Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration

Seminars in Immunopathology

Volumn 38, Issue 2, 2016, Pages 139-152

  Qualls, Joseph E ^a   Murray, Peter J ^b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Granuloma; Hypoxia; l arginine; l tryptophan; Metabolism; Tuberculosis

Indexed keywords

AMINO ACID; ARGINASE 1; ARGININE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; GLUCOSE; INDOLEAMINE 2,3 DIOXYGENASE; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTIC ACID; NITRIC OXIDE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRYPTOPHAN; COLLAGEN;

AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; CELL PROLIFERATION; CELL RESPIRATION; COLLAGEN SYNTHESIS; ENZYME ACTIVITY; GLYCOLYSIS; GRANULOMA; HUMAN; HYPOXIA; IMMUNOMETABOLISM; IMMUNOREGULATION; MACROPHAGE; METABOLISM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUTRIENT UPTAKE; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STRESS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUBERCULOSIS GRANULOMA; ADAPTATION; ANIMAL; BIOSYNTHESIS; COMPLICATION; ENERGY METABOLISM; HOST PATHOGEN INTERACTION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGICAL STRESS; TUBERCULOSIS;

ADAPTATION, PHYSIOLOGICAL; AMINO ACIDS; ANIMALS; ARGININE; CELL RESPIRATION; COLLAGEN; ENERGY METABOLISM; GRANULOMA; HOST-PATHOGEN INTERACTIONS; HUMANS; HYPOXIA; LYMPHOCYTE ACTIVATION; MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS; NITRIC OXIDE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; STRESS, PHYSIOLOGICAL; T-LYMPHOCYTES; TRYPTOPHAN; TUBERCULOSIS;

EID: 84959571803     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-015-0534-0     Document Type: Review

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