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Volumn 30, Issue 5, 2016, Pages 489-501

Mechanisms of metabolic dysfunction in cancer-associated cachexia

Author keywords

Cancer associated cachexia (CAC); Metabolic failure; Skeletal muscle atrophy; White adipose tissue (WAT) browning

Indexed keywords

LIPID;

EID: 84959459753     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.276733.115     Document Type: Review
Times cited : (240)

References (149)
  • 2
    • 79959247514 scopus 로고    scopus 로고
    • Mechanismsfor skeletal muscle insulin resistance in patients withpancreatic ductal adenocarcinoma
    • Agustsson T, D'Souza MA, Nowak G, Isaksson B. 2011. Mechanismsfor skeletal muscle insulin resistance in patients withpancreatic ductal adenocarcinoma. Nutrition 27: 796-801.
    • (2011) Nutrition , vol.27 , pp. 796-801
    • Agustsson, T.1    D'Souza, M.A.2    Nowak, G.3    Isaksson, B.4
  • 3
    • 0033035459 scopus 로고    scopus 로고
    • Cardiac cachexia: A syndrome with impairedsurvival and immune and neuroendocrine activation
    • Anker SD, Coats AJ. 1999. Cardiac cachexia: a syndrome with impairedsurvival and immune and neuroendocrine activation.Chest 115: 836-847.
    • (1999) Chest , vol.115 , pp. 836-847
    • Anker, S.D.1    Coats, A.J.2
  • 4
    • 17444443934 scopus 로고    scopus 로고
    • The role of cytokines in cancercachexia
    • Argiles JM, Lopez-Soriano FJ. 1999. The role of cytokines in cancercachexia. Med Res Rev 19: 223-248.
    • (1999) Med Res Rev , vol.19 , pp. 223-248
    • Argiles, J.M.1    Lopez-Soriano, F.J.2
  • 7
    • 0020678196 scopus 로고
    • Stimulation of muscle protein degradation and prostaglandinE2 release by leukocytic pyrogen (interleukin-1). A mechanismfor the increased degradation of muscle proteins duringfever
    • Baracos V, Rodemann HP, Dinarello CA, Goldberg AL. 1983.Stimulation of muscle protein degradation and prostaglandinE2 release by leukocytic pyrogen (interleukin-1). A mechanismfor the increased degradation of muscle proteins duringfever. N Engl J Med 308: 553-558.
    • (1983) N Engl J Med , vol.308 , pp. 553-558
    • Baracos, V.1    Rodemann, H.P.2    Dinarello, C.A.3    Goldberg, A.L.4
  • 8
    • 0029040739 scopus 로고
    • Activationof the ATP-ubiquitin-proteasome pathway in skeletal muscleof cachectic rats bearing a hepatoma
    • Baracos VE, DeVivo C, Hoyle DH, Goldberg AL. 1995. Activationof the ATP-ubiquitin-proteasome pathway in skeletal muscleof cachectic rats bearing a hepatoma. Am J Physiol 268:E996-E1006.
    • (1995) Am J Physiol , vol.268 , pp. E996-E1006
    • Baracos, V.E.1    DeVivo, C.2    Hoyle, D.H.3    Goldberg, A.L.4
  • 11
    • 76549236253 scopus 로고
    • Systemic effects of tumors inforce-fed rats
    • Begg RW, Dickinson TE. 1951. Systemic effects of tumors inforce-fed rats. Cancer Res 11: 409-412.
    • (1951) Cancer Res , vol.11 , pp. 409-412
    • Begg, R.W.1    Dickinson, T.E.2
  • 14
    • 0022485610 scopus 로고
    • Cachectin and tumour necrosis factoras two sides of the same biological coin
    • Beutler B, Cerami A. 1986. Cachectin and tumour necrosis factoras two sides of the same biological coin. Nature 320: 584-588.
    • (1986) Nature , vol.320 , pp. 584-588
    • Beutler, B.1    Cerami, A.2
  • 15
    • 0021836738 scopus 로고
    • Purificationof cachectin, a lipoprotein lipase-suppressing hormonesecreted by endotoxin-induced RAW 264.7 cells
    • Beutler B, Mahoney J, Le Trang N, Pekala P, Cerami A. 1985. Purificationof cachectin, a lipoprotein lipase-suppressing hormonesecreted by endotoxin-induced RAW 264.7 cells. J ExpMed 161: 984-995.
    • (1985) J ExpMed , vol.161 , pp. 984-995
    • Beutler, B.1    Mahoney, J.2    Le Trang, N.3    Pekala, P.4    Cerami, A.5
  • 16
    • 84883630019 scopus 로고
    • Studies on carbohydrate metabolismin patients with neoplastic disease. II. Response to insulin administration
    • Bishop JS, Marks PA. 1959. Studies on carbohydrate metabolismin patients with neoplastic disease. II. Response to insulin administration.J Clin Invest 38: 668-672.
    • (1959) J Clin Invest , vol.38 , pp. 668-672
    • Bishop, J.S.1    Marks, P.A.2
  • 20
    • 0036214982 scopus 로고    scopus 로고
    • Palliative care models: Internationalperspective
    • Bruera E, Sweeney C. 2002. Palliative care models: internationalperspective. J Palliat Med 5: 319-327.
    • (2002) J Palliat Med , vol.5 , pp. 319-327
    • Bruera, E.1    Sweeney, C.2
  • 21
    • 0034307162 scopus 로고    scopus 로고
    • Experimental cancer cachexia: The role of host-derivedcytokines interleukin (IL)-6, IL-12, interferon-γ, and tumornecrosis factor α evaluated in gene knockout, tumorbearingmice on C57 Bl background and eicosanoid-dependentcachexia
    • Cahlin C, Korner A, Axelsson H,WangW, Lundholm K, Svanberg E. 2000. Experimental cancer cachexia: the role of host-derivedcytokines interleukin (IL)-6, IL-12, interferon-γ, and tumornecrosis factor α evaluated in gene knockout, tumorbearingmice on C57 Bl background and eicosanoid-dependentcachexia. Cancer Res 60: 5488-5493.
    • (2000) Cancer Res , vol.60 , pp. 5488-5493
    • Cahlin, C.1    Korner, A.2    Axelsson, H.3    Wang, W.4    Lundholm, K.5    Svanberg, E.6
  • 24
    • 0022370580 scopus 로고
    • Weightloss associated with an endotoxin-induced mediator fromperitoneal macrophages: The role of cachectin (tumor necrosisfactor)
    • Cerami A, Ikeda Y, Le Trang N, Hotez PJ, Beutler B. 1985.Weightloss associated with an endotoxin-induced mediator fromperitoneal macrophages: the role of cachectin (tumor necrosisfactor). Immunol Lett 11: 173-177.
    • (1985) Immunol Lett , vol.11 , pp. 173-177
    • Cerami, A.1    Ikeda, Y.2    Le Trang, N.3    Hotez, P.J.4    Beutler, B.5
  • 27
    • 84925286847 scopus 로고    scopus 로고
    • Muscle wasting in disease:Molecular mechanisms and promising therapies
    • Cohen S, Nathan JA, Goldberg AL. 2015. Muscle wasting in disease:molecular mechanisms and promising therapies. NatRev Drug Discov 14: 58-74.
    • (2015) NatRev Drug Discov , vol.14 , pp. 58-74
    • Cohen, S.1    Nathan, J.A.2    Goldberg, A.L.3
  • 28
    • 33847797255 scopus 로고    scopus 로고
    • Skeletal musclelipid deposition and insulin resistance: Effect of dietary fattyacids and exercise
    • Corcoran MP, Lamon-Fava S, Fielding RA. 2007. Skeletal musclelipid deposition and insulin resistance: effect of dietary fattyacids and exercise. Am J Clin Nutr 85: 662-677.
    • (2007) Am J Clin Nutr , vol.85 , pp. 662-677
    • Corcoran, M.P.1    Lamon-Fava, S.2    Fielding, R.A.3
  • 29
    • 0000144989 scopus 로고
    • The carbohydrate metabolism of tumors:II. Changes in the sugar, lactic acid, and CO2-combining powerof blood passing through a tumor
    • Cori CF, Cori GT. 1925. The carbohydrate metabolism of tumors:II. Changes in the sugar, lactic acid, and CO2-combining powerof blood passing through a tumor. J Biol Chem 65: 397-405.
    • (1925) J Biol Chem , vol.65 , pp. 397-405
    • Cori, C.F.1    Cori, G.T.2
  • 30
    • 0017760424 scopus 로고
    • Cachexia, the metabolic component of neoplasticdiseases
    • Costa G. 1977. Cachexia, the metabolic component of neoplasticdiseases. Cancer Res 37: 2327-2335.
    • (1977) Cancer Res , vol.37 , pp. 2327-2335
    • Costa, G.1
  • 31
    • 0001354386 scopus 로고
    • Effects of Krebs-2 carcinoma on thelipide metabolism of male Swiss mice
    • Costa G, Holland JF. 1962. Effects of Krebs-2 carcinoma on thelipide metabolism of male Swiss mice. Cancer Res 22:1081-1083.
    • (1962) Cancer Res , vol.22 , pp. 1081-1083
    • Costa, G.1    Holland, J.F.2
  • 33
    • 0027051199 scopus 로고
    • Occurrence of brown adipocytes in ratwhite adipose tissue: Molecular and morphological characterization
    • Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, Penicaud L, Casteilla L. 1992. Occurrence of brown adipocytes in ratwhite adipose tissue: molecular and morphological characterization.J Cell Sci 103: 931-942.
    • (1992) J Cell Sci , vol.103 , pp. 931-942
    • Cousin, B.1    Cinti, S.2    Morroni, M.3    Raimbault, S.4    Ricquier, D.5    Penicaud, L.6    Casteilla, L.7
  • 40
    • 84875804562 scopus 로고    scopus 로고
    • Effects of enobosarm onmusclewasting and physical function in patients with cancer:A double-blind, randomised controlled phase 2 trial
    • Dobs AS, Boccia RV, Croot CC, Gabrail NY, Dalton JT, Hancock ML, Johnston MA, Steiner MS. 2013. Effects of enobosarm onmusclewasting and physical function in patients with cancer:a double-blind, randomised controlled phase 2 trial. LancetOncol 14: 335-345.
    • (2013) LancetOncol , vol.14 , pp. 335-345
    • Dobs, A.S.1    Boccia, R.V.2    Croot, C.C.3    Gabrail, N.Y.4    Dalton, J.T.5    Hancock, M.L.6    Johnston, M.A.7    Steiner, M.S.8
  • 41
    • 73449098791 scopus 로고
    • Malignant cachexia
    • Donovan H. 1954. Malignant cachexia. ProcR Soc Med 47: 27-31.
    • (1954) ProcR Soc Med , vol.47 , pp. 27-31
    • Donovan, H.1
  • 43
    • 84896397419 scopus 로고    scopus 로고
    • Highlights from the 7th cachexia conference: Musclewasting pathophysiological detection and novel treatmentstrategies
    • Ebner N, Steinbeck L, Doehner W, Anker SD, von Haehling S.2014. Highlights from the 7th cachexia conference: musclewasting pathophysiological detection and novel treatmentstrategies. J Cachexia Sarcopenia Muscle 5: 27-34.
    • (2014) J Cachexia Sarcopenia Muscle , vol.5 , pp. 27-34
    • Ebner, N.1    Steinbeck, L.2    Doehner, W.3    Anker, S.D.4    von Haehling, S.5
  • 44
    • 84959451956 scopus 로고
    • Cachexia in cancer
    • Editors
    • Editors. 1929. Cachexia in cancer. N Engl J Med 201: 956-957.
    • (1929) N Engl J Med , vol.201 , pp. 956-957
  • 45
    • 84977921008 scopus 로고
    • The natural history of cancer, with special referenceto its causation and prevention lectures on the pathology ofcancer
    • E.F.B. 1909. The natural history of cancer, with special referenceto its causation and prevention lectures on the pathology ofcancer. Nature 79: 391-392.
    • (1909) Nature , vol.79 , pp. 391-392
  • 46
    • 84893142272 scopus 로고    scopus 로고
    • Signaling pathways controllingskeletal muscle mass
    • Egerman MA, Glass DJ. 2014. Signaling pathways controllingskeletal muscle mass. Crit Rev Biochem Mol Biol 49: 59-68.
    • (2014) Crit Rev Biochem Mol Biol , vol.49 , pp. 59-68
    • Egerman, M.A.1    Glass, D.J.2
  • 48
    • 0030614331 scopus 로고    scopus 로고
    • Roleof melanocortinergic neurons in feeding and the agouti obesitysyndrome
    • FanW, Boston BA, Kesterson RA, Hruby VJ, Cone RD. 1997. Roleof melanocortinergic neurons in feeding and the agouti obesitysyndrome. Nature 385: 165-168.
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 50
    • 84864646651 scopus 로고    scopus 로고
    • Cancer cachexia: Mediators,signaling, and metabolic pathways
    • Fearon KC, Glass DJ, Guttridge DC. 2012. Cancer cachexia: mediators,signaling, and metabolic pathways. Cell Metab 16:153-166.
    • (2012) Cell Metab , vol.16 , pp. 153-166
    • Fearon, K.C.1    Glass, D.J.2    Guttridge, D.C.3
  • 51
    • 84873406669 scopus 로고    scopus 로고
    • Understanding the mechanismsand treatment options in cancer cachexia
    • Fearon K, Arends J, Baracos V. 2013. Understanding the mechanismsand treatment options in cancer cachexia. Nat RevClin Oncol 10: 90-99.
    • (2013) Nat RevClin Oncol , vol.10 , pp. 90-99
    • Fearon, K.1    Arends, J.2    Baracos, V.3
  • 52
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-inducedthermogenesis in mice exempt from thermal stress by livingat thermoneutrality
    • Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. 2009.UCP1 ablation induces obesity and abolishes diet-inducedthermogenesis in mice exempt from thermal stress by livingat thermoneutrality. Cell Metab 9: 203-209.
    • (2009) Cell Metab , vol.9 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 53
    • 84926320632 scopus 로고    scopus 로고
    • Malignant Drosophila tumorsinterrupt insulin signaling to induce cachexia-like wasting
    • Figueroa-Clarevega A, Bilder D. 2015. Malignant Drosophila tumorsinterrupt insulin signaling to induce cachexia-like wasting.Dev Cell 33: 47-55.
    • (2015) Dev Cell , vol.33 , pp. 47-55
    • Figueroa-Clarevega, A.1    Bilder, D.2
  • 55
    • 0022432237 scopus 로고
    • Molecular cloning of mouse tumour necrosisfactor cDNA and its eukaryotic expression
    • Fransen L, Muller R, Marmenout A, Tavernier J, Van der HeydenJ, Kawashima E, Chollet A, Tizard R, Van Heuverswyn H, Van Vliet A, et al. 1985. Molecular cloning of mouse tumour necrosisfactor cDNA and its eukaryotic expression. Nucleic AcidsRes 13: 4417-4429.
    • (1985) Nucleic AcidsRes , vol.13 , pp. 4417-4429
    • Vliet, A.1
  • 57
    • 84926127858 scopus 로고    scopus 로고
    • Anamorelin for patients with cancer cachexia:An integrated analysis of two phase 2, randomised, placebocontrolled,double-blind trials
    • Garcia JM, Boccia RV, Graham CD, Yan Y, Duus EM, Allen S, Friend J. 2015. Anamorelin for patients with cancer cachexia:an integrated analysis of two phase 2, randomised, placebocontrolled,double-blind trials. Lancet Oncol 16: 108-116.
    • (2015) Lancet Oncol , vol.16 , pp. 108-116
    • Garcia, J.M.1    Boccia, R.V.2    Graham, C.D.3    Yan, Y.4    Duus, E.M.5    Allen, S.6    Friend, J.7
  • 58
    • 0014471858 scopus 로고
    • Relationship between cortisoneand muscle work in determining muscle size
    • Goldberg AL, Goodman HM. 1969. Relationship between cortisoneand muscle work in determining muscle size. J Physiol200: 667-675.
    • (1969) J Physiol , vol.200 , pp. 667-675
    • Goldberg, A.L.1    Goodman, H.M.2
  • 59
    • 0004290450 scopus 로고
    • Academic Press,Inc., New York
    • Greenstein JP. 1947. Biochemistry of Cancer. Academic Press,Inc., New York.Grossberg AJ, Scarlett JM, Zhu X, Bowe DD, Batra AK, Braun TP
    • (1947) Biochemistry of Cancer
    • Greenstein, J.P.1
  • 60
    • 74949107835 scopus 로고    scopus 로고
    • Arcuate nucleus proopiomelanocortin neuronsmediate the acute anorectic actions of leukemia inhibitoryfactor via gp130
    • Grossberg AJ, Scarlett JM, Zhu X, Bowe DD, Batra AK, Braun TP, Marks DL. 2009. Arcuate nucleus proopiomelanocortin neuronsmediate the acute anorectic actions of leukemia inhibitoryfactor via gp130. Endocrinology 151: 606-616.
    • (2009) Endocrinology , vol.151 , pp. 606-616
    • Grossberg, A.J.1    Scarlett, J.M.2    Zhu, X.3    Bowe, D.D.4    Batra, A.K.5    Braun, T.P.6    Marks, D.L.7
  • 61
    • 0034730251 scopus 로고    scopus 로고
    • NF-κB-induced loss of MyoD messenger RNA: Possiblerole in muscle decay and cachexia
    • Guttridge DC, Mayo MW, Madrid LV, Wang CY, Baldwin AS Jr.2000. NF-κB-induced loss of MyoD messenger RNA: possiblerole in muscle decay and cachexia. Science 289: 2363-2366.
    • (2000) Science , vol.289 , pp. 2363-2366
    • Guttridge, D.C.1    Mayo, M.W.2    Madrid, L.V.3    Wang, C.Y.4    Baldwin, A.S.5
  • 62
    • 84885174406 scopus 로고    scopus 로고
    • Myostatin/activinpathway antagonism: Molecular basis and therapeutic potential
    • Han HQ, Zhou X, Mitch WE, Goldberg AL. 2013. Myostatin/activinpathway antagonism: molecular basis and therapeutic potential.Int J Biochem Cell Biol 45: 2333-2347.
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 2333-2347
    • Han, H.Q.1    Zhou, X.2    Mitch, W.E.3    Goldberg, A.L.4
  • 63
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The nextgeneration
    • Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: the nextgeneration. Cell 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 66
    • 0021743393 scopus 로고
    • Glucosemetabolism in cachectic patients with colorectal cancer
    • Holroyde CP, Skutches CL, Boden G, Reichard GA. 1984. Glucosemetabolism in cachectic patients with colorectal cancer.Cancer Res 44: 5910-5913.
    • (1984) Cancer Res , vol.44 , pp. 5910-5913
    • Holroyde, C.P.1    Skutches, C.L.2    Boden, G.3    Reichard, G.A.4
  • 67
    • 84899989426 scopus 로고    scopus 로고
    • MABp1,a first-in-class true human antibody targeting interleukin-1αin refractory cancers: An open-label, phase 1 dose-escalationand expansion study
    • Hong DS, Hui D, Bruera E, Janku F, Naing A, Falchook GS, Piha-Paul S, Wheler JJ, Fu S, Tsimberidou AM, et al. 2014. MABp1,a first-in-class true human antibody targeting interleukin-1αin refractory cancers: an open-label, phase 1 dose-escalationand expansion study. Lancet Oncol 15: 656-666.
    • (2014) Lancet Oncol , vol.15 , pp. 656-666
    • Hong, D.S.1    Hui, D.2    Bruera, E.3    Janku, F.4    Naing, A.5    Falchook, G.S.6    Piha-Paul, S.7    Wheler, J.J.8    Fu, S.9    Tsimberidou, A.M.10
  • 68
    • 0018091751 scopus 로고
    • Mechanismof impaired glucose tolerance in patients with neoplasia
    • Jasani B, Donaldson LJ, Ratcliffe JG, Sokhi GS. 1978. Mechanismof impaired glucose tolerance in patients with neoplasia. Br JCancer 38: 287-292.
    • (1978) Br JCancer , vol.38 , pp. 287-292
    • Jasani, B.1    Donaldson, L.J.2    Ratcliffe, J.G.3    Sokhi, G.S.4
  • 71
    • 0019447659 scopus 로고
    • Studies of endotoxin-induceddecrease in lipoprotein lipase activity
    • Kawakami M, Cerami A. 1981. Studies of endotoxin-induceddecrease in lipoprotein lipase activity. J Exp Med 154:631-639.
    • (1981) J Exp Med , vol.154 , pp. 631-639
    • Kawakami, M.1    Cerami, A.2
  • 72
    • 23944494119 scopus 로고    scopus 로고
    • Increasedexpression of proteasome subunits in skeletal muscleof cancer patients with weight loss
    • Khal J, Hine AV, Fearon KC, Dejong CH, Tisdale MJ. 2005. Increasedexpression of proteasome subunits in skeletal muscleof cancer patients with weight loss. Int J Biochem Cell Biol 37:2196-2206.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 2196-2206
    • Khal, J.1    Hine, A.V.2    Fearon, K.C.3    Dejong, C.H.4    Tisdale, M.J.5
  • 75
    • 84887882451 scopus 로고    scopus 로고
    • Gut barrierdysfunction and microbial translocation in cancer cachexia:A new therapeutic target
    • Klein GL, Petschow BW, Shaw AL, Weaver E. 2013. Gut barrierdysfunction and microbial translocation in cancer cachexia:a new therapeutic target. Curr Opin Support Palliat Care 7:361-367.
    • (2013) Curr Opin Support Palliat Care , vol.7 , pp. 361-367
    • Klein, G.L.1    Petschow, B.W.2    Shaw, A.L.3    Weaver, E.4
  • 76
    • 84926384423 scopus 로고    scopus 로고
    • Systemic organwasting induced by localized expressionof the secreted insulin/IGF antagonist ImpL2
    • Kwon Y, Song W, Droujinine IA, Hu Y, Asara JM, Perrimon N.2015. Systemic organwasting induced by localized expressionof the secreted insulin/IGF antagonist ImpL2. Dev Cell 33:36-46.
    • (2015) Dev Cell , vol.33 , pp. 36-46
    • Kwon, Y.1    Song, W.2    Droujinine, I.A.3    Hu, Y.4    Asara, J.M.5    Perrimon, N.6
  • 78
  • 79
    • 0029553958 scopus 로고
    • Negative impactof cancer chemotherapy on protein metabolism inhealthy and tumor-bearing rats
    • Le Bricon T, Gugins S, Cynober L, Baracos VE. 1995. Negative impactof cancer chemotherapy on protein metabolism inhealthy and tumor-bearing rats. Metabolism 44: 1340-1348.
    • (1995) Metabolism , vol.44 , pp. 1340-1348
    • Le Bricon, T.1    Gugins, S.2    Cynober, L.3    Baracos, V.E.4
  • 81
    • 0035979253 scopus 로고    scopus 로고
    • Regulation of myostatin activityand muscle growth
    • Lee SJ, McPherron AC. 2001. Regulation of myostatin activityand muscle growth. Proc Natl Acad Sci 98: 9306-9311.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 9306-9311
    • Lee, S.J.1    McPherron, A.C.2
  • 82
    • 0037049259 scopus 로고    scopus 로고
    • Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervationof brown adipose tissue and underlies one mechanism ofbody weight reduction in rats
    • Li G, Klein RL, Matheny M, King MA, Meyer EM, Scarpace PJ.2002. Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervationof brown adipose tissue and underlies one mechanism ofbody weight reduction in rats. Neuroscience 115: 879-889.
    • (2002) Neuroscience , vol.115 , pp. 879-889
    • Li, G.1    Klein, R.L.2    Matheny, M.3    King, M.A.4    Meyer, E.M.5    Scarpace, P.J.6
  • 84
    • 84930968311 scopus 로고    scopus 로고
    • Leucinesupplementation differentially enhances pancreatic cancergrowth in lean and overweight mice
    • Liu KA, Lashinger LM, Rasmussen AJ, Hursting SD. 2014. Leucinesupplementation differentially enhances pancreatic cancergrowth in lean and overweight mice. Cancer Metab 2: 6.
    • (2014) Cancer Metab , vol.2 , pp. 6
    • Liu, K.A.1    Lashinger, L.M.2    Rasmussen, A.J.3    Hursting, S.D.4
  • 85
    • 84949895181 scopus 로고    scopus 로고
    • Cachexia: The last illness
    • Lok C. 2015. Cachexia: the last illness. Nature 528: 182-183.
    • (2015) Nature , vol.528 , pp. 182-183
    • Lok, C.1
  • 87
    • 84903935131 scopus 로고    scopus 로고
    • Novel investigationalbiologics for the treatment of cancer cachexia
    • Ma JD, Heavey SF, Revta C, Roeland EJ. 2014. Novel investigationalbiologics for the treatment of cancer cachexia. ExpertOpin Biol Ther 14: 1113-1120.
    • (2014) ExpertOpin Biol Ther , vol.14 , pp. 1113-1120
    • Ma, J.D.1    Heavey, S.F.2    Revta, C.3    Roeland, E.J.4
  • 88
    • 27644533977 scopus 로고
    • Changes in skeletal muscle associatedwith cachexia
    • Marin OS, Denny-Brown D. 1962. Changes in skeletal muscle associatedwith cachexia. Am J Pathol 41: 23-39.
    • (1962) Am J Pathol , vol.41 , pp. 23-39
    • Marin, O.S.1    Denny-Brown, D.2
  • 91
    • 0028212481 scopus 로고
    • Metabolic acidosis stimulatesmuscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes
    • Mitch WE, Medina R, Grieber S, May RC, England BK, Price SR, Bailey JL, Goldberg AL. 1994. Metabolic acidosis stimulatesmuscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.J Clin Invest 93: 2127-2133.
    • (1994) J Clin Invest , vol.93 , pp. 2127-2133
    • Mitch, W.E.1    Medina, R.2    Grieber, S.3    May, R.C.4    England, B.K.5    Price, S.R.6    Bailey, J.L.7    Goldberg, A.L.8
  • 93
    • 84913586856 scopus 로고    scopus 로고
    • The browning of white adipose tissue:Some burning issues
    • Nedergaard J, Cannon B. 2014. The browning of white adipose tissue:some burning issues. Cell Metab 20: 396-407.
    • (2014) Cell Metab , vol.20 , pp. 396-407
    • Nedergaard, J.1    Cannon, B.2
  • 94
    • 34547631960 scopus 로고    scopus 로고
    • Unexpected evidencefor active brown adipose tissue in adult humans
    • Nedergaard J, Bengtsson T, Cannon B. 2007. Unexpected evidencefor active brown adipose tissue in adult humans. Am JPhysiol Endocrinol Metab 293: E444-E452.
    • (2007) Am JPhysiol Endocrinol Metab , vol.293 , pp. E444-E452
  • 102
    • 0029861468 scopus 로고    scopus 로고
    • Muscle wasting in insulinopenicrats results from activation of the ATP-dependent, ubiquitinproteasomeproteolytic pathway by a mechanism includinggene transcription
    • Price SR, Bailey JL, Wang X, Jurkovitz C, England BK, Ding X, Phillips LS, Mitch WE. 1996. Muscle wasting in insulinopenicrats results from activation of the ATP-dependent, ubiquitinproteasomeproteolytic pathway by a mechanism includinggene transcription. J Clin Invest 98: 1703-1708.
    • (1996) J Clin Invest , vol.98 , pp. 1703-1708
    • Price, S.R.1    Bailey, J.L.2    Wang, X.3    Jurkovitz, C.4    England, B.K.5    Ding, X.6    Phillips, L.S.7    Mitch, W.E.8
  • 103
    • 0031439207 scopus 로고    scopus 로고
    • Modulation ofhypothalamic-pituitary-adrenal function by transgenic expressionof interleukin-6 in the CNS of mice
    • Raber J, O'Shea RD, Bloom FE, Campbell IL. 1997. Modulation ofhypothalamic-pituitary-adrenal function by transgenic expressionof interleukin-6 in the CNS of mice. J Neurosci 17:9473-9480.
    • (1997) J Neurosci , vol.17 , pp. 9473-9480
    • Raber, J.1    O'Shea, R.D.2    Bloom, F.E.3    Campbell, I.L.4
  • 106
    • 0016636011 scopus 로고
    • Variation with age and diseaseof an amyloid A protein-related serum component
    • Rosenthal CJ, Franklin EC. 1975. Variation with age and diseaseof an amyloid A protein-related serum component. J Clin Invest55: 746-753.
    • (1975) J Clin Invest , vol.55 , pp. 746-753
    • Rosenthal, C.J.1    Franklin, E.C.2
  • 107
    • 0019077193 scopus 로고
    • Hypertriglyceridemia associatedwith Trypanosoma brucei brucei infection in rabbits: Role ofdefective triglyceride removal
    • Rouzer CA, Cerami A. 1980. Hypertriglyceridemia associatedwith Trypanosoma brucei brucei infection in rabbits: role ofdefective triglyceride removal. Mol Biochem Parasitol 2:31-38.
    • (1980) Mol Biochem Parasitol , vol.2 , pp. 31-38
    • Rouzer, C.A.1    Cerami, A.2
  • 108
    • 0036313033 scopus 로고    scopus 로고
    • Tumor necrosis factor-α suppresses adipocyte-specific genesand activates expression of preadipocyte genes in 3T3-L1 adipocytes:Nuclear factor-κB activation by TNF-α is obligatory
    • Ruan H, Hacohen N, Golub TR, Van Parijs L, Lodish HF. 2002.Tumor necrosis factor-α suppresses adipocyte-specific genesand activates expression of preadipocyte genes in 3T3-L1 adipocytes:nuclear factor-κB activation by TNF-α is obligatory.Diabetes 51: 1319-1336.
    • (2002) Diabetes , vol.51 , pp. 1319-1336
    • Ruan, H.1    Hacohen, N.2    Golub, T.R.3    Van Parijs, L.4    Lodish, H.F.5
  • 117
    • 84863577170 scopus 로고    scopus 로고
    • Cancer cachexia: Molecular targets andpathways for diagnosis and drug intervention
    • Shum AM, Polly P. 2012. Cancer cachexia: molecular targets andpathways for diagnosis and drug intervention. Endocr MetabImmune Disord Drug Targets 12: 247-259.
    • (2012) Endocr MetabImmune Disord Drug Targets , vol.12 , pp. 247-259
    • Shum, A.M.1    Polly, P.2
  • 119
  • 122
    • 0026689535 scopus 로고
    • Evidence forthe involvement of interleukin 6 in experimental cancer cachexia
    • Strassmann G, Fong M, Kenney JS, Jacob CO. 1992. Evidence forthe involvement of interleukin 6 in experimental cancer cachexia.J Clin Invest 89: 1681-1684.
    • (1992) J Clin Invest , vol.89 , pp. 1681-1684
    • Strassmann, G.1    Fong, M.2    Kenney, J.S.3    Jacob, C.O.4
  • 124
    • 0023619031 scopus 로고
    • Tumor-host wastingnot explained by adrenal hyperfunction in tumor-bearing animals
    • Svaninger G, Gelin J, Lundholm K. 1987. Tumor-host wastingnot explained by adrenal hyperfunction in tumor-bearing animals.J Natl Cancer Inst 79: 1135-1141.
    • (1987) J Natl Cancer Inst , vol.79 , pp. 1135-1141
    • Svaninger, G.1    Gelin, J.2    Lundholm, K.3
  • 125
    • 0028875908 scopus 로고
    • Thenatural history of nonalcoholic fatty liver: A follow-up study
    • Teli MR, James OF, Burt AD, Bennett MK, Day CP. 1995. Thenatural history of nonalcoholic fatty liver: a follow-up study.Hepatology 22: 1714-1719.
    • (1995) Hepatology , vol.22 , pp. 1714-1719
    • Teli, M.R.1    James, O.F.2    Burt, A.D.3    Bennett, M.K.4    Day, C.P.5
  • 127
    • 77950605203 scopus 로고    scopus 로고
    • Are tumoral factors responsible for host tissuewasting in cancer cachexia?
    • Tisdale MJ. 2010. Are tumoral factors responsible for host tissuewasting in cancer cachexia? Future Oncol 6: 503-513.
    • (2010) Future Oncol , vol.6 , pp. 503-513
    • Tisdale, M.J.1
  • 128
    • 0018768983 scopus 로고
    • Effect of glucocorticoidadministration on the rate of muscle protein breakdown invivo in rats, as measured by urinary excretion of N τ-methylhistidine
    • Tomas FM, Munro HN, Young VR. 1979. Effect of glucocorticoidadministration on the rate of muscle protein breakdown invivo in rats, as measured by urinary excretion of N τ-methylhistidine.Biochem J 178: 139-146.
    • (1979) Biochem J , vol.178 , pp. 139-146
    • Tomas, F.M.1    Munro, H.N.2    Young, V.R.3
  • 130
    • 84877919797 scopus 로고    scopus 로고
    • Cancer cachexia: Malignant inflammation,tumorkines, and metabolic mayhem
    • Tsoli M, Robertson G. 2012. Cancer cachexia: malignant inflammation,tumorkines, and metabolic mayhem. Trends EndocrinolMetab 24: 174-183.
    • (2012) Trends EndocrinolMetab , vol.24 , pp. 174-183
    • Tsoli, M.1    Robertson, G.2
  • 131
    • 84947475334 scopus 로고    scopus 로고
    • Lipolytic and thermogenicdepletion of adipose tissue in cancer cachexia
    • Tsoli M, Swarbrick MM, Robertson GR. 2015. Lipolytic and thermogenicdepletion of adipose tissue in cancer cachexia. SeminCell Dev Biol doi: 10.1016/j.semcdb.2015.10.039.
    • (2015) SeminCell Dev Biol
    • Tsoli, M.1    Swarbrick, M.M.2    Robertson, G.R.3
  • 134
    • 84930614892 scopus 로고    scopus 로고
    • Cancer metabolism: A waste ofinsulin interference
    • Wagner EF, Petruzzelli M. 2015. Cancer metabolism: a waste ofinsulin interference. Nature 521: 430-431.
    • (2015) Nature , vol.521 , pp. 430-431
    • Wagner, E.F.1    Petruzzelli, M.2
  • 136
    • 84897137086 scopus 로고    scopus 로고
    • Coming full circle-from endless complexityto simplicity and back again
    • Weinberg RA. 2014. Coming full circle-from endless complexityto simplicity and back again. Cell 157: 267-271.
    • (2014) Cell , vol.157 , pp. 267-271
    • Weinberg, R.A.1
  • 138
    • 0032863110 scopus 로고    scopus 로고
    • The expressionof genes in the ubiquitin-proteasome proteolytic pathwayis increased in skeletal muscle from patients with cancer
    • Williams A, Sun X, Fischer JE, Hasselgren PO. 1999. The expressionof genes in the ubiquitin-proteasome proteolytic pathwayis increased in skeletal muscle from patients with cancer. Surgery126: 744-749.
    • (1999) Surgery , vol.126 , pp. 744-749
    • Williams, A.1    Sun, X.2    Fischer, J.E.3    Hasselgren, P.O.4
  • 140
    • 0027460118 scopus 로고
    • Glucocorticoids activate the ATPubiquitin-dependent proteolytic system in skeletal muscleduring fasting
    • Wing SS, Goldberg AL. 1993. Glucocorticoids activate the ATPubiquitin-dependent proteolytic system in skeletal muscleduring fasting. Am J Physiol 264: E668-E676.
    • (1993) Am J Physiol , vol.264 , pp. E668-E676
    • Wing, S.S.1    Goldberg, A.L.2
  • 141
    • 0034919731 scopus 로고    scopus 로고
    • Reversalof cancer anorexia by blockade of central melanocortin receptorsin rats
    • Wisse BE, Frayo RS, Schwartz MW, Cummings DE. 2001. Reversalof cancer anorexia by blockade of central melanocortin receptorsin rats. Endocrinology 142: 3292-3301.
    • (2001) Endocrinology , vol.142 , pp. 3292-3301
    • Wisse, B.E.1    Frayo, R.S.2    Schwartz, M.W.3    Cummings, D.E.4
  • 142
    • 84949563243 scopus 로고    scopus 로고
    • Debugging the host browns thefat
    • Yeoh BS, Vijay-Kumar M. 2015. Debugging the host browns thefat. Nat Med 21: 1390-1391.
    • (2015) Nat Med , vol.21 , pp. 1390-1391
    • Yeoh, B.S.1    Vijay-Kumar, M.2
  • 144
    • 0033024678 scopus 로고    scopus 로고
    • Insulin resistancewas connected with the alterationsof substrate utilization in patients with cancer
    • Yoshikawa T, Noguchi Y, Doi C, Makino T, Okamoto T, Matsumoto A. 1999. Insulin resistancewas connected with the alterationsof substrate utilization in patients with cancer. CancerLett 141: 93-98.
    • (1999) CancerLett , vol.141 , pp. 93-98
    • Yoshikawa, T.1    Noguchi, Y.2    Doi, C.3    Makino, T.4    Okamoto, T.5    Matsumoto, A.6
  • 145
    • 0034941927 scopus 로고    scopus 로고
    • Insulinresistance in patients with cancer: Relationships with tumorsite, tumor stage, body-weight loss, acute-phase response,and energy expenditure
    • Yoshikawa T, Noguchi Y, Doi C, Makino T, Nomura K. 2001. Insulinresistance in patients with cancer: relationships with tumorsite, tumor stage, body-weight loss, acute-phase response,and energy expenditure. Nutrition 17: 590-593.
    • (2001) Nutrition , vol.17 , pp. 590-593
    • Yoshikawa, T.1    Noguchi, Y.2    Doi, C.3    Makino, T.4    Nomura, K.5
  • 146
    • 84874900503 scopus 로고    scopus 로고
    • Biochemistry and pathophysiologyof intravascular and intracellular lipolysis
    • Young SG, Zechner R. 2013. Biochemistry and pathophysiologyof intravascular and intracellular lipolysis. Genes Dev 27:459-484.
    • (2013) Genes Dev , vol.27 , pp. 459-484
    • Young, S.G.1    Zechner, R.2
  • 147
    • 36448968532 scopus 로고    scopus 로고
    • FoxO3 coordinately activatesprotein degradation by the autophagic/lysosomal and proteasomalpathways in atrophying muscle cells
    • Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL. 2007. FoxO3 coordinately activatesprotein degradation by the autophagic/lysosomal and proteasomalpathways in atrophying muscle cells. Cell Metab 6:472-483.
    • (2007) Cell Metab , vol.6 , pp. 472-483
    • Zhao, J.1    Brault, J.J.2    Schild, A.3    Cao, P.4    Sandri, M.5    Schiaffino, S.6    Lecker, S.H.7    Goldberg, A.L.8


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