Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality

American Journal of Respiratory and Critical Care Medicine

Volumn 187, Issue 9, 2013, Pages 967-976

  Mickiewicz, Beata ^a   Vogel, Hans J ^a   Wong, Hector R ^b   Winston, Brent W ^c  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

Biomarkers; Metabolomics; Mortality; Pediatric septic shock; Proton nuclear magnetic resonance spectroscopy

Indexed keywords

BIOLOGICAL MARKER;

ARTICLE; BLOOD LEVEL; CHILD; CHILDHOOD MORTALITY; CONTROLLED STUDY; DIAGNOSTIC TEST; DISCRIMINANT ANALYSIS; EARLY DIAGNOSIS; FEMALE; HUMAN; INFANT; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; METABOLITE; METABOLOMICS; NEWBORN; ORTHOGONAL PARTIAL LEAST SQUARES DISCRIMINANT ANALYSIS; PARTIAL LEAST SQUARES DISCRIMINANT ANALYSIS; PREDICTIVE VALUE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; SEPTIC SHOCK; STATISTICAL MODEL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; EARLY DIAGNOSIS; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INTENSIVE CARE UNITS, PEDIATRIC; LEAST-SQUARES ANALYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; PROGNOSIS; SHOCK, SEPTIC;

EID: 84877128328     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201209-1726OC     Document Type: Article

References (49)

1. Pollack MM, Fields AI, Ruttimann UE Sequential cardiopulmonary variables of infants and children in septic shock. Crit Care Med 1984; 12:554-559.
2. Pollack MM, Fields AI, Ruttimann UE Distributions of cardiopulmonary variables in pediatric survivors and nonsurvivors of septic shock. Crit Care Med 1985; 13:454-459.
3. Czaja AS, Zimmerman JJ, Nathens AB Readmission and late mortality after pediatric severe sepsis. Pediatrics 2009; 123:849-857.
4. Watson RS, Carcillo JA, Linde-Zwirble WT, Clermont G., Lidicker J, Angus DC The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med 2003; 167:695-701.
5. Lodha R, Oleti TP, Kabra SK Management of septic shock. Indian J Pediatr 2011; 78:726-733.
6. Singh D, Chopra A, Pooni P.A., Bhatia RC A clinical profile of shock in children in Punjab, India. Indian Pediatr 2006; 43:619-623.
7. Pediatric Sepsis Initiative [accessed 2012 Feb]. Available from: http://www.pediatricsepsis.org/
8. Lawrence K. Pediatric sepsis and multiorgan dysfunction syndrome: progress and continued challenges. Crit Care Nurs Clin North Am 2011; 23:323-337.
9. Rivers E, Nguyen B, Havstad S., Ressler J, Muzzin A, Knoblich B., Peterson E, Tomlanovich M. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-1377.
10. Brierley J, Carcillo JA, Choong K, Cornell T., Decaen A, Deymann A, Doctor A., Davis A, Duff J, Dugas MA, et al. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med 2009; 37:666-688.
11. Han YY, Carcillo JA, Dragotta M.A., Bills DM, Watson RS, Westerman ME, Orr RA Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome. Pediatrics 2003; 112:793-799.
12. Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate N.L., Shapiro NI, Parrillo JE, Hollenberg SM. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 2008; 34:2210-2217.
13. Lindon JC, Holmes E, Bollard M.E., Stanley EG, Nicholson JK Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers 2004; 9:1-31.
14. Nicholson JK, Lindon JC, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999; 29:1181-1189.
15. Laiakis EC, Morris GA, Fornace A.J., Howie SR Metabolomic analysis in severe childhood pneumonia in the Gambia, West Africa: findings from a pilot study. PLoS ONE 2010; 5:e12655.
16. Godoy MM, Lopes EP, Silva R.O., Hallwass F., Koury LC, Moura IM, Goncalves SM, Simas AM Hepatitis C virus infection diagnosis using metabonomics. J Viral Hepat 2010; 17:854-858.
17. Izquierdo-Garcia J.L., Nin N, Ruiz-Cabello J, Rojas Y., de Paula M, Lopez-Cuenca S, Morales L., Martinez-Caro L, Fernandez-Segoviano P, Esteban A, et al. A metabolomic approach for diagnosis of experimental sepsis. Intensive Care Med 2011; 37:2023-2032.
18. Lin ZY, Xu PB, Yan S.K., Meng HB, Yang GJ, Dai WX, Liu XR, Li J.B., Deng XM, Zhang WD. A metabonomic approach to early prognostic evaluation of experimental sepsis by (1)H NMR and pattern recognition. NMR Biomed 2009; 22:601-608.
19. Xu PB, Lin ZY, Meng H.B., Yan SK, Yang Y, Liu XR, Li JB, Deng X.M., Zhang WD. A metabonomic approach to early prognostic evaluation of experimental sepsis. J Infect 2008; 56:474-481.
20. Weljie AM, Newton J, Mercier P., Carlson E, Slupsky CM Targeted profiling: quantitative analysis of 1H NMR metabolomics data. Anal Chem 2006; 78:4430-4442.
21. Eriksson L, Johansson E, Kettaneh-Wold N, Trygg J., Wikström C, Wold S. Multi-and megavariate data analysis part I: basic principles and applications. Umeå, Sweden: Umetrics AB; 2006. p. 425.
22. Trygg J, Wold S. Orthogonal projections to latent structures (O-PLS). J Chemometr 2002; 16:119-128.
23. Kramer R. Chemometric techniques for quantitative analysis. New York, NY: Marcel Dekker, Inc.; 1998.
24. Mickiewicz B, Wong HR, Vogel H.J., Winston BW Metabolomic profiling of serum samples by 1H NMR spectroscopy as a novel approach for diagnosis of pediatric septic shock. Am J Respir Crit Care Med 2012; 185:A4911.
25. Nicholson JK, Foxall PJ, Spraul M, Farrant R.D., Lindon JC 750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma. Anal Chem 1995; 67:793-811.
26. Dieterle F, Ross A, Schlotterbeck G., Senn H. Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures: application in 1H NMR metabonomics. Anal Chem 2006; 78:4281-4290.
27. Picard RR, Cook DR Cross-validation of regression models. J Am Stat Assoc 1984; 79:575-583.
28. Fawcett T. An introduction to ROC analysis. Pattern Recognit Lett 2006; 27:861-874.
29. Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6:2-8.
30. Carcillo JA, Davis AL, Zaritsky A. Role of early fluid resuscitation in pediatric septic shock. JAMA 1991; 266:1242-1245.
31. Kissoon N, Carcillo JA, Espinosa V, Argent A., Devictor D, Madden M, Singhi S., van der Voort E, Latour J. World Federation of Pediatric Intensive Care and Critical Care Societies: Global Sepsis Initiative. Pediatr Crit Care Med 2011; 12:494-503.
32. Wynn JL, Cvijanovich NZ, Allen G.L., Thomas NJ, Freishtat RJ, Anas N, Meyer K., Checchia PA, Lin R, Shanley TP, et al. The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med 2011; 17:1146-1156.
33. Liebich HM, Forst C. Hydroxycarboxylic and oxocarboxylic acids in urine: products from branched-chain amino acid degradation and from ketogenesis. J Chromatogr A 1984; 309:225-242.
34. Landaas S, Pettersen JE Clinical conditions associated with urinary excretion of 2-hydroxybutyric acid. Scand J Clin Lab Invest 1975; 35:259-266.
35. Mizock BA, Falk JL Lactic acidosis in critical illness. Crit Care Med 1992; 20:80-93.
36. Kovarik M, Muthny T, Sispera L., Holecek M. Effects of beta-hydroxy-beta-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats. J Physiol Biochem 2010; 66:311-319.
37. Wishart DS, Knox C, Guo A.C., Eisner R., Young N, Gautam B, Hau D.D., Psychogios N., Dong E, Bouatra S, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res 2009; 37:D603-D610.
38. Hasselgren PO, Talamini M, James J.H., Fischer JE Protein metabolism in different types of skeletal muscle during early and late sepsis in rats. Arch Surg 1986; 121:918-923.
39. Wannemacher RW J.r., Klainer AS, Dinterman R.E., Beisel WR The significance and mechanism of an increased serum phenylalanine-tyrosine ratio during infection. Am J Clin Nutr 1976; 29:997-1006.
40. Goldman R. The clinical evaluation of renal function. Calif Med 1956; 85: 376-380.
41. Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem J 1994; 298:249-258.
42. Bruins MJ, Lamers WH, Meijer A.J., Soeters PB, Deutz NE In vivo measurement of nitric oxide production in porcine gut, liver and muscle during hyperdynamic endotoxaemia. Br J Pharmacol 2002; 137:1225-1236.
43. Wu G, Flynn NE, Flynn S.P., Jolly CA, Davis PK Dietary protein or arginine deficiency impairs constitutive and inducible nitric oxide synthesis by young rats. J Nutr 1999; 129:1347-1354.
44. Leteurtre S, Martinot A, Duhamel A., Proulx F, Grandbastien B, Cotting J., Gottesman R, Joffe A, Pfenninger J, Hubert P, et al. Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet 2003; 362:192-197.
45. Leteurtre S, Duhamel A, Grandbastien B., Lacroix J, Leclerc F. Paediatric logistic organ dysfunction (PELOD) score. Lancet 2006; 367:897, author reply 900-902.
46. Wilkinson JD, Pollack MM, Glass N.L., Kanter RK, Katz RW, Steinhart CM Mortality associated with multiple organ system failure and sepsis in pediatric intensive care unit. J Pediatr 1987; 111:324-328.
47. Pollack MM, Ruttimann UE, Getson PR Pediatric risk of mortality (PRISM) score. Crit Care Med 1988; 16:1110-1116.
48. Pollack MM, Patel KM, Ruttimann UE The Pediatric Risk of Mortality III-Acute Physiology Score (PRISM III-APS): a method of assessing physiologic instability for pediatric intensive care unit patients. J Pediatr 1997; 131:575-581.
49. Pollack MM, Patel KM, Ruttimann UE PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med 1996; 24:743-752.