Pro-apoptotic effect of new quinolone 7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate on cervical cancer cell line HeLa alone/with UVA irradiation

Toxicology in Vitro

Volumn 33, Issue , 2016, Pages 35-44

  Jantová, Soňa ^a   Mrvová, Nataša ^a,b   Hudec, Roman ^a   Sedlák, Ján ^c   Pánik, Miroslav ^a   Milata, Viktor ^a  

^a SLOVAK UNIVERSITY OF TECHNOLOGY   (Slovakia)

^b INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^c CANCER RESEARCH INSTITUTE   (Slovakia)

Author keywords

Apoptosis; Cell cycle arrest; HeLa cells; Quinolone derivative; UVA irradiation

Indexed keywords

7 ETHYL 9 ETHYL 6 OXO 6,9 DIHYDRO[1,2,5]SELENADIAZOLO[3,4 H]QUINOLINE 7 CARBOXYLATE; CASPASE 3; QUINOLONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 7-ETHYL 9-ETHYL-6-OXO-6,9-DIHYDRO(1,2,5)SELENADIAZOLO(3,4-H)QUINOLINE-7-CARBOXYLATE; ANTINEOPLASTIC AGENT; ORGANOSELENIUM DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER MORPHOLOGY; CHEMORADIOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; ENZYME ACTIVATION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL LINE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; ULTRAVIOLET RADIATION; UPREGULATION; UTERINE CERVIX CANCER; CELL SURVIVAL; DRUG EFFECTS; FEMALE; METABOLISM; RADIATION RESPONSE; UTERINE CERVIX TUMOR;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL SURVIVAL; FEMALE; HELA CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; ORGANOSELENIUM COMPOUNDS; QUINOLONES; REACTIVE OXYGEN SPECIES; ULTRAVIOLET RAYS; UTERINE CERVICAL NEOPLASMS;

EID: 84959500097     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2016.02.012     Document Type: Article

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