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Volumn 29, Issue 16, 2015, Pages 2071-2080

Quantification of naive and memory T-cell turnover during HIV-1 infection

Author keywords

HIV; labeling; lifespan; lymphocytes; mathematical modeling; stable isotope; T cells

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIRETROVIRUS AGENT;

EID: 84964893968     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000822     Document Type: Article
Times cited : (27)

References (50)
  • 1
    • 34547752932 scopus 로고    scopus 로고
    • Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease
    • Choudhary SK, Vrisekoop N, Jansen CA, Otto SA, Schuitemaker H, Miedema F, et al. Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease. J Virol 2007; 81:8838-8842.
    • (2007) J Virol , vol.81 , pp. 8838-8842
    • Choudhary, S.K.1    Vrisekoop, N.2    Jansen, C.A.3    Otto, S.A.4    Schuitemaker, H.5    Miedema, F.6
  • 2
    • 3843056825 scopus 로고    scopus 로고
    • Immune activation set point during early HIV infection predicts subsequent CD4R T-cell changes independent of viral load
    • Deeks SG, Kitchen CM, Liu L, Guo H, Gascon R, Narvaez AB, et al. Immune activation set point during early HIV infection predicts subsequent CD4R T-cell changes independent of viral load. Blood 2004; 104:942-947.
    • (2004) Blood , vol.104 , pp. 942-947
    • Deeks, S.G.1    Kitchen, C.M.2    Liu, L.3    Guo, H.4    Gascon, R.5    Narvaez, A.B.6
  • 3
    • 0032955651 scopus 로고    scopus 로고
    • Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
    • Giorgi JV, Hultin LE, McKeating JA, Johnson TD, Owens B, Jacobson LP, et al. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999; 179:859-870.
    • (1999) J Infect Dis , vol.179 , pp. 859-870
    • Giorgi, J.V.1    Hultin, L.E.2    McKeating, J.A.3    Johnson, T.D.4    Owens, B.5    Jacobson, L.P.6
  • 4
    • 0041327667 scopus 로고    scopus 로고
    • Persistent immune activation in HIV-1 infection is associated with progression to AIDS
    • Hazenberg MD, Otto SA, van Benthem BH, Roos MT, Coutinho RA, Lange JM, et al. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS 2003; 17:1881-1888.
    • (2003) AIDS , vol.17 , pp. 1881-1888
    • Hazenberg, M.D.1    Otto, S.A.2    Van Benthem, B.H.3    Roos, M.T.4    Coutinho, R.A.5    Lange, J.M.6
  • 5
    • 0037343278 scopus 로고    scopus 로고
    • Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia
    • Silvestri G, Sodora DL, Koup RA, Paiardini M, O'Neil SP, McClure HM, et al. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity 2003; 18:441-452.
    • (2003) Immunity , vol.18 , pp. 441-452
    • Silvestri, G.1    Sodora, D.L.2    Koup, R.A.3    Paiardini, M.4    O'Neil, S.P.5    McClure, H.M.6
  • 6
    • 0033592913 scopus 로고    scopus 로고
    • Antigen-driven CD4RT cell and HIV-1 dynamics: Residual viral replication under highly active antiretroviral therapy
    • Ferguson NM, deWolf F, Ghani AC, Fraser C, Donnelly CA, Reiss P, et al. Antigen-driven CD4RT cell and HIV-1 dynamics: residual viral replication under highly active antiretroviral therapy. Proc Natl Acad Sci U S A 1999; 96:15167-15172.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 15167-15172
    • Ferguson, N.M.1    DeWolf, F.2    Ghani, A.C.3    Fraser, C.4    Donnelly, C.A.5    Reiss, P.6
  • 7
    • 17444379333 scopus 로고    scopus 로고
    • Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
    • Hellerstein M, Hanley MB, Cesar D, Siler S, Papageorgopoulos C, Wieder E, et al. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nat Med 1999; 5:83-89.
    • (1999) Nat Med , vol.5 , pp. 83-89
    • Hellerstein, M.1    Hanley, M.B.2    Cesar, D.3    Siler, S.4    Papageorgopoulos, C.5    Wieder, E.6
  • 8
    • 0035905463 scopus 로고    scopus 로고
    • Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV
    • Kovacs JA, Lempicki RA, Sidorov IA, Adelsberger JW, Herpin B, Metcalf JA, et al. Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV. J Exp Med 2001; 194:1731-1741.
    • (2001) J Exp Med , vol.194 , pp. 1731-1741
    • Kovacs, J.A.1    Lempicki, R.A.2    Sidorov, I.A.3    Adelsberger, J.W.4    Herpin, B.5    Metcalf, J.A.6
  • 9
    • 23644439060 scopus 로고    scopus 로고
    • Induction of prolonged survival of CD4R T lymphocytes by intermittent IL-2 therapy in HIV-infected patients
    • Kovacs JA, Lempicki RA, Sidorov IA, Adelsberger JW, Sereti I, Sachau W, et al. Induction of prolonged survival of CD4R T lymphocytes by intermittent IL-2 therapy in HIV-infected patients. J Clin Invest 2005; 115:2139-2148.
    • (2005) J Clin Invest , vol.115 , pp. 2139-2148
    • Kovacs, J.A.1    Lempicki, R.A.2    Sidorov, I.A.3    Adelsberger, J.W.4    Sereti, I.5    Sachau, W.6
  • 10
    • 12944331410 scopus 로고    scopus 로고
    • Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4R and CD8R T cell turnover in HIV-infected patients
    • Lempicki RA, Kovacs JA, Baseler MW, Adelsberger JW, Dewar RL, Natarajan V, et al. Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4R and CD8R T cell turnover in HIV-infected patients. Proc Natl Acad Sci U S A 2000; 97:13778-13783.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13778-13783
    • Lempicki, R.A.1    Kovacs, J.A.2    Baseler, M.W.3    Adelsberger, J.W.4    Dewar, R.L.5    Natarajan, V.6
  • 12
    • 0035169609 scopus 로고    scopus 로고
    • Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy
    • Mohri H, Perelson AS, Tung K, Ribeiro RM, Ramratnam B, Markowitz M, et al. Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy. J Exp Med 2001; 194:1277-1287.
    • (2001) J Exp Med , vol.194 , pp. 1277-1287
    • Mohri, H.1    Perelson, A.S.2    Tung, K.3    Ribeiro, R.M.4    Ramratnam, B.5    Markowitz, M.6
  • 13
    • 0031301825 scopus 로고    scopus 로고
    • Dynamics of HIV-1 and CD4R lymphocytes in vivo
    • Perelson AS, Essunger P, Ho DD. Dynamics of HIV-1 and CD4R lymphocytes in vivo. AIDS 1997; 11 (Suppl A):S17-S24.
    • (1997) AIDS , vol.11 , pp. S17-S24
    • Perelson, A.S.1    Essunger, P.2    Ho, D.D.3
  • 14
    • 0032550369 scopus 로고    scopus 로고
    • Turnover of CD4R and CD8R T lymphocytes in HIV-1 infection as measured by Ki-67 antigen
    • Sachsenberg N, Perelson AS, Yerly S, Schockmel GA, Leduc D, Hirschel B, et al. Turnover of CD4R and CD8R T lymphocytes in HIV-1 infection as measured by Ki-67 antigen. J Exp Med 1998; 187:1295-1303.
    • (1998) J Exp Med , vol.187 , pp. 1295-1303
    • Sachsenberg, N.1    Perelson, A.S.2    Yerly, S.3    Schockmel, G.A.4    Leduc, D.5    Hirschel, B.6
  • 16
  • 17
    • 0034532632 scopus 로고    scopus 로고
    • CD4RKi67R lymphocytes in HIV-infected patients are effector T cells accumulated in the G1 phase of the cell cycle
    • Combadere B, Blanc C, Li T, Carcelain G, Delaugerre C, Calvez V, et al. CD4RKi67R lymphocytes in HIV-infected patients are effector T cells accumulated in the G1 phase of the cell cycle. Eur J Immunol 2000; 30:3598-3603.
    • (2000) Eur J Immunol , vol.30 , pp. 3598-3603
    • Combadere, B.1    Blanc, C.2    Li, T.3    Carcelain, G.4    Delaugerre, C.5    Calvez, V.6
  • 18
    • 50949130685 scopus 로고    scopus 로고
    • Central memory CD8R T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression
    • Ladell K, Hellerstein MK, Cesar D, Busch R, Boban D, McCune JM. Central memory CD8R T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression. J Immunol 2008; 180:7907-7918.
    • (2008) J Immunol , vol.180 , pp. 7907-7918
    • Ladell, K.1    Hellerstein, M.K.2    Cesar, D.3    Busch, R.4    Boban, D.5    McCune, J.M.6
  • 21
    • 0037180499 scopus 로고    scopus 로고
    • In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: Why are CD4R but not CD8R T cells depleted?
    • Ribeiro RM, Mohri H, Ho DD, Perelson AS. In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: why are CD4R but not CD8R T cells depleted? Proc Natl Acad Sci U S A 2002; 99:15572-15577.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15572-15577
    • Ribeiro, R.M.1    Mohri, H.2    Ho, D.D.3    Perelson, A.S.4
  • 23
    • 84876857459 scopus 로고    scopus 로고
    • Accelerated in vivo proliferation of memory phenotype CD4(R) T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism
    • Zhang Y, De Lara C, Worth A, Hegedus A, Laamanen K, Beverley P, et al. Accelerated in vivo proliferation of memory phenotype CD4(R) T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism. PLoS Pathog 2013; 9:e1003310.
    • (2013) PLoS Pathog , vol.9
    • Zhang, Y.1    De Lara, C.2    Worth, A.3    Hegedus, A.4    Laamanen, K.5    Beverley, P.6
  • 24
    • 84907424123 scopus 로고    scopus 로고
    • Protection versus pathology in aviremic and high viral load HIV-2 infection-the pivotal role of immune activation and T-cell kinetics
    • Hegedus A, Nyamweya S, Zhang Y, Govind S, Aspinall R, Mashanova A, et al. Protection versus pathology in aviremic and high viral load HIV-2 infection-the pivotal role of immune activation and T-cell kinetics. J Infect Dis 2014; 210:752-761.
    • (2014) J Infect Dis , vol.210 , pp. 752-761
    • Hegedus, A.1    Nyamweya, S.2    Zhang, Y.3    Govind, S.4    Aspinall, R.5    Mashanova, A.6
  • 25
    • 0018864615 scopus 로고
    • Total body water volumes for adult males and females estimated from simple anthropometric measurements
    • Watson PE, Watson ID, Batt RD. Total body water volumes for adult males and females estimated from simple anthropometric measurements. Am J Clin Nutr 1980; 33:27-39.
    • (1980) Am J Clin Nutr , vol.33 , pp. 27-39
    • Watson, P.E.1    Watson, I.D.2    Batt, R.D.3
  • 26
    • 84880963291 scopus 로고    scopus 로고
    • Quantitating lymphocyte homeostasis in vivo in humans using stable isotope tracers
    • Westera L, Zhang Y, Tesselaar K, Borghans JA, Macallan DC. Quantitating lymphocyte homeostasis in vivo in humans using stable isotope tracers. Methods Mol Biol 2013; 979:107-131.
    • (2013) Methods Mol Biol , vol.979 , pp. 107-131
    • Westera, L.1    Zhang, Y.2    Tesselaar, K.3    Borghans, J.A.4    Macallan, D.C.5
  • 27
    • 0037180449 scopus 로고    scopus 로고
    • Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA
    • Neese RA, Misell LM, Turner S, Chu A, Kim J, Cesar D, et al. Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA. Proc Natl Acad Sci U S A 2002; 99:15345-15350.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15345-15350
    • Neese, R.A.1    Misell, L.M.2    Turner, S.3    Chu, A.4    Kim, J.5    Cesar, D.6
  • 28
    • 0029664923 scopus 로고    scopus 로고
    • Assay of the 13C and 2H mass isotopomer distribution of phosphoenolpyruvate by gas chromatography/mass spectrometry
    • Previs SF, Des RC, Beylot M, David F, Brunengraber H. Assay of the 13C and 2H mass isotopomer distribution of phosphoenolpyruvate by gas chromatography/mass spectrometry. J Mass Spectrom 1996; 31:643-648.
    • (1996) J Mass Spectrom , vol.31 , pp. 643-648
    • Previs, S.F.1    Des, R.C.2    Beylot, M.3    David, F.4    Brunengraber, H.5
  • 29
    • 77649194239 scopus 로고    scopus 로고
    • Explicit kinetic heterogeneity: Mathematical models for interpretation of deuterium labeling of heterogeneous cell populations
    • Ganusov V, Borghans JAM, De Boer RJ. Explicit kinetic heterogeneity: mathematical models for interpretation of deuterium labeling of heterogeneous cell populations. PLoS Comput Biol 2010; 6:e1000666.
    • (2010) PLoS Comput Biol , vol.6
    • Ganusov, V.1    Borghans, J.A.M.2    De Boer, R.J.3
  • 30
    • 84887335296 scopus 로고    scopus 로고
    • Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans
    • Westera L, Drylewicz J, den Braber I, Mugwagwa T, van der Maas I, Kwast L, et al. Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans. Blood 2013; 122:2205-2212.
    • (2013) Blood , vol.122 , pp. 2205-2212
    • Westera, L.1    Drylewicz, J.2    Den Braber, I.3    Mugwagwa, T.4    Van Der Maas, I.5    Kwast, L.6
  • 31
    • 0343920019 scopus 로고    scopus 로고
    • T-cell division in human immunodeficiency virus (HIV) -1 infection is mainly due to immune activation: A longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)
    • Hazenberg MD, Stuart JW, Otto SA, Borleffs JC, Boucher CA, de Boer RJ, et al. T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 2000; 95:249-255.
    • (2000) Blood , vol.95 , pp. 249-255
    • Hazenberg, M.D.1    Stuart, J.W.2    Otto, S.A.3    Borleffs, J.C.4    Boucher, C.A.5    De Boer, R.J.6
  • 33
    • 84876093634 scopus 로고    scopus 로고
    • Quantifying T lymphocyte turnover
    • De Boer RJ, Perelson AS. Quantifying T lymphocyte turnover. J Theor Biol 2013; 327:45-87.
    • (2013) J Theor Biol , vol.327 , pp. 45-87
    • De Boer, R.J.1    Perelson, A.S.2
  • 34
    • 33947225091 scopus 로고    scopus 로고
    • Quantification of T-cell dynamics: From telomeres to DNA labeling
    • Borghans JA, De Boer RJ. Quantification of T-cell dynamics: from telomeres to DNA labeling. Immunol Rev 2007; 216:35-47.
    • (2007) Immunol Rev , vol.216 , pp. 35-47
    • Borghans, J.A.1    De Boer, R.J.2
  • 35
    • 84946095465 scopus 로고    scopus 로고
    • Reconciling estimates of cell proliferation from stable isotope labeling experiments
    • Ahmed R, Westera L, Drylewicz J, Elemans M, Zhang Y, Kelly E, et al. Reconciling estimates of cell proliferation from stable isotope labeling experiments. PLoS Comp Biol 2015 doi:10.1371/journal.pcbi.1004355.
    • (2015) PLoS Comp Biol
    • Ahmed, R.1    Westera, L.2    Drylewicz, J.3    Elemans, M.4    Zhang, Y.5    Kelly, E.6
  • 36
    • 10344246581 scopus 로고    scopus 로고
    • HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation
    • Dion ML, Poulin JF, Bordi R, Sylvestre M, Corsini R, Kettaf N, et al. HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation. Immunity 2004; 21:757-768.
    • (2004) Immunity , vol.21 , pp. 757-768
    • Dion, M.L.1    Poulin, J.F.2    Bordi, R.3    Sylvestre, M.4    Corsini, R.5    Kettaf, N.6
  • 38
    • 0035138982 scopus 로고    scopus 로고
    • Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: Implications for T-cell homeostasis
    • Napolitano LA, Grant RM, Deeks SG, Schmidt D, De Rosa SC, Herzenberg LA, et al. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 2001; 7:73-79.
    • (2001) Nat Med , vol.7 , pp. 73-79
    • Napolitano, L.A.1    Grant, R.M.2    Deeks, S.G.3    Schmidt, D.4    De Rosa, S.C.5    Herzenberg, L.A.6
  • 39
    • 0032402257 scopus 로고    scopus 로고
    • IL-7-dependent extrathymic expansion of CD45RAR T cells enables preservation of a naive repertoire
    • Soares MV, Borthwick NJ, Maini MK, Janossy G, Salmon M, Akbar AN. IL-7-dependent extrathymic expansion of CD45RAR T cells enables preservation of a naive repertoire. J Immunol 1998; 161:5909-5917.
    • (1998) J Immunol , vol.161 , pp. 5909-5917
    • Soares, M.V.1    Borthwick, N.J.2    Maini, M.K.3    Janossy, G.4    Salmon, M.5    Akbar, A.N.6
  • 40
    • 0036566249 scopus 로고    scopus 로고
    • Interleukin-7- treated naive T cells can be productively infected by T-celladapted and primary isolates of human immunodeficiency virus 1
    • Steffens CM, Managlia EZ, Landay A, Al-Harthi L. Interleukin-7- treated naive T cells can be productively infected by T-celladapted and primary isolates of human immunodeficiency virus 1. Blood 2002; 99:3310-3318.
    • (2002) Blood , vol.99 , pp. 3310-3318
    • Steffens, C.M.1    Managlia, E.Z.2    Landay, A.3    Al-Harthi, L.4
  • 41
    • 79960453203 scopus 로고    scopus 로고
    • Differential effects of HIV viral load and CD4 count on proliferation of naive and memory CD4 and CD8 T lymphocytes
    • Srinivasula S, Lempicki RA, Adelsberger JW, Huang CY, Roark J, Lee PI, et al. Differential effects of HIV viral load and CD4 count on proliferation of naive and memory CD4 and CD8 T lymphocytes. Blood 2011; 118:262-270.
    • (2011) Blood , vol.118 , pp. 262-270
    • Srinivasula, S.1    Lempicki, R.A.2    Adelsberger, J.W.3    Huang, C.Y.4    Roark, J.5    Lee, P.I.6
  • 42
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006; 12:1365-1371.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3    Asher, T.E.4    Silvestri, G.5    Rao, S.6
  • 43
    • 15244358107 scopus 로고    scopus 로고
    • TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen- presenting cells
    • Herbeuval JP, Boasso A, Grivel JC, Hardy AW, Anderson SA, Dolan MJ, et al. TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen- presenting cells. Blood 2005; 105:2458-2464.
    • (2005) Blood , vol.105 , pp. 2458-2464
    • Herbeuval, J.P.1    Boasso, A.2    Grivel, J.C.3    Hardy, A.W.4    Anderson, S.A.5    Dolan, M.J.6
  • 44
    • 38949102301 scopus 로고    scopus 로고
    • Chronic innate immune activation as a cause of HIV-1 immunopathogenesis
    • Boasso A, Shearer GM. Chronic innate immune activation as a cause of HIV-1 immunopathogenesis. Clin Immunol 2008; 126:235-242.
    • (2008) Clin Immunol , vol.126 , pp. 235-242
    • Boasso, A.1    Shearer, G.M.2
  • 45
    • 0034304597 scopus 로고    scopus 로고
    • T cell depletion in HIV-1 infection: How CD4R T cells go out of stock
    • Hazenberg MD, Hamann D, Schuitemaker H, Miedema F. T cell depletion in HIV-1 infection: how CD4R T cells go out of stock. Nat Immunol 2000; 1:285-289.
    • (2000) Nat Immunol , vol.1 , pp. 285-289
    • Hazenberg, M.D.1    Hamann, D.2    Schuitemaker, H.3    Miedema, F.4
  • 48
    • 0033831175 scopus 로고    scopus 로고
    • Increased cell division but not thymic dysfunction rapidly affects the TREC content of the naive T cell population in HIV-1 infection
    • Hazenberg MD, Otto SA, Cohen Stuart JWT, Verschuren MCM, Borleffs JCC, Boucher CAB, et al. Increased cell division but not thymic dysfunction rapidly affects the TREC content of the naive T cell population in HIV-1 infection. Nat Med 2000; 6:1036-1042.
    • (2000) Nat Med , vol.6 , pp. 1036-1042
    • Hazenberg, M.D.1    Otto, S.A.2    Cohen Stuart, J.W.T.3    Verschuren, M.C.M.4    Borleffs, J.C.C.5    Boucher, C.A.B.6
  • 49
    • 0032101049 scopus 로고    scopus 로고
    • The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool
    • Berzins SP, Boyd RL, Miller JF. The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool. J Exp Med 1998; 187:1839-1848.
    • (1998) J Exp Med , vol.187 , pp. 1839-1848
    • Berzins, S.P.1    Boyd, R.L.2    Miller, J.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.