Anticancer activity of cardiac glycosides: At the frontier between cell-autonomous and immunological effects

OncoImmunology

Volumn 1, Issue 9, 2012, Pages 1640-1642

  Kepp, Oliver ^a,b,c   Menger, Laurie ^a,b,c   Vacchelli, Erika ^a,b,c   Adjemian, Sandy ^a,b,c   Martins, Isabelle ^a,b,c   Ma, Yuting ^a,b,c   Sukkurwala, Abdul Qader ^a,b,c   Michaud, Mickaël ^a,b,c   Galluzzi, Lorenzo ^d,e   Zitvogel, Laurence ^a,b,c   Kroemer, Guido ^a,b,d,e,f  

^a Institut Gustave Roussy   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e CENTRE DE RECHERCHE DES CORDELIERS   (France)

^f HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

Calreticulin; Digitoxin; Digoxin; HMGB1; Immunogenic cell death; Na+ K+ ATPase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTHRACYCLINE; CARDIAC GLYCOSIDE; CISPLATIN; DIGITOXIN; DIGOXIN; DOUBLE STRANDED DNA; DOUBLE STRANDED RNA; ESTROGEN RECEPTOR; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOMYCIN; OXALIPLATIN; PHYTOESTROGEN; POTASSIUM; SODIUM; SODIUM CALCIUM EXCHANGE PROTEIN;

ANTINEOPLASTIC ACTIVITY; BREAST CARCINOMA; CANCER CELL; CANCER PATIENT; CANCER SURVIVAL; COLORECTAL CARCINOMA; ENDOPLASMIC RETICULUM; HEAD AND NECK CARCINOMA; HUMAN; IMMUNE RESPONSE; LIFE EXPECTANCY; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; MITOCHONDRION; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL; PROSTATE CARCINOMA; RETROSPECTIVE STUDY;

EID: 84876131792     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.21684     Document Type: Note

References (12)

1. Ehle M, Patel C, Giugliano RP. Digoxin: clinical highlights: a review of digoxin and its use in contemporary medicine. Crit Pathw Cardiol 2011; 10:93- 8; PMID:21988950; http://dx.doi.org/10.1097/HPC.0b013e318221e7dd.
2. Newman RA, Yang P, Pawlus AD, Block KI. Cardiac glycosides as novel cancer therapeutic agents. Mol Interv 2008; 8:36-49; PMID:18332483; http://dx.doi.org/10.1124/mi.8.1.8.
3. Tailler M, Senovilla L, Lainey E, Thépot S, Métivier D, Sébert M, et al. Antineoplastic activity of ouabain and pyrithione zinc in acute myeloid leukemia. Oncogene 2012; 31:3536-46; PMID:22105358; http://dx.doi.org/10.1038/onc.2011.521.
4. Perne A, Muellner MK, Steinrueck M, Craig-Mueller N, Mayerhofer J, Schwarzinger I, et al. Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis. PLoS One 2009; 4:e8292; PMID:20016840; http://dx.doi.org/10.1371/journal.pone.0008292.
5. Ye J, Chen S, Maniatis T. Cardiac glycosides are potent inhibitors of interferon-β gene expression. Nat Chem Biol 2011; 7:25-33; PMID:21076398; http://dx.doi.org/10.1038/nchembio.476.
6. Menger L, Vacchelli E, Adjemian S, Martins I, Ma Y, Shen S, et al. Cardiac glycosides exert anticancer effects by inducing immunogenic cell death. Sci Transl Med 2012; 4:143ra99; PMID:22814852; http://dx.doi.org/10.1126/scitranslmed.3003807.
7. Zitvogel L, Kepp O, Kroemer G. Decoding cell death signals in inflammation and immunity. Cell 2010; 140:798-804; PMID:20303871; http://dx.doi.org/10.1016/j.cell.2010.02.015.
8. Galluzzi L, Senovilla L, Zitvogel L, Kroemer G. The secret ally: immunostimulation by anticancer drugs. Nat Rev Drug Discov 2012; 11:215-33; PMID:22301798; http://dx.doi.org/10.1038/nrd3626.
9. Vacchelli E, Galluzzi L, Fridman WH, Galon J, Sautès-Fridman C, Tartour E, et al. Trial watch: Chemotherapy with immunogenic cell death inducers. Oncoimmunology 2012; 1:179-88; PMID:22720239; http://dx.doi.org/10.4161/onci.1.2.19026.
10. Biggar RJ, Wohlfahrt J, Oudin A, Hjuler T, Melbye M. Digoxin use and the risk of breast cancer in women. J Clin Oncol 2011; 29:2165-70; PMID:21422417; http://dx.doi.org/10.1200/JCO.2010.32.8146.
11. Platz EA, Yegnasubramanian S, Liu JO, Chong CR, Shim JS, Kenfield SA, et al. A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment. Cancer Discov 2011; 1:68-77; PMID:22140654; http://dx.doi.org/10.1158/2159-8274.CD-10-0020.
12. Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka RR, et al. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature 2011; 472:486-90; PMID:21441909; http://dx.doi.org/10.1038/nature09978.