Initial trophic vs full enteral feeding in patients with acute lung injury: The EDEN randomized trial

JAMA

Volumn 307, Issue 8, 2012, Pages 795-803

  Rice, Todd W ^a   Wheeler, Arthur P ^a   Thompson, B Taylor ^b   Steingrub, Jay ^c   Hite, R Duncan ^d   Moss, Marc ^e   Morris, Alan ^f   Dong, Ning ^b   Rock, Peter ^g  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BAYSTATE MEDICAL CENTER   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIARRHEAL AGENT; GLUCOSE; PROKINETIC AGENT;

ABDOMINAL CRAMP; ABDOMINAL DISTENSION; ACUTE LUNG INJURY; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; ARTIFICIAL VENTILATION; CALORIC INTAKE; CLINICAL ASSESSMENT; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; ENTERIC FEEDING; FEMALE; FOOD ASPIRATION; FOOD REGURGITATION; GASTROINTESTINAL DISEASE; GLUCOSE BLOOD LEVEL; HUMAN; HYPOKALEMIA; HYPOMAGNESEMIA; HYPOPHOSPHATEMIA; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; PATIENT CARE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RESIDUAL VOLUME; THERAPY EFFECT; VOMITING; AGED; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; GASTROINTESTINAL TRACT; INFECTION; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; TIME; TREATMENT OUTCOME;

ACUTE LUNG INJURY; ADULT; AGED; ENERGY INTAKE; ENTERAL NUTRITION; FEMALE; GASTROINTESTINAL TRACT; HUMANS; INFECTION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RESPIRATION, ARTIFICIAL; TIME FACTORS; TREATMENT OUTCOME;

EID: 84857427752     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2012.137     Document Type: Article

References (29)

1. McClave SA, Martindale RG, Vanek VW, et al; A.S.P.E.N. Board of Directors; American College of Critical Care Medicine; Society of Critical Care Medicine. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient. JPEN J Parenter Enteral Nutr. 2009;33(3):277-316.
2. Heyland DK, Dhaliwal R, Drover JW, Gramlich L, Dodek P; Canadian Critical Care Clinical Practice Guidelines Committee. Canadian Clinical Practice Guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr. 2003;27(5):355-373. (Pubitemid 37022781)
3. Heyland DK, Schroter-Noppe D, Drover JW, et al. Nutrition support in the critical care setting: current practice in Canadian ICUs - opportunities for improvement? JPEN J Parenter Enteral Nutr. 2003; 27(1):74-83. (Pubitemid 36105648)
4. Heyland DK, Dhaliwal R, Day A, Jain M, Drover J. Validation of the Canadian Clinical Practice Guidelines for nutrition support in mechanically ventilated, critically ill adult patients: results of a prospective observational study. Crit Care Med. 2004;32(11): 2260-2266. (Pubitemid 39491806)
5. Rice TW, Swope T, Bozeman S, Wheeler AP. Variation in enteral nutrition delivery in mechanically ventilated patients. Nutrition. 2005;21(7-8):786-792. (Pubitemid 40828801)
6. Barr J, Hecht M, Flavin KE, Khorana A, Gould MK. Outcomes in critically ill patients before and after the implementation of an evidence-based nutritional management protocol. Chest. 2004;125(4):1446-1457. (Pubitemid 38501362)
7. Doig GS, Simpson F, Finfer S, et al, Nutrition Guidelines Investigators of the ANZICS Clinical Trials Group. Effect of evidence-based feeding guidelines on mortality of critically ill adults: a cluster randomized controlled trial. JAMA. 2008;300(23):2731-2741.
8. Rubinson L, Diette GB, Song X, Brower RG, Krishnan JA. Low caloric intake is associated with nosocomial bloodstream infections in patients in the medical intensive care unit. Crit Care Med. 2004;32(2):350-357. (Pubitemid 38234110)
9. Dickerson RN, Boschert KJ, Kudsk KA, Brown RO. Hypocaloric enteral tube feeding in critically ill obese patients. Nutrition. 2002;18(3):241-246. (Pubitemid 34204135)
10. Ibrahim EH, Mehringer L, Prentice D, et al. Early versus late enteral feeding of mechanically ventilated patients: results of a clinical trial. JPEN J Parenter Enteral Nutr. 2002;26(3):174-181. (Pubitemid 34429482)
11. Krishnan JA, Parce PB, Martinez A, Diette GB, Brower RG. Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes. Chest. 2003;124(1):297-305. (Pubitemid 36851366)
12. Arabi YM, Haddad SH, Tamim HM, et al. Neartarget caloric intake in critically ill medical-surgical patients is associated with adverse outcomes. JPEN J Parenter Enteral Nutr. 2010;34(3):280-288.
13. Hadfield RJ, Sinclair DG, Houldsworth PE, Evans TW. Effects of enteral and parenteral nutrition on gut mucosal permeability in the critically ill. Am J Respir Crit Care Med. 1995;152(5, pt 1):1545-1548.
14. Hernandez G, Velasco N, Wainstein C, et al. Gut mucosal atrophy after a short enteral fasting period in critically ill patients. J Crit Care. 1999;14(2): 73-77. (Pubitemid 29278264)
15. McClure RJ, Newell SJ. Randomised controlled study of clinical outcome following trophic feeding. Arch Dis Child Fetal Neonatal Ed. 2000;82(1): F29-F33. (Pubitemid 30316481)
16. Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994; 149(3, pt 1):818-824. (Pubitemid 24082248)
17. Rice TW, Wheeler AP, Thompson BT, deBoisblanc BP, Steingrub J, Rock P; NHLBI ARDS Clinical Trials Network. Enteral omega-3 fatty acid, γ-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA. 2011;306(14):1574-1581.
18. Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogué S, Ferrer M. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet. 1999; 354(9193):1851-1858.
19. Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1301-1308.
20. Wiedemann HP, Wheeler AP, Bernard GR, et al National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006; 354(24):2564-2575. (Pubitemid 43882352)
21. Artinian V, Krayem H, DiGiovine B. Effects of early enteral feeding on the outcome of critically ill mechanically ventilated medical patients. Chest. 2006; 129(4):960-967.
22. Doig GS, Heighes PT, Simpson F, Sweetman EA, Davies AR. Early enteral nutrition, provided within 24 h of injury or intensive care unit admission, significantly reduces mortality in critically ill patients: ametaanalysis of randomised controlled trials. Intensive Care Med. 2009;35(12):2018-2027.
23. Burrin DG, Stoll B, Jiang R, et al. Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough? Am J Clin Nutr. 2000; 71(6):1603-1610. (Pubitemid 30395911)
24. Omura K, Hirano K, Kanehira E, et al. Small amount of low-residue diet with parenteral nutrition can prevent decreases in intestinal mucosal integrity. Ann Surg. 2000;231(1):112-118. (Pubitemid 30043947)
25. Owens L, Burrin DG, Berseth CL. Minimal enteral feeding induces maturation of intestinal motor function but not mucosal growth in neonatal dogs. J Nutr. 2002;132(9):2717-2722. (Pubitemid 35013260)
26. Matthay MA, Brower RG, Carson S, et al National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Randomized, placebo-controlled clinical trial of an aerosolized β-agonist for treatment of acute lung injury. Am J Respir Crit Care Med. 2011;184(5): 561-568.
27. Rice TW, Mogan S, Hays MA, Bernard GR, Jensen GL, Wheeler AP. Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med. 2011;39(5):967-974.
28. Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011;365(6):506-517.
29. Clermont G, Kong L, Weissfeld LA, et al NHLBI ARDS Clinical Trials Network. The effect of pulmonary artery catheter use on costs and long-term outcomes of acute lung injury. PLoS One. 2011;6 (7):e22512.