The editorialist replies

New England Journal of Medicine

Volumn 371, Issue 4, 2014, Pages 386-387

  Lilly, Craig M ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; CLINICAL PRACTICE; DRUG INDICATION; HUMAN; LETTER; MORTALITY; PRIORITY JOURNAL; SEPTIC SHOCK; SURVIVAL RATE; CLINICAL PROTOCOL; FEMALE; MALE; NOTE; RESUSCITATION; STANDARD;

CLINICAL PROTOCOLS; FEMALE; HOSPITAL MORTALITY; HUMANS; MALE; RESUSCITATION; SHOCK, SEPTIC;

EID: 84904559933     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1406745     Document Type: Letter

References (4)

1. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77.
2. Kumar A, Ellis P, Arabi Y, et al. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009;136:1237-48.
3. Kumar A, Zarychanski R, Light B, et al. Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis. Crit Care Med 2010;38:1773-85.
4. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34:1589-96. (Pubitemid 43810035)