Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection

AIDS

Volumn 29, Issue 1, 2015, Pages 23-33

  Radebe, Mopo ^a,b   Gounder, Kamini ^a,b   Mokgoro, Mammekwa ^a   Ndhlovu, Zaza M ^a,c   Mncube, Zenele ^a   Mkhize, Lungile ^a   Van Der Stok, Mary ^a   Jaggernath, Manjeetha ^a   Walker, Bruce D ^a,b,c,d   Ndung'u, Thumbi ^a,b,c,e  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

^c HARVARD UNIVERSITY   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

Author keywords

Acute HIV 1 infection; CD8+ T cells; Central CD8+ T cell memory responses; Gag specific responses; Immune escape; Persistent CD8+ T cell responses

Indexed keywords

GAG PROTEIN; GAMMA INTERFERON; PROTEOME; VIRUS RNA; EPITOPE;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 SUBTYPE C; IMMUNE RESPONSE; MALE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEROCONVERSION; VIRAL LOAD TESTING; VIREMIA; VIROGENESIS; VIRUS LOAD; CHEMISTRY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY;

ADULT; CD8-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSPOT ASSAY; FEMALE; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV INFECTIONS; HIV-1; HUMANS; IMMUNODOMINANT EPITOPES; INTERFERON-GAMMA; MALE; SEQUENCE ANALYSIS, RNA; VIRAL LOAD;

EID: 84928047018     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000508     Document Type: Article

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