Synthesis, antiviral activity and molecular modeling of oxoquinoline derivatives

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 15, 2009, Pages 5476-5481

  Santos, Fernanda da C ^a   Abreu, Paula ^a   Castro, Helena C ^a   Paixão, Izabel C P P ^a   Cirne Santos, Claudio C ^c   Giongo, Viveca ^a   Barbosa, Juliana E ^a   Simonetti, Bruno R ^a   Garrido, Valéria ^a   Bou Habib, Dumith Chequer ^c   Silva, David de O ^a   Batalha, Pedro N ^a   Temerozo, Jairo R ^c   Souza, Thiago M ^a   Nogueira, Christiane M ^a   Cunha, Anna C ^a   Rodrigues, Carlos R ^b   Ferreira, Vitor F ^a   de Souza, Maria C B V ^a  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Antiviral; HIV 1; Oxoquinoline; Structure activity relationship (SAR)

Indexed keywords

6 CHLORO 1 [(2' HYDROXYETHOXY)METHYL] N [(PHENYL)METHYL] 1,4 DIHYDRO 4 OXOQUINOLINE 3 CARBOXAMIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIRETROVIRUS AGENT; CHLOROXOQUINOLINIC RIBONUCLEOSIDE 6 CHLORO 1,4 DIHYDRO 4 OXO 1 (DEXTRO RIBOFURANOSYL)QUINOLINE 3 CARBOXYLIC ACID; EFAVIRENZ; NEVIRAPINE; OXOQUINOLINE DERIVATIVE; QUINOLINE DERIVATIVE; RECOMBINANT INTERLEUKIN 2; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; MOLECULAR MODEL; MUTAGEN TESTING; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; VERO CELL;

ANIMALS; ANTI-HIV AGENTS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 67749119956     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.037     Document Type: Article

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