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Volumn 33, Issue 1, 2015, Pages 47-55

Malignant drosophila tumors interrupt insulin signaling to induce cachexia-like wasting

Author keywords

[No Author keywords available]

Indexed keywords

FAT DROPLET; GLYCOGEN; IMPL2 PROTEIN; INSULIN; INTERLEUKIN 6; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR YKI; TREHALOSE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; DROSOPHILA PROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; TRANSACTIVATOR PROTEIN; YORKIE PROTEIN, DROSOPHILA;

EID: 84926320632     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2015.03.001     Document Type: Article
Times cited : (167)

References (50)
  • 1
    • 33746826011 scopus 로고    scopus 로고
    • JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions
    • Arbouzova N.I., Zeidler M.P. JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions. Development 2006, 133:2605-2616.
    • (2006) Development , vol.133 , pp. 2605-2616
    • Arbouzova, N.I.1    Zeidler, M.P.2
  • 2
    • 73449091872 scopus 로고    scopus 로고
    • Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice
    • Asp M.L., Tian M., Wendel A.A., Belury M.A. Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice. Int. J. Cancer 2010, 126:756-763.
    • (2010) Int. J. Cancer , vol.126 , pp. 756-763
    • Asp, M.L.1    Tian, M.2    Wendel, A.A.3    Belury, M.A.4
  • 3
    • 84899657374 scopus 로고    scopus 로고
    • IGF binding proteins in cancer: mechanistic and clinical insights
    • Baxter R.C. IGF binding proteins in cancer: mechanistic and clinical insights. Nat. Rev. Cancer 2014, 14:329-341.
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 329-341
    • Baxter, R.C.1
  • 4
    • 80051585152 scopus 로고    scopus 로고
    • Animal models of the cancer anorexia-cachexia syndrome
    • Bennani-Baiti N., Walsh D. Animal models of the cancer anorexia-cachexia syndrome. Support. Care Cancer 2011, 19:1451-1463.
    • (2011) Support. Care Cancer , vol.19 , pp. 1451-1463
    • Bennani-Baiti, N.1    Walsh, D.2
  • 5
    • 4043170088 scopus 로고    scopus 로고
    • Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors
    • Bilder D. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev. 2004, 18:1909-1925.
    • (2004) Genes Dev. , vol.18 , pp. 1909-1925
    • Bilder, D.1
  • 6
    • 84872094183 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of muscle atrophy
    • Bonaldo P., Sandri M. Cellular and molecular mechanisms of muscle atrophy. Dis. Model. Mech. 2013, 6:25-39.
    • (2013) Dis. Model. Mech. , vol.6 , pp. 25-39
    • Bonaldo, P.1    Sandri, M.2
  • 7
    • 0036484062 scopus 로고    scopus 로고
    • Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions
    • Britton J.S., Lockwood W.K., Li L., Cohen S.M., Edgar B.A. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell 2002, 2:239-249.
    • (2002) Dev. Cell , vol.2 , pp. 239-249
    • Britton, J.S.1    Lockwood, W.K.2    Li, L.3    Cohen, S.M.4    Edgar, B.A.5
  • 8
    • 0242641565 scopus 로고    scopus 로고
    • Scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
    • Brumby A.M., Richardson H.E. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 2003, 22:5769-5779.
    • (2003) EMBO J. , vol.22 , pp. 5769-5779
    • Brumby, A.M.1    Richardson, H.E.2
  • 10
    • 67649878194 scopus 로고    scopus 로고
    • Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response
    • Charroux B., Royet J. Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response. Proc. Natl. Acad. Sci. USA 2009, 106:9797-9802.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9797-9802
    • Charroux, B.1    Royet, J.2
  • 11
    • 33745589773 scopus 로고    scopus 로고
    • Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    • Clark I.E., Dodson M.W., Jiang C., Cao J.H., Huh J.R., Seol J.H., Yoo S.J., Hay B.A., Guo M. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 2006, 441:1162-1166.
    • (2006) Nature , vol.441 , pp. 1162-1166
    • Clark, I.E.1    Dodson, M.W.2    Jiang, C.3    Cao, J.H.4    Huh, J.R.5    Seol, J.H.6    Yoo, S.J.7    Hay, B.A.8    Guo, M.9
  • 12
    • 84860491077 scopus 로고    scopus 로고
    • Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing
    • Colombani J., Andersen D.S., Léopold P. Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. Science 2012, 336:582-585.
    • (2012) Science , vol.336 , pp. 582-585
    • Colombani, J.1    Andersen, D.S.2    Léopold, P.3
  • 14
    • 84861943484 scopus 로고    scopus 로고
    • Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
    • Dar A.C., Das T.K., Shokat K.M., Cagan R.L. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature 2012, 486:80-84.
    • (2012) Nature , vol.486 , pp. 80-84
    • Dar, A.C.1    Das, T.K.2    Shokat, K.M.3    Cagan, R.L.4
  • 15
    • 0017260831 scopus 로고
    • Demonstration of sensory neurones in the ectopic cuticle of spineless-aristapedia, a homoeotic mutant of Drosophila
    • Deak I.I. Demonstration of sensory neurones in the ectopic cuticle of spineless-aristapedia, a homoeotic mutant of Drosophila. Nature 1976, 260:252-254.
    • (1976) Nature , vol.260 , pp. 252-254
    • Deak, I.I.1
  • 16
    • 78650918920 scopus 로고    scopus 로고
    • FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
    • Demontis F., Perrimon N. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell 2010, 143:813-825.
    • (2010) Cell , vol.143 , pp. 813-825
    • Demontis, F.1    Perrimon, N.2
  • 17
    • 84888363022 scopus 로고    scopus 로고
    • Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models
    • Demontis F., Piccirillo R., Goldberg A.L., Perrimon N. Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis. Model. Mech. 2013, 6:1339-1352.
    • (2013) Dis. Model. Mech. , vol.6 , pp. 1339-1352
    • Demontis, F.1    Piccirillo, R.2    Goldberg, A.L.3    Perrimon, N.4
  • 18
    • 55749090654 scopus 로고    scopus 로고
    • The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
    • Deng H., Dodson M.W., Huang H., Guo M. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. Natl. Acad. Sci. USA 2008, 105:14503-14508.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 14503-14508
    • Deng, H.1    Dodson, M.W.2    Huang, H.3    Guo, M.4
  • 19
    • 33750023633 scopus 로고    scopus 로고
    • Aktand FOXO dysregulation contribute to infection-induced wasting in Drosophila
    • Dionne M.S., Pham L.N., Shirasu-Hiza M., Schneider D.S. Aktand FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr. Biol. 2006, 16:1977-1985.
    • (2006) Curr. Biol. , vol.16 , pp. 1977-1985
    • Dionne, M.S.1    Pham, L.N.2    Shirasu-Hiza, M.3    Schneider, D.S.4
  • 21
    • 0035281979 scopus 로고    scopus 로고
    • Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis
    • Drummond-Barbosa D., Spradling A.C. Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis. Dev. Biol. 2001, 231:265-278.
    • (2001) Dev. Biol. , vol.231 , pp. 265-278
    • Drummond-Barbosa, D.1    Spradling, A.C.2
  • 22
    • 0028674969 scopus 로고
    • Regulation of feeding behavior in adult Drosophila melanogaster varies with feeding regime and nutritional state
    • Edgecomb R.S., Harth C.E., Schneiderman A.M. Regulation of feeding behavior in adult Drosophila melanogaster varies with feeding regime and nutritional state. J.Exp. Biol. 1994, 197:215-235.
    • (1994) J.Exp. Biol. , vol.197 , pp. 215-235
    • Edgecomb, R.S.1    Harth, C.E.2    Schneiderman, A.M.3
  • 23
    • 84871909004 scopus 로고    scopus 로고
    • The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man
    • Elsum I., Yates L., Humbert P.O., Richardson H.E. The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man. Essays Biochem. 2012, 53:141-168.
    • (2012) Essays Biochem. , vol.53 , pp. 141-168
    • Elsum, I.1    Yates, L.2    Humbert, P.O.3    Richardson, H.E.4
  • 24
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany M.B., Bender W.W. A Drosophila model of Parkinson's disease. Nature 2000, 404:394-398.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 25
    • 84864646651 scopus 로고    scopus 로고
    • Cancer cachexia: mediators, signaling, and metabolic pathways
    • Fearon K.C.H., Glass D.J., Guttridge D.C. Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metab. 2012, 16:153-166.
    • (2012) Cell Metab. , vol.16 , pp. 153-166
    • Fearon, K.C.H.1    Glass, D.J.2    Guttridge, D.C.3
  • 26
    • 84873406669 scopus 로고    scopus 로고
    • Understanding the mechanisms and treatment options in cancer cachexia
    • Fearon K., Arends J., Baracos V. Understanding the mechanisms and treatment options in cancer cachexia. Nat. Rev. Clin. Oncol. 2013, 10:90-99.
    • (2013) Nat. Rev. Clin. Oncol. , vol.10 , pp. 90-99
    • Fearon, K.1    Arends, J.2    Baracos, V.3
  • 27
    • 84860487216 scopus 로고    scopus 로고
    • Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation
    • Garelli A., Gontijo A.M., Miguela V., Caparros E., Dominguez M. Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation. Science 2012, 336:579-582.
    • (2012) Science , vol.336 , pp. 579-582
    • Garelli, A.1    Gontijo, A.M.2    Miguela, V.3    Caparros, E.4    Dominguez, M.5
  • 28
    • 84875412051 scopus 로고    scopus 로고
    • Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics
    • Gonzalez C. Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics. Nat. Rev. Cancer 2013, 13:172-183.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 172-183
    • Gonzalez, C.1
  • 29
    • 33846279755 scopus 로고    scopus 로고
    • Specialized hepatocyte-like cells regulate Drosophila lipid metabolism
    • Gutierrez E., Wiggins D., Fielding B., Gould A.P. Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature 2007, 445:275-280.
    • (2007) Nature , vol.445 , pp. 275-280
    • Gutierrez, E.1    Wiggins, D.2    Fielding, B.3    Gould, A.P.4
  • 30
    • 24944578683 scopus 로고
    • Differenzierungsleistungen wiederholt fragmentierter Teilstücke männlicher Genitalscheiben von Drosophila melanogaster nach Kultur invivo [Differentiation services repeatedly fragmented pieces of male genital part of Drosophila melanogaster slices after culture invivo]
    • Hadorn E. Differenzierungsleistungen wiederholt fragmentierter Teilstücke männlicher Genitalscheiben von Drosophila melanogaster nach Kultur invivo [Differentiation services repeatedly fragmented pieces of male genital part of Drosophila melanogaster slices after culture invivo]. Dev. Biol. 1963, 7:617-629.
    • (1963) Dev. Biol. , vol.7 , pp. 617-629
    • Hadorn, E.1
  • 32
    • 42249108516 scopus 로고    scopus 로고
    • Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    • Honegger B., Galic M., Köhler K., Wittwer F., Brogiolo W., Hafen E., Stocker H. Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance. J.Biol. 2008, 7:10.
    • (2008) J.Biol. , vol.7 , pp. 10
    • Honegger, B.1    Galic, M.2    Köhler, K.3    Wittwer, F.4    Brogiolo, W.5    Hafen, E.6    Stocker, H.7
  • 33
    • 84866540191 scopus 로고    scopus 로고
    • The role of insulin resistance in the development of muscle wasting during cancer cachexia
    • Honors M.A., Kinzig K.P. The role of insulin resistance in the development of muscle wasting during cancer cachexia. J.Cachexia Sarcopenia Muscle 2012, 3:5-11.
    • (2012) J.Cachexia Sarcopenia Muscle , vol.3 , pp. 5-11
    • Honors, M.A.1    Kinzig, K.P.2
  • 35
    • 0031964429 scopus 로고    scopus 로고
    • Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues
    • Karim F.D., Rubin G.M. Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. Development 1998, 125:1-9.
    • (1998) Development , vol.125 , pp. 1-9
    • Karim, F.D.1    Rubin, G.M.2
  • 36
    • 84926384423 scopus 로고    scopus 로고
    • Systemic organ wasting induced by localized expression of thesecreted insulin/IGF antagonist ImpL2
    • this issue
    • Kwon Y., Song W., Droujinine I.A., Hu Y., Asara J.M., Perrimon N. Systemic organ wasting induced by localized expression of thesecreted insulin/IGF antagonist ImpL2. Dev. Cell 2015, 33:36-46. this issue.
    • (2015) Dev. Cell , vol.33 , pp. 36-46
    • Kwon, Y.1    Song, W.2    Droujinine, I.A.3    Hu, Y.4    Asara, J.M.5    Perrimon, N.6
  • 37
    • 36049044765 scopus 로고    scopus 로고
    • Drosophila and the genetics of the internal milieu
    • Leopold P., Perrimon N. Drosophila and the genetics of the internal milieu. Nature 2007, 450:186-188.
    • (2007) Nature , vol.450 , pp. 186-188
    • Leopold, P.1    Perrimon, N.2
  • 38
    • 84872309064 scopus 로고    scopus 로고
    • A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila
    • Okamoto N., Nakamori R., Murai T., Yamauchi Y., Masuda A., Nishimura T. A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila. Genes Dev. 2013, 27:87-97.
    • (2013) Genes Dev. , vol.27 , pp. 87-97
    • Okamoto, N.1    Nakamori, R.2    Murai, T.3    Yamauchi, Y.4    Masuda, A.5    Nishimura, T.6
  • 39
    • 0242666126 scopus 로고    scopus 로고
    • A genetic screen in Drosophila for metastatic behavior
    • Pagliarini R.A., Xu T. A genetic screen in Drosophila for metastatic behavior. Science 2003, 302:1227-1231.
    • (2003) Science , vol.302 , pp. 1227-1231
    • Pagliarini, R.A.1    Xu, T.2
  • 40
    • 77957883342 scopus 로고    scopus 로고
    • The hippo signaling pathway in development and cancer
    • Pan D. The hippo signaling pathway in development and cancer. Dev. Cell 2010, 19:491-505.
    • (2010) Dev. Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 42
    • 60649118070 scopus 로고    scopus 로고
    • An innate immune response of blood cells to tumors and tissue damage in Drosophila
    • discussion 153
    • Pastor-Pareja J.C., Wu M., Xu T. An innate immune response of blood cells to tumors and tissue damage in Drosophila. Dis. Model. Mech. 2008, 1:144-154. discussion 153.
    • (2008) Dis. Model. Mech. , vol.1 , pp. 144-154
    • Pastor-Pareja, J.C.1    Wu, M.2    Xu, T.3
  • 43
    • 84901271886 scopus 로고    scopus 로고
    • Tissue design: how Drosophila tumors remodel their neighborhood
    • Patel P.H., Edgar B.A. Tissue design: how Drosophila tumors remodel their neighborhood. Semin. Cell Dev. Biol. 2014, 28:86-95.
    • (2014) Semin. Cell Dev. Biol. , vol.28 , pp. 86-95
    • Patel, P.H.1    Edgar, B.A.2
  • 44
    • 84866978180 scopus 로고    scopus 로고
    • Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion
    • Rajan A., Perrimon N. Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell 2012, 151:123-137.
    • (2012) Cell , vol.151 , pp. 123-137
    • Rajan, A.1    Perrimon, N.2
  • 45
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • Scott R.C., Schuldiner O., Neufeld T.P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 2004, 7:167-178.
    • (2004) Dev. Cell , vol.7 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 46
    • 0002031074 scopus 로고
    • Developmental genetics of oogenesis
    • Cold Spring Harbor Press, M. Bate, A. Martinez-Arias (Eds.)
    • Spradling A.C. Developmental genetics of oogenesis. The Development of Drosophila melanogaster 1993, 1-70. Cold Spring Harbor Press. M. Bate, A. Martinez-Arias (Eds.).
    • (1993) The Development of Drosophila melanogaster , pp. 1-70
    • Spradling, A.C.1
  • 47
    • 0036830917 scopus 로고    scopus 로고
    • Cachexia in cancer patients
    • Tisdale M.J. Cachexia in cancer patients. Nat. Rev. Cancer 2002, 2:862-871.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 862-871
    • Tisdale, M.J.1
  • 48
    • 67649982995 scopus 로고    scopus 로고
    • Mechanisms of cancer cachexia
    • Tisdale M.J. Mechanisms of cancer cachexia. Physiol. Rev. 2009, 89:381-410.
    • (2009) Physiol. Rev. , vol.89 , pp. 381-410
    • Tisdale, M.J.1
  • 49
    • 80053321476 scopus 로고    scopus 로고
    • Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model
    • Willecke M., Toggweiler J., Basler K. Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model. Oncogene 2011, 30:4067-4074.
    • (2011) Oncogene , vol.30 , pp. 4067-4074
    • Willecke, M.1    Toggweiler, J.2    Basler, K.3
  • 50
    • 0031893101 scopus 로고    scopus 로고
    • Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes
    • Woodhouse E., Hersperger E., Shearn A. Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes. Dev. Genes Evol. 1998, 207:542-550.
    • (1998) Dev. Genes Evol. , vol.207 , pp. 542-550
    • Woodhouse, E.1    Hersperger, E.2    Shearn, A.3


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