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Volumn 103, Issue 4, 1999, Pages 517-524

Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; COLLAGEN TYPE 1; COLLAGENASE; PARATHYROID HORMONE;

EID: 0033557316     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5481     Document Type: Article
Times cited : (182)

References (54)
  • 1
    • 0002304218 scopus 로고    scopus 로고
    • Parathyroid hormone and parathyroid hormone-related peptide in calcium homeostasis, bone metabolism, and bone development: The proteins, their genes, and receptors
    • LV. Avioli and S.M. Krane, editors. Academic Press. San Diego, CA
    • Potts, J.T., Jr., and Jüppner, H. 1997. Parathyroid hormone and parathyroid hormone-related peptide in calcium homeostasis, bone metabolism, and bone development: the proteins, their genes, and receptors. In Metabolic bone disease and clinically related disorders. LV. Avioli and S.M. Krane, editors. Academic Press. San Diego, CA. 51-94.
    • (1997) Metabolic Bone Disease and Clinically Related Disorders , pp. 51-94
    • Potts J.T., Jr.1    Jüppner, H.2
  • 2
    • 85003152202 scopus 로고
    • Modulation of osteoclast differentiation
    • Suda, T., Takahashi, N., and Martin, T.J. 1992. Modulation of osteoclast differentiation. Endocr. Rev. 13:66-80.
    • (1992) Endocr. Rev. , vol.13 , pp. 66-80
    • Suda, T.1    Takahashi, N.2    Martin, T.J.3
  • 3
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotogerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    • Yasuda, H., et al. 1998. Osteoclast differentiation factor is a ligand for osteoprotogerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL Proc. Natl. Acad. Sci. USA. 95:3597-3602.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3597-3602
    • Yasuda, H.1
  • 4
    • 0345935809 scopus 로고
    • Collagenolytic activity in amphibian tissues: A tissue culture assay
    • Gross, J., and Lapière, C.M. 1962. Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc. Natl. Acad. Sci. USA. 48:1014-1022.
    • (1962) Proc. Natl. Acad. Sci. USA , vol.48 , pp. 1014-1022
    • Gross, J.1    Lapière, C.M.2
  • 5
    • 0007683531 scopus 로고
    • A collagenolytic factor in rat bone promoted by parathyroid extract
    • Walker, D.G., Lapière, C.M., and Gross, J. 1964. A collagenolytic factor in rat bone promoted by parathyroid extract. Biochem. Biophys. Res. Commun. 15:397-402.
    • (1964) Biochem. Biophys. Res. Commun. , vol.15 , pp. 397-402
    • Walker, D.G.1    Lapière, C.M.2    Gross, J.3
  • 6
    • 84996085990 scopus 로고
    • Skeletal remodeling and metabolic bone disease
    • R. V. Talmage, M. Owen, and J.A. Parsons, editors. Excerpta Medica. Amsterdam, The Netherlands
    • Krane, S.M. 1975. Skeletal remodeling and metabolic bone disease. In Calcium-regulating hormones. R. V. Talmage, M. Owen, and J.A. Parsons, editors. Excerpta Medica. Amsterdam, The Netherlands. 57-65.
    • (1975) Calcium-regulating Hormones , pp. 57-65
    • Krane, S.M.1
  • 7
    • 0344974207 scopus 로고
    • Actinomycin D and the response to parathyroid hormone
    • Rasmussen, H., Arnaud, C., and Hawker, C. 1964. Actinomycin D and the response to parathyroid hormone. Science. 144:1019-1021.
    • (1964) Science , vol.144 , pp. 1019-1021
    • Rasmussen, H.1    Arnaud, C.2    Hawker, C.3
  • 8
    • 0013773980 scopus 로고
    • Mechanism of parathyroid hormone action. Effects of actinomycin D on hormone-stimulated ion movement in vivo and in vitro
    • Tashjian, A.M., Jr., Ontjes, D.A., and Goodfriend, T.L. 1964. Mechanism of parathyroid hormone action. Effects of actinomycin D on hormone-stimulated ion movement in vivo and in vitro. Biochem. Biophys. Res. Commun. 16:209-215.
    • (1964) Biochem. Biophys. Res. Commun. , vol.16 , pp. 209-215
    • Tashjian A.M., Jr.1    Ontjes, D.A.2    Goodfriend, T.L.3
  • 9
    • 0344973147 scopus 로고
    • Inhibition by puromycin of the calcium-mobilizing activity of parathyroid extract
    • Kunin, A.S., and Krane, S.M. 1965. Inhibition by puromycin of the calcium-mobilizing activity of parathyroid extract. Endocrinology. 76:343-344.
    • (1965) Endocrinology , vol.76 , pp. 343-344
    • Kunin, A.S.1    Krane, S.M.2
  • 10
    • 0016661019 scopus 로고
    • Collagenase and bone resorption: Isolation of collagenase from culture medium containing serum after stimulation of bone resorption by addition of parathyroid hormone extract
    • Sakamoto, S., Sakamoto, M., Goldhaber, P., and Glimcher, M.J. 1975. Collagenase and bone resorption: isolation of collagenase from culture medium containing serum after stimulation of bone resorption by addition of parathyroid hormone extract. Biochem. Biophys. Res. Commun. 63:172-178.
    • (1975) Biochem. Biophys. Res. Commun. , vol.63 , pp. 172-178
    • Sakamoto, S.1    Sakamoto, M.2    Goldhaber, P.3    Glimcher, M.J.4
  • 12
    • 0018104570 scopus 로고
    • Mouse bone collagenase. Purification of the enzyme by heparin-substituted Sepharose-4B affinity chromatography and preparation of specific antibody to the enzyme
    • Sakamoto, S., Sakamoto, M., Goldhaber, P., and Glimcher, M.J. 1978. Mouse bone collagenase. Purification of the enzyme by heparin-substituted Sepharose-4B affinity chromatography and preparation of specific antibody to the enzyme. Arch. Biochem. Biophys. 188:438-449.
    • (1978) Arch. Biochem. Biophys. , vol.188 , pp. 438-449
    • Sakamoto, S.1    Sakamoto, M.2    Goldhaber, P.3    Glimcher, M.J.4
  • 13
    • 0344973146 scopus 로고
    • Evidence that collagenase is involved in the mechanisms of bone resorption stimulated with parathyroid hormone: A study in two different bone culture systems
    • D.V. Cohn, T. Fujita, J.T. Potts, Jr., and R.V. Talmage, editors. Excerpta Medica. Amsterdam, The Netherlands
    • Sakamoto, S., Sakamoto, M., and Horton, J.E. 1984. Evidence that collagenase is involved in the mechanisms of bone resorption stimulated with parathyroid hormone: a study in two different bone culture systems. In Endocrine control of bone and calcium metabolism. D.V. Cohn, T. Fujita, J.T. Potts, Jr., and R.V. Talmage, editors. Excerpta Medica. Amsterdam, The Netherlands. 140-143.
    • (1984) Endocrine Control of Bone and Calcium Metabolism , pp. 140-143
    • Sakamoto, S.1    Sakamoto, M.2    Horton, J.E.3
  • 14
    • 0023269833 scopus 로고
    • Hormonal regulation of the production of collagenase and a collagenase inhibitor activity by rat osteogenic sarcoma cells
    • Partridge, N.C., et al. 1987. Hormonal regulation of the production of collagenase and a collagenase inhibitor activity by rat osteogenic sarcoma cells. Endocrinology. 120:1956-1962.
    • (1987) Endocrinology , vol.120 , pp. 1956-1962
    • Partridge, N.C.1
  • 15
    • 0025614357 scopus 로고
    • Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells
    • Quinn, C.O., et al. 1990. Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells. J. Biol Chem. 265:22342-22347.
    • (1990) J. Biol Chem. , vol.265 , pp. 22342-22347
    • Quinn, C.O.1
  • 16
    • 0026722877 scopus 로고
    • Cloning and sequencing of mouse collagenase cDNA. Divergence of mouse and rat collagenases from the other mammalian collagenases
    • Henriet, P., Rousseau, G.G., and Eeckhout, Y. 1992. Cloning and sequencing of mouse collagenase cDNA. Divergence of mouse and rat collagenases from the other mammalian collagenases. FEBS Lett. 310:175-178.
    • (1992) FEBS Lett. , vol.310 , pp. 175-178
    • Henriet, P.1    Rousseau, G.G.2    Eeckhout, Y.3
  • 17
    • 0028322352 scopus 로고
    • Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas
    • Freije, J.M.P., et al. 1994. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J. Biol. Chem. 269:16766-16773.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16766-16773
    • Freije, J.M.P.1
  • 18
    • 0028223234 scopus 로고
    • High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development
    • Reporten, P., Sahlberg, C., Munaut, C., Thesleff, I., and Tryggvason, K. 1994. High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development. J. Cell Biol. 124:1091-1102.
    • (1994) J. Cell Biol. , vol.124 , pp. 1091-1102
    • Reporten, P.1    Sahlberg, C.2    Munaut, C.3    Thesleff, I.4    Tryggvason, K.5
  • 19
    • 0343554712 scopus 로고    scopus 로고
    • Identification of the membrane-type matrix metalloproteinase MTI-MMP in osteoclasts
    • Sato, T., et al. 1997. Identification of the membrane-type matrix metalloproteinase MTI-MMP in osteoclasts. J. Cell Sci. 110:589-596.
    • (1997) J. Cell Sci. , vol.110 , pp. 589-596
    • Sato, T.1
  • 20
    • 0027731213 scopus 로고
    • (Pro)collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment
    • Delaissé, J.M., et al. 1993. (Pro)collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment. J. Cell Sci. 106:1071-1082.
    • (1993) J. Cell Sci. , vol.106 , pp. 1071-1082
    • Delaissé, J.M.1
  • 21
    • 0027055233 scopus 로고
    • Parathyroid hormone induces transcription of collagenase in rat osteoblastic cells by a mechanism using cyclic adenosine 3′,5′-monophosphate and requiring protein synthesis
    • Scott, D.K., Brakenhoff, K.D., Clohisy, J.C., Quinn, C.O., and Partridge, N.C. 1992. Parathyroid hormone induces transcription of collagenase in rat osteoblastic cells by a mechanism using cyclic adenosine 3′,5′-monophosphate and requiring protein synthesis. Mol. Endocrinol. 6:2153-2159.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 2153-2159
    • Scott, D.K.1    Brakenhoff, K.D.2    Clohisy, J.C.3    Quinn, C.O.4    Partridge, N.C.5
  • 22
    • 0028925605 scopus 로고
    • Expression of interstitial collagenase is restricted to skeletal tissue during mouse embryogenesis
    • Mattot, V., et al. 1995. Expression of interstitial collagenase is restricted to skeletal tissue during mouse embryogenesis. J. Cell Sci. 108:529-535.
    • (1995) J. Cell Sci. , vol.108 , pp. 529-535
    • Mattot, V.1
  • 23
    • 0029010425 scopus 로고
    • Localisation of mRNA for collagenase in osteocytic, bone surface and chondrocytic cells bur not osteoclasts
    • Fuller, K., and Chambers, T.J. 1995. Localisation of mRNA for collagenase in osteocytic, bone surface and chondrocytic cells bur not osteoclasts. J. Cell Sci. 108:2221-2230.
    • (1995) J. Cell Sci. , vol.108 , pp. 2221-2230
    • Fuller, K.1    Chambers, T.J.2
  • 24
    • 0029063214 scopus 로고
    • Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes
    • Gack, S., et al. 1995. Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes. Cell Growth Differ. 6:759-767.
    • (1995) Cell Growth Differ. , vol.6 , pp. 759-767
    • Gack, S.1
  • 25
    • 0027080592 scopus 로고
    • Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines
    • Meikle, M.C., et al. 1991. Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines. J. Cell Sci. 103:1093-1099.
    • (1991) J. Cell Sci. , vol.103 , pp. 1093-1099
    • Meikle, M.C.1
  • 26
    • 0031785284 scopus 로고    scopus 로고
    • The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone
    • Lanske, B., et al. 1998. The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology. 139:5194-5204.
    • (1998) Endocrinology , vol.139 , pp. 5194-5204
    • Lanske, B.1
  • 27
    • 9344241375 scopus 로고    scopus 로고
    • PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth
    • Lanske, B., et al. 1996. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science. 273:663-666.
    • (1996) Science , vol.273 , pp. 663-666
    • Lanske, B.1
  • 28
    • 0022259759 scopus 로고
    • Mammalian collagenase predisposes bone surfaces to osteoclastic resorption
    • Chambers, T.J., Darby, J.A., and Fuller, K. 1985. Mammalian collagenase predisposes bone surfaces to osteoclastic resorption. Cell Tissue Res. 421:671-675.
    • (1985) Cell Tissue Res. , vol.421 , pp. 671-675
    • Chambers, T.J.1    Darby, J.A.2    Fuller, K.3
  • 29
    • 0025333287 scopus 로고
    • Generation of collagenase-resistant collagen by site-directed mutagenesis of murine proα1(I) collagen gene
    • Wu, H., et al. 1990. Generation of collagenase-resistant collagen by site-directed mutagenesis of murine proα1(I) collagen gene. Proc. Natl. Acad. Sci. USA. 87:5888-5892.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 5888-5892
    • Wu, H.1
  • 30
    • 0029002420 scopus 로고
    • A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling
    • Liu, X., et al. 1995. A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. J. Cell Biol. 130:227-237.
    • (1995) J. Cell Biol. , vol.130 , pp. 227-237
    • Liu, X.1
  • 32
    • 0023871244 scopus 로고
    • Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents
    • Yates, A.J.P., et al. 1988. Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents. J. Clin. Invest. 81:932-938.
    • (1988) J. Clin. Invest. , vol.81 , pp. 932-938
    • Yates, A.J.P.1
  • 33
    • 0032055157 scopus 로고    scopus 로고
    • Isolation and characterization of the cDNA formouse neutrophil collagenase: Demonstration of shared negative regulatory pathways for neutrophil secondary granule protein gene expression
    • Lawson, N.D., Khanna-Gupta, A., and Berliner, N. 1998. Isolation and characterization of the cDNA formouse neutrophil collagenase: demonstration of shared negative regulatory pathways for neutrophil secondary granule protein gene expression. Blood. 91:2517-2524.
    • (1998) Blood , vol.91 , pp. 2517-2524
    • Lawson, N.D.1    Khanna-Gupta, A.2    Berliner, N.3
  • 34
    • 0003005424 scopus 로고
    • An essay on biological degradation of collagen
    • E.D. Hay, editor. Plenum Press. New York, NY
    • Gross, J. 1981. An essay on biological degradation of collagen. In Cell biology of the extracellular matrix. E.D. Hay, editor. Plenum Press. New York, NY. 217-258.
    • (1981) Cell Biology of the Extracellular Matrix , pp. 217-258
    • Gross, J.1
  • 36
    • 10344231985 scopus 로고    scopus 로고
    • Different collagenase gene products have different roles in degradation of type 1 collagen
    • Krane, S.M., et al. 1996. Different collagenase gene products have different roles in degradation of type 1 collagen. J. Biol. Chem. 271:28509-28515.
    • (1996) J. Biol. Chem. , vol.271 , pp. 28509-28515
    • Krane, S.M.1
  • 37
    • 0027520745 scopus 로고
    • Extracellular-matrix degradation at acid pH. Avian osteoclast acid collagenase isolation and characterization
    • Blair, H.C., et al. 1993. Extracellular-matrix degradation at acid pH. Avian osteoclast acid collagenase isolation and characterization. Biochem. J. 290:873-884.
    • (1993) Biochem. J. , vol.290 , pp. 873-884
    • Blair, H.C.1
  • 38
    • 0002889277 scopus 로고
    • Degradation of collagen by non-specific proteinases
    • A.J. Barrett, editor. Elsevier Science. Amsterdam, The Netherlands
    • Burleigh, M.C. 1977. Degradation of collagen by non-specific proteinases. In Proteinases in mammalian cells and tissues. A.J. Barrett, editor. Elsevier Science. Amsterdam, The Netherlands. 285-309.
    • (1977) Proteinases in Mammalian Cells and Tissues , pp. 285-309
    • Burleigh, M.C.1
  • 39
    • 15844422855 scopus 로고    scopus 로고
    • Cathepsin K, but not cathepsin B, L, or S, is abundantly expressed in human osteoclasts
    • Drake, F.H., et al. 1996. Cathepsin K, but not cathepsin B, L, or S, is abundantly expressed in human osteoclasts. J. Biol. Chem. 271:12511-12516.
    • (1996) J. Biol. Chem. , vol.271 , pp. 12511-12516
    • Drake, F.H.1
  • 40
    • 15844397808 scopus 로고    scopus 로고
    • Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification
    • Bossard, M.J., et al. 1996. Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification. J. Biol. Chem. 271:12517-12524.
    • (1996) J. Biol. Chem. , vol.271 , pp. 12517-12524
    • Bossard, M.J.1
  • 41
    • 1542792345 scopus 로고
    • Modulation of type β transforming growth factor activity in bone cultures by osteotropic hormones
    • Pfeilschifter, J., and Mundy, G.R. 1987. Modulation of type β transforming growth factor activity in bone cultures by osteotropic hormones. Proc. Natl. Acad. Sci. USA. 84:2024-2028.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 2024-2028
    • Pfeilschifter, J.1    Mundy, G.R.2
  • 42
    • 0031046958 scopus 로고    scopus 로고
    • Effects of retinol on activation of latenct transforming growth factor-β by isolated osteoclasts
    • Bonewald, L.F., et al. 1997. Effects of retinol on activation of latenct transforming growth factor-β by isolated osteoclasts. Endocrinology. 138:657-666.
    • (1997) Endocrinology , vol.138 , pp. 657-666
    • Bonewald, L.F.1
  • 43
    • 0029133135 scopus 로고
    • Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
    • Hughes, D.E., et al. 1995. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J. Bone Miner. Res. 10:1478-1487.
    • (1995) J. Bone Miner. Res. , vol.10 , pp. 1478-1487
    • Hughes, D.E.1
  • 44
    • 0029798819 scopus 로고    scopus 로고
    • Estiogen promotes apoptosis of murine osteoclasts mediated by TGF-β
    • Hughes, D.E., et al. 1996. Estiogen promotes apoptosis of murine osteoclasts mediated by TGF-β. Nat. Med. 2:1132-1136.
    • (1996) Nat. Med. , vol.2 , pp. 1132-1136
    • Hughes, D.E.1
  • 45
    • 0030722948 scopus 로고    scopus 로고
    • Apoptosis in bone physiology and disease
    • Hughes, D.E., and Boyce, B.F. 1997. Apoptosis in bone physiology and disease. Mol. Pathol. 50:132-137.
    • (1997) Mol. Pathol. , vol.50 , pp. 132-137
    • Hughes, D.E.1    Boyce, B.F.2
  • 47
    • 0030949650 scopus 로고    scopus 로고
    • The activity of collagenase-1 is required for keratinocyte migration on type I collagen matrix
    • Pilcher, B.K., et al. 1997. The activity of collagenase-1 is required for keratinocyte migration on type I collagen matrix. J. Cell Biol. 137:1445-1457.
    • (1997) J. Cell Biol. , vol.137 , pp. 1445-1457
    • Pilcher, B.K.1
  • 48
    • 0028670298 scopus 로고
    • Integrin αvβ3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen
    • Montgomery, A.M.P., Reisfeld, R.A., and Cheresh, D.A. 1994. Integrin αvβ3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc. Natl. Acad. Sci. USA. 91:8856-8860.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8856-8860
    • Montgomery, A.M.P.1    Reisfeld, R.A.2    Cheresh, D.A.3
  • 49
    • 15844420283 scopus 로고    scopus 로고
    • Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3
    • Brooks, P.C., et al. 1996. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3. Cell. 85:683-693.
    • (1996) Cell , vol.85 , pp. 683-693
    • Brooks, P.C.1
  • 51
    • 0030272585 scopus 로고    scopus 로고
    • β1 integrins and osteoclast function: Involvement in collagen recognition and bone resorption
    • Helfrich, M., et al. 1996. β1 integrins and osteoclast function: involvement in collagen recognition and bone resorption. Bone. 19:317-328.
    • (1996) Bone , vol.19 , pp. 317-328
    • Helfrich, M.1
  • 52
    • 0030832038 scopus 로고    scopus 로고
    • Initiation of osteoclastic bone resorption by interstitial collagenase
    • Holliday, L.S., et al. 1997. Initiation of osteoclastic bone resorption by interstitial collagenase. J. Biol. Chem. 272:22053-22058.
    • (1997) J. Biol. Chem. , vol.272 , pp. 22053-22058
    • Holliday, L.S.1
  • 53
    • 0030924375 scopus 로고    scopus 로고
    • A peptidomimetic antagonist of the αvβ3 integrin inhibits bone resorption and prevents osteoporosis in vivo
    • Engleman, V.W., et al. 1997. A peptidomimetic antagonist of the αvβ3 integrin inhibits bone resorption and prevents osteoporosis in vivo. J. Clin. Invest. 99:2284-2292.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2284-2292
    • Engleman, V.W.1
  • 54
    • 85038195232 scopus 로고    scopus 로고
    • Phosphatidyl inositol 3-kinase activity is required for bone resorption and osteoclast survival in vitro
    • Abstr.
    • Rani, S., Xing, L., Chen, H., Dai, A., and Boyce, B.F. 1997. Phosphatidyl inositol 3-kinase activity is required for bone resorption and osteoclast survival in vitro. J. Bone Miner. Res. 12:S420. (Abstr.)
    • (1997) J. Bone Miner. Res. , vol.12
    • Rani, S.1    Xing, L.2    Chen, H.3    Dai, A.4    Boyce, B.F.5


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