Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Nature Neuroscience

Volumn 18, Issue 2, 2015, Pages 182-184

  Tian, Di ^a,b   Stoppel, Laura J ^a   Heynen, Arnold J ^a   Lindemann, Lothar ^c   Jaeschke, Georg ^c   Mills, Alea A ^d   Bear, Mark F ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Saban Research Institute   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METABOTROPIC RECEPTOR 5; 2-CHLORO-4-((2,5-DIMETHYL-1-(4-(TRIFLUOROMETHOXY)PHENYL)-1H-IMIDAZOL-4-YL)ETHYNYL)PYRIDINE; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTISM; COGNITIVE DEFECT; GENE DELETION; GENE DOSAGE; HIPPOCAMPUS; HUMAN CHROMOSOME; HUMAN CHROMOSOME 16P11.2; LONG TERM CARE; LONG TERM DEPRESSION; MALE; MEMORY DISORDER; MICRODELETION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA TRANSLATION; SYNAPTIC TRANSMISSION; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CHROMOSOME; CHROMOSOME 16; CHROMOSOME DELETION; CHROMOSOME DISORDER; DISEASE MODEL; DRUG EFFECTS; GENETICS; INTELLECTUAL IMPAIRMENT; MEMORY DISORDERS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; AUTISTIC DISORDER; BEHAVIOR, ANIMAL; CHROMOSOME DELETION; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, MAMMALIAN; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; IMIDAZOLES; INTELLECTUAL DISABILITY; MALE; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONAL PLASTICITY; PYRIDINES; RECEPTOR, METABOTROPIC GLUTAMATE 5; SIGNAL TRANSDUCTION;

EID: 84923198963     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3911     Document Type: Article

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