메뉴 건너뛰기




Volumn 4, Issue 9, 2012, Pages 861-865

Opportunities and challenges for anti-CD73 cancer therapy

Author keywords

adenosine; CD73; ecto 5 nucleotidase; immunosuppression; microenvironment; tumor

Indexed keywords

5' NUCLEOTIDASE; ADENOSINE A2 RECEPTOR; ADENOSINE PHOSPHATE; CD39 ANTIGEN; DEATH RECEPTOR 5; GAMMA INTERFERON; INTERLEUKIN 1BETA; PROSTAGLANDIN E2; SMALL INTERFERING RNA; TENASCIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84867351931     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.12.83     Document Type: Review
Times cited : (18)

References (54)
  • 2
    • 0030785819 scopus 로고    scopus 로고
    • The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine
    • Blay J, White TD, Hoskin DW. The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. Cancer Res. 57, 2602-2605 (1997). (Pubitemid 27283766)
    • (1997) Cancer Research , vol.57 , Issue.13 , pp. 2602-2605
    • Blay, J.1    White, T.D.2    Hoskin, D.W.3
  • 3
    • 0031933227 scopus 로고    scopus 로고
    • Ecto-enzyme and signaling functions of lymphocyte CD73
    • Resta R, Yamashita Y, Thompson LF. Ecto-enzyme and signaling functions of lymphocyte CD73. Immunol. Rev. 161, 95-109 (1998).
    • (1998) Immunol. Rev. , vol.161 , pp. 95-109
    • Resta, R.1    Yamashita, Y.2    Thompson, L.F.3
  • 5
    • 77955750932 scopus 로고    scopus 로고
    • CD73: A novel target for cancer immunotherapy
    • Zhang B. CD73: a novel target for cancer immunotherapy. Cancer Res. 70, 6407-6411 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 6407-6411
    • Zhang, B.1
  • 6
    • 79955960780 scopus 로고    scopus 로고
    • Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity
    • Deaglio S, Robson SC. Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity. Adv. Pharmacol. 61, 301-332 (2011).
    • (2011) Adv. Pharmacol. , vol.61 , pp. 301-332
    • Deaglio, S.1    Robson, S.C.2
  • 7
    • 84860388676 scopus 로고    scopus 로고
    • CD73: A potent suppressor of antitumor immune responses
    • Beavis PA, Stagg J, Darcy PK, Smyth MJ. CD73: a potent suppressor of antitumor immune responses. Trends Immunol. 33, 231-237 (2012).
    • (2012) Trends Immunol. , vol.33 , pp. 231-237
    • Beavis, P.A.1    Stagg, J.2    Darcy, P.K.3    Smyth, M.J.4
  • 8
    • 40249106427 scopus 로고    scopus 로고
    • Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review)
    • Hoskin DW, Mader JS, Furlong SJ, Conrad DM, Blay J. Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (review). Int. J. Oncol. 32, 527-535 (2008). (Pubitemid 351330458)
    • (2008) International Journal of Oncology , vol.32 , Issue.3 , pp. 527-535
    • Hoskin, D.W.1    Mader, J.S.2    Furlong, S.J.3    Conrad, D.M.4    Blay, J.5
  • 9
    • 77957564570 scopus 로고    scopus 로고
    • Extracellular adenosine triphosphate and adenosine in cancer
    • Stagg J, Smyth MJ. Extracellular adenosine triphosphate and adenosine in cancer. Oncogene 29, 5346-5358 (2010).
    • (2010) Oncogene. , vol.29 , pp. 5346-5358
    • Stagg, J.1    Smyth, M.J.2
  • 10
    • 0033796779 scopus 로고    scopus 로고
    • Tumor-promoting functions of adenosine
    • Spychala J. Tumor-promoting functions of adenosine. Pharmacol. Ther. 87, 161-173 (2000).
    • (2000) Pharmacol. Ther. , vol.87 , pp. 161-173
    • Spychala, J.1
  • 11
    • 77950231071 scopus 로고    scopus 로고
    • CD73 on tumor cells impairs antitumor T-cell responses: A novel mechanism of tumor-induced immune suppression
    • Jin D, Fan J, Wang L et al. CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res. 70, 2245-2255 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 2245-2255
    • Jin, D.1    Fan, J.2    Wang, L.3
  • 12
    • 75949112218 scopus 로고    scopus 로고
    • Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
    • Stagg J, Divisekera U, McLaughlin N et al. Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc. Natl Acad. Sci. USA 107, 1547-1552 (2010).
    • (2010) Proc. Natl Acad. Sci. USA. , vol.107 , pp. 1547-1552
    • Stagg, J.1    Divisekera, U.2    McLaughlin, N.3
  • 13
    • 80054109170 scopus 로고    scopus 로고
    • Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity
    • Hausler SF, Montalban Del Barrio I, Strohschein J et al. Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity. Cancer Immunol. Immunother. 60(10), 1405-1418 (2011).
    • (2011) Cancer Immunol. Immunother. , vol.60 , Issue.10 , pp. 1405-1418
    • Hausler, S.F.1    Montalban Del Barrio, I.2    Strohschein, J.3
  • 14
    • 79960516623 scopus 로고    scopus 로고
    • Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production
    • Clayton A, Al-Taei S, Webber J, Mason MD, Tabi Z. Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production. J. Immunol. 187, 676-683 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 676-683
    • Clayton, A.1    Al-Taei, S.2    Webber, J.3    Mason, M.D.4    Tabi, Z.5
  • 15
    • 79954576658 scopus 로고    scopus 로고
    • CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis
    • Stagg J, Divisekera U, Duret H et al. CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis. Cancer Res. 71, 2892-2900 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 2892-2900
    • Stagg, J.1    Divisekera, U.2    Duret, H.3
  • 16
    • 79955153842 scopus 로고    scopus 로고
    • Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
    • Yegutkin GG, Marttila-Ichihara F, Karikoski M et al. Altered purinergic signaling in CD73-deficient mice inhibits tumor progression. Eur. J. Immunol. 41, 1231-1241 (2011).
    • (2011) Eur. J. Immunol. , vol.41 , pp. 1231-1241
    • Yegutkin, G.G.1    Marttila-Ichihara, F.2    Karikoski, M.3
  • 17
    • 79957921286 scopus 로고    scopus 로고
    • CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice
    • Wang L, Fan J, Thompson LF et al. CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice. J. Clin. Invest. 121, 2371-2382 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 2371-2382
    • Wang, L.1    Fan, J.2    Thompson, L.F.3
  • 19
    • 84860382842 scopus 로고    scopus 로고
    • CD73-deficient mice are resistant to carcinogenesis
    • Stagg J, Beavis PA, Divisekera U et al. CD73-deficient mice are resistant to carcinogenesis. Cancer Res. 72, 2190-2196 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 2190-2196
    • Stagg, J.1    Beavis, P.A.2    Divisekera, U.3
  • 20
    • 69849107597 scopus 로고    scopus 로고
    • Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
    • Kryczek I, Banerjee M, Cheng P et al. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood 114, 1141-1149 (2009).
    • (2009) Blood , vol.114 , pp. 1141-1149
    • Kryczek, I.1    Banerjee, M.2    Cheng, P.3
  • 21
    • 84858795377 scopus 로고    scopus 로고
    • Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression
    • Chalmin F, Mignot G, Bruchard M et al. Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. Immunity 36, 362-373 (2012).
    • (2012) Immunity. , vol.36 , pp. 362-373
    • Chalmin, F.1    Mignot, G.2    Bruchard, M.3
  • 22
    • 82755162136 scopus 로고    scopus 로고
    • Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells
    • Ryzhov S, Novitskiy SV, Goldstein AE et al. Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells. J. Immunol. 187, 6120-6129 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 6120-6129
    • Ryzhov, S.1    Novitskiy, S.V.2    Goldstein, A.E.3
  • 23
    • 84930472274 scopus 로고    scopus 로고
    • Inhibition of T-cell proliferation by murine multipotent mesenchymal stromal cells is mediated by CD39 expression and adenosine generation
    • Sattler C, Steinsdoerfer M, Offers M et al. Inhibition of T-cell proliferation by murine multipotent mesenchymal stromal cells is mediated by CD39 expression and adenosine generation. Cell Transplant. 20, 1221-1230 (2011).
    • (2011) Cell Transplant. , vol.20 , pp. 1221-1230
    • Sattler, C.1    Steinsdoerfer, M.2    Offers, M.3
  • 24
    • 79956361542 scopus 로고    scopus 로고
    • Mesenchymal stromal cells up-regulate CD39 and increase adenosine production to suppress activated T-lymphocytes
    • Saldanha-Araujo F, Ferreira FI, Palma PV et al. Mesenchymal stromal cells up-regulate CD39 and increase adenosine production to suppress activated T-lymphocytes. Stem Cell Res. 7, 66-74 (2011).
    • (2011) Stem Cell Res. , vol.7 , pp. 66-74
    • Saldanha-Araujo, F.1    Ferreira, F.I.2    Palma, P.V.3
  • 25
    • 0025055084 scopus 로고
    • Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5'-nucleotidase (CD73)
    • Thomson LF, Ruedi JM, Glass A et al. Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5′-nucleotidase (CD73). Tissue Antigens 35, 9-19 (1990). (Pubitemid 20044689)
    • (1990) Tissue Antigens , vol.35 , Issue.1 , pp. 9-19
    • Thomson, L.F.1    Ruedi, J.M.2    Glass, A.3    Moldenhauer, G.4    Moller, P.5    Low, M.G.6    Klemens, M.R.7    Massaia, M.8    Lucas, A.H.9
  • 27
    • 0029817963 scopus 로고    scopus 로고
    • CD73 mediates adhesion of B cells to follicular dendritic cells
    • Airas L, Jalkanen S. CD73 mediates adhesion of B cells to follicular dendritic cells. Blood 88, 1755-1764 (1996). (Pubitemid 26307072)
    • (1996) Blood , vol.88 , Issue.5 , pp. 1755-1764
    • Airas, L.1    Jalkanen, S.2
  • 28
    • 33750472374 scopus 로고    scopus 로고
    • Ecto-5′-nucleotidase (eN, CD73) is coexpressed with metastasis promoting antigens in human melanoma cells
    • DOI 10.1080/15257770600894188, PII UH7184R5228M1178
    • Sadej R, Spychala J, Skladanowski AC. Ecto-5′-nucleotidase (eN, CD73) is coexpressed with metastasis promoting antigens in human melanoma cells. Nucleosides Nucleotides Nucleic Acids 25, 1119-1123 (2006). (Pubitemid 44651858)
    • (2006) Nucleosides, Nucleotides and Nucleic Acids , vol.25 , Issue.9-11 , pp. 1119-1123
    • Sadej, R.1    Spychala, J.2    Skladanowski, A.C.3
  • 29
    • 39149111587 scopus 로고    scopus 로고
    • Tenascin C interacts with ecto-5′-nucleotidase (eN) and regulates adenosine generation in cancer cells
    • Sadej R, Inai K, Rajfur Z et al. Tenascin C interacts with ecto-5′-nucleotidase (eN) and regulates adenosine generation in cancer cells. Biochim. Biophys. Acta 1782, 35-40 (2008).
    • (2008) Biochim. Biophys. Acta. , vol.1782 , pp. 35-40
    • Sadej, R.1    Inai, K.2    Rajfur, Z.3
  • 31
    • 47949117265 scopus 로고    scopus 로고
    • CD73 participates in cellular multiresistance program and protects against TRAIL-induced apoptosis
    • Mikhailov A, Sokolovskaya A, Yegutkin GG et al. CD73 participates in cellular multiresistance program and protects against TRAIL-induced apoptosis. J. Immunol. 181, 464-475 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 464-475
    • Mikhailov, A.1    Sokolovskaya, A.2    Yegutkin, G.G.3
  • 32
    • 0034669958 scopus 로고    scopus 로고
    • CD73 engagement promotes lymphocyte binding to endothelial cells via a lymphocyte function-associated antigen-1-dependent mechanism
    • Airas L, Niemela J, Jalkanen S. CD73 engagement promotes lymphocyte binding to endothelial cells via a lymphocyte function-associated antigen-1-dependent mechanism. J. Immunol. 165, 5411-5417 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 5411-5417
    • Airas, L.1    Niemela, J.2    Jalkanen, S.3
  • 33
    • 0031047221 scopus 로고    scopus 로고
    • Differential regulation and function of CD73, a glycosyl- phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells
    • DOI 10.1083/jcb.136.2.421
    • Airas L, Niemela J, Salmi M, Puurunen T, Smith DJ, Jalkanen S. Differential regulation and function of CD73, a glycosyl-phosphatidylinositol- linked 70 kD adhesion molecule, on lymphocytes and endothelial cells. J. Cell Biol. 136, 421-431 (1997). (Pubitemid 27063091)
    • (1997) Journal of Cell Biology , vol.136 , Issue.2 , pp. 421-431
    • Airas, L.1    Niemela, J.2    Salmi, M.3    Puurunen, T.4    Smith, D.J.5    Jalkanen, S.6
  • 35
    • 84856759921 scopus 로고    scopus 로고
    • Disarming suppressor cells to improve immunotherapy
    • Whiteside TL. Disarming suppressor cells to improve immunotherapy. Cancer Immunol. Immunother. 61, 283-288 (2012).
    • (2012) Cancer Immunol. Immunother. , vol.61 , pp. 283-288
    • Whiteside, T.L.1
  • 36
    • 33744534978 scopus 로고    scopus 로고
    • Cancer Immunotherapy and Preclinical Studies: Why We Are Not Wasting Our Time with Animal Experiments
    • DOI 10.1016/j.hoc.2006.03.001, PII S0889858806000499
    • Schreiber K, Rowley DA, Riethmuller G, Schreiber H. Cancer immunotherapy and preclinical studies: why we are not wasting our time with animal experiments. Hematol. Oncol. Clin. North Am. 20, 567-584 (2006). (Pubitemid 43817442)
    • (2006) Hematology/Oncology Clinics of North America , vol.20 , Issue.3 , pp. 567-584
    • Schreiber, K.1    Rowley, D.A.2    Riethmuller, G.3    Schreiber, H.4
  • 37
    • 0015118045 scopus 로고
    • Cancer chemotherapy is many things: G.H.A. Clowes Memorial Lecture
    • Skipper HE. Cancer chemotherapy is many things: G.H.A. Clowes Memorial Lecture. Cancer Res. 31, 1173-1180 (1971).
    • (1971) Cancer Res. , vol.31 , pp. 1173-1180
    • Skipper, H.E.1
  • 38
    • 84860528921 scopus 로고    scopus 로고
    • A systematic analysis of experimental immunotherapies on tumors differing in size and duration of growth
    • Wen FT, Thisted RA, Rowley DA, Schreiber H. A systematic analysis of experimental immunotherapies on tumors differing in size and duration of growth. Oncoimmunology 1, 172-178 (2012).
    • (2012) Oncoimmunology. , vol.1 , pp. 172-178
    • Wen, F.T.1    Thisted, R.A.2    Rowley, D.A.3    Schreiber, H.4
  • 39
    • 76249128304 scopus 로고    scopus 로고
    • Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity
    • Aymeric L, Apetoh L, Ghiringhelli F et al. Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity. Cancer Res. 70, 855-858 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 855-858
    • Aymeric, L.1    Apetoh, L.2    Ghiringhelli, F.3
  • 40
    • 68349141085 scopus 로고    scopus 로고
    • Heightened NTPDase-1/CD39 expression and angiogenesis in radiation proctitis
    • Sheth S, Bleibel W, Thukral C et al. Heightened NTPDase-1/CD39 expression and angiogenesis in radiation proctitis. Purinergic Signal. 5, 321-326 (2009).
    • (2009) Purinergic Signal. , vol.5 , pp. 321-326
    • Sheth, S.1    Bleibel, W.2    Thukral, C.3
  • 41
    • 77749246293 scopus 로고    scopus 로고
    • Involvement of purinergic signaling in cellular response to gamma radiation
    • Tsukimoto M, Homma T, Ohshima Y, Kojima S. Involvement of purinergic signaling in cellular response to gamma radiation. Radiat. Res. 173, 298-309 (2010).
    • (2010) Radiat. Res. , vol.173 , pp. 298-309
    • Tsukimoto, M.1    Homma, T.2    Ohshima, Y.3    Kojima, S.4
  • 42
    • 82955217840 scopus 로고    scopus 로고
    • CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death
    • Serra S, Horenstein AL, Vaisitti T et al. CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death. Blood 118, 6141-6152 (2011).
    • (2011) Blood , vol.118 , pp. 6141-6152
    • Serra, S.1    Horenstein, A.L.2    Vaisitti, T.3
  • 43
    • 80051789855 scopus 로고    scopus 로고
    • CD73 (5′-nucleotidase) expression has no prognostic value in children with acute lymphoblastic leukemia
    • Wieten E, van der Linden-Schrever BE, Sonneveld E, Veerman AJ, Pieters R. CD73 (5′-nucleotidase) expression has no prognostic value in children with acute lymphoblastic leukemia. Leukemia 25, 1374-1376 (2011).
    • (2011) Leukemia. , vol.25 , pp. 1374-1376
    • Wieten, E.1    Van Der Linden-Schrever, B.E.2    Sonneveld, E.3    Veerman, A.J.4    Pieters, R.5
  • 44
    • 84863722239 scopus 로고    scopus 로고
    • High expression of CD73 as a poor prognostic biomarker in human colorectal cancer
    • Wu XR, He XS, Chen YF et al. High expression of CD73 as a poor prognostic biomarker in human colorectal cancer. J. Surg. Oncol. 106(2), 130-137 (2012).
    • (2012) J. Surg. Oncol. , vol.106 , Issue.2 , pp. 130-137
    • Wu, X.R.1    He, X.S.2    Chen, Y.F.3
  • 47
    • 1642444080 scopus 로고    scopus 로고
    • IFN-α Induced Adenosine Production on the Endothelium: A Mechanism Mediated by CD73 (Ecto-5′-Nucleotidase) Up-Regulation
    • Niemela J, Henttinen T, Yegutkin GG et al. IFN-alpha induced adenosine production on the endothelium: a mechanism mediated by CD73 (ecto-5′- nucleotidase) up-regulation. J. Immunol. 172, 1646-1653 (2004). (Pubitemid 38116812)
    • (2004) Journal of Immunology , vol.172 , Issue.3 , pp. 1646-1653
    • Niemela, J.1    Henttinen, T.2    Yegutkin, G.G.3    Airas, L.4    Kujari, A.-M.5    Rajala, P.6    Jalkanen, S.7
  • 48
    • 79957553355 scopus 로고    scopus 로고
    • Homing-associated molecules CD73 and VAP-1 as targets to prevent harmful inflammations and cancer spread
    • Salmi M, Jalkanen S. Homing-associated molecules CD73 and VAP-1 as targets to prevent harmful inflammations and cancer spread. FEBS Lett. 585, 1543-1550 (2011).
    • (2011) FEBS Lett. , vol.585 , pp. 1543-1550
    • Salmi, M.1    Jalkanen, S.2
  • 50
    • 84860538096 scopus 로고    scopus 로고
    • Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease
    • Tsukamoto H, Chernogorova P, Ayata K et al. Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease. Blood 119, 4554-4564 (2012).
    • (2012) Blood , vol.119 , pp. 4554-4564
    • Tsukamoto, H.1    Chernogorova, P.2    Ayata, K.3
  • 51
    • 79961011452 scopus 로고    scopus 로고
    • Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer
    • Kunzli BM, Bernlochner MI, Rath S et al. Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer. Purinergic Signal. 7, 231-241 (2011).
    • (2011) Purinergic Signal. , vol.7 , pp. 231-241
    • Kunzli, B.M.1    Bernlochner, M.I.2    Rath, S.3
  • 52
    • 77956134431 scopus 로고    scopus 로고
    • CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice
    • Sun X, Wu Y, Gao W et al. CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice. Gastroenterology 139, 1030-1040 (2010).
    • (2010) Gastroenterology. , vol.139 , pp. 1030-1040
    • Sun, X.1    Wu, Y.2    Gao, W.3
  • 53
    • 50949115838 scopus 로고    scopus 로고
    • Host A(2B) adenosine receptors promote carcinoma growth
    • Ryzhov S, Novitskiy SV, Zaynagetdinov R et al. Host A(2B) adenosine receptors promote carcinoma growth. Neoplasia 10, 987-995 (2008).
    • (2008) Neoplasia. , vol.10 , pp. 987-995
    • Ryzhov, S.1    Novitskiy, S.V.2    Zaynagetdinov, R.3
  • 54
    • 84855408091 scopus 로고    scopus 로고
    • Adenosine A2B receptor blockade slows growth of bladder and breast tumors
    • Cekic C, Sag D, Li Y, Theodorescu D, Strieter RM, Linden J. Adenosine A2B receptor blockade slows growth of bladder and breast tumors. J. Immunol. 188, 198-205 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 198-205
    • Cekic, C.1    Sag, D.2    Li, Y.3    Theodorescu, D.4    Strieter, R.M.5    Linden, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.