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Volumn 17, Issue 2, 2015, Pages 96-106

Clinical relevance of kynurenine pathway in HIV/AIDS: An immune checkpoint at the crossroads of metabolism and inflammation

Author keywords

HIV; IDO; Kyn; Microbiota; Th17.; Treg; Trp

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CD4 ANTIGEN; GAMMA INTERFERON; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3 DIOXYGENASE 1; INDOLEAMINE 2,3 DIOXYGENASE 2; KYNURENINE; N METHYLTRYPTOPHAN; NEF PROTEIN; TRANSACTIVATOR PROTEIN; TRYPTOPHAN; TRYPTOPHAN 2,3 DIOXYGENASE; UNCLASSIFIED DRUG; INDOLEAMINE 2,3-DIOXYGENASE 1, HUMAN; INDOLEAMINE 2,3-DIOXYGENASE 2, HUMAN;

EID: 84936754064     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (57)

References (87)
  • 1
    • 3843056825 scopus 로고    scopus 로고
    • Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load
    • Deeks SG, Kitchen CM, Liu L, et al. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood. 2004;104:942-7.
    • (2004) Blood , vol.104 , pp. 942-947
    • Deeks, S.G.1    Kitchen, C.M.2    Liu, L.3
  • 2
    • 84910010874 scopus 로고    scopus 로고
    • Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment
    • Tenorio AR, Zheng Y, Bosch RJ, et al. Soluble markers of inflammation and coagulation but not T-cell activation predict non-AIDS-defining morbid events during suppressive antiretroviral treatment. J Infect Dis. 2014;210:1248-59.
    • (2014) J Infect Dis , vol.210 , pp. 1248-1259
    • Tenorio, A.R.1    Zheng, Y.2    Bosch, R.J.3
  • 4
    • 84902281875 scopus 로고    scopus 로고
    • Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection
    • Hunt PW, Sinclair E, Rodriguez B, et al. Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection. J Infect Dis. 2014;210:1228-38.
    • (2014) J Infect Dis , vol.210 , pp. 1228-1238
    • Hunt, P.W.1    Sinclair, E.2    Rodriguez, B.3
  • 6
    • 0035575775 scopus 로고    scopus 로고
    • Evidence for increased T cell turnover and decreased thymic output in HIV infection
    • Douek DC, Betts MR, Hill BJ, et al. Evidence for increased T cell turnover and decreased thymic output in HIV infection. J Immunol. 2001;167:6663-8.
    • (2001) J Immunol , vol.167 , pp. 6663-6668
    • Douek, D.C.1    Betts, M.R.2    Hill, B.J.3
  • 7
    • 33646492298 scopus 로고    scopus 로고
    • CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands
    • Ancuta P, Autissier P, Wurcel A, Zaman T, Stone D, Gabuzda D. CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands. J Immunol. 2006;176:5760-71.
    • (2006) J Immunol , vol.176 , pp. 5760-5771
    • Ancuta, P.1    Autissier, P.2    Wurcel, A.3    Zaman, T.4    Stone, D.5    Gabuzda, D.6
  • 8
    • 84859824979 scopus 로고    scopus 로고
    • A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers
    • Lajoie J, Juno J, Burgener A, et al. A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers. Mucosal Immunol. 2012;5:277-87.
    • (2012) Mucosal Immunol , vol.5 , pp. 277-287
    • Lajoie, J.1    Juno, J.2    Burgener, A.3
  • 9
    • 84896895575 scopus 로고    scopus 로고
    • Interferon responses in HIV infection: From protection to disease
    • Sivro A, Su RC, Plummer FA, Ball TB. Interferon responses in HIV infection: from protection to disease. AIDS Rev. 2014;16:43-51.
    • (2014) AIDS Rev , vol.16 , pp. 43-51
    • Sivro, A.1    Su, R.C.2    Plummer, F.A.3    Ball, T.B.4
  • 10
    • 84885764222 scopus 로고    scopus 로고
    • Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers
    • Jenabian MA, Patel M, Kema I, et al. Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers. PLoS One. 2013;8:e78146.
    • (2013) PLoS One , vol.8 , pp. e78146
    • Jenabian, M.A.1    Patel, M.2    Kema, I.3
  • 11
    • 34548680261 scopus 로고    scopus 로고
    • Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction
    • Kaufmann DE, Kavanagh DG, Pereyra F, et al. Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol. 2007;8:1246-54.
    • (2007) Nat Immunol , vol.8 , pp. 1246-1254
    • Kaufmann, D.E.1    Kavanagh, D.G.2    Pereyra, F.3
  • 12
    • 33749009709 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
    • Trautmann L, Janbazian L, Chomont N, et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med. 2006;12:1198-202.
    • (2006) Nat Med , vol.12 , pp. 1198-1202
    • Trautmann, L.1    Janbazian, L.2    Chomont, N.3
  • 13
    • 84936810525 scopus 로고    scopus 로고
    • Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection
    • Epub ahead of print
    • Jenabian MA, El-Far M, Vyboh K, et al. Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection. J Infect Dis. 2015. [Epub ahead of print].
    • (2015) J Infect Dis
    • Jenabian, M.A.1    El-Far, M.2    Vyboh, K.3
  • 14
    • 77952977625 scopus 로고    scopus 로고
    • Tryptophan catabolism by indoleamine 2, 3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    • Favre D, Mold J, Hunt PW, et al. Tryptophan catabolism by indoleamine 2, 3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med. 2010;2:32ra6.
    • (2010) Sci Transl Med , vol.2 , pp. 32ra6
    • Favre, D.1    Mold, J.2    Hunt, P.W.3
  • 15
    • 84923351469 scopus 로고    scopus 로고
    • Immune suppression by myeloid cells in HIV infection: New targets for immunotherapy
    • Mehraj V, Jenabian MA, Vyboh K, Routy JP. Immune suppression by myeloid cells in HIV infection: New targets for immunotherapy. Open AIDS J. 2014;8:66-78.
    • (2014) Open AIDS J , vol.8 , pp. 66-78
    • Mehraj, V.1    Jenabian, M.A.2    Vyboh, K.3    Routy, J.P.4
  • 16
    • 84908205837 scopus 로고    scopus 로고
    • Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection
    • Jenabian MA, Patel M, Kema I, et al. Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection. Clin Exp Immunol. 2014;178:102-11.
    • (2014) Clin Exp Immunol , vol.178 , pp. 102-111
    • Jenabian, M.A.1    Patel, M.2    Kema, I.3
  • 17
    • 84919712776 scopus 로고    scopus 로고
    • New Insights into IDO Biology in bacterial and viral infections
    • Schmidt SV, Schultze JL. New Insights into IDO Biology in bacterial and viral infections. Front Immunol. 2014;5:384.
    • (2014) Front Immunol , vol.5 , pp. 384
    • Schmidt, S.V.1    Schultze, J.L.2
  • 18
    • 84918503438 scopus 로고    scopus 로고
    • Muscling in on depression
    • Harkin A. Muscling in on depression. N Engl J Med. 2014;371:2333-4.
    • (2014) N Engl J Med , vol.371 , pp. 2333-2334
    • Harkin, A.1
  • 20
    • 84882260715 scopus 로고    scopus 로고
    • Remarkable role of indoleamine 2, 3-dioxygenase and tryptophan metabolites in infectious diseases: Potential role in macrophage-mediated inflammatory diseases
    • Murakami Y, Hoshi M, Imamura Y, Arioka Y, Yamamoto Y, Saito K. Remarkable role of indoleamine 2, 3-dioxygenase and tryptophan metabolites in infectious diseases: potential role in macrophage-mediated inflammatory diseases. Mediators Inflamm. 2013;2013:391984.
    • (2013) Mediators Inflamm 2013 , pp. 391984
    • Murakami, Y.1    Hoshi, M.2    Imamura, Y.3    Arioka, Y.4    Yamamoto, Y.5    Saito, K.6
  • 21
    • 84908653795 scopus 로고    scopus 로고
    • HIV/dendritic cell interaction: Consequences in the pathogenesis of HIV infection
    • Barroca P, Calado M, Azevedo-Pereira JM. HIV/dendritic cell interaction: consequences in the pathogenesis of HIV infection. AIDS Rev. 2014;16:223-35.
    • (2014) AIDS Rev , vol.16 , pp. 223-235
    • Barroca, P.1    Calado, M.2    Azevedo-Pereira, J.M.3
  • 23
    • 0000056144 scopus 로고
    • Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan
    • Pfefferkorn ER. Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Natl Acad Sci USA. 1984;81:908-12.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 908-912
    • Pfefferkorn, E.R.1
  • 24
    • 58249103970 scopus 로고    scopus 로고
    • Indoleamine 2, 3-dioxygenase in infection: The paradox of an evasive strategy that benefits the host
    • Zelante T, Fallarino F, Bistoni F, Puccetti P, Romani L. Indoleamine 2, 3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host. Microbes Infect. 2009;11:133-41.
    • (2009) Microbes Infect , vol.11 , pp. 133-141
    • Zelante, T.1    Fallarino, F.2    Bistoni, F.3    Puccetti, P.4    Romani, L.5
  • 25
    • 84890037649 scopus 로고    scopus 로고
    • Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing
    • Zhang YJ, Reddy MC, Ioerger TR, et al. Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell. 2013;155:1296-308.
    • (2013) Cell , vol.155 , pp. 1296-1308
    • Zhang, Y.J.1    Reddy, M.C.2    Ioerger, T.R.3
  • 26
    • 84899019947 scopus 로고    scopus 로고
    • The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes
    • Nino-Castro A, Abdullah Z, Popov A, et al. The IDO1-induced kynurenines play a major role in the antimicrobial effect of human myeloid cells against Listeria monocytogenes. Innate Immun. 2014;20:401-11.
    • (2014) Innate Immun , vol.20 , pp. 401-411
    • Nino-Castro, A.1    Abdullah, Z.2    Popov, A.3
  • 27
    • 84883231780 scopus 로고    scopus 로고
    • Monocyte responses in the context of Q fever: From a static polarized model to a kinetic model of activation
    • Mehraj V, Textoris J, Ben Amara A, et al. Monocyte responses in the context of Q fever: from a static polarized model to a kinetic model of activation. J Infect Dis. 2013;208:942-51.
    • (2013) J Infect Dis , vol.208 , pp. 942-951
    • Mehraj, V.1    Textoris, J.2    Ben Amara, A.3
  • 28
    • 3242683496 scopus 로고    scopus 로고
    • Inhibition of human herpes simplex virus type 2 by interferon gamma and tumor necrosis factor alpha is mediated by indoleamine 2, 3-dioxygenase
    • Adams O, Besken K, Oberdorfer C, MacKenzie CR, Russing D, Daubener W. Inhibition of human herpes simplex virus type 2 by interferon gamma and tumor necrosis factor alpha is mediated by indoleamine 2, 3-dioxygenase. Microbes Infect. 2004;6:806-12.
    • (2004) Microbes Infect , vol.6 , pp. 806-812
    • Adams, O.1    Besken, K.2    Oberdorfer, C.3    Mackenzie, C.R.4    Russing, D.5    Daubener, W.6
  • 29
    • 19944397134 scopus 로고    scopus 로고
    • Indoleamine 2, 3-dioxygenase mediates cell type-specific anti-measles virus activity of gamma interferon
    • Obojes K, Andres O, Kim KS, Daubener W, Schneider-Schaulies J. Indoleamine 2, 3-dioxygenase mediates cell type-specific anti-measles virus activity of gamma interferon. J Virol. 2005;79:7768-76.
    • (2005) J Virol , vol.79 , pp. 7768-7776
    • Obojes, K.1    Andres, O.2    Kim, K.S.3    Daubener, W.4    Schneider-Schaulies, J.5
  • 30
    • 84916887206 scopus 로고    scopus 로고
    • Microbiota control of a tryptophan-AhR pathway in disease tolerance to fungi
    • Romani L, Zelante T, De Luca A, et al. Microbiota control of a tryptophan-AhR pathway in disease tolerance to fungi. Eur J Immunol. 2014; 44:3192-200.
    • (2014) Eur J Immunol , vol.44 , pp. 3192-3200
    • Romani, L.1    Zelante, T.2    De Luca, A.3
  • 31
    • 84904216760 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor control of a disease tolerance defence pathway
    • Bessede A, Gargaro M, Pallotta MT, et al. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature. 2014;511:184-90.
    • (2014) Nature , vol.511 , pp. 184-190
    • Bessede, A.1    Gargaro, M.2    Pallotta, M.T.3
  • 32
    • 77957978790 scopus 로고    scopus 로고
    • Indoleamine 2, 3-dioxygenase: Is it an immune suppressor?
    • Soliman H, Mediavilla-Varela M, Antonia S. Indoleamine 2, 3-dioxygenase: is it an immune suppressor? Cancer J. 2010;16:354-9.
    • (2010) Cancer J , vol.16 , pp. 354-359
    • Soliman, H.1    Mediavilla-Varela, M.2    Antonia, S.3
  • 34
    • 78649880396 scopus 로고    scopus 로고
    • An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
    • Mezrich JD, Fechner JH, Zhang X, Johnson BP, Burlingham WJ, Bradfield CA. An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol. 2010;185:3190-8.
    • (2010) J Immunol , vol.185 , pp. 3190-3198
    • Mezrich, J.D.1    Fechner, J.H.2    Zhang, X.3    Johnson, B.P.4    Burlingham, W.J.5    Bradfield, C.A.6
  • 35
    • 80054041992 scopus 로고    scopus 로고
    • An endogenous tumourpromoting ligand of the human aryl hydrocarbon receptor
    • Opitz CA, Litzenburger UM, Sahm F, et al. An endogenous tumourpromoting ligand of the human aryl hydrocarbon receptor. Nature. 2011;478:197-203.
    • (2011) Nature , vol.478 , pp. 197-203
    • Opitz, C.A.1    Litzenburger, U.M.2    Sahm, F.3
  • 36
    • 78650788688 scopus 로고    scopus 로고
    • Regulation of tryptophan 2, 3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling
    • Doherty LF, Kwon HE, Taylor HS. Regulation of tryptophan 2, 3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling. Am J Physiol Endocrinol Metab. 2011;300:E86-93.
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , pp. E86-93
    • Doherty, L.F.1    Kwon, H.E.2    Taylor, H.S.3
  • 37
    • 59149092788 scopus 로고    scopus 로고
    • Exploring the mechanism of tryptophan 2, 3-dioxygenase
    • Thackray SJ, Mowat CG, Chapman SK. Exploring the mechanism of tryptophan 2, 3-dioxygenase. Biochem Soc Trans. 2008;36:1120-3.
    • (2008) Biochem Soc Trans , vol.36 , pp. 1120-1123
    • Thackray, S.J.1    Mowat, C.G.2    Chapman, S.K.3
  • 38
    • 81255138408 scopus 로고    scopus 로고
    • Indoleamine 2, 3-dioxygenase expression in human cancers: Clinical and immunologic perspectives
    • Godin-Ethier J, Hanafi LA, Piccirillo CA, Lapointe R. Indoleamine 2, 3-dioxygenase expression in human cancers: clinical and immunologic perspectives. Clin Cancer Res. 2011;17:6985-91.
    • (2011) Clin Cancer Res , vol.17 , pp. 6985-6991
    • Godin-Ethier, J.1    Hanafi, L.A.2    Piccirillo, C.A.3    Lapointe, R.4
  • 39
    • 34147115208 scopus 로고    scopus 로고
    • HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2, 3-dioxygenase in plasmacytoid dendritic cells
    • Boasso A, Herbeuval JP, Hardy AW, et al. HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2, 3-dioxygenase in plasmacytoid dendritic cells. Blood. 2007;109:3351-9.
    • (2007) Blood , vol.109 , pp. 3351-3359
    • Boasso, A.1    Herbeuval, J.P.2    Hardy, A.W.3
  • 40
    • 0037136328 scopus 로고    scopus 로고
    • Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2, 3-dioxygenase
    • Frumento G, Rotondo R, Tonetti M, Damonte G, Benatti U, Ferrara GB. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2, 3-dioxygenase. J Exp Med. 2002;196:459-68.
    • (2002) J Exp Med , vol.196 , pp. 459-468
    • Frumento, G.1    Rotondo, R.2    Tonetti, M.3    Damonte, G.4    Benatti, U.5    Ferrara, G.B.6
  • 41
    • 15844427653 scopus 로고    scopus 로고
    • Involvement of quinolinic acid in AIDS dementia complex
    • Guillemin GJ, Kerr SJ, Brew BJ. Involvement of quinolinic acid in AIDS dementia complex. Neurotox Res. 2005;7:103-23.
    • (2005) Neurotox Res , vol.7 , pp. 103-123
    • Guillemin, G.J.1    Kerr, S.J.2    Brew, B.J.3
  • 42
    • 70149093957 scopus 로고    scopus 로고
    • Indoleamine 2, 3-dioxygenaseexpressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells
    • Chung DJ, Rossi M, Romano E, et al. Indoleamine 2, 3-dioxygenaseexpressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells. Blood. 2009;114:555-63.
    • (2009) Blood , vol.114 , pp. 555-563
    • Chung, D.J.1    Rossi, M.2    Romano, E.3
  • 43
    • 84884491148 scopus 로고    scopus 로고
    • HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: Effect on T cells proliferation
    • Planes R, Bahraoui E. HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation. PLoS One. 2013;8:e74551.
    • (2013) PLoS One , vol.8 , pp. e74551
    • Planes, R.1    Bahraoui, E.2
  • 44
    • 81855221935 scopus 로고    scopus 로고
    • Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis
    • Changsirivathanathamrong D, Wang Y, Rajbhandari D, et al. Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. Crit Care Med. 2011;39:2678-83.
    • (2011) Crit Care Med , vol.39 , pp. 2678-2683
    • Changsirivathanathamrong, D.1    Wang, Y.2    Rajbhandari, D.3
  • 45
    • 0031900585 scopus 로고    scopus 로고
    • Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients
    • Huengsberg M, Winer JB, Gompels M, Round R, Ross J, Shahmanesh M. Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients. Clin Chem. 1998;44:858-62.
    • (1998) Clin Chem , vol.44 , pp. 858-862
    • Huengsberg, M.1    Winer, J.B.2    Gompels, M.3    Round, R.4    Ross, J.5    Shahmanesh, M.6
  • 46
    • 0036750583 scopus 로고    scopus 로고
    • Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection
    • Zangerle R, Widner B, Quirchmair G, Neurauter G, Sarcletti M, Fuchs D. Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection. Clin Immunol. 2002;104:242-7.
    • (2002) Clin Immunol , vol.104 , pp. 242-247
    • Zangerle, R.1    Widner, B.2    Quirchmair, G.3    Neurauter, G.4    Sarcletti, M.5    Fuchs, D.6
  • 47
    • 84904314814 scopus 로고    scopus 로고
    • The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy
    • Byakwaga H, Boum Y, Huang Y, et al. The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy. J Infect Dis. 2014;210:383-91.
    • (2014) J Infect Dis , vol.210 , pp. 383-391
    • Byakwaga, H.1    Boum, Y.2    Huang, Y.3
  • 48
    • 84903731105 scopus 로고    scopus 로고
    • Anti-retroviral therapy decreases but does not normalize indoleamine 2, 3-dioxygenase activity in HIV-infected patients
    • Chen J, Shao J, Cai R, et al. Anti-retroviral therapy decreases but does not normalize indoleamine 2, 3-dioxygenase activity in HIV-infected patients. PLoS One. 2014;9:e100446.
    • (2014) PLoS One , vol.9 , pp. e100446
    • Chen, J.1    Shao, J.2    Cai, R.3
  • 49
    • 84864469250 scopus 로고    scopus 로고
    • HIV replication and immune status are independent predictors of the risk of myocardial infarction in HIV-infected individuals
    • Lang S, Mary-Krause M, Simon A, et al. HIV replication and immune status are independent predictors of the risk of myocardial infarction in HIV-infected individuals. Clin Infect Dis. 2012;55:600-7.
    • (2012) Clin Infect Dis , vol.55 , pp. 600-607
    • Lang, S.1    Mary-Krause, M.2    Simon, A.3
  • 50
    • 80053068720 scopus 로고    scopus 로고
    • Cardiovascular risk factors and HIV disease
    • Fedele F, Bruno N, Mancone M. Cardiovascular risk factors and HIV disease. AIDS Rev. 2011;13:119-29.
    • (2011) AIDS Rev , vol.13 , pp. 119-129
    • Fedele, F.1    Bruno, N.2    Mancone, M.3
  • 51
    • 84901686066 scopus 로고    scopus 로고
    • HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality
    • Serrano-Villar S, Sainz T, Lee SA, et al. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014; 10:e1004078.
    • (2014) PLoS Pathog , vol.10 , pp. e1004078
    • Serrano-Villar, S.1    Sainz, T.2    Lee, S.A.3
  • 52
    • 79956196632 scopus 로고    scopus 로고
    • Higher levels of CRP, Ddimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death
    • Boulware DR, Hullsiek KH, Puronen CE, et al. Higher levels of CRP, Ddimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death. J Infect Dis. 2011;203:1637-46.
    • (2011) J Infect Dis , vol.203 , pp. 1637-1646
    • Boulware, D.R.1    Hullsiek, K.H.2    Puronen, C.E.3
  • 53
    • 84858132523 scopus 로고    scopus 로고
    • Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV?
    • Justice AC, Freiberg MS, Tracy R, et al. Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV? Clin Infect Dis. 2012;54:984-94.
    • (2012) Clin Infect Dis , vol.54 , pp. 984-994
    • Justice, A.C.1    Freiberg, M.S.2    Tracy, R.3
  • 54
    • 80055049890 scopus 로고    scopus 로고
    • Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy
    • Hunt PW, Cao HL, Muzoora C, et al. Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy. AIDS. 2011;25:2123-31.
    • (2011) AIDS , vol.25 , pp. 2123-2131
    • Hunt, P.W.1    Cao, H.L.2    Muzoora, C.3
  • 55
    • 0034793925 scopus 로고    scopus 로고
    • Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat
    • Smith DG, Guillemin GJ, Pemberton L, et al. Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat. J Neurovirol. 2001;7:56-60.
    • (2001) J Neurovirol , vol.7 , pp. 56-60
    • Smith, D.G.1    Guillemin, G.J.2    Pemberton, L.3
  • 56
    • 84879318140 scopus 로고    scopus 로고
    • Immune activation and HIV persistence: Implications for curative approaches to HIV infection
    • Klatt NR, Chomont N, Douek DC, Deeks SG. Immune activation and HIV persistence: implications for curative approaches to HIV infection. Immunol Rev. 2013;254:326-42.
    • (2013) Immunol Rev , vol.254 , pp. 326-342
    • Klatt, N.R.1    Chomont, N.2    Douek, D.C.3    Deeks, S.G.4
  • 57
    • 34247274287 scopus 로고    scopus 로고
    • Indoleamine-2, 3-dioxygenase and other interferon-gammamediated pathways in patients with human immunodeficiency virus infection
    • Schroecksnadel K, Zangerle R, Bellmann-Weiler R, Garimorth K, Weiss G, Fuchs D. Indoleamine-2, 3-dioxygenase and other interferon-gammamediated pathways in patients with human immunodeficiency virus infection. Curr Drug Metab. 2007;8:225-36.
    • (2007) Curr Drug Metab , vol.8 , pp. 225-236
    • Schroecksnadel, K.1    Zangerle, R.2    Bellmann-Weiler, R.3    Garimorth, K.4    Weiss, G.5    Fuchs, D.6
  • 58
    • 84878622154 scopus 로고    scopus 로고
    • Tryptophan metabolism: Entering the field of aging and age-related pathologies
    • van der Goot AT, Nollen EA. Tryptophan metabolism: entering the field of aging and age-related pathologies. Trends Mol Med. 2013;19:336-44.
    • (2013) Trends Mol Med , vol.19 , pp. 336-344
    • Van Der Goot, A.T.1    Nollen, E.A.2
  • 59
    • 84867889088 scopus 로고    scopus 로고
    • Regulatory T cells in HIV infection: Can immunotherapy regulate the regulator?
    • Jenabian MA, Ancuta P, Gilmore N, Routy JP. Regulatory T cells in HIV infection: can immunotherapy regulate the regulator? Clin Dev Immunol. 2012;2012:908314.
    • (2012) Clin Dev Immunol 2012 , pp. 908314
    • Jenabian, M.A.1    Ancuta, P.2    Gilmore, N.3    Routy, J.P.4
  • 60
    • 80055115449 scopus 로고    scopus 로고
    • Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers
    • Shaw JM, Hunt PW, Critchfield JW, et al. Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers. J Virol. 2011;85:11422-34.
    • (2011) J Virol , vol.85 , pp. 11422-11434
    • Shaw, J.M.1    Hunt, P.W.2    Critchfield, J.W.3
  • 61
    • 84936786978 scopus 로고    scopus 로고
    • HIV and the Gut Microbiota, partners in crime: Breaking the vicious cycle to unearth new therapeutic targets
    • Epub ahead of print
    • Vyboh K, Jenabian MA, Mehraj V, Routy JP. HIV and the Gut Microbiota, partners in crime: Breaking the vicious cycle to unearth new therapeutic targets. J Immunol Res. 2014. [Epub ahead of print].
    • (2014) J Immunol Res
    • Vyboh, K.1    Jenabian, M.A.2    Mehraj, V.3    Routy, J.P.4
  • 62
    • 84880540665 scopus 로고    scopus 로고
    • Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism
    • Vujkovic-Cvijin I, Dunham RM, Iwai S, et al. Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med. 2013;5:193ra91.
    • (2013) Sci Transl Med , vol.5 , pp. 193ra91
    • Vujkovic-Cvijin, I.1    Dunham, R.M.2    Iwai, S.3
  • 63
    • 84884379881 scopus 로고    scopus 로고
    • Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection
    • Perez-Santiago J, Gianella S, Massanella M, et al. Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS. 2013;27:1921-31.
    • (2013) AIDS , vol.27 , pp. 1921-1931
    • Perez-Santiago, J.1    Gianella, S.2    Massanella, M.3
  • 64
    • 84882664672 scopus 로고    scopus 로고
    • Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
    • Zelante T, Iannitti RG, Cunha C, et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity. 2013;39:372-85.
    • (2013) Immunity , vol.39 , pp. 372-385
    • Zelante, T.1    Iannitti, R.G.2    Cunha, C.3
  • 65
    • 84898542916 scopus 로고    scopus 로고
    • The role of microbiome in central nervous system disorders
    • Wang Y, Kasper LH. The role of microbiome in central nervous system disorders. Brain Behav Immun. 2014;38:1-12.
    • (2014) Brain Behav Immun , vol.38 , pp. 1-12
    • Wang, Y.1    Kasper, L.H.2
  • 66
    • 84859568305 scopus 로고    scopus 로고
    • The kynurenine pathway and quinolinic acid: Pivotal roles in HIV associated neurocognitive disorders
    • Kandanearatchi A, Brew BJ. The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders. FEBS J. 2012;279:1366-74.
    • (2012) FEBS J , vol.279 , pp. 1366-1374
    • Kandanearatchi, A.1    Brew, B.J.2
  • 67
    • 84871332723 scopus 로고    scopus 로고
    • Neurologic disorders incidence in HIV+ vs HIV-men: Multicenter AIDS Cohort Study 1996-2011
    • Mateen FJ, Shinohara RT, Carone M, et al. Neurologic disorders incidence in HIV+ vs HIV-men: Multicenter AIDS Cohort Study, 1996-2011. Neurology. 2012;79:1873-80.
    • (2012) Neurology , vol.79 , pp. 1873-1880
    • Mateen, F.J.1    Shinohara, R.T.2    Carone, M.3
  • 68
    • 42549112547 scopus 로고    scopus 로고
    • Kynurenine pathway metabolism in human blood-brain-barrier cells: Implications for immune tolerance and neurotoxicity
    • Owe-Young R, Webster NL, Mukhtar M, et al. Kynurenine pathway metabolism in human blood-brain-barrier cells: implications for immune tolerance and neurotoxicity. J Neurochem. 2008;105:1346-57.
    • (2008) J Neurochem , vol.105 , pp. 1346-1357
    • Owe-Young, R.1    Webster, N.L.2    Mukhtar, M.3
  • 70
    • 0026061120 scopus 로고
    • Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: Relationship to clinical and neurological status
    • Heyes MP, Brew BJ, Martin A, et al. Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. Ann Neurol. 1991;29:202-9.
    • (1991) Ann Neurol , vol.29 , pp. 202-209
    • Heyes, M.P.1    Brew, B.J.2    Martin, A.3
  • 72
    • 84897998324 scopus 로고    scopus 로고
    • Reversal of the Kynurenine pathway of tryptophan catabolism may improve depression in ART-treated HIV-infected Ugandans
    • Martinez P, Tsai AC, Muzoora C, et al. Reversal of the Kynurenine pathway of tryptophan catabolism may improve depression in ART-treated HIV-infected Ugandans. J Acquir Immune Defic Syndr. 2014;65:456-62.
    • (2014) J Acquir Immune Defic Syndr , vol.65 , pp. 456-462
    • Martinez, P.1    Tsai, A.C.2    Muzoora, C.3
  • 73
    • 84907486069 scopus 로고    scopus 로고
    • Skeletal muscle PGC-1alpha1 modulates kynurenine metabolism and mediates resilience to stress-induced depression
    • Agudelo LZ, Femenia T, Orhan F, et al. Skeletal muscle PGC-1alpha1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell. 2014;159:33-45.
    • (2014) Cell , vol.159 , pp. 33-45
    • Agudelo, L.Z.1    Femenia, T.2    Orhan, F.3
  • 74
    • 84878145540 scopus 로고    scopus 로고
    • Indoleamine 2, 3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice
    • Corona AW, Norden DM, Skendelas JP, et al. Indoleamine 2, 3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX(3)CR1)-deficient mice. Brain Behav Immun. 2013;31:134-42.
    • (2013) Brain Behav Immun , vol.31 , pp. 134-142
    • Corona, A.W.1    Norden, D.M.2    Skendelas, J.P.3
  • 75
    • 27144489077 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2, 3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis
    • Potula R, Poluektova L, Knipe B, et al. Inhibition of indoleamine 2, 3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis. Blood. 2005;106:2382-90.
    • (2005) Blood , vol.106 , pp. 2382-2390
    • Potula, R.1    Poluektova, L.2    Knipe, B.3
  • 76
    • 64249110601 scopus 로고    scopus 로고
    • Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques
    • Boasso A, Vaccari M, Fuchs D, et al. Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques. J Immunol. 2009;182:4313-20.
    • (2009) J Immunol , vol.182 , pp. 4313-4320
    • Boasso, A.1    Vaccari, M.2    Fuchs, D.3
  • 77
    • 84872953130 scopus 로고    scopus 로고
    • Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: A pilot study testing inhibition of indoleamine 2, 3-dioxygenase
    • Dunham RM, Gordon SN, Vaccari M, et al. Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2, 3-dioxygenase. AIDS Res Hum Retroviruses. 2013;29:207-14.
    • (2013) AIDS Res Hum Retroviruses , vol.29 , pp. 207-214
    • Dunham, R.M.1    Gordon, S.N.2    Vaccari, M.3
  • 78
    • 84860852600 scopus 로고    scopus 로고
    • Blocking IDO activity to enhance anti-tumor immunity
    • Munn DH. Blocking IDO activity to enhance anti-tumor immunity. Front Biosci (Elite Ed). 2012;4:734-45.
    • (2012) Front Biosci (Elite Ed , vol.4 , pp. 734-745
    • Munn, D.H.1
  • 79
    • 84890857180 scopus 로고    scopus 로고
    • Antitumour agents as inhibitors of tryptophan 2, 3-dioxygenase
    • Pantouris G, Mowat CG. Antitumour agents as inhibitors of tryptophan 2, 3-dioxygenase. Biochem Biophys Res Commun. 2014;443:28-31.
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 28-31
    • Pantouris, G.1    Mowat, C.G.2
  • 80
    • 84902589930 scopus 로고    scopus 로고
    • Fludarabine downregulates indoleamine 2, 3-dioxygenase in tumors via a proteasome-mediated degradation mechanism
    • Hanafi LA, Gauchat D, Godin-Ethier J, et al. Fludarabine downregulates indoleamine 2, 3-dioxygenase in tumors via a proteasome-mediated degradation mechanism. PLoS One. 2014;9:e99211.
    • (2014) PLoS One , vol.9 , pp. e99211
    • Hanafi, L.A.1    Gauchat, D.2    Godin-Ethier, J.3
  • 81
    • 84908005764 scopus 로고    scopus 로고
    • A first in man phase i trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors
    • Soliman HH, Jackson E, Neuger T, et al. A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors. Oncotarget. 2014;5:8136-46.
    • (2014) Oncotarget , vol.5 , pp. 8136-8146
    • Soliman, H.H.1    Jackson, E.2    Neuger, T.3
  • 83
    • 84922346962 scopus 로고    scopus 로고
    • Targeting key dioxygenases in tryptophankynurenine metabolism for immunomodulation and cancer chemotherapy
    • [pub ahead of print]
    • Austin CJ, Rendina LM. Targeting key dioxygenases in tryptophankynurenine metabolism for immunomodulation and cancer chemotherapy. Drug Discov Today. 2014. [pub ahead of print].
    • (2014) Drug Discov Today
    • Austin, C.J.1    Rendina, L.M.2
  • 84
    • 84977161108 scopus 로고    scopus 로고
    • Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment
    • Spranger S, Koblish HK, Horton B, Scherle PA, Newton R, Gajewski TF. Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment. J Immunother Cancer. 2014;2:3.
    • (2014) J Immunother Cancer , vol.2 , pp. 3
    • Spranger, S.1    Koblish, H.K.2    Horton, B.3    Scherle, P.A.4    Newton, R.5    Gajewski, T.F.6
  • 85
    • 84904061991 scopus 로고    scopus 로고
    • Durable therapeutic efficacy utilizing combinatorial blockade against IDO CTLA-4 and PD-L1 in mice with brain tumors
    • Wainwright DA, Chang AL, Dey M, et al. Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors. Clin Cancer Res. 2014;20:5290-301.
    • (2014) Clin Cancer Res , vol.20 , pp. 5290-5301
    • Wainwright, D.A.1    Chang, A.L.2    Dey, M.3
  • 87
    • 84904549329 scopus 로고    scopus 로고
    • Parallels between cancer and infectious disease
    • Hotchkiss RS, Moldawer LL. Parallels between cancer and infectious disease. N Engl J Med. 2014;371:380-3.
    • (2014) N Engl J Med , vol.371 , pp. 380-383
    • Hotchkiss, R.S.1    Moldawer, L.L.2


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