472948     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.113.125625     Document Type: Article

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