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Volumn 6, Issue MAY, 2015, Pages

Anatomy of a discovery: M1 and M2 macrophages

Author keywords

Cancer; Innate immunity; M1; M2; Macrophages; Th1 Th2; Wound

Indexed keywords

ARGINASE; ARGININE; CITRULLINE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MANNOSE RECEPTOR; NITRITE; ORNITHINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84934271896     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00212     Document Type: Review
Times cited : (365)

References (84)
  • 1
    • 84908653357 scopus 로고    scopus 로고
    • M1 and M2 macrophages: the chicken and the egg of immunity
    • Mills CD, Ley K. M1 and M2 macrophages: the chicken and the egg of immunity. J Innate Immun (2014) 6:716-26. doi:10.1159/000364945
    • (2014) J Innate Immun , vol.6 , pp. 716-726
    • Mills, C.D.1    Ley, K.2
  • 2
    • 0024325070 scopus 로고
    • Heterogeneity of cytokine secretion patterns and functions of helper T cells
    • Mosmann TR, Coffman RL. Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol (1989) 46:111-47. doi:10.1016/S0065-2776(08)60652-5
    • (1989) Adv Immunol , vol.46 , pp. 111-147
    • Mosmann, T.R.1    Coffman, R.L.2
  • 3
    • 0024854755 scopus 로고
    • Role of cytokines and CD4+ T-cell subsets in the regulation of parasite immunity and disease
    • Scott P, Pearce E, Cheever AW, Coffman RL, Sher A. Role of cytokines and CD4+ T-cell subsets in the regulation of parasite immunity and disease. Immunol Rev (1989) 112:161-82. doi:10.1111/j.1600-065X.1989.tb00557.x
    • (1989) Immunol Rev , vol.112 , pp. 161-182
    • Scott, P.1    Pearce, E.2    Cheever, A.W.3    Coffman, R.L.4    Sher, A.5
  • 5
    • 0028361047 scopus 로고
    • Role of cytokines in determining T-lymphocyte function
    • O'Garra A, Murphy KM. Role of cytokines in determining T-lymphocyte function. Curr Opin Immunol (1994) 6:458-66. doi:10.1016/0952-7915(94)90128-7
    • (1994) Curr Opin Immunol , vol.6 , pp. 458-466
    • O'Garra, A.1    Murphy, K.M.2
  • 6
    • 0028906593 scopus 로고
    • T cell genetic background determines default T helper phenotype development in vitro
    • Hsieh CS, Macatonia SE, O'Garra A, Murphy KM. T cell genetic background determines default T helper phenotype development in vitro. J Exp Med (1995) 181:713-21. doi:10.1084/jem.181.2.713
    • (1995) J Exp Med , vol.181 , pp. 713-721
    • Hsieh, C.S.1    Macatonia, S.E.2    O'Garra, A.3    Murphy, K.M.4
  • 7
    • 79551598939 scopus 로고    scopus 로고
    • The ancestry and cumulative evolution of immune reactions
    • Dzik JM. The ancestry and cumulative evolution of immune reactions. Acta Biochim Pol (2010) 57:443-66.
    • (2010) Acta Biochim Pol , vol.57 , pp. 443-466
    • Dzik, J.M.1
  • 8
    • 84918534306 scopus 로고    scopus 로고
    • Evolution of innate immunity: clues from invertebrates via fish to mammals
    • Buchmann K. Evolution of innate immunity: clues from invertebrates via fish to mammals. Front Immunol (2014) 5:459. doi:10.3389/fimmu.2014
    • (2014) Front Immunol , vol.5 , pp. 459
    • Buchmann, K.1
  • 9
    • 84873743410 scopus 로고    scopus 로고
    • M1 and M2 macrophages: oracles of health and disease
    • Mills CD. M1 and M2 macrophages: oracles of health and disease. Crit Rev Immunol (2012) 32:463-88. doi:10.1159/000364945
    • (2012) Crit Rev Immunol , vol.32 , pp. 463-488
    • Mills, C.D.1
  • 10
    • 84859707586 scopus 로고    scopus 로고
    • Secretory products of macrophages: twenty-five years on
    • Nathan CF. Secretory products of macrophages: twenty-five years on. J Clin Invest (2012) 122:1189-90. doi:10.1172/JCI62930
    • (2012) J Clin Invest , vol.122 , pp. 1189-1190
    • Nathan, C.F.1
  • 11
    • 0018426597 scopus 로고
    • Microenvironmental arginine depletion by macrophages in vivo
    • Currie GA, Gyure L, Cifuentes L. Microenvironmental arginine depletion by macrophages in vivo. Br J Cancer (1979) 6:613-20. doi:10.1038/bjc.1979.112
    • (1979) Br J Cancer , vol.6 , pp. 613-620
    • Currie, G.A.1    Gyure, L.2    Cifuentes, L.3
  • 12
    • 0023142137 scopus 로고
    • l-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells
    • Hibbs JB, Vavrin Z, Taintor RR. l-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J Immunol (1987) 138:550-65.
    • (1987) J Immunol , vol.138 , pp. 550-565
    • Hibbs, J.B.1    Vavrin, Z.2    Taintor, R.R.3
  • 13
    • 0024600411 scopus 로고
    • Regulation of macrophage functions by l-arginine
    • Albina JE, Caldwell MS, Henry WL, Mills CD. Regulation of macrophage functions by l-arginine. J Exp Med (1989) 169:1021-9. doi:10.1084/jem.169.3.1021
    • (1989) J Exp Med , vol.169 , pp. 1021-1029
    • Albina, J.E.1    Caldwell, M.S.2    Henry, W.L.3    Mills, C.D.4
  • 14
    • 0025329074 scopus 로고
    • Temporal expression of different pathways of 1-arginine metabolism in healing wounds
    • Albina JE, Mills CD, Henry WL Jr, Caldwell MD. Temporal expression of different pathways of 1-arginine metabolism in healing wounds. J Immunol (1990) 144:3877-80.
    • (1990) J Immunol , vol.144 , pp. 3877-3880
    • Albina, J.E.1    Mills, C.D.2    Henry, W.L.3    Caldwell, M.D.4
  • 15
    • 0032533159 scopus 로고    scopus 로고
    • Arginine metabolism: nitric oxide and beyond
    • Wu G, Morris SM. Arginine metabolism: nitric oxide and beyond. Biochem J (1998) 336(Pt 1):1-17.
    • (1998) Biochem J , vol.336 , pp. 1-17
    • Wu, G.1    Morris, S.M.2
  • 16
  • 17
    • 0035727293 scopus 로고    scopus 로고
    • Macrophage arginine metabolism to ornithine/urea or nitric oxide/citrulline: a life or death issue
    • Mills CD. Macrophage arginine metabolism to ornithine/urea or nitric oxide/citrulline: a life or death issue. Crit Rev Immunol (2001) 21:399-425. doi:10.1615/CritRevImmunol.v21.i5.10
    • (2001) Crit Rev Immunol , vol.21 , pp. 399-425
    • Mills, C.D.1
  • 18
    • 0000642969 scopus 로고
    • The immunologic basis of acquired cellular resistance
    • Mackaness GB. The immunologic basis of acquired cellular resistance. J Exp Med (1964) 120:105-20. doi:10.1084/jem.120.1.105
    • (1964) J Exp Med , vol.120 , pp. 105-120
    • Mackaness, G.B.1
  • 19
    • 0026762988 scopus 로고
    • Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
    • Stein M, Keshav S, Harris N, Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med (1992) 176:287-92. doi:10.1084/jem.176.1.287
    • (1992) J Exp Med , vol.176 , pp. 287-292
    • Stein, M.1    Keshav, S.2    Harris, N.3    Gordon, S.4
  • 20
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: mechanism and functions
    • Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity (2010) 32:593-604. doi:10.1016/j.immuni.2010.05.007
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 21
    • 34848837386 scopus 로고    scopus 로고
    • Taking dendritic cells into medicine
    • Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature (2007) 449:419-26. doi:10.1038/nature06175
    • (2007) Nature , vol.449 , pp. 419-426
    • Steinman, R.M.1    Banchereau, J.2
  • 22
    • 58749083404 scopus 로고    scopus 로고
    • Macrophages as APC and the dendritic cell myth
    • Hume DA. Macrophages as APC and the dendritic cell myth. J Immunol (2008) 181:5829-35. doi:10.4049/jimmunol.181.9.5829
    • (2008) J Immunol , vol.181 , pp. 5829-5835
    • Hume, D.A.1
  • 24
    • 0001163252 scopus 로고
    • Uber den jetzigen Stand der Karzinomforschung
    • Himmelweit F, editor, London: Pergamon Press
    • Erhlich P. Uber den jetzigen Stand der Karzinomforschung. In: Himmelweit F, editor. The Collected Papers of Paul Erlich. (Vol. II), London: Pergamon Press (1957). p. 550-62.
    • (1957) The Collected Papers of Paul Erlich , vol.2 , pp. 550-562
    • Erhlich, P.1
  • 25
    • 0002314163 scopus 로고
    • Reactions to homologous tissue antigens in relation to hypersensitivity
    • Lawrence HS, editor. New York, NY: Hoeber-Harper
    • Thomas L. Reactions to homologous tissue antigens in relation to hypersensitivity. In: Lawrence HS, editor. Cellular and Humoral Aspects of the Hypersensitive States. New York, NY: Hoeber-Harper (1959). p. 529-32.
    • (1959) Cellular and Humoral Aspects of the Hypersensitive States , pp. 529-532
    • Thomas, L.1
  • 26
    • 0014887939 scopus 로고
    • The concept of immunological surveillance
    • Burnet FM. The concept of immunological surveillance. Prog Exp Tumor Res (1970) 13:1-27.
    • (1970) Prog Exp Tumor Res , vol.13 , pp. 1-27
    • Burnet, F.M.1
  • 27
    • 0016294747 scopus 로고
    • Type B virus and human breast cancer
    • Henderson BE. Type B virus and human breast cancer. Cancer (1974) 34(Suppl):1386-9. doi:10.1002/1097-0142(197410)34:8+<1386::AID-CNCR2820340808>3.0.CO;2-5
    • (1974) Cancer , vol.34 , pp. 1386-1389
    • Henderson, B.E.1
  • 28
    • 0016787526 scopus 로고
    • Evolution and modes of transmission of RNA tumor viruses
    • Todaro GJ. Evolution and modes of transmission of RNA tumor viruses. Am J Pathol (1975) 3:590-606.
    • (1975) Am J Pathol , vol.3 , pp. 590-606
    • Todaro, G.J.1
  • 29
    • 79958246224 scopus 로고
    • Evaluation of the evidence for immune surveillance
    • Landy M, editor. New York, NY: Academic Press
    • Good RA, Prehn RT, Lawrence HS. Evaluation of the evidence for immune surveillance. In: Landy M, editor. Immune Surveillance. New York, NY: Academic Press (1970). p. 437-518.
    • (1970) Immune Surveillance , pp. 437-518
    • Good, R.A.1    Prehn, R.T.2    Lawrence, H.S.3
  • 30
    • 0017597630 scopus 로고
    • Induction of cell-mediated immunity to chemically modified antigens in guinea pigs I. Characterization of the immune response to lipid-conjugated protein antigens
    • Dailey MO, Hunter RL. Induction of cell-mediated immunity to chemically modified antigens in guinea pigs. I. Characterization of the immune response to lipid-conjugated protein antigens. J Immunol (1977) 118:957-62.
    • (1977) J Immunol , vol.118 , pp. 957-962
    • Dailey, M.O.1    Hunter, R.L.2
  • 32
    • 0016345568 scopus 로고
    • Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system
    • Zinkernagel RM, Doherty PC. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature (1974) 248:701-2. doi:10.1038/248701a0
    • (1974) Nature , vol.248 , pp. 701-702
    • Zinkernagel, R.M.1    Doherty, P.C.2
  • 33
    • 0018418872 scopus 로고
    • T-cell lines which cooperate in generation of specific cytolytic activity
    • Glasebrook AL, Fitch FW. T-cell lines which cooperate in generation of specific cytolytic activity. Nature (1979) 278:171-3. doi:10.1038/278171a0
    • (1979) Nature , vol.278 , pp. 171-173
    • Glasebrook, A.L.1    Fitch, F.W.2
  • 34
    • 0019449750 scopus 로고
    • Mechanisms of anti-tumor action of Corynebacterium parvum II. Potentiated cytolytic T cell response and its tumor-induced suppression
    • Mills CD, North RJ, Dye ES. Mechanisms of anti-tumor action of Corynebacterium parvum. II. Potentiated cytolytic T cell response and its tumor-induced suppression. J Exp Med (1981) 154:621-30. doi:10.1084/jem.154.3.621
    • (1981) J Exp Med , vol.154 , pp. 621-630
    • Mills, C.D.1    North, R.J.2    Dye, E.S.3
  • 35
    • 0020532080 scopus 로고
    • Expression of passively transferred immunity against an established tumor depends on the generation of cytolytic T cells in the recipient. Inhibition by suppressor T cells
    • Mills CD, North RJ. Expression of passively transferred immunity against an established tumor depends on the generation of cytolytic T cells in the recipient. Inhibition by suppressor T cells. J Exp Med (1983) 157:1448-60. doi:10.1084/jem.157.5.1448
    • (1983) J Exp Med , vol.157 , pp. 1448-1460
    • Mills, C.D.1    North, R.J.2
  • 36
    • 0023876165 scopus 로고
    • The immunologic treatment of cancer
    • Lotze MT, Rosenberg SA. The immunologic treatment of cancer. CA Cancer J Clin (1988) 38:68-94. doi:10.3322/canjclin.38.2.68
    • (1988) CA Cancer J Clin , vol.38 , pp. 68-94
    • Lotze, M.T.1    Rosenberg, S.A.2
  • 37
    • 0015977440 scopus 로고
    • Tumor development after 3-methylcholanthrene in immunologically deficient athymic-nude mice
    • Stutman O. Tumor development after 3-methylcholanthrene in immunologically deficient athymic-nude mice. Science (1974) 183:534-6. doi:10.1126/science.183.4124.534
    • (1974) Science , vol.183 , pp. 534-536
    • Stutman, O.1
  • 38
    • 0015505604 scopus 로고
    • The immune reaction as a stimulator of tumor growth
    • Prehn RT. The immune reaction as a stimulator of tumor growth. Science (1972) 176:170-1. doi:10.1126/science.176.4031.170
    • (1972) Science , vol.176 , pp. 170-171
    • Prehn, R.T.1
  • 39
    • 0024460113 scopus 로고
    • Review of interleukin-2 alone and interleukin-2/LAK clinical trials in metastatic malignant melanoma
    • Sznol M, Dutcher JP, Atkins MB, Rayner RA, Margolin KA, Gaynor ER, et al. Review of interleukin-2 alone and interleukin-2/LAK clinical trials in metastatic malignant melanoma. Cancer Treat Rev (1989) 16:29-38. doi:10.1016/0305-7372(89)90020-0
    • (1989) Cancer Treat Rev , vol.16 , pp. 29-38
    • Sznol, M.1    Dutcher, J.P.2    Atkins, M.B.3    Rayner, R.A.4    Margolin, K.A.5    Gaynor, E.R.6
  • 40
    • 0016740002 scopus 로고
    • Another look at immune surveillance
    • Schwartz RS. Another look at immune surveillance. N Engl J Med (1975) 293:181-4. doi:10.1056/NEJM197507242930406
    • (1975) N Engl J Med , vol.293 , pp. 181-184
    • Schwartz, R.S.1
  • 41
    • 0347099755 scopus 로고
    • Electron microscopal observations on the peritoenal macrophages of normal mice and mice immunised with listereria monocytogenes II. Structure of macrophages from immune mice and the early cytoplasmic response to the presence of ingested bacteria
    • North RJ, Mackaness GB. Electron microscopal observations on the peritoenal macrophages of normal mice and mice immunised with listereria monocytogenes. II. Structure of macrophages from immune mice and the early cytoplasmic response to the presence of ingested bacteria. Br J Exp Pathol (1963) 44:608-11.
    • (1963) Br J Exp Pathol , vol.44 , pp. 608-611
    • North, R.J.1    Mackaness, G.B.2
  • 42
    • 0015815788 scopus 로고
    • Function of macrophages in antigen recognition by guinea pig T lymphocytes II. Role of the macrophage in the regulation of genetic control of the immune response
    • Shevach EM, Rosenthal AS. Function of macrophages in antigen recognition by guinea pig T lymphocytes. II. Role of the macrophage in the regulation of genetic control of the immune response. J Exp Med (1973) 138:1213-29. doi:10.1084/jem.138.5.1213
    • (1973) J Exp Med , vol.138 , pp. 1213-1229
    • Shevach, E.M.1    Rosenthal, A.S.2
  • 43
    • 0021550018 scopus 로고
    • Antigen-presenting function of the macrophage
    • Unanue ER. Antigen-presenting function of the macrophage. Annu Rev Immunol (1984) 2:395-428. doi:10.1146/annurev.iy.02.040184.002143
    • (1984) Annu Rev Immunol , vol.2 , pp. 395-428
    • Unanue, E.R.1
  • 44
    • 0024244657 scopus 로고
    • Nitric oxide: a cytotoxic activated macrophage effector molecule
    • Hibbs JB, Taintor RR, Vavrin Z, Rachlin EM. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun (1988) 157:87-94. doi:10.1016/S0006-291X(88)80015-9
    • (1988) Biochem Biophys Res Commun , vol.157 , pp. 87-94
    • Hibbs, J.B.1    Taintor, R.R.2    Vavrin, Z.3    Rachlin, E.M.4
  • 45
    • 0026722310 scopus 로고
    • Macrophage arginine metabolism and the inhibition or stimulation of cancer
    • Mills CD, Shearer J, Evans R, Caldwell MD. Macrophage arginine metabolism and the inhibition or stimulation of cancer. J Immunol (1992) 149:2709-14.
    • (1992) J Immunol , vol.149 , pp. 2709-2714
    • Mills, C.D.1    Shearer, J.2    Evans, R.3    Caldwell, M.D.4
  • 46
    • 0032934731 scopus 로고    scopus 로고
    • In vivo blockage of nitric oxide with aminoguanidine inhibits immunosuppression by an attenuated strain of Salmonella typhimurium, potentiates Salmonella infection, and inhibits macrophage and polymorphonuclear leukocyte influx into the spleen
    • MacFarlance AS, Schwacha MG, Eisenstein TK. In vivo blockage of nitric oxide with aminoguanidine inhibits immunosuppression by an attenuated strain of Salmonella typhimurium, potentiates Salmonella infection, and inhibits macrophage and polymorphonuclear leukocyte influx into the spleen. Infect Immun (1999) 67:891-8.
    • (1999) Infect Immun , vol.67 , pp. 891-898
    • MacFarlance, A.S.1    Schwacha, M.G.2    Eisenstein, T.K.3
  • 47
    • 0345593709 scopus 로고    scopus 로고
    • Improved clearance of Mycobacterium avium upon disruption of the inducible nitric oxide synthase gene
    • Gomes MS, Florido M, Pais TF, Appelberg R. Improved clearance of Mycobacterium avium upon disruption of the inducible nitric oxide synthase gene. J Immunol (1999) 162:6734-9.
    • (1999) J Immunol , vol.162 , pp. 6734-6739
    • Gomes, M.S.1    Florido, M.2    Pais, T.F.3    Appelberg, R.4
  • 48
    • 0025753367 scopus 로고
    • Molecular basis of "suppressor" macrophages
    • Mills CD. Molecular basis of "suppressor" macrophages. J Immunol (1991) 146:2719-23.
    • (1991) J Immunol , vol.146 , pp. 2719-2723
    • Mills, C.D.1
  • 50
    • 0033485941 scopus 로고    scopus 로고
    • Augementation of antitumor CTL response in vivo by inhibition of suppressor macrophage nitric oxide
    • Medot-Pirenne M, Heilman MJ, Saxena M, McDermott PE, Mills CD. Augementation of antitumor CTL response in vivo by inhibition of suppressor macrophage nitric oxide. J Immunol (1999) 163:5877-82.
    • (1999) J Immunol , vol.163 , pp. 5877-5882
    • Medot-Pirenne, M.1    Heilman, M.J.2    Saxena, M.3    McDermott, P.E.4    Mills, C.D.5
  • 51
    • 0029901890 scopus 로고    scopus 로고
    • Nitric oxide mediates early dysfunction of rat and mouse islets following transplantation
    • Stevens RB, Ansite JD, Mills CD, Lokeh A, Rossini TJ, Saxena M, et al. Nitric oxide mediates early dysfunction of rat and mouse islets following transplantation. Transplantation (1996) 61:1740-9. doi:10.1097/00007890-199606270-00014
    • (1996) Transplantation , vol.61 , pp. 1740-1749
    • Stevens, R.B.1    Ansite, J.D.2    Mills, C.D.3    Lokeh, A.4    Rossini, T.J.5    Saxena, M.6
  • 53
    • 9944233058 scopus 로고    scopus 로고
    • Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle
    • Kolios G, Valatas V, Ward SG. Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle. Immunology (2004) 113:427-37. doi:10.1111/j.1365-2567.2004.01984.x
    • (2004) Immunology , vol.113 , pp. 427-437
    • Kolios, G.1    Valatas, V.2    Ward, S.G.3
  • 54
    • 84902343228 scopus 로고    scopus 로고
    • Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases
    • Ryan BJ, Nissim A, Winyard PG. Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases. Redox Biol (2014) 2:715-24. doi:10.1016/j.redox.2014.05.004
    • (2014) Redox Biol , vol.2 , pp. 715-724
    • Ryan, B.J.1    Nissim, A.2    Winyard, P.G.3
  • 55
    • 84918801828 scopus 로고    scopus 로고
    • Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity
    • Eshleman EM, Lenz LL. Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity. Front Immunol (2014) 5:431. doi:10.3389/fimmu.2014.00431
    • (2014) Front Immunol , vol.5 , pp. 431
    • Eshleman, E.M.1    Lenz, L.L.2
  • 56
    • 84938292218 scopus 로고    scopus 로고
    • M1 and M2 immune activation in Parkinson's disease: foe and ally?
    • Moehle MS, West AB. M1 and M2 immune activation in Parkinson's disease: foe and ally? Neuroscience (2014). doi:10.1016/j.neuroscience.2014.11.018
    • (2014) Neuroscience
    • Moehle, M.S.1    West, A.B.2
  • 57
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol (2011) 11:723-37. doi:10.1038/nri3073
    • (2011) Nat Rev Immunol , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 58
    • 33845970192 scopus 로고    scopus 로고
    • Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
    • Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, et al. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest (2007) 117:195-205. doi:10.1172/JCI29950
    • (2007) J Clin Invest , vol.117 , pp. 195-205
    • Swirski, F.K.1    Libby, P.2    Aikawa, E.3    Alcaide, P.4    Luscinskas, F.W.5    Weissleder, R.6
  • 59
    • 84907766487 scopus 로고    scopus 로고
    • Vascular oxidative stress, nitric oxide and atherosclerosis
    • Li H, Horke S, Förstermann U. Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis (2014) 237:208-19. doi:10.1016/j.atherosclerosis.2014.09.001
    • (2014) Atherosclerosis , vol.237 , pp. 208-219
    • Li, H.1    Horke, S.2    Förstermann, U.3
  • 60
    • 84883809756 scopus 로고    scopus 로고
    • Myeloid cells in atherosclerosis: a delicate balance of anti-inflammatory and proinflammatory mechanisms
    • Koltsova EK, Hedrick CC, Ley K. Myeloid cells in atherosclerosis: a delicate balance of anti-inflammatory and proinflammatory mechanisms. Curr Opin Lipidol (2013) 5:371-80. doi:10.1097/MOL.0b013e328363d298
    • (2013) Curr Opin Lipidol , vol.5 , pp. 371-380
    • Koltsova, E.K.1    Hedrick, C.C.2    Ley, K.3
  • 61
    • 0024540908 scopus 로고
    • Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expression of distinct helper subsets
    • Heinzel FG, Sadick MD, Holaday BJ, Coffman RL, Locksley RM. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expression of distinct helper subsets. J Exp Med (1989) 169:59-72. doi:10.1084/jem.169.1.59
    • (1989) J Exp Med , vol.169 , pp. 59-72
    • Heinzel, F.G.1    Sadick, M.D.2    Holaday, B.J.3    Coffman, R.L.4    Locksley, R.M.5
  • 62
    • 0026034432 scopus 로고
    • Role of nitric oxide synthesis in macrophage antimicrobial activity
    • Nathan CF, Hibbs JB. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol (1991) 1:65-70. doi:10.1016/0952-7915(91)90079-G
    • (1991) Curr Opin Immunol , vol.1 , pp. 65-70
    • Nathan, C.F.1    Hibbs, J.B.2
  • 63
    • 0023706894 scopus 로고
    • Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production
    • Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J Immunol (1988) 141:2407-12.
    • (1988) J Immunol , vol.141 , pp. 2407-2412
    • Ding, A.H.1    Nathan, C.F.2    Stuehr, D.J.3
  • 65
    • 84904338340 scopus 로고    scopus 로고
    • Tumour-induced immune suppression: role of inflammatory mediators released by myelomonocytic cells
    • Mao Y, Poschke I, Kiessling R. Tumour-induced immune suppression: role of inflammatory mediators released by myelomonocytic cells. J Intern Med (2014) 276:154-70. doi:10.1111/joim.12229
    • (2014) J Intern Med , vol.276 , pp. 154-170
    • Mao, Y.1    Poschke, I.2    Kiessling, R.3
  • 66
    • 84919427210 scopus 로고    scopus 로고
    • Evolutionary roots of arginase expression and regulation
    • Dzik JM. Evolutionary roots of arginase expression and regulation. Front Immunol (2014) 5:544. doi:10.3389/fimmu.2014.00544
    • (2014) Front Immunol , vol.5 , pp. 544
    • Dzik, J.M.1
  • 67
    • 33750813483 scopus 로고    scopus 로고
    • Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression
    • Martinez FO, Gordon S, Locati M, Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol (2006) 177:7303-11. doi:10.4049/jimmunol.177.10.7303
    • (2006) J Immunol , vol.177 , pp. 7303-7311
    • Martinez, F.O.1    Gordon, S.2    Locati, M.3    Mantovani, A.4
  • 68
    • 84904993091 scopus 로고    scopus 로고
    • Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators
    • Raza S, Barnett MW, Barnett-Itzhaki Z, Amit I, Hume DA, Freeman TC. Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators. J Leukoc Biol (2014) 96:167-83. doi:10.1189/jlb.6HI0313-169R
    • (2014) J Leukoc Biol , vol.96 , pp. 167-183
    • Raza, S.1    Barnett, M.W.2    Barnett-Itzhaki, Z.3    Amit, I.4    Hume, D.A.5    Freeman, T.C.6
  • 69
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol (2004) 25:677-86. doi:10.1016/j.it.2004.09.015
    • (2004) Trends Immunol , vol.25 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 70
    • 33845398215 scopus 로고    scopus 로고
    • Biochemical and functional characterization of three activated macrophage populations
    • Edwards JP, Zhang X, Frauwirth KA, Mosser DM. Biochemical and functional characterization of three activated macrophage populations. J Leukoc Biol (2006) 6:1298-307. doi:10.1189/jlb.0406249
    • (2006) J Leukoc Biol , vol.6 , pp. 1298-1307
    • Edwards, J.P.1    Zhang, X.2    Frauwirth, K.A.3    Mosser, D.M.4
  • 71
    • 80052180187 scopus 로고    scopus 로고
    • Regulatory macrophages: setting the threshold for therapy
    • Fleming BD, Mosser DM. Regulatory macrophages: setting the threshold for therapy. Eur J Immunol (2011) 41:2498-502. doi:10.1002/eji.201141717
    • (2011) Eur J Immunol , vol.41 , pp. 2498-2502
    • Fleming, B.D.1    Mosser, D.M.2
  • 72
    • 84904394690 scopus 로고    scopus 로고
    • Macrophage activation and polarization: nomenclature and experimental guidelines
    • Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity (2014) 41:14-20. doi:10.1016/j.immuni.2014.06.008
    • (2014) Immunity , vol.41 , pp. 14-20
    • Murray, P.J.1    Allen, J.E.2    Biswas, S.K.3    Fisher, E.A.4    Gilroy, D.W.5    Goerdt, S.6
  • 73
    • 4344706372 scopus 로고    scopus 로고
    • Functional plasticity of macrophages: reversible adaptation to changing microenvironments
    • Stout RD, Suttles J. Functional plasticity of macrophages: reversible adaptation to changing microenvironments. J Leukoc Biol (2004) 76:509-13. doi:10.1189/jlb.0504272
    • (2004) J Leukoc Biol , vol.76 , pp. 509-513
    • Stout, R.D.1    Suttles, J.2
  • 74
    • 0037310024 scopus 로고    scopus 로고
    • The many faces of macrophage activation
    • Mosser DM. The many faces of macrophage activation. J Leukoc Biol (2003) 73:209-21. doi:10.1189/jlb.0602325
    • (2003) J Leukoc Biol , vol.73 , pp. 209-221
    • Mosser, D.M.1
  • 75
    • 84892865013 scopus 로고    scopus 로고
    • Clinical significance of macrophage heterogeneity in human malignant tumors
    • Komohara Y, Jinushi M, Takeya M. Clinical significance of macrophage heterogeneity in human malignant tumors. Cancer Sci (2014) 105:1-8. doi:10.1111/cas.12314
    • (2014) Cancer Sci , vol.105 , pp. 1-8
    • Komohara, Y.1    Jinushi, M.2    Takeya, M.3
  • 76
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: from mechanisms to therapy
    • Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity (2014) 41:49-61. doi:10.1016/j.immuni.2014.06.010
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 77
    • 84872529636 scopus 로고    scopus 로고
    • Anti-tumor strategies to target tumor-associated macrophages
    • Tang X, Mo C, Wang Y, Wei D, Xiao H. Anti-tumor strategies to target tumor-associated macrophages. Immunology (2012) 138:92-104. doi:10.1111/imm.12023
    • (2012) Immunology , vol.138 , pp. 92-104
    • Tang, X.1    Mo, C.2    Wang, Y.3    Wei, D.4    Xiao, H.5
  • 78
    • 47049089532 scopus 로고    scopus 로고
    • Nitric oxide, apoptosis and macrophage polarization during tumor progression
    • Weigert A, Brune B. Nitric oxide, apoptosis and macrophage polarization during tumor progression. Nitric Oxide (2008) 2:95-102. doi:10.1016/j.niox.2008.04.021
    • (2008) Nitric Oxide , vol.2 , pp. 95-102
    • Weigert, A.1    Brune, B.2
  • 79
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    • Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 282:2085-8. doi:10.1126/science.282.5396.2085
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3    Liu, M.Y.4    Van Huffel, C.5    Du, X.6
  • 80
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila toll protein signals activation of adaptive immunity
    • Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila toll protein signals activation of adaptive immunity. Nature (1997) 388:394-7. doi:10.1038/41131
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway, C.A.3
  • 81
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 1:443-51. doi:10.1016/S1074-7613(00)80119-3
    • (1999) Immunity , vol.1 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6
  • 82
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol (2002) 23:549-55. doi:10.1016/S1471-4906(02)02302-5
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 83
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    • Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 11:889-96. doi:10.1038/ni.1937
    • (2010) Nat Immunol , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 84
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun W, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science (2011) 331:1612-6. doi:10.1126/science.1198443
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3    Saboury, B.4    Teitelbaum, U.R.5    Sun, W.6


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