Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification

Journal of Medicinal Chemistry

Volumn 52, Issue 18, 2009, Pages 5649-5661

  You, Qi Dong ^a   Li, Zhi Yu ^a   Huang, Chiung Hua ^c   Yang, Qian ^a   Wang, Xiao Jian ^a   Guo, Qing Long ^a   Chen, Xiao Guang ^b   He, Xun Gui ^a   Li, Tsai Kun ^d   Chern, Ji Wang ^c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHYL 3 (6 NITROBENZOXAZOL 2 YL) 6,8 DIFLUORO 7 (3 METHYLPIPERAZIN 1 YL) 4(1H) QUINOLONE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA; DNA TOPOISOMERASE INHIBITOR; NAPHTHYRIDINE DERIVATIVE; QUINOLONE DERIVATIVE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL STRAIN HT29; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DNA CONTENT; DNA STRAND BREAKAGE; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; NUDE MOUSE; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DRUG DISCOVERY; ENZYME INHIBITORS; FEMALE; HUMANS; MICE; MICE, NUDE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NAPHTHYRIDINES; NEOPLASMS; QUINOLONES; TOPOISOMERASE I INHIBITORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 70349410539     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900469e     Document Type: Article

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