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Volumn 13, Issue 1, 2016, Pages 1-12

Molecular mechanisms of bone metastasis

Author keywords

Bisphosphonates; Bone tropism of metastasis; Denosumab; Genes mediating and modulating bone metastasis; Preand metastatic niche(s); Review; Vicious cycle

Indexed keywords

ALENDRONIC ACID; BHQ 880; BISPHOSPHONIC ACID DERIVATIVE; BORTEZOMIB; CHEMOKINE RECEPTOR CXCR4; CLODRONIC ACID; DASATINIB; DENOSUMAB; ETIDRONIC ACID; GLYCOPROTEIN; IBANDRONIC ACID; LENALIDOMIDE; MICRORNA; MONOCLONAL ANTIBODY; ODANACATIB; PAMIDRONIC ACID; PHOSPHOPROTEIN; POMALIDOMIDE; PROTEASOME INHIBITOR; SARACATINIB; SMALL INTEGRIN BINDING N LINKED GLYCOPROTEIN; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

EID: 84959363249     PISSN: 11096535     EISSN: 17906245     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (74)

References (110)
  • 1
    • 79953300698 scopus 로고    scopus 로고
    • The seed and soil hypothesis revisited-the role of tumor-stroma interactions in metastasis to different organs
    • Langley RR and Fidler IJ: The seed and soil hypothesis revisited-the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer 128:2527-2535, 2011.
    • (2011) Int J Cancer , vol.128 , pp. 2527-2535
    • Langley, R.R.1    Fidler, I.J.2
  • 5
    • 0036978280 scopus 로고    scopus 로고
    • The vicious cycle of bone metastasis
    • Guise TA: The vicious cycle of bone metastasis. J Musculoskelet Interact 2:570-572, 2002.
    • (2002) J Musculoskelet Interact , vol.2 , pp. 570-572
    • Guise, T.A.1
  • 6
    • 4644261592 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Rodman GD: Mechanisms of bone metastasis. N Engl J Med 350:1655-1664, 2004.
    • (2004) N Engl J Med , vol.350 , pp. 1655-1664
    • Rodman, G.D.1
  • 7
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • Nguyen DX, Bos PD, Massaggue J: Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9:274-284, 2009.
    • (2009) Nat Rev Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massaggue, J.3
  • 8
    • 83455205837 scopus 로고    scopus 로고
    • Neoplastic bone marrow niche: Hematopoietic and mesenchymal stem cells
    • Saki N, Abroun S, Farshdoushi Hagh M and Asgharei F: Neoplastic bone marrow niche: hematopoietic and mesenchymal stem cells. Cell J 13:131-136, 2011.
    • (2011) Cell J , vol.13 , pp. 131-136
    • Saki, N.1    Abroun, S.2    Farshdoushi Hagh, M.3    Asgharei, F.4
  • 9
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: Building a framework
    • Gupta GP and Massague J: Cancer metastasis: building a framework. Cell 127:679-695, 2006.
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 10
    • 58149102321 scopus 로고    scopus 로고
    • Molecular basis of metastasis
    • Chiang AC and Massague J: Molecular basis of metastasis. N Engl J Med 359:2814-2823, 2008.
    • (2008) N Engl J Med , vol.359 , pp. 2814-2823
    • Chiang, A.C.1    Massague, J.2
  • 12
    • 84887981252 scopus 로고    scopus 로고
    • Mechanisms governing metastatic dormancy and reactivation
    • Giancotti FG: Mechanisms governing metastatic dormancy and reactivation. Cell 155:750-764, 2013.
    • (2013) Cell , vol.155 , pp. 750-764
    • Giancotti, F.G.1
  • 13
    • 84859455517 scopus 로고    scopus 로고
    • Biology of bone metastasis
    • Theriault RL: Biology of bone metastasis. Cancer Control 19:92-101, 2012
    • (2012) Cancer Control , vol.19 , pp. 92-101
    • Theriault, R.L.1
  • 14
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: Causes, consequences and therapeutic opportunities
    • Mundy GR: Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2:584-593, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 584-593
    • Mundy, G.R.1
  • 15
    • 84855999380 scopus 로고    scopus 로고
    • Molecular pathways: Osteoclast-dependent and osteoclast-independent roles of the RANKL/RANK/OPG pathway in tumorigenesis and metastasis
    • Dougall WC: Molecular pathways: osteoclast-dependent and osteoclast-independent roles of the RANKL/RANK/OPG pathway in tumorigenesis and metastasis. Clin Cancer Res 18:326-335, 2012.
    • (2012) Clin Cancer Res , vol.18 , pp. 326-335
    • Dougall, W.C.1
  • 17
    • 77955357297 scopus 로고    scopus 로고
    • Receptor activator of NF-kappaB ligand enhances breasr cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147
    • Rucci N, Millimaggi D, Mari M, Del Fattore A, Bologna A, Teti A, Angelucci A and Dolo V: Receptor activator of NF-kappaB ligand enhances breasr cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147. Cancer Res 70:6150-6160, 2010.
    • (2010) Cancer Res , vol.70 , pp. 6150-6160
    • Rucci, N.1    Millimaggi, D.2    Mari, M.3    Del Fattore, A.4    Bologna, A.5    Teti, A.6    Angelucci, A.7    Dolo, V.8
  • 19
    • 78651513543 scopus 로고    scopus 로고
    • Do RANKL inhibitors (denosumab) affect inflammation and immunity?
    • Ferrari-Lacraz S and Ferrari S: Do RANKL inhibitors (denosumab) affect inflammation and immunity? Osteoporosis Int 22:435-446, 2011.
    • (2011) Osteoporosis Int , vol.22 , pp. 435-446
    • Ferrari-Lacraz, S.1    Ferrari, S.2
  • 21
    • 84864453110 scopus 로고    scopus 로고
    • The multifaceted actions of PTHrP in skeletal metastasis
    • Soki FN, Park SI, McCauley LK: The multifaceted actions of PTHrP in skeletal metastasis. Future Oncol 8:803-817, 2012.
    • (2012) Future Oncol , vol.8 , pp. 803-817
    • Soki, F.N.1    Park, S.I.2    McCauley, L.K.3
  • 22
    • 84916212617 scopus 로고    scopus 로고
    • Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets
    • Rucci N, Sanita P, Delle Monache S, Alesse E and Angelucci A: Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets. World J Clin Oncol 5:335-347, 2014.
    • (2014) World J Clin Oncol , vol.5 , pp. 335-347
    • Rucci, N.1    Sanita, P.2    Delle Monache, S.3    Alesse, E.4    Angelucci, A.5
  • 24
    • 84935020030 scopus 로고    scopus 로고
    • Bone metastases: When and how lung cancer interacts with bone
    • Roato I: Bone metastases: When and how lung cancer interacts with bone. World J Clin Oncol 10:149-155, 2014.
    • (2014) World J Clin Oncol , vol.10 , pp. 149-155
    • Roato, I.1
  • 25
    • 34548066096 scopus 로고    scopus 로고
    • Bone metastasis in prostate cancer: Molecular and cellular mechanisms
    • Ye L, Kynaston HG and Jiang WG: Bone metastasis in prostate cancer: molecular and cellular mechanisms. Int J Mol Med 20:103-111, 2007.
    • (2007) Int J Mol Med , vol.20 , pp. 103-111
    • Ye, L.1    Kynaston, H.G.2    Jiang, W.G.3
  • 26
    • 84930003076 scopus 로고    scopus 로고
    • Prostate cancer progression and metastasis: Potential regulatory pathways for therapeutic targeting
    • Nandana S and Chung LW: Prostate cancer progression and metastasis: potential regulatory pathways for therapeutic targeting. Am J Clin Exp Urol 12:92-101, 2014.
    • (2014) Am J Clin Exp Urol , vol.12 , pp. 92-101
    • Nandana, S.1    Chung, L.W.2
  • 29
    • 0035740252 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator system in prostate cancer metastasis
    • Sheng S. The urokinase-type plasminogen activator system in prostate cancer metastasis. Cancer Metastasis Rev 20:287-296, 2001.
    • (2001) Cancer Metastasis Rev , vol.20 , pp. 287-296
    • Sheng, S.1
  • 30
    • 84904194751 scopus 로고    scopus 로고
    • Dissecting the role of bone marrow stromal cells on bone metastasis
    • Buenrostro D, Park SI and Sterling JA: Dissecting the role of bone marrow stromal cells on bone metastasis. Biomed Res Int 2014:875305, 2014.
    • (2014) Biomed Res Int , vol.2014 , pp. 875305
    • Buenrostro, D.1    Park, S.I.2    Sterling, J.A.3
  • 31
    • 0030211390 scopus 로고    scopus 로고
    • Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: Inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts
    • Cramer SD, Chen Z and Peehl DM: Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts. J Urol 156:526-531, 1996.
    • (1996) J Urol , vol.156 , pp. 526-531
    • Cramer, S.D.1    Chen, Z.2    Peehl, D.M.3
  • 32
    • 33846044750 scopus 로고    scopus 로고
    • Bone marrow cells in the "pre-metastatic niche": Within bone and beyond
    • Kaplan RN, Psaila B and Lyden D: Bone marrow cells in the "pre-metastatic niche": within bone and beyond. Cancer Metastasis Rev 25:521-529, 2006.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 521-529
    • Kaplan, R.N.1    Psaila, B.2    Lyden, D.3
  • 33
    • 79952070774 scopus 로고    scopus 로고
    • The secreted factors for pre-metastatic niche formation: Old sayings and new thoughts
    • Peinado H, Lavotshkin S and Lyden D: The secreted factors for pre-metastatic niche formation: old sayings and new thoughts. Semin Cancer Biol 21:139-146, 2011.
    • (2011) Semin Cancer Biol , vol.21 , pp. 139-146
    • Peinado, H.1    Lavotshkin, S.2    Lyden, D.3
  • 34
    • 84881112672 scopus 로고    scopus 로고
    • The evolution of the cancer niche during multistage carcinogenesis
    • Barcellos-Hoff MH, Lyden D and Wang TC: The evolution of the cancer niche during multistage carcinogenesis. Nat Rev Cancer 13:511-518, 2013.
    • (2013) Nat Rev Cancer , vol.13 , pp. 511-518
    • Barcellos-Hoff, M.H.1    Lyden, D.2    Wang, T.C.3
  • 35
    • 63049121364 scopus 로고    scopus 로고
    • The metastatic niche: Adapting the foreign soil
    • Psaila B and Lyden D: The metastatic niche: adapting the foreign soil. Nat Rev Cancer 9:285-293, 2009.
    • (2009) Nat Rev Cancer , vol.9 , pp. 285-293
    • Psaila, B.1    Lyden, D.2
  • 37
    • 84877814639 scopus 로고    scopus 로고
    • Treating breast cancer in the 21st century: Emerging biological therapies
    • Tinoco G, Warsch S, Glück S, Avancha K and Montero AJ: Treating breast cancer in the 21st century: emerging biological therapies. J Cancer 4:117-132, 2013.
    • (2013) J Cancer , vol.4 , pp. 117-132
    • Tinoco, G.1    Warsch, S.2    Glück, S.3    Avancha, K.4    Montero, A.J.5
  • 38
    • 77950633401 scopus 로고    scopus 로고
    • New strategies in estrogen receptor-positive breast cancer
    • Johnston SR: New strategies in estrogen receptor-positive breast cancer. Clin Cancer Res 16:1979-1987, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 1979-1987
    • Johnston, S.R.1
  • 41
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: Composition, biogenesis and function
    • Thery C, Zitvogel L and Amigorena S: Exosomes: composition, biogenesis and function. Nat Rev Immunol 2:569-579, 2002.
    • (2002) Nat Rev Immunol , vol.2 , pp. 569-579
    • Thery, C.1    Zitvogel, L.2    Amigorena, S.3
  • 42
    • 84870586668 scopus 로고    scopus 로고
    • The genomic and proteomic content of cancer cell-derived exosomes
    • Henderson MC and Azorsa DO: The genomic and proteomic content of cancer cell-derived exosomes. Front Oncol 2:38, 2012.
    • (2012) Front Oncol , vol.2 , pp. 38
    • Henderson, M.C.1    Azorsa, D.O.2
  • 44
    • 42649100970 scopus 로고    scopus 로고
    • Detection, clinical relevance and specific biological properties of disseminated tumor cells
    • Pantel K, Brakenhoff RH and Brandt B: Detection, clinical relevance and specific biological properties of disseminated tumor cells. Nat Rev Cancer 8:329-340, 2008.
    • (2008) Nat Rev Cancer , vol.8 , pp. 329-340
    • Pantel, K.1    Brakenhoff, R.H.2    Brandt, B.3
  • 45
    • 35548936833 scopus 로고    scopus 로고
    • Models, mechanisms and clinical evidence for cancer dormancy
    • Aguirre-Ghiso JA: Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 7:834-846, 2007.
    • (2007) Nat Rev Cancer , vol.7 , pp. 834-846
    • Aguirre-Ghiso, J.A.1
  • 46
    • 52649162338 scopus 로고    scopus 로고
    • Circulating tumor cells and bone marrow micrometastasis
    • Alix-Panabieres C, Riethdorf S and Pantel K: Circulating tumor cells and bone marrow micrometastasis. Clin Cancer Res 14:5013-5021, 2008.
    • (2008) Clin Cancer Res , vol.14 , pp. 5013-5021
    • Alix-Panabieres, C.1    Riethdorf, S.2    Pantel, K.3
  • 50
    • 84861527239 scopus 로고    scopus 로고
    • To differentiate or not-routes towards metastasis
    • Brabletz T: To differentiate or not-routes towards metastasis. Nat Rev Cancer 12:425-436, 2012.
    • (2012) Nat Rev Cancer , vol.12 , pp. 425-436
    • Brabletz, T.1
  • 51
    • 79953147370 scopus 로고    scopus 로고
    • A perspective of cancer cell metastasis
    • Chaffer CL and Weinberg RA: A perspective of cancer cell metastasis. Science 331:1559-1564, 2011.
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 52
    • 79251468712 scopus 로고    scopus 로고
    • Mouse models of advanced spontaneous metastasis for experimental therapeutics
    • Francia G, Cruz-Munoz W, Man S, Xu P and Kerbel RS: Mouse models of advanced spontaneous metastasis for experimental therapeutics. Nat Rev Cancer 11:135-141, 2011.
    • (2011) Nat Rev Cancer , vol.11 , pp. 135-141
    • Francia, G.1    Cruz-Munoz, W.2    Man, S.3    Xu, P.4    Kerbel, R.S.5
  • 55
    • 79751472667 scopus 로고    scopus 로고
    • Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer cells by engaging notch signalling in bone cells
    • Sethi N, Dai X, Winter CG and Kang Y: Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer cells by engaging notch signalling in bone cells. Cancer Cell 19:192-205, 2011.
    • (2011) Cancer Cell , vol.19 , pp. 192-205
    • Sethi, N.1    Dai, X.2    Winter, C.G.3    Kang, Y.4
  • 58
    • 80052867880 scopus 로고    scopus 로고
    • ERK1/2 and p38α/β in tumor quiescence: Opportunities to control dormant residual disease
    • Sosa MS, Avivar-Valderas A, Bragado P, Wen HC and Aguirre-Ghiso JA: ERK1/2 and p38α/β in tumor quiescence: opportunities to control dormant residual disease. Clin Cancer Res 17:5850-5857, 2011.
    • (2011) Clin Cancer Res , vol.17 , pp. 5850-5857
    • Sosa, M.S.1    Avivar-Valderas, A.2    Bragado, P.3    Wen, H.C.4    Aguirre-Ghiso, J.A.5
  • 59
    • 39749187284 scopus 로고    scopus 로고
    • Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): Multifunctional proteins in cancer
    • Bellahcene A, Castronovo V, Ogbureke KU, Fisher LW and Fedarko NS: Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. Nat Rev Cancer 8:212-216, 2008.
    • (2008) Nat Rev Cancer , vol.8 , pp. 212-216
    • Bellahcene, A.1    Castronovo, V.2    Ogbureke, K.U.3    Fisher, L.W.4    Fedarko, N.S.5
  • 60
    • 0942279599 scopus 로고    scopus 로고
    • Downregulation of osteopontin and bone sialoprotein II is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells
    • Adwan H, Bäuerle TJ and Berger MR: Downregulation of osteopontin and bone sialoprotein II is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells. Cancer Gene Ther 11:109-120, 2004.
    • (2004) Cancer Gene Ther , vol.11 , pp. 109-120
    • Adwan, H.1    Bäuerle, T.J.2    Berger, M.R.3
  • 61
    • 17844383523 scopus 로고    scopus 로고
    • Characterization of a rat model with site-specific bone metastasis induced by MDA-MB-231 breast cancer cells and its application to the effects of an antibody against bone sialoprotein
    • Bäuerle T, Adwan H, Kiessling F, Hilbig H, Armbruster FP and Berger MR: Characterization of a rat model with site-specific bone metastasis induced by MDA-MB-231 breast cancer cells and its application to the effects of an antibody against bone sialoprotein. Int J Cancer 115:177-186, 2005.
    • (2005) Int J Cancer , vol.115 , pp. 177-186
    • Bäuerle, T.1    Adwan, H.2    Kiessling, F.3    Hilbig, H.4    Armbruster, F.P.5    Berger, M.R.6
  • 63
    • 84931061995 scopus 로고    scopus 로고
    • Osteoprotogerin in breast cancer: Beyond bone remodelling
    • Weichhaus M, Chung ST and Connelly L: Osteoprotogerin in breast cancer: beyond bone remodelling. Mol Cancer 14:117, 2015.
    • (2015) Mol Cancer , vol.14 , pp. 117
    • Weichhaus, M.1    Chung, S.T.2    Connelly, L.3
  • 66
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161-174, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 67
    • 0033557316 scopus 로고    scopus 로고
    • Bone resorption induced by parathyroid hormone is strikingly diminished in collgenase-resistant mutant mice
    • Zhao W, Byrne MH, Boyce BF and Krane SM: Bone resorption induced by parathyroid hormone is strikingly diminished in collgenase-resistant mutant mice. J Clin Invest 103:517-524, 1999.
    • (1999) J Clin Invest , vol.103 , pp. 517-524
    • Zhao, W.1    Byrne, M.H.2    Boyce, B.F.3    Krane, S.M.4
  • 68
    • 0029877965 scopus 로고    scopus 로고
    • Mathieu-Costello O and Hammond HK: Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart
    • Giordano FJ, Ping P, McKirnan MD, Nozaki S, DeMaria AN, Dillmann WH, Mathieu-Costello O and Hammond HK: Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat Med 2:534-539, 1996.
    • (1996) Nat Med , vol.2 , pp. 534-539
    • Giordano, F.J.1    Ping, P.2    McKirnan, M.D.3    Nozaki, S.4    DeMaria, A.N.5    Dillmann, W.H.6
  • 69
    • 0033813903 scopus 로고    scopus 로고
    • Connective tissue growth factor: What's in a name?
    • Moussad EE and Brigstock DR: Connective tissue growth factor: what's in a name? Mol Genet Metab 71:276-292, 2000.
    • (2000) Mol Genet Metab , vol.71 , pp. 276-292
    • Moussad, E.E.1    Brigstock, D.R.2
  • 70
    • 0029166052 scopus 로고
    • Role of cytokines in bone resorption
    • Manolagas SC: Role of cytokines in bone resorption. Bone 17:63S-67S, 1995.
    • (1995) Bone , vol.17 , pp. 63S-67S
    • Manolagas, S.C.1
  • 72
    • 84942892113 scopus 로고    scopus 로고
    • ITGBL1 is a Runx2 transcriptional target and promotes breast cancer bone metastasis by activating the TGF-β signalling pathway
    • Li XQ, Du X, Li DM, Kong PZ, Sun Y, Liu PF, Wang QS and Feng YM: ITGBL1 is a Runx2 transcriptional target and promotes breast cancer bone metastasis by activating the TGF-β signalling pathway. Cancer Res 75:3302-3313, 2015.
    • (2015) Cancer Res , vol.75 , pp. 3302-3313
    • Li, X.Q.1    Du, X.2    Li, D.M.3    Kong, P.Z.4    Sun, Y.5    Liu, P.F.6    Wang, Q.S.7    Feng, Y.M.8
  • 73
    • 0033106290 scopus 로고    scopus 로고
    • Cloning and characterization of a novel beta integrin-related cDNA coding for the protein TIED ("ten beta integrin EGF-like repeat domains") that maps to chromosome band 13q33: A divergent stand-alone integrin stalk structure
    • Berg RW, Leung E, Gough S, Morris C, Yao WP, Wang SX, Ni J and Krissansen GW: Cloning and characterization of a novel beta integrin-related cDNA coding for the protein TIED ("ten beta integrin EGF-like repeat domains") that maps to chromosome band 13q33: A divergent stand-alone integrin stalk structure. Genomics 56:169-178, 1999.
    • (1999) Genomics , vol.56 , pp. 169-178
    • Berg, R.W.1    Leung, E.2    Gough, S.3    Morris, C.4    Yao, W.P.5    Wang, S.X.6    Ni, J.7    Krissansen, G.W.8
  • 75
    • 33846058844 scopus 로고    scopus 로고
    • The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis
    • Wang J, Loberg R and Taichman RS: The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis. Cancer Metastasis Rev 25:573-587, 2006.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 573-587
    • Wang, J.1    Loberg, R.2    Taichman, R.S.3
  • 76
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment
    • Burger JA and Kipps TJ: CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107:1761-1767, 2006.
    • (2006) Blood , vol.107 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 81
    • 33845769269 scopus 로고    scopus 로고
    • Expression and activation of alpa v beta 3 integrins by SDF1/CXCL12 increases the aggressiveness of prostate cancer cells
    • Sun YX, Fang M, Wang J, Cooper CR, Pienta KJ and Taichman RS: Expression and activation of alpa v beta 3 integrins by SDF1/CXCL12 increases the aggressiveness of prostate cancer cells. Prostate 67:61-73, 2007.
    • (2007) Prostate , vol.67 , pp. 61-73
    • Sun, Y.X.1    Fang, M.2    Wang, J.3    Cooper, C.R.4    Pienta, K.J.5    Taichman, R.S.6
  • 83
    • 29344451650 scopus 로고    scopus 로고
    • CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: The role of the bone microenvironment-associated CXCL12
    • Chinni SR, Sivalogan S, Dong Z, Filho JC, Deng X, Bonfil RD and Cher ML: CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of the bone microenvironment-associated CXCL12. Prostate 66:32-48, 2006.
    • (2006) Prostate , vol.66 , pp. 32-48
    • Chinni, S.R.1    Sivalogan, S.2    Dong, Z.3    Filho, J.C.4    Deng, X.5    Bonfil, R.D.6    Cher, M.L.7
  • 84
    • 24344436325 scopus 로고    scopus 로고
    • Diverse signalling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis
    • Wang J, Wang J, Sun Y, Song W, Nor JE, Wang CY and Taichman RS: Diverse signalling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis. Cell Signal 17:1578-1592, 2005.
    • (2005) Cell Signal , vol.17 , pp. 1578-1592
    • Wang, J.1    Wang, J.2    Sun, Y.3    Song, W.4    Nor, J.E.5    Wang, C.Y.6    Taichman, R.S.7
  • 85
    • 23044472971 scopus 로고    scopus 로고
    • CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation
    • Cabioglu N, Summy J, Miller C, Parikh NU, Sahin AA, Tuzlali S, Pumiglia K, Gallick GE and Price JE: CXCL-12/stromal cell-derived factor-1alpha transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation. Cancer Res 65:6493-6497, 2005.
    • (2005) Cancer Res , vol.65 , pp. 6493-6497
    • Cabioglu, N.1    Summy, J.2    Miller, C.3    Parikh, N.U.4    Sahin, A.A.5    Tuzlali, S.6    Pumiglia, K.7    Gallick, G.E.8    Price, J.E.9
  • 86
    • 84869866890 scopus 로고    scopus 로고
    • MicroRNA and cancer
    • Jansson MD and Lund AH: MicroRNA and cancer. Mol Oncol 6:590-610, 2012.
    • (2012) Mol Oncol , vol.6 , pp. 590-610
    • Jansson, M.D.1    Lund, A.H.2
  • 92
    • 84889050270 scopus 로고    scopus 로고
    • Targeting breast cancer osteomimetic genes by microRNAs-30 decreases the formation of metastatic osteolytic lesions in mice
    • Croset M, Bachelier R, Allioli N, Song SS, Agami R and Clezardin P: Targeting breast cancer osteomimetic genes by microRNAs-30 decreases the formation of metastatic osteolytic lesions in mice. Bull Cancer 98:S29-S30, 2011.
    • (2011) Bull Cancer , vol.98 , pp. S29-S30
    • Croset, M.1    Bachelier, R.2    Allioli, N.3    Song, S.S.4    Agami, R.5    Clezardin, P.6
  • 93
    • 84863263055 scopus 로고    scopus 로고
    • MiR-30 family members negatively regulate osteoblast differentiation
    • Wu T, Zhou H, Hong Y, Li J, Jiang X and Huang H: MiR-30 family members negatively regulate osteoblast differentiation. J Biol Chem 287:7503-7511, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 7503-7511
    • Wu, T.1    Zhou, H.2    Hong, Y.3    Li, J.4    Jiang, X.5    Huang, H.6
  • 94
    • 84876012965 scopus 로고    scopus 로고
    • MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein
    • Kuo PL, Liao SH, Hung JY, Huang MS and Hsu YL: MicroRNA-33a functions as a bone metastasis suppressor in lung cancer by targeting parathyroid hormone related protein. Biochim Biophys Acta 1830:3756-3766, 2013.
    • (2013) Biochim Biophys Acta , vol.1830 , pp. 3756-3766
    • Kuo, P.L.1    Liao, S.H.2    Hung, J.Y.3    Huang, M.S.4    Hsu, Y.L.5
  • 95
    • 84885065624 scopus 로고    scopus 로고
    • First microRNA mimic enters clinic
    • Bouchie A: First microRNA mimic enters clinic. Nat Biotechnol 31:577, 2013.
    • (2013) Nat Biotechnol , vol.31 , pp. 577
    • Bouchie, A.1
  • 96
    • 85011669516 scopus 로고    scopus 로고
    • Treatment and prevention of bone metastasis from breast cancer: A comprehensive review of evidence for clinical practice
    • Li BT, Wong MH and Pavlakis N: Treatment and prevention of bone metastasis from breast cancer: A comprehensive review of evidence for clinical practice. J Clin Med 3:1-24, 2014.
    • (2014) J Clin Med , vol.3 , pp. 1-24
    • Li, B.T.1    Wong, M.H.2    Pavlakis, N.3
  • 97
    • 84872181358 scopus 로고    scopus 로고
    • Optimal management of bone metastases in breast cancer patients
    • Wong M and Pavlakis N: Optimal management of bone metastases in breast cancer patients. Breast Cancer 3:35-60, 2011.
    • (2011) Breast Cancer , vol.3 , pp. 35-60
    • Wong, M.1    Pavlakis, N.2
  • 98
    • 0035460134 scopus 로고    scopus 로고
    • The molecular mechanism of action of the antiresorptive and anti-inflammatory drug clodrante: Evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis
    • Frith JC, Mönkkönen J, Auriola S, Mönkkönen H and Rogers MJ: The molecular mechanism of action of the antiresorptive and anti-inflammatory drug clodrante: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis. Arthritis Rheum 44:2201-2210, 2001.
    • (2001) Arthritis Rheum , vol.44 , pp. 2201-2210
    • Frith, J.C.1    Mönkkönen, J.2    Auriola, S.3    Mönkkönen, H.4    Rogers, M.J.5
  • 99
    • 79958695940 scopus 로고    scopus 로고
    • Bisphosphonates: The first 40 years
    • Russell RG: Bisphosphonates: the first 40 years. Bone 49:2-19, 2011.
    • (2011) Bone , vol.49 , pp. 2-19
    • Russell, R.G.1
  • 100
    • 84896920836 scopus 로고    scopus 로고
    • Medical treatment of breast cancer bone metastasis: From bisphosphonates to targeted drugs
    • Erdogan B and Cicin I: Medical treatment of breast cancer bone metastasis: from bisphosphonates to targeted drugs. Asian Pac J Cancer Prev 15:1503-1510, 2014.
    • (2014) Asian Pac J Cancer Prev , vol.15 , pp. 1503-1510
    • Erdogan, B.1    Cicin, I.2
  • 101
    • 79551534789 scopus 로고    scopus 로고
    • Denosumab in breast cancer
    • Lipton A: Denosumab in breast cancer. Curr Oncol Rep 13:1-4, 2011.
    • (2011) Curr Oncol Rep , vol.13 , pp. 1-4
    • Lipton, A.1
  • 103
    • 24644479228 scopus 로고    scopus 로고
    • Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid
    • Coleman RE, Major P, Lipton A, Brown JE, Lee KA, Smith M, Saad F, Zheng M, Hei YJ, Seaman J and Cook R: Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid. J Clin Oncol 23:4925-4935, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 4925-4935
    • Coleman, R.E.1    Major, P.2    Lipton, A.3    Brown, J.E.4    Lee, K.A.5    Smith, M.6    Saad, F.7    Zheng, M.8    Hei, Y.J.9    Seaman, J.10    Cook, R.11
  • 104
    • 77955708280 scopus 로고    scopus 로고
    • Combining Src inhibitors and aromatase inhibitors: A novel strategy for overcoming endocrine resistance and bone loss
    • Hiscox S, Barrett-Lee P, Borley AC and Nicholson RI: Combining Src inhibitors and aromatase inhibitors: a novel strategy for overcoming endocrine resistance and bone loss. Eur J Cancer 46:2187-2195, 2010.
    • (2010) Eur J Cancer , vol.46 , pp. 2187-2195
    • Hiscox, S.1    Barrett-Lee, P.2    Borley, A.C.3    Nicholson, R.I.4
  • 105
    • 84858081400 scopus 로고    scopus 로고
    • Effects of Src kinase inhibition by saracatinib (AZD0530) on bone turnover in advanced malignancy in a Phase I study
    • Hannon RA, Finkelman RD, Clack G, Iacona RB, Rimmer M, Gossiel F, Baselga J and Easell R: Effects of Src kinase inhibition by saracatinib (AZD0530) on bone turnover in advanced malignancy in a Phase I study. Bone 50:885-892, 2012.
    • (2012) Bone , vol.50 , pp. 885-892
    • Hannon, R.A.1    Finkelman, R.D.2    Clack, G.3    Iacona, R.B.4    Rimmer, M.5    Gossiel, F.6    Baselga, J.7    Easell, R.8
  • 106
    • 84899466947 scopus 로고    scopus 로고
    • Reducing bone resorption by cathepsin K inhibitor and treatment of osteoporosis
    • Watanabe R and Okazaki R: Reducing bone resorption by cathepsin K inhibitor and treatment of osteoporosis. Clin Calcium 24:59-67, 2014.
    • (2014) Clin Calcium , vol.24 , pp. 59-67
    • Watanabe, R.1    Okazaki, R.2
  • 110
    • 84906934662 scopus 로고    scopus 로고
    • Tumor-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
    • Kir S, White JP, Kleiner S, Kazak L, Cohen P, Baracos VE and Spiegelman B: Tumor-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature 513:100-104, 2014.
    • (2014) Nature , vol.513 , pp. 100-104
    • Kir, S.1    White, J.P.2    Kleiner, S.3    Kazak, L.4    Cohen, P.5    Baracos, V.E.6    Spiegelman, B.7


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