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Volumn 9, Issue 1, 2016, Pages 265-274

The effect of timing of antiretroviral therapy on CD4+ T-cell reconstitution in the intestine of HIV-infected patients

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; C REACTIVE PROTEIN; KI 67 ANTIGEN;

EID: 84953329705     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2015.58     Document Type: Article
Times cited : (33)

References (49)
  • 1
    • 4644342929 scopus 로고    scopus 로고
    • CD4+ Tcell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    • Brenchley J.M., et al.CD4+ Tcell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J. Exp. Med. 200, 749-759 (2004
    • (2004) J Exp. Med , vol.200 , pp. 749-759
    • Brenchley, J.M.1
  • 2
    • 4644289983 scopus 로고    scopus 로고
    • Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
    • Mehandru S., et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J. Exp. Med. 200, 761-770 (2004
    • (2004) J. Exp. Med , vol.200 , pp. 761-770
    • Mehandru, S.1
  • 3
    • 0028811367 scopus 로고
    • Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood Berlin diarrhea/wasting syndrome study group
    • Schneider, T., Jahn, H.U., Schmidt, W., Riecken, E.O., Zeitz, M., & Ullrich, R. Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Berlin Diarrhea/Wasting Syndrome Study Group. Gut 37, 524-529 (1995
    • (1995) Gut , vol.37 , pp. 524-529
    • Schneider, T.1    Jahn, H.U.2    Schmidt, W.3    Riecken, E.O.4    Zeitz, M.5    Ullrich, R.6
  • 4
    • 0043169683 scopus 로고    scopus 로고
    • Highthroughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection
    • George, M.D., Sankaran, S., Reay, E., Gelli, A.C., & Dandekar, S. Highthroughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection. Virology 312, 84-94 (2003
    • (2003) Virology , vol.312 , pp. 84-94
    • George, M.D.1    Sankaran, S.2    Reay, E.3    Gelli, A.C.4    Dandekar, S.5
  • 5
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley J.M., et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 12, 1365-1371 (2006
    • (2006) Nat. Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1
  • 6
    • 34548413609 scopus 로고    scopus 로고
    • Progressive CD4+ centralmemory Tcell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection
    • Okoye A., et al. Progressive CD4+ centralmemory Tcell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J. Exp. Med. 204, 2171-2185 (2007
    • (2007) J. Exp. Med , vol.204 , pp. 2171-2185
    • Okoye, A.1
  • 7
    • 75649127335 scopus 로고    scopus 로고
    • Increased tissue factor expression on circulating monocytes in chronic HIV infection: Relationship to in vivo coagulation and immune activation
    • Funderburg N.T., et al. Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation. Blood 115, 161-167 (2010
    • (2010) Blood , vol.115 , pp. 161-167
    • Funderburg, N.T.1
  • 8
    • 84863991281 scopus 로고    scopus 로고
    • HIV and inflammation: Mechanisms and consequences
    • Hunt, P.W. HIV and inflammation: mechanisms and consequences. Curr. HIV/AIDS Rep. 9, 139-147 (2012
    • (2012) Curr. HIV/AIDS Rep , vol.9 , pp. 139-147
    • Hunt, P.W.1
  • 9
    • 61849131811 scopus 로고    scopus 로고
    • HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity
    • Deeks, S.G., & Phillips, A.N. HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity. BMJ 338, a3172 (2009
    • (2009) BMJ , vol.338 , pp. a3172
    • Deeks, S.G.1    Phillips, A.N.2
  • 10
    • 34249889602 scopus 로고    scopus 로고
    • CD4 cell counts of 800 cells/mm3 or greater after 7 years of highly active antiretroviral therapy are feasible in most patients starting with 350 cells/mm3 or greater
    • Gras L., et al. CD4 cell counts of 800 cells/mm3 or greater after 7 years of highly active antiretroviral therapy are feasible in most patients starting with 350 cells/mm3 or greater. J. Acquir. Immune Defic. Syndr. 45, 183-192 (2007
    • (2007) J. Acquir. Immune Defic. Syndr , vol.45 , pp. 183-192
    • Gras, L.1
  • 11
    • 62449222132 scopus 로고    scopus 로고
    • Incomplete peripheral CD4+ cell count restoration in HIVinfected patients receiving long-Term antiretroviral treatment
    • Kelley C.F., et al. Incomplete peripheral CD4+ cell count restoration in HIVinfected patients receiving long-Term antiretroviral treatment. Clin. Infect. Dis 48, 787-794 (2009
    • (2009) Clin. Infect. Dis , vol.48 , pp. 787-794
    • Kelley, C.F.1
  • 12
    • 22544453346 scopus 로고    scopus 로고
    • Characteristics determinants, and clinical relevance of CD4 T cell recovery to o500 cells/microL in HIV type 1-infected individuals receiving potent antiretroviral therapy
    • Kaufmann, G.R., et al. Characteristics, determinants, and clinical relevance of CD4 T cell recovery to o500 cells/microL in HIV type 1-infected individuals receiving potent antiretroviral therapy. Clin. Infect. Dis. 41, 361-372 (2005
    • (2005) Clin. Infect. Dis , vol.41 , pp. 361-372
    • Kaufmann, G.R.1
  • 14
    • 0142092389 scopus 로고    scopus 로고
    • Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy
    • Guadalupe, M., et al. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J. Virol. 77, 11708-11717 (2003
    • (2003) J. Virol , vol.77 , pp. 11708-11717
    • Guadalupe, M.1
  • 15
    • 33746791047 scopus 로고    scopus 로고
    • Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection
    • Guadalupe M., et al. Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection. J. Virol. 80, 8236-8247 (2006
    • (2006) J. Virol , vol.80 , pp. 8236-8247
    • Guadalupe, M.1
  • 16
    • 50249123398 scopus 로고    scopus 로고
    • Immune reconstitution in the sigmoid colon after longterm HIV therapy
    • Sheth P.M., et al. Immune reconstitution in the sigmoid colon after longterm HIV therapy. Mucosal Immunol. 1, 382-388 (2008
    • (2008) Mucosal Immunol , vol.1 , pp. 382-388
    • Sheth, P.M.1
  • 17
    • 54449084622 scopus 로고    scopus 로고
    • Effective CD4+ T-cell restoration in gut-Associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses
    • Macal M., et al. Effective CD4+ T-cell restoration in gut-Associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses. Mucosal Immunol. 1, 475-488 (2008
    • (2008) Mucosal Immunol , vol.1 , pp. 475-488
    • Macal, M.1
  • 18
    • 0035144630 scopus 로고    scopus 로고
    • Virologic and immunologic effect of antiretroviral therapy on HIV-1 in gut-Associated lymphoid tissue
    • Talal A.H., et al. Virologic and immunologic effect of antiretroviral therapy on HIV-1 in gut-Associated lymphoid tissue. J. Acquir. Immune Defic. Syndr. 26, 1-7 (2001
    • (2001) J. Acquir. Immune Defic. Syndr , vol.26 , pp. 1-7
    • Talal, A.H.1
  • 19
    • 84927590232 scopus 로고    scopus 로고
    • Early initiation of combined antiretroviral therapy preserves immune function in the gut of HIV-infected patients
    • Kok A., et al. Early initiation of combined antiretroviral therapy preserves immune function in the gut of HIV-infected patients. Mucosal Immunol. 8, 127-140 (2015
    • (2015) Mucosal Immunol , vol.8 , pp. 127-140
    • Kok, A.1
  • 20
    • 33845904393 scopus 로고    scopus 로고
    • Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection
    • Mehandru S., et al. Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infection. PLoSMed. 3, e484 (2006
    • (2006) PLoSMed , vol.3 , pp. e484
    • Mehandru, S.1
  • 21
    • 77249172740 scopus 로고    scopus 로고
    • Cycling of gut mucosal CD4+ T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels
    • Ciccone E.J., et al. Cycling of gut mucosal CD4+ T cells decreases after prolonged anti-retroviral therapy and is associated with plasma LPS levels. Mucosal Immunol. 3, 172-181 (2010
    • (2010) Mucosal Immunol , vol.3 , pp. 172-181
    • Ciccone, E.J.1
  • 22
    • 84865466195 scopus 로고    scopus 로고
    • Gastrointestinal-Associated lymphoid tissue immune reconstitution in a randomized clinical trial of raltegravir versus nonnucleoside reverse transcriptase inhibitor-based regimens
    • Asmuth D.M., et al. Gastrointestinal-Associated lymphoid tissue immune reconstitution in a randomized clinical trial of raltegravir versus nonnucleoside reverse transcriptase inhibitor-based regimens. AIDS 26, 1625-1634 (2012
    • (2012) AIDS , vol.26 , pp. 1625-1634
    • Asmuth, D.M.1
  • 23
    • 84887300950 scopus 로고    scopus 로고
    • Impaired CD4+ T-cell restoration in the small versus large intestine of HIV-1-positive South Africans receiving combination antiretroviral therapy
    • Cassol E., et al. Impaired CD4+ T-cell restoration in the small versus large intestine of HIV-1-positive South Africans receiving combination antiretroviral therapy. J. Infect. Dis. 208, 1113-1122 (2013
    • (2013) J. Infect. Dis , vol.208 , pp. 1113-1122
    • Cassol, E.1
  • 24
    • 84872772721 scopus 로고    scopus 로고
    • Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets
    • Sathaliyawala T., et al. Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity 38, 187-197 (2013
    • (2013) Immunity , vol.38 , pp. 187-197
    • Sathaliyawala, T.1
  • 25
    • 0033984235 scopus 로고    scopus 로고
    • The Ki-67 protein: From the known and the unknown
    • Scholzen, T., & Gerdes, J. The Ki-67 protein: from the known and the unknown. J. Cell Physiol. 182, 311-322 (2000
    • (2000) J. Cell Physiol , vol.182 , pp. 311-322
    • Scholzen, T.1    Gerdes, J.2
  • 26
    • 16844366717 scopus 로고    scopus 로고
    • CD38 is expressed selectively during the activation of a subset of mature T cells with reduced proliferation but improved potential to produce cytokines
    • Sandoval-Montes, C., & Santos-Argumedo, L. CD38 is expressed selectively during the activation of a subset of mature T cells with reduced proliferation but improved potential to produce cytokines. J. Leukoc. Biol. 77, 513-521 (2005
    • (2005) J. Leukoc. Biol , vol.77 , pp. 513-521
    • Sandoval-Montes, C.1    Santos-Argumedo, L.2
  • 27
    • 84969297277 scopus 로고
    • Cell surface markers of t-cell activation
    • Aversa, GGaH & Bruce, M. Cell Surface Markers of T-Cell Activation. Transplant Rev. 5, 22 (1991
    • (1991) Transplant Rev , vol.5 , pp. 22
    • GGaH, A.1    Bruce, M.2
  • 28
    • 0027323671 scopus 로고
    • Expression of CD69 antigen on synovial fluid T cells in patients with rheumatoid arthritis and other chronic synovitis
    • Afeltra A., et al. Expression of CD69 antigen on synovial fluid T cells in patients with rheumatoid arthritis and other chronic synovitis. Ann. Rheum. Dis. 52, 457-460 (1993
    • (1993) Ann. Rheum. Dis , vol.52 , pp. 457-460
    • Afeltra, A.1
  • 29
    • 58949102533 scopus 로고    scopus 로고
    • Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients
    • Epple H.J., et al. Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut 58, 220-227 (2009
    • (2009) Gut , vol.58 , pp. 220-227
    • Epple, H.J.1
  • 30
    • 84898543418 scopus 로고    scopus 로고
    • Effect of age on the CD4(+) T-cell impairment in HIVinfected persons without and with cART
    • Allers K., et al. Effect of age on the CD4(+) T-cell impairment in HIVinfected persons without and with cART. J. Acquir. Immune Defic. Syndr. 66, 7-15 (2014
    • (2014) J. Acquir. Immune Defic. Syndr , vol.66 , pp. 7-15
    • Allers, K.1
  • 31
    • 34547100323 scopus 로고    scopus 로고
    • Simian immunodeficiency virus infection induces severe loss of intestinal central memory Tcells which impairs CD4+ T-cell restoration during antiretroviral therapy
    • Verhoeven, D., Sankaran, S., & Dandekar, S. Simian immunodeficiency virus infection induces severe loss of intestinal central memory Tcells which impairs CD4+ T-cell restoration during antiretroviral therapy. J. Med. Primatol. 36, 219-227 (2007
    • (2007) J. Med. Primatol , vol.36 , pp. 219-227
    • Verhoeven, D.1    Sankaran, S.2    Dandekar, S.3
  • 32
    • 9244220630 scopus 로고    scopus 로고
    • Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection
    • Picker L.J., et al. Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J. Exp. Med. 200, 1299-1314 (2004
    • (2004) J. Exp. Med , vol.200 , pp. 1299-1314
    • Picker, L.J.1
  • 33
    • 66649114758 scopus 로고    scopus 로고
    • High antigen levels are the cause of T cell exhaustion during chronic viral infection
    • Mueller, S.N., & Ahmed, R. High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc. Natl Acad. Sci. USA 106, 8623-8628 (2009
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 8623-8628
    • Mueller, S.N.1    Ahmed, R.2
  • 34
    • 79952705605 scopus 로고    scopus 로고
    • Revisiting immune exhaustion during HIV infection
    • Khaitan, A., & Unutmaz, D. Revisiting immune exhaustion during HIV infection. Curr. HIV/AIDS Rep. 8, 4-11 (2011
    • (2011) Curr. HIV/AIDS Rep , vol.8 , pp. 4-11
    • Khaitan, A.1    Unutmaz, D.2
  • 35
    • 1642415940 scopus 로고    scopus 로고
    • Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections
    • Fuller, M.J., Khanolkar, A., Tebo, A.E., & Zajac, A.J. Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections. J. Immunol. 172, 4204-4214 (2004
    • (2004) J. Immunol , vol.172 , pp. 4204-4214
    • Fuller, M.J.1    Khanolkar, A.2    Tebo, A.E.3    Zajac, A.J.4
  • 36
    • 84855417479 scopus 로고    scopus 로고
    • Altered CD4+ Tcell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals
    • Mavigner M., et al. Altered CD4+ Tcell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals. J. Clin. Invest. 122, 62-69 (2012
    • (2012) J. Clin. Invest , vol.122 , pp. 62-69
    • Mavigner, M.1
  • 37
    • 48749093073 scopus 로고    scopus 로고
    • Collagen deposition limits immune reconstitution in the gut
    • Estes J., et al. Collagen deposition limits immune reconstitution in the gut. J. Infect. Dis. 198, 456-464 (2008
    • (2008) J. Infect. Dis , vol.198 , pp. 456-464
    • Estes, J.1
  • 38
    • 33747193214 scopus 로고    scopus 로고
    • Use of flexible sigmoidoscopy to screen for colorectal cancer in HIV-infected patients 50 years of age and older
    • Bini, E.J., Park, J., & Francois, F. Use of flexible sigmoidoscopy to screen for colorectal cancer in HIV-infected patients 50 years of age and older. Arch. Intern. Med. 166, 1626-1631 (2006
    • (2006) Arch. Intern. Med , vol.166 , pp. 1626-1631
    • Bini, E.J.1    Park, J.2    Francois, F.3
  • 39
    • 67650245514 scopus 로고    scopus 로고
    • Screening colonoscopy for the detection of neoplastic lesions in asymptomatic HIV-infected subjects
    • Bini, E.J., Green, B., & Poles, M.A. Screening colonoscopy for the detection of neoplastic lesions in asymptomatic HIV-infected subjects. Gut 58, 1129-1134 (2009
    • (2009) Gut , vol.58 , pp. 1129-1134
    • Bini, E.J.1    Green, B.2    Poles, M.A.3
  • 40
    • 42549121220 scopus 로고    scopus 로고
    • Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ARTat baseline in the SMARTstudy
    • Emery S., et al. Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ARTat baseline in the SMARTstudy. J. Infect. Dis. 197, 1133-1144 (2008
    • (2008) J. Infect. Dis , vol.197 , pp. 1133-1144
    • Emery, S.1
  • 41
    • 80051633217 scopus 로고    scopus 로고
    • Prevention of HIV-1 infection with early antiretroviral therapy
    • Cohen M.S., et al. Prevention of HIV-1 infection with early antiretroviral therapy. N. Engl. J. Med. 365, 493-505 (2011
    • (2011) N. Engl. J. Med , vol.365 , pp. 493-505
    • Cohen, M.S.1
  • 42
    • 64349118898 scopus 로고    scopus 로고
    • Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: A collaborative analysis of 18 HIV cohort studies
    • Sterne J.A., et al. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet 373, 1352-1363 (2009
    • (2009) Lancet , vol.373 , pp. 1352-1363
    • Sterne, J.A.1
  • 43
    • 84893792899 scopus 로고    scopus 로고
    • Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration
    • Sereti I., et al. Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration. PLoS Pathog. 10, e1003890 (2014
    • (2014) PLoS Pathog , vol.10 , pp. e1003890
    • Sereti, I.1
  • 44
    • 33745202622 scopus 로고    scopus 로고
    • IL-15 induces CD4 effectormemory Tcell production and tissue emigration in nonhuman primates
    • Picker L.J., et al. IL-15 induces CD4 effectormemory Tcell production and tissue emigration in nonhuman primates. J. Clin. Invest. 116, 1514-1524 (2006
    • (2006) J. Clin. Invest , vol.116 , pp. 1514-1524
    • Picker, L.J.1
  • 45
    • 48249087613 scopus 로고    scopus 로고
    • Correlation of Tcell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines
    • Aebischer T., et al. Correlation of Tcell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines. Gut 57, 1065-1072 (2008
    • (2008) Gut , vol.57 , pp. 1065-1072
    • Aebischer, T.1
  • 46
    • 84894251437 scopus 로고    scopus 로고
    • Macrophages accumulate in the gut mucosa of untreated HIV-infected patients
    • Allers K., et al. Macrophages accumulate in the gut mucosa of untreated HIV-infected patients. J. Infect. Dis. 209, 739-748 (2014
    • (2014) J. Infect. Dis , vol.209 , pp. 739-748
    • Allers, K.1
  • 47
    • 77949416171 scopus 로고    scopus 로고
    • Gut mucosal FOXP3+ regulatory CD4+ T cells and Nonregulatory CD4+ T cells are differentially affected by simian immunodeficiency virus infection in rhesusmacaques
    • Allers K., et al. Gut mucosal FOXP3+ regulatory CD4+ T cells and Nonregulatory CD4+ T cells are differentially affected by simian immunodeficiency virus infection in rhesusmacaques. J. Virol. 84, 3259-3269 (2010
    • (2010) J. Virol , vol.84 , pp. 3259-3269
    • Allers, K.1
  • 48
    • 77957352033 scopus 로고    scopus 로고
    • Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells epithelial apoptosis, and a mucosal barrier defect
    • Epple, H.J., et al. Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect. Gastroenterology 139, 1289-1300 (2010
    • (2010) Gastroenterology , vol.139 , pp. 1289-1300
    • Epple, H.J.1
  • 49
    • 79953117041 scopus 로고    scopus 로고
    • Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation
    • Allers K., et al. Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood 117, 2791-2799 (2011
    • (2011) Blood , vol.117 , pp. 2791-2799
    • Allers, K.1


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