CD8 T-cell expansion and inflammation linked to CMV coinfection in ART-treated HIV infection

Clinical Infectious Diseases

Volumn 62, Issue 3, 2016, Pages 392-396

  Freeman, Michael L ^a   Mudd, Joseph C ^a,f   Shive, Carey L ^a,b   Younes, Souheil Antoine ^a   Panigrahi, Soumya ^a   Sieg, Scott F ^a   Lee, Sulggi A ^c   Hunt, Peter W ^c   Calabrese, Leonard H ^d   Gianella, Sara ^e   Rodriguez, Benigno ^a   Lederman, Michael M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

CD8 T cell expansion; CMV; coinfection; HIV; inflammation

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; D DIMER; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR RECEPTOR 2; ANTIRETROVIRUS AGENT; CYTOKINE;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CD4 CD8 RATIO; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CLINICAL ARTICLE; CLINICAL LABORATORY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTOSIS; MALE; MIXED INFECTION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; BLOOD; CHEMISTRY; COHORT ANALYSIS; COMPLICATION; HIV INFECTIONS; IMMUNOLOGY; LYMPHOCYTE COUNT; MIDDLE AGED; PATHOLOGY; PLASMA;

ADULT; ANTI-RETROVIRAL AGENTS; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; COINFECTION; CYTOKINES; CYTOMEGALOVIRUS INFECTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIV INFECTIONS; HUMANS; LYMPHOCYTE COUNT; LYMPHOCYTOSIS; MALE; MIDDLE AGED; PLASMA;

EID: 84962221927     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ840     Document Type: Article

References (39)

1. Antinori S. Histoplasma capsulatum: more widespread than previously thought. Am J Trop Med Hyg 2014; 90: 982-3
2. Chang P, Rodas C. Skin lesions in histoplasmosis. Clin Dermatol 2012; 30: 592-8
3. Pfaller MA, Diekema DJ. Epidemiology of invasive mycoses in North America. Crit Rev Microbiol 2010; 36: 1-53
4. Lee J-H, Slifman NR, Gershon SK., et al. Life-Threatening histoplasmosis complicating immunotherapy with tumor necrosis factor alpha antagonists infliximab and etanercept. Arthritis Rheum 2002; 46: 2565-70
5. Tobón AM, Agudelo CA, Rosero DS., et al. Disseminated histoplasmosis: a comparative study between patients with acquired immunodeficiency syndrome and non-human immunodeficiency virus-infected individuals. Am J Trop Med Hyg 2005; 73: 576-82
6. Smith JA, Riddell J, Kauffman CA. Cutaneous manifestations of endemic mycoses. Curr Infect Dis Rep 2013; 15: 440-9
7. Wheat LJ, Freifeld AG, Kleiman MB., et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 2007; 45: 807-25
8. Staras SA, Dollard SC, Radford KW, Flanders WD, Pass RF, Cannon MJ. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin Infect Dis 2006; 43: 1143-51
9. Robain M, Carre N, Dussaix E, Salmon-Ceron D, Meyer L. Incidence and sexual risk factors of cytomegalovirus seroconversion in HIV-infected subjects. The SEROCO Study Group. Sex Transm Dis 1998; 25: 476-80
10. Lederman MM, Calabrese L, Funderburg NT., et al. Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J Infect Dis 2011; 204: 1217-26
11. Shive CL, Jiang W, Anthony DD, Lederman MM. Soluble CD14 is a nonspecific marker of monocyte activation. AIDS 2015; 29: 1263-5
12. Kaplan RC, Kingsley LA, Gange SJ., et al. Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men. AIDS 2008; 22: 1615-24
13. Stylianou E, Aukrust P, Bendtzen K, Muller F, Froland SS. Interferons and interferon (IFN)-inducible protein 10 during highly active anti-retroviral therapy (HAART)-possible immunosuppressive role of IFN-Alpha in HIV infection. Clin Exp Immunol 2000; 119: 479-85
14. Deeks SG. HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med 2011; 62: 141-55
15. Lederman MM, Funderburg NT, Sekaly RP, Klatt NR, Hunt PW. Residual immune dysregulation syndrome in treated HIV infection. Adv Immunol 2013; 119: 51-83
16. Sylwester AW, Mitchell BL, Edgar JB., et al. Broadly targeted human cytomegalovirusspecific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med 2005; 202: 673-85
17. Khan N, Shariff N, Cobbold M., et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002; 169: 1984-92
18. Khan N, Cobbold M, Cummerson J, Moss PA. Persistent viral infection in humans can drive high frequency low-Affinity T-cell expansions. Immunology 2010; 131: 537-48
19. Ouyang Q, Wagner WM, Zheng W, Wikby A, Remarque EJ, Pawelec G. Dysfunctional CMV-specific CD8+ T cells accumulate in the elderly. Exp Gerontol 2004; 39: 607-13
20. Chidrawar S, Khan N, Wei W., et al. Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin Exp Immunol 2009; 155: 423-32
21. Barrett L, Stapleton SN, Fudge NJ, Grant MD. Immune resilience in HIV-infected individuals seronegative for cytomegalovirus. AIDS 2014; 28: 2045-9
22. Rinaldo CR Jr, Kingsley LA, Ho M, Armstrong JA, Zhou SY. Enhanced shedding of cytomegalovirus in semen of human immunodeficiency virus-seropositive homosexual men. J Clin Microbiol 1992; 30: 1148-55
23. Ouyang Q, Wagner WM, Wikby A., et al. Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol 2003; 23: 247-57
24. Naeger DM, Martin JN, Sinclair E., et al. Cytomegalovirus-specific T cells persist at very high levels during long-Term antiretroviral treatment of HIV disease. PLoS One 2010; 5: e8886
25. Hsue PY, Hunt PW, Sinclair E., et al. Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses. AIDS 2006; 20: 2275-83
26. Stone SF, Price P, Khan N, Moss PA, French M.A. HIV patients on antiretroviral therapy have high frequencies of CD8 T cells specific for Immediate Early protein-1 of cytomegalovirus. AIDS 2005; 19: 555-62
27. Stone SF, Price P, French M.A. Cytomegalovirus (CMV)-specific CD8+ T cells in individuals with HIV infection: correlation with protection from CMV disease. J Antimicrob Chemother 2006; 57: 585-8
28. Fawaz LM, Sharif-Askari E, Menezes J. Up-regulation of NK cytotoxic activity via IL-15 induction by different viruses: a comparative study. J Immunol 1999; 163: 4473-80
29. Mueller YM, Katsikis PD. IL-15 in HIV infection: pathogenic or therapeutic potential? Eur Cytokine Netw 2010; 21: 219-21
30. Appay V, Dunbar PR, Callan M., et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 2002; 8: 379-85
31. Lee SA, Sinclair E, Hatano H., et al. Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging. PLoS One 2014; 9: e89444
32. Hunt PW, Martin JN, Sinclair E., et al. Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. J Infect Dis 2011; 203: 1474-83
33. Valle Y, Ledezma-Lozano IY, Torres-Carrillo N., et al. Circulating TNFRI and TNFRII levels correlated with the disease activity score (DAS28) in rheumatoid arthritis. Scand J Rheumatol 2009; 38: 332-5
34. NoktaM, Rossero R, Loesch K, Pollard RB. Kinetics of tumor necrosis factor alpha and soluble TNFRII in HIV-infected patients treated with a triple combination of stavudine, didanosine, and hydroxyurea. AIDS Res Hum Retroviruses 1997; 13: 1633-8
35. Humbert M, Roux-Lombard P, Cerrina J., et al. Soluble TNF receptors (TNF-sR55 and TNF-sR75) in lung allograft recipients displaying cytomegalovirus pneumonitis. Am J Respir Crit Care Med 1994; 149: 1681-5
36. Jakobsen PH, Dodt KK, Meyer CN, Katzenstein T, Gerstoft J, Skinhoj P. Increased levels of soluble tumour necrosis factor receptor-I (P55) and decreased IgG1 reactivities in HIV-1 patients with cytomegalovirus disease. Scand J Immunol 1998; 47: 591-5
37. Ramirez LA, Arango TA, Thompson E, Naji M, Tebas P, Boyer JD. High IP-10 levels decrease T cell function in HIV-1-infected individuals on ART. J Leukoc Biol 2014; 96: 1055-63
38. Weseslindtner L, Nachbagauer R, Kundi M., et al. Human cytomegalovirus infection in lung transplant recipients triggers a CXCL-10 response. Am J Transplant 2011; 11: 542-52
39. Hsue PY, Lo JC, Franklin A., et al. Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infection. Circulation 2004; 109: 1603-8