Design, synthesis, biological evaluation, and molecular docking studies of quinolone derivatives as potential antitumor topoisomerase I inhibitors

Chemical and Pharmaceutical Bulletin

Volumn 61, Issue 6, 2013, Pages 631-636

  Shou, Kai Jun ^a   Li, Jie ^b   Jin, Yi ^b   Lv, Yan Wen ^b,c  

^a ZHUJI PEOPLE S HOSPITAL OF ZHEJIANG PROVINCE   (China)

^b QUZHOU UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Antitumor; Molecular docking; Quinolone derivative; Topoisomerase I

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 4 OXO 7 [4 (N TOSYLCARBAMIMIDOYL)PIPERAZIN 1 YL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 4 OXO 7 [4 [N (PHENYLSULFONYL)CARBAMIMIDOYL]PIPERAZIN 1 YL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 4 OXO 7 [4 [N [2 (TRIFLUOROMETHYL)PHENYLSULFONYL]CARBAMIMIDOYL]PIPERAZIN 1 YL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 4 OXO 7 [4 [N [4 (TRIFLUOROMETHYL)PHENYLSULFONYL]CARBAMIMIDOYL]PIPERAZIN 1 YL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 4 OXO 7 [4 (N TOSYLCARBAMIMIDOYL)PIPERAZIN 1 YL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 4 OXO 7 [4 [N (PHENYLSULFONYL)CARBAMIMIDOYL]PIPERAZIN 1 YL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 4 OXO 7 [4 [N [2 (TRIFLUOROMETHYL)PHENYLSULFONYL]CARBAMIMIDOYL]PIPERAZIN 1 YL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 ETHYL 6 FLUORO 4 OXO 7 [4 [N [4 (TRIFLUOROMETHYL)PHENYLSULFONYL]CARBAMIMIDOYL]PIPERAZIN 1 YL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [N (2 CHLOROPHENYLSULFONYL)CARBAMIMIDOYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4-OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [N (2 CHLOROPHENYLSULFONYL)CARBAMIMIDOYL]PIPERAZIN 1 YL] 1 ETHYL 6 FLUORO 4-OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [N (3 CHLOROPHENYLSULFONYL)CARBAMIMIDOYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [N (3 CHLOROPHENYLSULFONYL)CARBAMIMIDOYL]PIPERAZIN 1 YL] 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [N (4 CHLOROPHENYLSULFONYL)CARBAMIMIDOYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 [4 [N (4 CHLOROPHENYLSULFONYL)CARBAMIMIDOYL]PIPERAZIN 1 YL] 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; DNA TOPOISOMERASE INHIBITOR; IRINOTECAN; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; MULTIPLE CANCER; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE I; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; HYDROGEN BONDING; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, TERTIARY; QUINOLONES; TOPOISOMERASE I INHIBITORS;

EID: 84878802813     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c13-00040     Document Type: Article

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