메뉴 건너뛰기




Volumn 19, Issue 1, 2016, Pages

Elevation and persistence of CD8 T-cells in HIV infection: The Achilles heel in the ART era

Author keywords

Antiretroviral therapy; Bystander activation; CD8 T cell persistence; HIV; T cell exhaustion

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CYTOKINE;

EID: 84960154698     PISSN: None     EISSN: 17582652     Source Type: Journal    
DOI: 10.7448/IAS.19.1.20697     Document Type: Article
Times cited : (85)

References (92)
  • 1
    • 84930464569 scopus 로고    scopus 로고
    • Course and clinical significance of CD8+ T-cell counts in a large cohort of HIV-infected individuals
    • Helleberg M, Kronborg G, Ullum H, Ryder LP, Obel N, Gerstoft J. Course and clinical significance of CD8+ T-cell counts in a large cohort of HIV-infected individuals. J Infect Dis. 2015; 211(11): 1726-34.
    • (2015) J Infect Dis. , vol.211 , Issue.11 , pp. 1726-1734
    • Helleberg, M.1    Kronborg, G.2    Ullum, H.3    Ryder, L.P.4    Obel, N.5    Gerstoft, J.6
  • 2
    • 84905664062 scopus 로고    scopus 로고
    • Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease
    • Emu B, Moretto WJ, Hoh R, Krone M, Martin JN, Nixon DF, et al. Composition and function of T cell subpopulations are slow to change despite effective antiretroviral treatment of HIV disease. PLoS One. 2014; 9(1): 85613.
    • (2014) PLoS One. , vol.9 , Issue.1 , pp. 85613
    • Emu, B.1    Moretto, W.J.2    Hoh, R.3    Krone, M.4    Martin, J.N.5    Nixon, D.F.6
  • 3
    • 84901686066 scopus 로고    scopus 로고
    • HIVinfected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality
    • Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, et al. HIVinfected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014; 10(5): 1004078.
    • (2014) PLoS Pathog. , vol.10 , Issue.5 , pp. 1004078
    • Serrano-Villar, S.1    Sainz, T.2    Lee, S.A.3    Hunt, P.W.4    Sinclair, E.5    Shacklett, B.L.6
  • 6
    • 84962221927 scopus 로고    scopus 로고
    • CD8 T-Cell expansion and inflammation linked to CMV coinfection in ART-Treated HIV infection
    • Freeman ML, Mudd JC, Shive CL, Younes SA, Panigrahi S, Sieg SF, et al. CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-Treated HIV Infection. Clin Infect Dis. 2016; 62(3): 392-6.
    • (2016) Clin Infect Dis. , vol.62 , Issue.3 , pp. 392-396
    • Freeman, M.L.1    Mudd, J.C.2    Shive, C.L.3    Younes, S.A.4    Panigrahi, S.5    Sieg, S.F.6
  • 7
    • 0035915757 scopus 로고    scopus 로고
    • Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study
    • Olsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, Ferguson FG. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study. Mech Age Dev. 2000; 121(1-3): 187-201.
    • (2000) Mech Age Dev. , vol.121 , Issue.1-3 , pp. 187-201
    • Olsson, J.1    Wikby, A.2    Johansson, B.3    Lofgren, S.4    Nilsson, B.O.5    Ferguson, F.G.6
  • 8
    • 0037012021 scopus 로고    scopus 로고
    • Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: The Swedish NONA immune study
    • Wikby A, Johansson B, Olsson J, Lofgren S, Nilsson BO, Ferguson F. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: The Swedish NONA immune study. Exp Gerontol. 2002; 37(2-3): 445-53.
    • (2002) Exp Gerontol. , vol.37 , Issue.2-3 , pp. 445-453
    • Wikby, A.1    Johansson, B.2    Olsson, J.3    Lofgren, S.4    Nilsson, B.O.5    Ferguson, F.6
  • 9
    • 0028839467 scopus 로고
    • Immune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and nonsurvivors
    • Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B. Immune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and nonsurvivors. J Gerontol A Biol Sci Med Sci. 1995; 50(6): B378-82.
    • (1995) J Gerontol A Biol Sci Med Sci. , vol.50 , Issue.6 , pp. B378-B382
    • Ferguson, F.G.1    Wikby, A.2    Maxson, P.3    Olsson, J.4    Johansson, B.5
  • 10
    • 20544476197 scopus 로고    scopus 로고
    • An immune risk phenotype, cognitive impairment, and survival in very late life: Impact of allostatic load in Swedish octogenarian and nonagenarian humans
    • Wikby A, Ferguson F, Forsey R, Thompson J, Strindhall J, Lofgre S, et al. An immune risk phenotype, cognitive impairment, and survival in very late life: Impact of allostatic load in Swedish octogenarian and nonagenarian humans. J Gerontol A Biol Sci Med Sci. 2005; 60(5): 556-65.
    • (2005) J Gerontol A Biol Sci Med Sci. , vol.60 , Issue.5 , pp. 556-565
    • Wikby, A.1    Ferguson, F.2    Forsey, R.3    Thompson, J.4    Strindhall, J.5    Lofgre, S.6
  • 11
    • 84880571275 scopus 로고    scopus 로고
    • The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: The Swedish HEXA immune study
    • Strindhall J, Skog M, Ernerudh J, Bengner M, Lofgren S, Matussek A, et al. The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: The Swedish HEXA immune study. Age (Dordr). 2013; 35(3): 985-91.
    • (2013) Age (Dordr). , vol.35 , Issue.3 , pp. 985-991
    • Strindhall, J.1    Skog, M.2    Ernerudh, J.3    Bengner, M.4    Lofgren, S.5    Matussek, A.6
  • 12
    • 3342995295 scopus 로고    scopus 로고
    • Inflamm-Aging: Autoimmunity, and the immunerisk phenotype
    • Boren E, Gershwin ME. Inflamm-Aging: Autoimmunity, and the immunerisk phenotype. Autoimmun Rev. 2004; 3(5): 401-6.
    • (2004) Autoimmun Rev. , vol.3 , Issue.5 , pp. 401-406
    • Boren, E.1    Gershwin, M.E.2
  • 13
    • 79551614790 scopus 로고    scopus 로고
    • HIV infection, inflammation, immunosenescence, and aging
    • Deeks SG. HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med. 2011; 62: 141-55.
    • (2011) Annu Rev Med. , vol.62 , pp. 141-155
    • Deeks, S.G.1
  • 14
    • 84922361609 scopus 로고    scopus 로고
    • Comprehensive evaluation of the immune risk phenotype in successfully treated HIV-infected individuals
    • Ndumbi P, Gilbert L, Tsoukas CM. Comprehensive evaluation of the immune risk phenotype in successfully treated HIV-infected individuals. PLoS One. 2015; 10(2): 0117039.
    • (2015) PLoS One. , vol.10 , Issue.2 , pp. 0117039
    • Ndumbi, P.1    Gilbert, L.2    Tsoukas, C.M.3
  • 15
    • 67449147145 scopus 로고    scopus 로고
    • The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
    • Goonetilleke N, Liu MK, Salazar-Gonzalez JF, Ferrari G, Giorgi E, Ganusov VV, et al. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J Exp Med. 2009; 206(6): 1253-72.
    • (2009) J Exp Med. , vol.206 , Issue.6 , pp. 1253-1272
    • Goonetilleke, N.1    Liu, M.K.2    Salazar-Gonzalez, J.F.3    Ferrari, G.4    Giorgi, E.5    Ganusov, V.V.6
  • 16
    • 84907967547 scopus 로고    scopus 로고
    • Emergence of individual HIV-specific CD8 T cell responses during primary HIV-1 infection can determine long-Term disease outcome
    • Streeck H, Lu R, Beckwith N, Milazzo M, Liu M, Routy JP, et al. Emergence of individual HIV-specific CD8 T cell responses during primary HIV-1 infection can determine long-Term disease outcome. J Virol. 2014; 88(21): 12793-801.
    • (2014) J Virol. , vol.88 , Issue.21 , pp. 12793-12801
    • Streeck, H.1    Lu, R.2    Beckwith, N.3    Milazzo, M.4    Liu, M.5    Routy, J.P.6
  • 17
    • 79960014190 scopus 로고    scopus 로고
    • Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension
    • Lewis MG, DaFonseca S, Chomont N, Palamara AT, Tardugno M, Mai A, et al. Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension. AIDS. 2011; 25(11): 1347-56.
    • (2011) AIDS. , vol.25 , Issue.11 , pp. 1347-1356
    • Lewis, M.G.1    DaFonseca, S.2    Chomont, N.3    Palamara, A.T.4    Tardugno, M.5    Mai, A.6
  • 21
    • 84861114268 scopus 로고    scopus 로고
    • T-cell subset distribution in HIV-1-infected patients after 12 years of treatment-induced viremic suppression
    • Ronsholt FF, Ullum H, Katzenstein TL, Gerstoft J, Ostrowski SR. T-cell subset distribution in HIV-1-infected patients after 12 years of treatment-induced viremic suppression. J Acquir Immune Defic Syndr. 2012; 61(3): 270-8.
    • (2012) J Acquir Immune Defic Syndr. , vol.61 , Issue.3 , pp. 270-278
    • Ronsholt, F.F.1    Ullum, H.2    Katzenstein, T.L.3    Gerstoft, J.4    Ostrowski, S.R.5
  • 22
    • 84960079561 scopus 로고    scopus 로고
    • Early initiation rather than prolonged duration of antiretroviral therapy in HIV infection contributes to the normalization of CD8 T-cell counts
    • Cao W, Mehraj V, Trottier B, Baril JG, Leblanc R, Lebouche B, et al. Early initiation rather than prolonged duration of antiretroviral therapy in HIV infection contributes to the normalization of CD8 T-cell counts. Clin Infect Dis. 2016; 62(2): 250-7.
    • (2016) Clin Infect Dis. , vol.62 , Issue.2 , pp. 250-257
    • Cao, W.1    Mehraj, V.2    Trottier, B.3    Baril, J.G.4    Leblanc, R.5    Lebouche, B.6
  • 23
    • 85026938616 scopus 로고    scopus 로고
    • Normalization of CD4/CD8 ratio after long-Term antiretroviral therapy: Gender and aging issues. Abstract O064
    • 2015 Apr 30-May 3; Toronto, ON, Canada
    • Lu W, Mehraj V, Vyboh K, Cao W, Pexos C, Routy JP. Normalization of CD4/CD8 ratio after long-Term antiretroviral therapy: Gender and aging issues. Abstract O064. In: The 24th Annual Canadian Conference on HIV/AIDS Research; 2015 Apr 30-May 3; Toronto, ON, Canada; 2015.
    • (2015) The 24th Annual Canadian Conference on HIV/AIDS Research
    • Lu, W.1    Mehraj, V.2    Vyboh, K.3    Cao, W.4    Pexos, C.5    Routy, J.P.6
  • 24
    • 84964893968 scopus 로고    scopus 로고
    • Quantification of naive and memory T-cell turnover during HIV-1 infection
    • Vrisekoop N, Drylewicz J, Van Gent R, Mugwagwa T, Van Lelyveld S, Veel E, et al. Quantification of naive and memory T-cell turnover during HIV-1 infection. AIDS. 2015; 29(16): 2071-80.
    • (2015) AIDS. , vol.29 , Issue.16 , pp. 2071-2080
    • Vrisekoop, N.1    Drylewicz, J.2    Van Gent, R.3    Mugwagwa, T.4    Van Lelyveld, S.5    Veel, E.6
  • 25
    • 84901244816 scopus 로고    scopus 로고
    • Clinical, immunological and treatment-related factors associated with normalised CD4+/CD8+T-cell ratio: Effect of naive and memory T-cell subsets
    • Tinago W, Coghlan E, Macken A, McAndrews J, Doak B, Prior-Fuller C, et al. Clinical, immunological and treatment-related factors associated with normalised CD4+/CD8+T-cell ratio: Effect of naive and memory T-cell subsets. PLoS One. 2014; 9(5): E97011.
    • (2014) PLoS One. , vol.9 , Issue.5 , pp. e97011
    • Tinago, W.1    Coghlan, E.2    Macken, A.3    McAndrews, J.4    Doak, B.5    Prior-Fuller, C.6
  • 26
    • 84936810525 scopus 로고    scopus 로고
    • Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection
    • Jenabian MA, El-Far M, Vyboh K, Kema I, Kema I, Costiniuk CT, Thomas R, et al. Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection. J Infect Dis. 2015; 212(3): 355-66.
    • (2015) J Infect Dis. , vol.212 , Issue.3 , pp. 355-366
    • Jenabian, M.A.1    El-Far, M.2    Vyboh, K.3    Kema, I.4    Kema, I.5    Costiniuk, C.T.6    Thomas, R.7
  • 27
    • 0033010954 scopus 로고    scopus 로고
    • Phenotypic and functional characterization of lymphocytes derived from normal and HIV-1-infected human lymph nodes
    • Tedla N, Dwyer J, Truskett P, Taub D, Wakefield D, Lloyd A. Phenotypic and functional characterization of lymphocytes derived from normal and HIV-1-infected human lymph nodes. Clin Exp Immunol. 1999; 117(1): 92-9.
    • (1999) Clin Exp Immunol. , vol.117 , Issue.1 , pp. 92-99
    • Tedla, N.1    Dwyer, J.2    Truskett, P.3    Taub, D.4    Wakefield, D.5    Lloyd, A.6
  • 28
    • 34248400051 scopus 로고    scopus 로고
    • Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1
    • Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, et al. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood. 2007; 109(10): 4272-9.
    • (2007) Blood. , vol.109 , Issue.10 , pp. 4272-4279
    • Biancotto, A.1    Grivel, J.C.2    Iglehart, S.J.3    Vanpouille, C.4    Lisco, A.5    Sieg, S.F.6
  • 29
    • 84953329705 scopus 로고    scopus 로고
    • The effect of timing of antiretroviral therapy on CD4 T-cell reconstitution in the intestine of HIV-infected patients
    • Allers K, Puyskens A, Epple HJ, Schurmann D, Hofmann J, Moos V, et al. The effect of timing of antiretroviral therapy on CD4 T-cell reconstitution in the intestine of HIV-infected patients. Mucosal Immunol. 2016; 9(1): 265-74.
    • (2016) Mucosal Immunol. , vol.9 , Issue.1 , pp. 265-274
    • Allers, K.1    Puyskens, A.2    Epple, H.J.3    Schurmann, D.4    Hofmann, J.5    Moos, V.6
  • 30
    • 84900412744 scopus 로고    scopus 로고
    • Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio
    • Serrano-Villar S, Perez-Elias MJ, Dronda F, Casado JL, Moreno A, Royuela A, et al. Increased risk of serious non-AIDS-related events in HIV-infected subjects on antiretroviral therapy associated with a low CD4/CD8 ratio. PLoS One. 2014; 9(1): E85798.
    • (2014) PLoS One. , vol.9 , Issue.1 , pp. e85798
    • Serrano-Villar, S.1    Perez-Elias, M.J.2    Dronda, F.3    Casado, J.L.4    Moreno, A.5    Royuela, A.6
  • 31
    • 84937938856 scopus 로고    scopus 로고
    • Association of microbial translocation biomarkers with clinical outcome in controllers HIVinfected patients
    • Leon A, Leal L, Torres B, Lucero C, Inciarte A, Arnedo M, et al. Association of microbial translocation biomarkers with clinical outcome in controllers HIVinfected patients. AIDS. 2015; 29(6): 675-81.
    • (2015) AIDS. , vol.29 , Issue.6 , pp. 675-681
    • Leon, A.1    Leal, L.2    Torres, B.3    Lucero, C.4    Inciarte, A.5    Arnedo, M.6
  • 32
    • 84945450441 scopus 로고    scopus 로고
    • Markers of renal disease and function are associated with systemic inflammation in HIV infection
    • Gupta SK, Kitch D, Tierney C, Melbourne K, Ha B, McComsey GA. Markers of renal disease and function are associated with systemic inflammation in HIV infection. HIV Med. 2015; 16(10): 591-8.
    • (2015) HIV Med. , vol.16 , Issue.10 , pp. 591-598
    • Gupta, S.K.1    Kitch, D.2    Tierney, C.3    Melbourne, K.4    Ha, B.5    McComsey, G.A.6
  • 33
    • 84925555604 scopus 로고    scopus 로고
    • Interleukin-6, high sensitivity C-reactive protein, and the development of type 2 diabetes among HIV-positive patients taking antiretroviral therapy
    • Betene ADC, De Wit S, Neuhaus J, Palfreeman A, Pepe R, Pankow JS, et al. Interleukin-6, high sensitivity C-reactive protein, and the development of type 2 diabetes among HIV-positive patients taking antiretroviral therapy. J Acquir Immune Defic Syndr. 2014; 67(5): 538-46.
    • (2014) J Acquir Immune Defic Syndr. , vol.67 , Issue.5 , pp. 538-546
    • Betene, A.D.C.1    De Wit, S.2    Neuhaus, J.3    Palfreeman, A.4    Pepe, R.5    Pankow, J.S.6
  • 34
    • 4043102575 scopus 로고    scopus 로고
    • CD8+ T cells specific for EBV, cytomegalovirus, and influenza virus are activated during primary HIV infection
    • Doisne JM, Urrutia A, Lacabaratz-Porret C, Goujard C, Meyer L, Chaix ML, et al. CD8+ T cells specific for EBV, cytomegalovirus, and influenza virus are activated during primary HIV infection. J Immunol. 2004; 173(4): 2410-8.
    • (2004) J Immunol. , vol.173 , Issue.4 , pp. 2410-2418
    • Doisne, J.M.1    Urrutia, A.2    Lacabaratz-Porret, C.3    Goujard, C.4    Meyer, L.5    Chaix, M.L.6
  • 35
    • 0001426414 scopus 로고    scopus 로고
    • Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection
    • Wilson JD, Ogg GS, Allen RL, Davis C, Shaunak S, Downie J, et al. Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection. AIDS. 2000; 14(3): 225-33.
    • (2000) AIDS. , vol.14 , Issue.3 , pp. 225-233
    • Wilson, J.D.1    Ogg, G.S.2    Allen, R.L.3    Davis, C.4    Shaunak, S.5    Downie, J.6
  • 36
    • 0035198096 scopus 로고    scopus 로고
    • Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: Relationship to viral load in untreated HIV infection
    • Betts MR, Ambrozak DR, Douek DC, Bonhoeffer S, Brenchley JM, Casazza JP, et al. Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: Relationship to viral load in untreated HIV infection. J Virol. 2001; 75(24): 11983-91.
    • (2001) J Virol. , vol.75 , Issue.24 , pp. 11983-11991
    • Betts, M.R.1    Ambrozak, D.R.2    Douek, D.C.3    Bonhoeffer, S.4    Brenchley, J.M.5    Casazza, J.P.6
  • 37
    • 0006922163 scopus 로고    scopus 로고
    • Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy
    • Ogg GS, Jin X, Bonhoeffer S, Moss P, Nowak MA, Monard S, et al. Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy. J Virol. 1999; 73(1): 797-800.
    • (1999) J Virol. , vol.73 , Issue.1 , pp. 797-800
    • Ogg, G.S.1    Jin, X.2    Bonhoeffer, S.3    Moss, P.4    Nowak, M.A.5    Monard, S.6
  • 38
    • 0030036342 scopus 로고    scopus 로고
    • Induction of bystander T cell proliferation by viruses and type I interferon in vivo
    • Tough DF, Borrow P, Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science. 1996; 272(5270): 1947-50.
    • (1996) Science. , vol.272 , Issue.5270 , pp. 1947-1950
    • Tough, D.F.1    Borrow, P.2    Sprent, J.3
  • 39
    • 0036644324 scopus 로고    scopus 로고
    • Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation
    • Kim SK, Brehm MA, Welsh RM, Selin LK. Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation. J Immunol. 2002; 169(1): 90-8.
    • (2002) J Immunol. , vol.169 , Issue.1 , pp. 90-98
    • Kim, S.K.1    Brehm, M.A.2    Welsh, R.M.3    Selin, L.K.4
  • 40
    • 84894247943 scopus 로고    scopus 로고
    • CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals
    • Bastidas S, Graw F, Smith MZ, Kuster H, Gunthard HF, Oxenius A. CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals. J Immunol. 2014; 192(4): 1732-44.
    • (2014) J Immunol. , vol.192 , Issue.4 , pp. 1732-1744
    • Bastidas, S.1    Graw, F.2    Smith, M.Z.3    Kuster, H.4    Gunthard, H.F.5    Oxenius, A.6
  • 41
    • 0034968096 scopus 로고    scopus 로고
    • Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses
    • McNally JM, Zarozinski CC, Lin MY, Brehm MA, Chen HD, Welsh RM. Attrition of bystander CD8 T cells during virus-induced T-cell and interferon responses. J Virol. 2001; 75(13): 5965-76.
    • (2001) J Virol. , vol.75 , Issue.13 , pp. 5965-5976
    • McNally, J.M.1    Zarozinski, C.C.2    Lin, M.Y.3    Brehm, M.A.4    Chen, H.D.5    Welsh, R.M.6
  • 42
    • 58149337062 scopus 로고    scopus 로고
    • Memory CD8 T-cell compartment grows in size with immunological experience
    • Vezys V, Yates A, Casey KA, Lanier G, Ahmed R, Antia R, et al. Memory CD8 T-cell compartment grows in size with immunological experience. Nature. 2009; 457(7226): 196-9.
    • (2009) Nature. , vol.457 , Issue.7226 , pp. 196-199
    • Vezys, V.1    Yates, A.2    Casey, K.A.3    Lanier, G.4    Ahmed, R.5    Antia, R.6
  • 43
    • 84891751192 scopus 로고    scopus 로고
    • A candidate anti-HIV reservoir compound, auranofin, exerts a selective 'antimemory' effect by exploiting the baseline oxidative status of lymphocytes
    • Chirullo B, Sgarbanti R, Limongi D, Shytaj IL, Alvarez D, Das B, et al. A candidate anti-HIV reservoir compound, auranofin, exerts a selective 'antimemory' effect by exploiting the baseline oxidative status of lymphocytes. Cell Death Dis. 2013; 4: E944.
    • (2013) Cell Death Dis. , vol.4 , pp. e944
    • Chirullo, B.1    Sgarbanti, R.2    Limongi, D.3    Shytaj, I.L.4    Alvarez, D.5    Das, B.6
  • 44
    • 15444363618 scopus 로고    scopus 로고
    • Depletion of regulatory T cells in HIV infection is associated with immune activation
    • Eggena MP, Barugahare B, Jones N, Okello M, Mutalya S, Kityo C, et al. Depletion of regulatory T cells in HIV infection is associated with immune activation. J Immunol. 2005; 174(7): 4407-14.
    • (2005) J Immunol. , vol.174 , Issue.7 , pp. 4407-4414
    • Eggena, M.P.1    Barugahare, B.2    Jones, N.3    Okello, M.4    Mutalya, S.5    Kityo, C.6
  • 45
    • 3543098686 scopus 로고    scopus 로고
    • CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
    • Kinter AL, Hennessey M, Bell A, Kern S, Lin Y, Daucher M, et al. CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med. 2004; 200(3): 331-43.
    • (2004) J Exp Med. , vol.200 , Issue.3 , pp. 331-343
    • Kinter, A.L.1    Hennessey, M.2    Bell, A.3    Kern, S.4    Lin, Y.5    Daucher, M.6
  • 46
    • 84885764222 scopus 로고    scopus 로고
    • Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers
    • Jenabian MA, Patel M, Kema I, Kanagaratham C, Radzioch D, Thebault P, et al. Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers. PLoS One. 2013; 8(10): 78146.
    • (2013) PLoS One. , vol.8 , Issue.10 , pp. 78146
    • Jenabian, M.A.1    Patel, M.2    Kema, I.3    Kanagaratham, C.4    Radzioch, D.5    Thebault, P.6
  • 47
    • 84906048133 scopus 로고    scopus 로고
    • Editorial overview: Cell dysfunction and exhaustion in HIV infection
    • Seddiki N, Kaufmann DE. Editorial overview: Cell dysfunction and exhaustion in HIV infection. Curr Opin HIV AIDS. 2014; 9(5): 437-8.
    • (2014) Curr Opin HIV AIDS. , vol.9 , Issue.5 , pp. 437-438
    • Seddiki, N.1    Kaufmann, D.E.2
  • 48
    • 84928047018 scopus 로고    scopus 로고
    • Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection
    • Radebe M, Gounder K, Mokgoro M, Ndhlovu ZM, Mncube Z, Mkhize L, et al. Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection. AIDS. 2015; 29(1): 23-33.
    • (2015) AIDS. , vol.29 , Issue.1 , pp. 23-33
    • Radebe, M.1    Gounder, K.2    Mokgoro, M.3    Ndhlovu, Z.M.4    Mncube, Z.5    Mkhize, L.6
  • 49
    • 84866176745 scopus 로고    scopus 로고
    • CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction
    • Peretz Y, He Z, Shi Y, Yassine-Diab B, Goulet JP, Bordi R, et al. CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction. PLoS Pathog. 2012; 8(8): 1002840.
    • (2012) PLoS Pathog. , vol.8 , Issue.8 , pp. 1002840
    • Peretz, Y.1    He, Z.2    Shi, Y.3    Yassine-Diab, B.4    Goulet, J.P.5    Bordi, R.6
  • 50
    • 0037561928 scopus 로고    scopus 로고
    • Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
    • Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood. 2003; 101(7): 2711-20.
    • (2003) Blood. , vol.101 , Issue.7 , pp. 2711-2720
    • Brenchley, J.M.1    Karandikar, N.J.2    Betts, M.R.3    Ambrozak, D.R.4    Hill, B.J.5    Crotty, L.E.6
  • 51
    • 77249105912 scopus 로고    scopus 로고
    • Early immune senescence in HIV disease
    • Desai S, Landay A. Early immune senescence in HIV disease. Curr HIV/AIDS Rep. 2010; 7(1): 4-10.
    • (2010) Curr HIV/AIDS Rep. , vol.7 , Issue.1 , pp. 4-10
    • Desai, S.1    Landay, A.2
  • 52
    • 84880119204 scopus 로고    scopus 로고
    • Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells
    • Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, et al. Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. J Immunol. 2013; 191(2): 540-4.
    • (2013) J Immunol. , vol.191 , Issue.2 , pp. 540-544
    • Youngblood, B.1    Noto, A.2    Porichis, F.3    Akondy, R.S.4    Ndhlovu, Z.M.5    Austin, J.W.6
  • 54
    • 67649217469 scopus 로고    scopus 로고
    • IL-21 is required to control chronic viral infection
    • Elsaesser H, Sauer K, Brooks DG. IL-21 is required to control chronic viral infection. Science. 2009; 324(5934): 1569-72.
    • (2009) Science. , vol.324 , Issue.5934 , pp. 1569-1572
    • Elsaesser, H.1    Sauer, K.2    Brooks, D.G.3
  • 55
    • 67649203681 scopus 로고    scopus 로고
    • A vital role for interleukin-21 in the control of a chronic viral infection
    • Yi JS, Du M, Zajac AJ. A vital role for interleukin-21 in the control of a chronic viral infection. Science. 2009; 324(5934): 1572-6.
    • (2009) Science. , vol.324 , Issue.5934 , pp. 1572-1576
    • Yi, J.S.1    Du, M.2    Zajac, A.J.3
  • 56
    • 73949110184 scopus 로고    scopus 로고
    • Dynamics and consequences of IL-21 production in HIV-infected individuals: A longitudinal and cross-sectional study
    • Iannello A, Boulassel MR, Samarani S, Debbeche O, Tremblay C, Toma E, et al. Dynamics and consequences of IL-21 production in HIV-infected individuals: A longitudinal and cross-sectional study. J Immunol. 2010; 184(1): 114-26.
    • (2010) J Immunol. , vol.184 , Issue.1 , pp. 114-126
    • Iannello, A.1    Boulassel, M.R.2    Samarani, S.3    Debbeche, O.4    Tremblay, C.5    Toma, E.6
  • 57
    • 78649516786 scopus 로고    scopus 로고
    • HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function
    • Chevalier MF, Julg B, Pyo A, Flanders M, Ranasinghe S, Soghoian DZ, et al. HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function. J Virol. 2011; 85(2): 733-41.
    • (2011) J Virol. , vol.85 , Issue.2 , pp. 733-741
    • Chevalier, M.F.1    Julg, B.2    Pyo, A.3    Flanders, M.4    Ranasinghe, S.5    Soghoian, D.Z.6
  • 58
    • 84928139237 scopus 로고    scopus 로고
    • Addition of interleukin-21 for expansion of T-cells for adoptive immunotherapy of murine melanoma
    • Zoon CK, Wan W, Graham L, Bear HD. Addition of interleukin-21 for expansion of T-cells for adoptive immunotherapy of murine melanoma. Int J Mol Sci. 2015; 16(4): 8744-60.
    • (2015) Int J Mol Sci. , vol.16 , Issue.4 , pp. 8744-8760
    • Zoon, C.K.1    Wan, W.2    Graham, L.3    Bear, H.D.4
  • 59
    • 84937683919 scopus 로고    scopus 로고
    • Prolonged antiretroviral therapy preserves HIV-1-specific CD8 T cells with stem cell-like properties
    • Vigano S, Negron J, Ouyang Z, Rosenberg ES, Walker BD, Lichterfeld M, et al. Prolonged antiretroviral therapy preserves HIV-1-specific CD8 T cells with stem cell-like properties. J Virol. 2015; 89(15): 7829-40.
    • (2015) J Virol. , vol.89 , Issue.15 , pp. 7829-7840
    • Vigano, S.1    Negron, J.2    Ouyang, Z.3    Rosenberg, E.S.4    Walker, B.D.5    Lichterfeld, M.6
  • 60
    • 84937837169 scopus 로고    scopus 로고
    • Molecular and cellular insights into T cell exhaustion
    • Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015; 15(8): 486-99.
    • (2015) Nat Rev Immunol. , vol.15 , Issue.8 , pp. 486-499
    • Wherry, E.J.1    Kurachi, M.2
  • 61
    • 84893710050 scopus 로고    scopus 로고
    • Human memory T cells: Generation, compartmentalization and homeostasis
    • Farber DL, Yudanin NA, Restifo NP. Human memory T cells: Generation, compartmentalization and homeostasis. Nat Rev Immunol. 2014; 14(1): 24-35.
    • (2014) Nat Rev Immunol. , vol.14 , Issue.1 , pp. 24-35
    • Farber, D.L.1    Yudanin, N.A.2    Restifo, N.P.3
  • 62
    • 0038577099 scopus 로고    scopus 로고
    • Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: Association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes
    • Kalayjian RC, Landay A, Pollard RB, Taub DD, Gross BH, Francis IR, et al. Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: Association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes. J Infect Dis. 2003; 187(12): 1924-33.
    • (2003) J Infect Dis. , vol.187 , Issue.12 , pp. 1924-1933
    • Kalayjian, R.C.1    Landay, A.2    Pollard, R.B.3    Taub, D.D.4    Gross, B.H.5    Francis, I.R.6
  • 63
    • 33749512800 scopus 로고    scopus 로고
    • High cytotoxic and specific migratory potencies of senescent CD8+ CD57+ cells in HIV-infected and uninfected individuals
    • Le Priol Y, Puthier D, Lecureuil C, Combadiere C, Debre P, Nguyen C, et al. High cytotoxic and specific migratory potencies of senescent CD8+ CD57+ cells in HIV-infected and uninfected individuals. J Immunol. 2006; 177(8): 5145-54.
    • (2006) J Immunol. , vol.177 , Issue.8 , pp. 5145-5154
    • Le Priol, Y.1    Puthier, D.2    Lecureuil, C.3    Combadiere, C.4    Debre, P.5    Nguyen, C.6
  • 64
    • 19344370239 scopus 로고    scopus 로고
    • Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection
    • Papagno L, Spina CA, Marchant A, Salio M, Rufer N, Little S, et al. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol. 2004; 2(2): E20.
    • (2004) PLoS Biol. , vol.2 , Issue.2 , pp. E20
    • Papagno, L.1    Spina, C.A.2    Marchant, A.3    Salio, M.4    Rufer, N.5    Little, S.6
  • 65
    • 84977944890 scopus 로고    scopus 로고
    • Cytomegalovirus infection and memory T cell inflation
    • Kim J, Kim AR, Shin EC. Cytomegalovirus infection and memory T cell inflation. Immune Netw. 2015; 15(4): 186-90.
    • (2015) Immune Netw. , vol.15 , Issue.4 , pp. 186-190
    • Kim, J.1    Kim, A.R.2    Shin, E.C.3
  • 66
    • 68149148869 scopus 로고    scopus 로고
    • Biomarkers of human immunosenescence: Impact of Cytomegalovirus infection
    • Derhovanessian E, Larbi A, Pawelec G. Biomarkers of human immunosenescence: Impact of Cytomegalovirus infection. Curr Opin Immunol. 2009; 21(4): 440-5.
    • (2009) Curr Opin Immunol. , vol.21 , Issue.4 , pp. 440-445
    • Derhovanessian, E.1    Larbi, A.2    Pawelec, G.3
  • 67
    • 84896348458 scopus 로고    scopus 로고
    • Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging
    • Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, et al. Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging. PLoS One. 2014; 9(2): 89444.
    • (2014) PLoS One. , vol.9 , Issue.2 , pp. 89444
    • Lee, S.A.1    Sinclair, E.2    Hatano, H.3    Hsue, P.Y.4    Epling, L.5    Hecht, F.M.6
  • 68
    • 84902284706 scopus 로고    scopus 로고
    • Low proportions of CD28-CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection
    • Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, et al. Low proportions of CD28-CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection. J Infect Dis. 2014; 210(3): 374-82.
    • (2014) J Infect Dis. , vol.210 , Issue.3 , pp. 374-382
    • Lee, S.A.1    Sinclair, E.2    Jain, V.3    Huang, Y.4    Epling, L.5    Van Natta, M.6
  • 69
    • 0036109159 scopus 로고    scopus 로고
    • Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
    • Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L, et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002; 8(4): 379-85.
    • (2002) Nat Med. , vol.8 , Issue.4 , pp. 379-385
    • Appay, V.1    Dunbar, P.R.2    Callan, M.3    Klenerman, P.4    Gillespie, G.M.5    Papagno, L.6
  • 70
    • 58149378337 scopus 로고    scopus 로고
    • HIV infection-Associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells
    • Catalfamo M, Di Mascio M, Hu Z, Srinivasula S, Thaker V, Adelsberger J, et al. HIV infection-Associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells. Proc Natl Acad Sci USA. 2008; 105(50): 19851-6.
    • (2008) Proc Natl Acad Sci USA. , vol.105 , Issue.50 , pp. 19851-19856
    • Catalfamo, M.1    Di Mascio, M.2    Hu, Z.3    Srinivasula, S.4    Thaker, V.5    Adelsberger, J.6
  • 71
    • 79951825000 scopus 로고    scopus 로고
    • CD4 and CD8 T cell immune activation during chronic HIV infection: Roles of homeostasis, HIV, type I IFN, and IL-7
    • Catalfamo M, Wilhelm C, Tcheung L, Proschan M, Friesen T, Park JH, et al. CD4 and CD8 T cell immune activation during chronic HIV infection: Roles of homeostasis, HIV, type I IFN, and IL-7. J Immunol. 2011; 186(4): 2106-16.
    • (2011) J Immunol. , vol.186 , Issue.4 , pp. 2106-2116
    • Catalfamo, M.1    Wilhelm, C.2    Tcheung, L.3    Proschan, M.4    Friesen, T.5    Park, J.H.6
  • 72
    • 84895729048 scopus 로고    scopus 로고
    • Longitudinal analysis of distribution and function of plasmacytoid dendritic cells in peripheral blood and gut mucosa of HIV infected patients
    • Lehmann C, Jung N, Forster K, Koch N, Leifeld L, Fischer J, et al. Longitudinal analysis of distribution and function of plasmacytoid dendritic cells in peripheral blood and gut mucosa of HIV infected patients. J Infect Dis. 2014; 209(6): 940-9.
    • (2014) J Infect Dis. , vol.209 , Issue.6 , pp. 940-949
    • Lehmann, C.1    Jung, N.2    Forster, K.3    Koch, N.4    Leifeld, L.5    Fischer, J.6
  • 73
    • 84936754064 scopus 로고    scopus 로고
    • Clinical relevance of kynurenine pathway in HIV/AIDS: An immune checkpoint at the crossroads of metabolism and inflammation
    • Routy JP, Mehraj V, Vyboh K, Cao W, Kema I, Jenabian MA. Clinical relevance of kynurenine pathway in HIV/AIDS: An immune checkpoint at the crossroads of metabolism and inflammation. AIDS Rev. 2015; 17(2): 96-106.
    • (2015) AIDS Rev. , vol.17 , Issue.2 , pp. 96-106
    • Routy, J.P.1    Mehraj, V.2    Vyboh, K.3    Cao, W.4    Kema, I.5    Jenabian, M.A.6
  • 74
    • 11844252670 scopus 로고    scopus 로고
    • Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-Alpha beta and IFN-gamma
    • Kamath AT, Sheasby CE, Tough DF. Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-Alpha beta and IFN-gamma. J Immunol. 2005; 174(2): 767-76.
    • (2005) J Immunol. , vol.174 , Issue.2 , pp. 767-776
    • Kamath, A.T.1    Sheasby, C.E.2    Tough, D.F.3
  • 75
    • 80052413595 scopus 로고    scopus 로고
    • IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques
    • Lugli E, Mueller YM, Lewis MG, Villinger F, Katsikis PD, Roederer M. IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques. Blood. 2011; 118(9): 2520-9.
    • (2011) Blood. , vol.118 , Issue.9 , pp. 2520-2529
    • Lugli, E.1    Mueller, Y.M.2    Lewis, M.G.3    Villinger, F.4    Katsikis, P.D.5    Roederer, M.6
  • 76
    • 84901675589 scopus 로고    scopus 로고
    • Inflammatory cytokines drive CD4+T-cell cycling and impaired responsiveness to interleukin 7: Implications for immune failure in HIV disease
    • Shive CL, Mudd JC, Funderburg NT, Sieg SF, Kyi B, Bazdar DA, et al. Inflammatory cytokines drive CD4+T-cell cycling and impaired responsiveness to interleukin 7: Implications for immune failure in HIV disease. J Infect Dis. 2014; 210(4): 619-29.
    • (2014) J Infect Dis. , vol.210 , Issue.4 , pp. 619-629
    • Shive, C.L.1    Mudd, J.C.2    Funderburg, N.T.3    Sieg, S.F.4    Kyi, B.5    Bazdar, D.A.6
  • 77
    • 84937816637 scopus 로고    scopus 로고
    • Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells
    • Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, et al. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nat Immunol. 2015; 16(8): 871-9.
    • (2015) Nat Immunol. , vol.16 , Issue.8 , pp. 871-879
    • Laidlaw, B.J.1    Cui, W.2    Amezquita, R.A.3    Gray, S.M.4    Guan, T.5    Lu, Y.6
  • 79
    • 84922031960 scopus 로고    scopus 로고
    • Monocyte-Activation phenotypes are associated with biomarkers of inflammation and coagulation in chronic HIV infection
    • Wilson EM, Singh A, Hullsiek KH, Gibson D, Henry WK, Lichtenstein K, et al. Monocyte-Activation phenotypes are associated with biomarkers of inflammation and coagulation in chronic HIV infection. J Infect Dis. 2014; 210(9): 1396-406.
    • (2014) J Infect Dis. , vol.210 , Issue.9 , pp. 1396-1406
    • Wilson, E.M.1    Singh, A.2    Hullsiek, K.H.3    Gibson, D.4    Henry, W.K.5    Lichtenstein, K.6
  • 80
    • 84944456832 scopus 로고    scopus 로고
    • Elevated abundance, size and microRNA content of plasma extracellular vesicles in viremic HIV-1+ patients: Correlations with known markers of disease progression
    • Hubert A, Subra C, Jenabian MA, Tremblay Labrecque PF, Tremblay C, Laffont B, et al. Elevated abundance, size and microRNA content of plasma extracellular vesicles in viremic HIV-1+ patients: Correlations with known markers of disease progression. J Acquir Immune Defic Syndr. 2015; 70(3): 219-27.
    • (2015) J Acquir Immune Defic Syndr. , vol.70 , Issue.3 , pp. 219-227
    • Hubert, A.1    Subra, C.2    Jenabian, M.A.3    Tremblay Labrecque, P.F.4    Tremblay, C.5    Laffont, B.6
  • 81
    • 84904916851 scopus 로고    scopus 로고
    • Cytokine/Chemokine responses in activated CD4+ and CD8+ T cells isolated from peripheral blood, bone marrow, and axillary lymph nodes during acute simian immunodeficiency virus infection
    • Kenway-Lynch CS, Das A, Lackner AA, Pahar B. Cytokine/Chemokine responses in activated CD4+ and CD8+ T cells isolated from peripheral blood, bone marrow, and axillary lymph nodes during acute simian immunodeficiency virus infection. J Virol. 2014; 88(16): 9442-57.
    • (2014) J Virol. , vol.88 , Issue.16 , pp. 9442-9457
    • Kenway-Lynch, C.S.1    Das, A.2    Lackner, A.A.3    Pahar, B.4
  • 82
    • 2942737129 scopus 로고    scopus 로고
    • Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: Implications for immune control of HIV-1 infection
    • Shacklett BL, Cox CA, Quigley MF, Kreis C, Stollman NH, Jacobson MA, et al. Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: Implications for immune control of HIV-1 infection. J Immunol. 2004; 173(1): 641-8.
    • (2004) J Immunol. , vol.173 , Issue.1 , pp. 641-648
    • Shacklett, B.L.1    Cox, C.A.2    Quigley, M.F.3    Kreis, C.4    Stollman, N.H.5    Jacobson, M.A.6
  • 83
    • 84942565653 scopus 로고    scopus 로고
    • Impact of hepatitis C virus coinfection on T-cell dynamics in long-Term HIV-suppressors under combined antiretroviral therapy
    • Zaegel-Faucher O, Bregigeon S, Cano CE, Obry-Roguet V, Nicolino-Brunet C, Tamalet C, et al. Impact of hepatitis C virus coinfection on T-cell dynamics in long-Term HIV-suppressors under combined antiretroviral therapy. AIDS. 2015; 29(12): 1505-10.
    • (2015) AIDS. , vol.29 , Issue.12 , pp. 1505-1510
    • Zaegel-Faucher, O.1    Bregigeon, S.2    Cano, C.E.3    Obry-Roguet, V.4    Nicolino-Brunet, C.5    Tamalet, C.6
  • 84
    • 84904782907 scopus 로고    scopus 로고
    • Factors associated with CD8+ T-cell activation in HIV-1-infected patients on long-Term antiretroviral therapy
    • Zheng L, Taiwo B, Gandhi RT, Hunt PW, Collier AC, Flexner C, et al. Factors associated with CD8+ T-cell activation in HIV-1-infected patients on long-Term antiretroviral therapy. J Acquir Immune Defic Syndr. 2014; 67(2): 153-60.
    • (2014) J Acquir Immune Defic Syndr. , vol.67 , Issue.2 , pp. 153-160
    • Zheng, L.1    Taiwo, B.2    Gandhi, R.T.3    Hunt, P.W.4    Collier, A.C.5    Flexner, C.6
  • 85
    • 33749009709 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
    • Trautmann L, Janbazian L, Chomont N, Said EA, Gimmig S, Bessette B, et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med. 2006; 12(10): 1198-202.
    • (2006) Nat Med. , vol.12 , Issue.10 , pp. 1198-1202
    • Trautmann, L.1    Janbazian, L.2    Chomont, N.3    Said, E.A.4    Gimmig, S.5    Bessette, B.6
  • 86
    • 84876131792 scopus 로고    scopus 로고
    • Anticancer activity of cardiac glycosides: At the frontier between cell-Autonomous and immunological effects
    • Kepp O, Menger L, Vacchelli E, Adjemian S, Martins I, Ma Y, et al. Anticancer activity of cardiac glycosides: At the frontier between cell-Autonomous and immunological effects. Oncoimmunology. 2012; 1(9): 1640-2.
    • (2012) Oncoimmunology. , vol.1 , Issue.9 , pp. 1640-1642
    • Kepp, O.1    Menger, L.2    Vacchelli, E.3    Adjemian, S.4    Martins, I.5    Ma, Y.6
  • 87
    • 84956938667 scopus 로고    scopus 로고
    • HIV-specific CD8+ T cells and HIV eradication
    • Jones RB,Walker BD. HIV-specific CD8+ T cells and HIV eradication. J Clin Invest. 2016; 126(2): 455-63.
    • (2016) J Clin Invest. , vol.126 , Issue.2 , pp. 455-463
    • Jones, R.B.1    Walker, B.D.2
  • 89
    • 84960166465 scopus 로고    scopus 로고
    • Comparison of the superagonist complex, ALT-803, to IL15 as cancer immunotherapeutics in animal models
    • Rhode PR, Egan JO, Xu W, Hong H,Webb GM, Chen X, et al. Comparison of the superagonist complex, ALT-803, to IL15 as cancer immunotherapeutics in animal models. Cancer Immunol Res. 2016; 4(1): 49-60.
    • (2016) Cancer Immunol Res. , vol.4 , Issue.1 , pp. 49-60
    • Rhode, P.R.1    Egan, J.O.2    Xu, W.3    Hong, H.4    Webb, G.M.5    Chen, X.6
  • 90
    • 84922611542 scopus 로고    scopus 로고
    • B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
    • Fukazawa Y, Lum R, Okoye AA, Park H, Matsuda K, Bae JY, et al. B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers. Nat Med. 2015; 21(2): 132-9.
    • (2015) Nat Med. , vol.21 , Issue.2 , pp. 132-139
    • Fukazawa, Y.1    Lum, R.2    Okoye, A.A.3    Park, H.4    Matsuda, K.5    Bae, J.Y.6
  • 91
    • 33751095383 scopus 로고    scopus 로고
    • B-cell-Targeted therapy for systemic lupus erythematosus
    • Sabahi R, Anolik JH. B-cell-Targeted therapy for systemic lupus erythematosus. Drugs. 2006; 66(15): 1933-48.
    • (2006) Drugs. , vol.66 , Issue.15 , pp. 1933-1948
    • Sabahi, R.1    Anolik, J.H.2
  • 92
    • 84965124729 scopus 로고    scopus 로고
    • Highlights from the seventh international workshop on HIV persistence during therapy, 8-11 December 2015, Miami, Florida, USA
    • Margolis DM, Salzwedel K, Chomont N, Psomas C, Routy J, Poli G, et al. Highlights from the Seventh International Workshop on HIV Persistence during Therapy, 8-11 December 2015, Miami, Florida, USA. J Virus Erad. 2015; 2(1): 57-65.
    • (2015) J Virus Erad. , vol.2 , Issue.1 , pp. 57-65
    • Margolis, D.M.1    Salzwedel, K.2    Chomont, N.3    Psomas, C.4    Routy, J.5    Poli, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.