메뉴 건너뛰기




Volumn 75, Issue 16, 2015, Pages 3302-3313

ITGBL1 is a Runx2 transcriptional target and promotes breast cancer bone metastasis by activating the TGFβ signaling pathway

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN BETA LIKE 1; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; TUMOR PROTEIN; UNCLASSIFIED DRUG; BETA1 INTEGRIN; ITGBL1 PROTEIN, HUMAN;

EID: 84942892113     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-0240     Document Type: Article
Times cited : (98)

References (42)
  • 1
    • 79751472667 scopus 로고    scopus 로고
    • Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells
    • Sethi N, Dai X, Winter CG, Kang Y. Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell 2011;19:192-205.
    • (2011) Cancer Cell , vol.19 , pp. 192-205
    • Sethi, N.1    Dai, X.2    Winter, C.G.3    Kang, Y.4
  • 2
    • 80052213519 scopus 로고    scopus 로고
    • Dual function of ERRalpha in breast cancer and bone metastasis formation: Implication of VEGF and osteoprotegerin
    • Fradet A, Sorel H, Bouazza L, Goehrig D, Depalle B, Bellahcene A, et al. Dual function of ERRalpha in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerin. Cancer Res 2011;71:5728-38.
    • (2011) Cancer Res , vol.71 , pp. 5728-5738
    • Fradet, A.1    Sorel, H.2    Bouazza, L.3    Goehrig, D.4    Depalle, B.5    Bellahcene, A.6
  • 3
    • 0033106290 scopus 로고    scopus 로고
    • Cloning and characterization of a novel beta integrin-related cDNA coding for the protein TIED ("ten beta integrin EGF-like repeat domains") that maps to chromosome band 13q33: A divergent stand-alone integrin stalk structure
    • Berg RW, Leung E, Gough S, Morris C, Yao WP, Wang SX, et al. Cloning and characterization of a novel beta integrin-related cDNA coding for the protein TIED ("ten beta integrin EGF-like repeat domains") that maps to chromosome band 13q33: a divergent stand-alone integrin stalk structure. Genomics 1999;56:169-78.
    • (1999) Genomics , vol.56 , pp. 169-178
    • Berg, R.W.1    Leung, E.2    Gough, S.3    Morris, C.4    Yao, W.P.5    Wang, S.X.6
  • 4
    • 0035949665 scopus 로고    scopus 로고
    • Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits
    • Takagi J, Beglova N, Yalamanchili P, Blacklow SC, Springer TA. Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits. Proc Natl Acad Sci U S A 2001;98:11175-80.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11175-11180
    • Takagi, J.1    Beglova, N.2    Yalamanchili, P.3    Blacklow, S.C.4    Springer, T.A.5
  • 7
    • 0037441529 scopus 로고    scopus 로고
    • Regulation of the osteoblast-specific transcription factor, runx2: Responsiveness to multiple signal transduction pathways
    • Franceschi RT, Xiao G. Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways. J Cell Biochem 2003;88:446-54.
    • (2003) J Cell Biochem , vol.88 , pp. 446-454
    • Franceschi, R.T.1    Xiao, G.2
  • 9
    • 3042825286 scopus 로고    scopus 로고
    • Fidelity of runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease
    • Barnes GL, Hebert KE, Kamal M, Javed A, Einhorn TA, Lian JB, et al. Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease. Cancer Res 2004;64:4506-13.
    • (2004) Cancer Res , vol.64 , pp. 4506-4513
    • Barnes, G.L.1    Hebert, K.E.2    Kamal, M.3    Javed, A.4    Einhorn, T.A.5    Lian, J.B.6
  • 10
    • 54249097017 scopus 로고    scopus 로고
    • Runx2 transcriptional activation of Indian hedgehog and a downstream bone metastatic pathway in breast cancer cells
    • Pratap J, Wixted JJ, Gaur T, Zaidi SK, Dobson J, Gokul KD, et al. Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. Cancer Res 2008;68: 7795-802.
    • (2008) Cancer Res , vol.68 , pp. 7795-7802
    • Pratap, J.1    Wixted, J.J.2    Gaur, T.3    Zaidi, S.K.4    Dobson, J.5    Gokul, K.D.6
  • 11
    • 17844383523 scopus 로고    scopus 로고
    • Characterization of a rat model with site-specific bone metastasis induced by MDA-MB-231 breast cancer cells and its application to the effects of an antibody against bone sialoprotein
    • Bauerle T, Adwan H, Kiessling F, Hilbig H, Armbruster FP, Berger MR. Characterization of a rat model with site-specific bone metastasis induced by MDA-MB-231 breast cancer cells and its application to the effects of an antibody against bone sialoprotein. Int J Cancer 2005; 115:177-86.
    • (2005) Int J Cancer , vol.115 , pp. 177-186
    • Bauerle, T.1    Adwan, H.2    Kiessling, F.3    Hilbig, H.4    Armbruster, F.P.5    Berger, M.R.6
  • 13
    • 67449123333 scopus 로고    scopus 로고
    • Extracellular engagement of alpha6 integrin inhibited urokinase-type plasminogen activator-mediated cleavage and delayed human prostate bone metastasis
    • Ports MO, Nagle RB, Pond GD, Cress AE. Extracellular engagement of alpha6 integrin inhibited urokinase-type plasminogen activator-mediated cleavage and delayed human prostate bone metastasis. Cancer Res 2009; 69:5007-14.
    • (2009) Cancer Res , vol.69 , pp. 5007-5014
    • Ports, M.O.1    Nagle, R.B.2    Pond, G.D.3    Cress, A.E.4
  • 14
    • 65249133572 scopus 로고    scopus 로고
    • Osteoblastic and osteolytic human osteosarcomas can be studied with a new xenograft mouse model producing spontaneous metastases
    • Yuan J, Ossendorf C, Szatkowski JP, Bronk JT, Maran A, Yaszemski M, et al. Osteoblastic and osteolytic human osteosarcomas can be studied with a new xenograft mouse model producing spontaneous metastases. Cancer Invest 2009;27:435-42.
    • (2009) Cancer Invest , vol.27 , pp. 435-442
    • Yuan, J.1    Ossendorf, C.2    Szatkowski, J.P.3    Bronk, J.T.4    Maran, A.5    Yaszemski, M.6
  • 17
    • 77956643639 scopus 로고    scopus 로고
    • Osteomimicry: How tumor cells try to deceive the bone
    • Rucci N, Teti A. Osteomimicry: how tumor cells try to deceive the bone. Front Biosci 2010;2:907-15.
    • (2010) Front Biosci , vol.2 , pp. 907-915
    • Rucci, N.1    Teti, A.2
  • 18
    • 13844310310 scopus 로고    scopus 로고
    • Geneexpression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    • Wang Y, Klijn JG, Zhang Y, Sieuwerts AM, Look MP, Yang F, et al. Geneexpression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 2005;365:671-9.
    • (2005) Lancet , vol.365 , pp. 671-679
    • Wang, Y.1    Klijn, J.G.2    Zhang, Y.3    Sieuwerts, A.M.4    Look, M.P.5    Yang, F.6
  • 20
    • 67649311599 scopus 로고    scopus 로고
    • Latent bone metastasis in breast cancer tied to src-dependent survival signals
    • Zhang XH, Wang Q, Gerald W, Hudis CA, Norton L, Smid M, et al. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell 2009;16:67-78.
    • (2009) Cancer Cell , vol.16 , pp. 67-78
    • Zhang, X.H.1    Wang, Q.2    Gerald, W.3    Hudis, C.A.4    Norton, L.5    Smid, M.6
  • 23
    • 10844293335 scopus 로고    scopus 로고
    • Role of tumor cell adhesion and migration in organ-specific metastasis formation
    • Gassmann P, Enns A, Haier J. Role of tumor cell adhesion and migration in organ-specific metastasis formation. Onkologie 2004;27:577-82.
    • (2004) Onkologie , vol.27 , pp. 577-582
    • Gassmann, P.1    Enns, A.2    Haier, J.3
  • 24
    • 84880059674 scopus 로고    scopus 로고
    • Cancer stem-like cell marker cd44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production
    • Hiraga T, Ito S, Nakamura H. Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production. Cancer Res 2013;73:4112-22.
    • (2013) Cancer Res , vol.73 , pp. 4112-4122
    • Hiraga, T.1    Ito, S.2    Nakamura, H.3
  • 25
    • 77950882020 scopus 로고    scopus 로고
    • The CXCR4/SDF-1 chemokine axis: A potential therapeutic target for bone metastases?
    • Hirbe AC, Morgan EA, Weilbaecher KN. The CXCR4/SDF-1 chemokine axis: a potential therapeutic target for bone metastases? Curr Pharm Des 2010;16:1284-90.
    • (2010) Curr Pharm Des , vol.16 , pp. 1284-1290
    • Hirbe, A.C.1    Morgan, E.A.2    Weilbaecher, K.N.3
  • 26
    • 84896500413 scopus 로고    scopus 로고
    • Contributions of the host microenvironment to cancer-induced bone disease
    • Olechnowicz SW, Edwards CM. Contributions of the host microenvironment to cancer-induced bone disease. Cancer Res 2014;74:1625-31.
    • (2014) Cancer Res , vol.74 , pp. 1625-1631
    • Olechnowicz, S.W.1    Edwards, C.M.2
  • 27
    • 34250865694 scopus 로고    scopus 로고
    • Tumor alphavbeta3 integrin is a therapeutic target for breast cancer bone metastases
    • Zhao Y, Bachelier R, Treilleux I, Pujuguet P, Peyruchaud O, Baron R, et al. Tumor alphavbeta3 integrin is a therapeutic target for breast cancer bone metastases. Cancer Res 2007;67:5821-30.
    • (2007) Cancer Res , vol.67 , pp. 5821-5830
    • Zhao, Y.1    Bachelier, R.2    Treilleux, I.3    Pujuguet, P.4    Peyruchaud, O.5    Baron, R.6
  • 28
    • 33746513396 scopus 로고    scopus 로고
    • Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone
    • Sloan EK, Pouliot N, Stanley KL, Chia J, Moseley JM, Hards DK, et al. Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone. Breast Cancer Res 2006;8:R20.
    • (2006) Breast Cancer Res , vol.8 , pp. R20
    • Sloan, E.K.1    Pouliot, N.2    Stanley, K.L.3    Chia, J.4    Moseley, J.M.5    Hards, D.K.6
  • 29
    • 3042819503 scopus 로고    scopus 로고
    • Integrin alpha5beta1 promotes survival of growth-arrested breast cancer cells: An in vitro paradigm for breast cancer dormancy in bone marrow
    • Korah R, Boots M, Wieder R. Integrin alpha5beta1 promotes survival of growth-arrested breast cancer cells: an in vitro paradigm for breast cancer dormancy in bone marrow. Cancer Res 2004;64:4514-22.
    • (2004) Cancer Res , vol.64 , pp. 4514-4522
    • Korah, R.1    Boots, M.2    Wieder, R.3
  • 30
    • 58149214627 scopus 로고    scopus 로고
    • Involvement of cell-cell and cell-matrix interactions in bone destruction induced by metastatic MDA-MB-231 human breast cancer cells in nude mice
    • Nakamura H, Hiraga T, Ninomiya T, Hosoya A, Fujisaki N, Yoneda T, et al. Involvement of cell-cell and cell-matrix interactions in bone destruction induced by metastatic MDA-MB-231 human breast cancer cells in nude mice. J Bone Miner Metab 2008;26:642-7.
    • (2008) J Bone Miner Metab , vol.26 , pp. 642-647
    • Nakamura, H.1    Hiraga, T.2    Ninomiya, T.3    Hosoya, A.4    Fujisaki, N.5    Yoneda, T.6
  • 31
    • 83455208311 scopus 로고    scopus 로고
    • VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging alpha4beta1-positive osteoclast progenitors
    • Lu X, Mu E, Wei Y, Riethdorf S, Yang Q, Yuan M, et al. VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging alpha4beta1-positive osteoclast progenitors. Cancer Cell 2011;20:701-14.
    • (2011) Cancer Cell , vol.20 , pp. 701-714
    • Lu, X.1    Mu, E.2    Wei, Y.3    Riethdorf, S.4    Yang, Q.5    Yuan, M.6
  • 32
    • 35548936833 scopus 로고    scopus 로고
    • Models, mechanisms and clinical evidence for cancer dormancy
    • Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 2007;7:834-46.
    • (2007) Nat Rev Cancer , vol.7 , pp. 834-846
    • Aguirre-Ghiso, J.A.1
  • 34
    • 80054833809 scopus 로고    scopus 로고
    • TNFalpha inhibits the development of osteoclasts through osteoblast-derived GM-CSF
    • Atanga E, Dolder S, Dauwalder T, Wetterwald A, Hofstetter W. TNFalpha inhibits the development of osteoclasts through osteoblast-derived GM-CSF. Bone 2011;49:1090-100.
    • (2011) Bone , vol.49 , pp. 1090-1100
    • Atanga, E.1    Dolder, S.2    Dauwalder, T.3    Wetterwald, A.4    Hofstetter, W.5
  • 35
    • 77649221616 scopus 로고    scopus 로고
    • Bioactive lipids lysophosphatidic acid and sphingosine 1-phosphate mediate breast cancer cell biological functions through distinct mechanisms
    • Boucharaba A, Guillet B, Menaa F, Hneino M, van Wijnen AJ, Clezardin P, et al. Bioactive lipids lysophosphatidic acid and sphingosine 1-phosphate mediate breast cancer cell biological functions through distinct mechanisms. Oncol Res 2009;18:173-84.
    • (2009) Oncol Res , vol.18 , pp. 173-184
    • Boucharaba, A.1    Guillet, B.2    Menaa, F.3    Hneino, M.4    Van Wijnen, A.J.5    Clezardin, P.6
  • 36
    • 84866542685 scopus 로고    scopus 로고
    • Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual
    • Bajayo A, Bar A, Denes A, Bachar M, Kram V, Attar-Namdar M, et al. Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual. Proc Natl Acad Sci U S A 2012;109:15455-60.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 15455-15460
    • Bajayo, A.1    Bar, A.2    Denes, A.3    Bachar, M.4    Kram, V.5    Attar-Namdar, M.6
  • 37
    • 84890458624 scopus 로고    scopus 로고
    • Dominant negative MCP-1 blocks human osteoclast differentiation
    • Morrison NA, Day CJ, Nicholson GC. Dominant negative MCP-1 blocks human osteoclast differentiation. J Cell Biochem 2014;115:303-12.
    • (2014) J Cell Biochem , vol.115 , pp. 303-312
    • Morrison, N.A.1    Day, C.J.2    Nicholson, G.C.3
  • 38
    • 78651294044 scopus 로고    scopus 로고
    • The macrophage stimulating protein/Ron pathway as a potential therapeutic target to impede multiple mechanisms involved in breast cancer progression
    • Kretschmann KL, Eyob H, Buys SS, Welm AL. The macrophage stimulating protein/Ron pathway as a potential therapeutic target to impede multiple mechanisms involved in breast cancer progression. Curr Drug Targets 2010;11:1157-68.
    • (2010) Curr Drug Targets , vol.11 , pp. 1157-1168
    • Kretschmann, K.L.1    Eyob, H.2    Buys, S.S.3    Welm, A.L.4
  • 39
    • 27144434594 scopus 로고    scopus 로고
    • A role for runx2 in normal mammary gland and breast cancer bone metastasis
    • Shore P. A role for Runx2 in normal mammary gland and breast cancer bone metastasis. J Cell Biochem 2005;96:484-9.
    • (2005) J Cell Biochem , vol.96 , pp. 484-489
    • Shore, P.1
  • 40
    • 36348941863 scopus 로고    scopus 로고
    • Bone metastasis: Pathogenesis and therapeutic implications
    • Clezardin P, Teti A. Bone metastasis: pathogenesis and therapeutic implications. Clin Exp Metastasis 2007;24:599-608.
    • (2007) Clin Exp Metastasis , vol.24 , pp. 599-608
    • Clezardin, P.1    Teti, A.2
  • 41
    • 77958522312 scopus 로고    scopus 로고
    • Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility
    • Leong DT, Lim J, Goh X, Pratap J, Pereira BP, Kwok HS, et al. Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility. Breast Cancer Res 2010;12:R89.
    • (2010) Breast Cancer Res , vol.12 , pp. R89
    • Leong, D.T.1    Lim, J.2    Goh, X.3    Pratap, J.4    Pereira, B.P.5    Kwok, H.S.6
  • 42
    • 13444306168 scopus 로고    scopus 로고
    • Impaired intranuclear trafficking of runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo
    • Javed A, Barnes GL, Pratap J, Antkowiak T, Gerstenfeld LC, van Wijnen AJ, et al. Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo. Proc Natl Acad Sci U S A 2005;102:1454-9.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1454-1459
    • Javed, A.1    Barnes, G.L.2    Pratap, J.3    Antkowiak, T.4    Gerstenfeld, L.C.5    Van Wijnen, A.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.