Determination of [11C]PBR28 binding potential in vivo: A first human TSPO blocking study

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 6, 2014, Pages 989-994

  Owen, David R ^a   Guo, Qi ^a,b,c   Kalk, Nicola J ^a,c   Colasanti, Alessandro ^a,c   Kalogiannopoulou, Dimitra ^d   Dimber, Rahul ^c   Lewis, Yvonne L ^c   Libri, Vincenzo ^d   Barletta, Julien ^c   Ramada Magalhaes, Joaquim ^c   Kamalakaran, Aruloly ^c   Nutt, David J ^a   Passchier, Jan ^c   Matthews, Paul M ^a,e   Gunn, Roger N ^a,c   Rabiner, Eugenii A ^b,c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c Imanova Ltd   (United Kingdom)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e GLAXOSMITHKLINE   (United Kingdom)

Author keywords

emapunil; rs6971 polymorphism; specific binding; TSPO; XBD173

Indexed keywords

CARBON 11; CARRIER PROTEIN; EMAPUNIL; PBR 28 C 11; RADIOLIGAND; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING KINETICS; BINDING POTENTIAL; DISTRIBUTION VOLUME; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; IN VIVO STUDY; MALE; NERVOUS SYSTEM INFLAMMATION; NORMAL HUMAN; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETAMIDES; ADULT; BRAIN; CARBON ISOTOPES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; MALE; POSITRON-EMISSION TOMOGRAPHY; PURINES; PYRIDINES; RECEPTORS, GABA;

EID: 84901848110     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.46     Document Type: Article

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