Multidimensional genome-wide analyses show accurate FVIII integration by ZFN in primary human cells

Molecular Therapy

Volumn 24, Issue 3, 2016, Pages 607-619

  Sivalingam, Jaichandran ^a,b,c   Kenanov, Dimitar ^d   Han, Hao ^d   Nirmal, Ajit Johnson ^a   Ng, Wai Har ^a   Lee, Sze Sing ^a   Masilamani, Jeyakumar ^e   Phan, Toan Thang ^b,e   Maurer Stroh, Sebastian ^d,f   Kon, Oi Lian ^a,b  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c AGENCY FOR SCIENCE   (Singapore)

^d BIOINFORMATICS INSTITUTE   (Singapore)

^e CellResearch Corp Pte Ltd   (Singapore)

^f NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BLOOD CLOTTING FACTOR 8; ZINC FINGER NUCLEASE; ENDONUCLEASE; PROTEIN BINDING; ZINC FINGER PROTEIN;

ARTICLE; BLOOD CLOTTING FACTOR 8 GENE; BONE MARROW CELL; CARCINOGENICITY; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA MODIFICATION; ENZYME ACTIVITY; EPITHELIUM CELL; FIBROBLAST; GENE SEQUENCE; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HUMAN; HUMAN CELL; HUMAN UMBILICAL CORD LINING EPITHELIAL CELL; INDEL MUTATION; NONVIRAL GENE DELIVERY SYSTEM; RNA SEQUENCE; STROMA CELL; TRANSGENE; TRANSGENICS; BINDING SITE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TARGETING; GENE TRANSFER; GENE VECTOR; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HIGH THROUGHPUT SEQUENCING; K-562 CELL LINE; METABOLISM;

BINDING SITES; ENDONUCLEASES; FACTOR VIII; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GENOME-WIDE ASSOCIATION STUDY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; K562 CELLS; MUTAGENESIS, INSERTIONAL; PROTEIN BINDING; TRANSGENES; ZINC FINGERS;

EID: 84960344622     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2015.223     Document Type: Article

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