Influence of Tryptophan Contained in 1-Methyl-Tryptophan on Antimicrobial and Immunoregulatory Functions of Indoleamine 2,3-Dioxygenase

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Schmidt, Silvia K ^a   Siepmann, Stephan ^a   Kuhlmann, Katja ^b   Meyer, Helmut E ^b   Metzger, Sabine ^a   Pudelko, Sabine ^a   Leineweber, Margret ^a   Däubener, Walter ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYLTRYPTOPHAN; INDOLEAMINE 2,3 DIOXYGENASE; N METHYLTRYPTOPHAN; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOREGULATION; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; STAPHYLOCOCCUS AUREUS; STEREOSPECIFICITY; T LYMPHOCYTE; TOXOPLASMA GONDII;

AMINO ACID SEQUENCE; CELL PROLIFERATION; ENZYME INHIBITORS; HELA CELLS; HUMANS; IMMUNOMODULATION; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MOLECULAR SEQUENCE DATA; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; T-LYMPHOCYTES; TOXOPLASMA; TRYPTOPHAN;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS; TOXOPLASMA GONDII;

EID: 84866386281     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044797     Document Type: Article

References (32)

1. Takikawa O, (2005) Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated L-tryptophan metabolism. Biochem Biophys Res Commun 338: 12-19.
2. Pfefferkorn ER, (1984) Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. PNAS 81: 908-912.
3. Schroten H, Spors B, Hucke C, Stins M, Kim KS, et al. (2001) Potential role of human brain microvascular endothelial cells in the pathogenesis of brain abscess: inhibition of Staphylococcus aureus by activation of indoleamine 2,3-dioxygenase. Neuropedriatrics 32: 206-210.
4. Adams O, Besken K, Oberdörfer C, MacKenzie CR, Takikawa O, et al. (2004) Role of indoleamine 2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections. J Virology 78: 2632-2636.
5. Mellor AL, Munn DH, (1999) Tryptophan catabolism and T cell tolerance: immunosuppression by starvation? Immunol Today 20: 469-473.
6. Grohmann U, Fallarino F, Puccetti P, (2003) Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol 24: 242-248.
7. Frumento G, Rotondo R, Tonetti M, Damonte G, Benatti U, et al. (2002) Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J Exp Med 196: 459-468.
8. Liu X-Q, Wang X, (2009) Indoleamine 2,3-dioxygenase in tumor induced tolerance. Chin Med J 122: 3072-3077.
9. Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, et al. (2006) The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naïve T cells. J Immunol 176: 6752-6761.
10. Cady SG, Sono M, (1991) 1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulphur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase. Arch Biochem Biophys 291: 326-333.
11. Heseler K, Spekker K, Schmidt SK, MacKenzie CR, Däubener W, (2008) Antimicrobial and immunoregulatory effects mediated by human lung cells: role of IFN-γ-induced tryptophan degradation. FEMS Immunol Med Microbiol 52: 273-281.
12. Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, et al. (1998) Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281: 1122-1124.
13. Qian F, Villella J, Wallace PK, Mhawech-Fauceglia P, Tario JD Jr, et al. (2009) Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing Indoleamine-2,3-Dioxygenase-mediated arrest of T cell proliferation in human epithelial ovarian cancer. Cancer Res 69: 5498-5504.
14. Löb S, Königsrainer A, Zieker D, Brücher BL, Rammensee HG, et al. (2009) IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism. Cancer Immunol Immunother 58: 153-157.
15. Schmidt SK, Müller A, Heseler K, Woite C, Spekker K, et al. (2009) Antimicrobial and immunoregulatory properties of human tryptophan 2,3-dioxygenase. Eur J Immunol 39: 2755-2764.
16. Hou DY, Muller AJ, Sharma MD, DuHadaway J, Banerjee T, et al. (2007) Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Res 67: 792-801.
17. Metz R, DuHadaway JB, Kamasani U, Laury-Kleintop L, Muller AJ, et al. (2007) Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res 67: 7082-7087.
18. Divanovic S, Sawtell NM, Trompette A, Warning JI, Dias A, et al. (2011) Opposing biological functions of tryptophan catabolising enzymes during intracellular infection. J Inf Dis 205: 152-161.
19. Yuasa HJ, Ball HJ, Austin CJ, Hunt NH, (2010) 1-L-Methyltryptophan is a more effective inhibitor of vertebrate IDO2enzymes than 1-D-Methyltryptophan. Comp Biochem Physiol B Biochem Mol Biol 175: 10-15.
20. Agaugué S, Perrin-Cocon L, Coutant F, Andre P, Lotteau V, (2006) 1-Methyl-tryptophan can interfere with TLR signalling in dendritic cells independently of IDO activity. J Immunol 177: 2061-2071.
21. Okamoto T, Toné S, Kanouchi H, Miyawaki C, Ono S, et al. (2007) Transcriptional regulation of indoleamine 2,3-dioxygenase (IDO) by tryptophan and its analogue. Cytotechnology 54: 107-113.
22. Opitz CA, Litzenburger UM, Opitz U, Sahm F, Ochs K, et al. (2011) The indoleamine 2,3-dioxygenase (IDO) inhibitor 1-Methyl-D-tryptophan upregulates IDO1 in human cancer cells. PLoS ONE DOI: 10.1371/journal.pone.0019823.
23. Curti A, Trabanelli S, Onofri C, Aluigi M, Salvestrini V, et al. (2010) Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells. Haematologica 95: 2022-2030.
24. Terness P, Chuang JJ, Opelz G, (2006) The immunoregulatory role of IDO-producing human dendritic cells revisited. Trends in Immunology 27: 68-73.
25. Capece L, Arrar M, Roitberg AE, Yeh SR, Marti MA, et al. (2010) Substrate stereo-specificity in tryptophan dioxygenase and indoleamine 2,3-dioxygenase. Proteins 78: 2961-2972.
26. Chauhan N, Thackray SJ, Rafice SA, Eaton G, Lee M, et al. (2008) Reassessment of the reaction mechanism in the heme dioxygenases. J Am Chem Soc 131: 4186-4187.
27. Liu X, Newton RC, Friedman SM, Scherle PA, (2009) Indoleamine 2,3-Dioxygenase, an emerging target for anti-cancer therapy. Curr Cancer Drug Targets 9: 938-52.
28. Bilzer T, Stavrou D, Dahme E, Keiditsch E, Burrig KF, et al. (1991) Morphological, immunocytochemical and growth characteristics of three human glioblastomas established in vitro. Virchows Arch A Pathol Anat Histopathol 418: 281-93.
29. Däubener W, Wanagat N, Pilz K, Seghrouchni S, Fischer HG, et al. (1994) A new, simple bioassay for human IFN-gamma. J Immunol Methods 168: 39-47.
30. MacKenzie CR, Hucke C, Müller D, Seidel K, Takikawa O, et al. (1999) Growth inhibition of multiresistent enterococci by interferon-gamma-activated human uro-epithelial cells. J Med Microbiol 48: 935-941.
31. Hucke C, MacKenzie CR, Adjogble KD, Takikawa O, Däubener W, (2004) Nitric oxide-mediated regulation of gamma interferon-induced bacteriostasis: inhibition and degradation of human indoleamine 2,3-dioxygenase. Infect Immun 72: 2723-2730.
32. Wiese S, Gronemeyer T, Ofman R, Kunze M, Grou CP, et al. (2007) Proteomics characterization of mouse kidney peroxisomes by tandem mass spectrometry and protein correlation profiling. Mol Cell Proteomics 6: 2045-2057.