The tumor microenvironment

Surgical Oncology

Volumn 21, Issue 3, 2012, Pages 172-177

  Weber, Cynthia E ^a   Kuo, Paul C ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Cancer; Cancer Stroma; Inflammation; Metastasis; Tumor microenvironment; Tumorogenesis

Indexed keywords

BEVACIZUMAB; BRCA1 PROTEIN; BRCA2 PROTEIN; CHEMOKINE RECEPTOR CXCR4; CXCL14 CHEMOKINE; CYTOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERYTHROPOIETIN; ESTROGEN RECEPTOR ALPHA; ETARACIZUMAB; GRANULOCYTE COLONY STIMULATING FACTOR; HYPOXIA INDUCIBLE FACTOR 1; IMATINIB; INTEGRIN; MARIMASTAT; MATRIX METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN; MONOCYTE COLONY STIMULATING FACTOR; NITRIC OXIDE SYNTHASE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PRINOMASTAT; PROTEIN P53; SCATTER FACTOR; SORAFENIB; SUNITINIB; TANOMASTAT; TRANSFORMING GROWTH FACTOR BETA; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

ANGIOGENESIS; AUTOPHAGY; BREAST CANCER; CANCER ASSOCIATED FIBROBLAST; CANCER CELL; CANCER GENETICS; CANCER SURGERY; CARCINOGENESIS; CELL ADHESION; CELL INVASION; CELL MIGRATION; COLORECTAL CANCER; DNA DAMAGE; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; FIBROBLAST; GASTROINTESTINAL TUMOR; GLIOBLASTOMA; KIDNEY CARCINOMA; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; METASTASIS; ONCOGENE; PRIORITY JOURNAL; REVIEW; SOLID TUMOR; STROMA; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

CELL TRANSFORMATION, NEOPLASTIC; EXTRACELLULAR MATRIX; HUMANS; NEOPLASMS; STROMAL CELLS; TUMOR MICROENVIRONMENT;

EID: 84864708409     PISSN: 09607404     EISSN: 18793320     Source Type: Journal    
DOI: 10.1016/j.suronc.2011.09.001     Document Type: Review

References (58)

1. S. Mohla, and I.P. Witz The 5th international conference on tumor microenvironment: progression, therapy and prevention versailles, france, October 20-24, 2009: conference summary Cancer Microenviron 3 1 2010 1 5
2. I.P. Witz, and O. Levy-Nissenbaum The tumor microenvironment in the post-PAGET era Cancer Lett 242 1 2006 1 10
3. I.P. Witz The tumor microenvironment: the making of a paradigm Cancer Microenviron 2 Suppl. 1 2009 9 17
4. J. Villanueva, and M. Herlyn Melanoma and the tumor microenvironment Curr Oncol Rep 10 5 2008 439 446
5. M. Augsten, C. Hagglof, C. Pena, and A. Ostman A digest on the role of the tumor microenvironment in gastrointestinal cancers Cancer Microenviron 3 1 2010 167 176
6. G. Klein, E. Vellenga, M.W. Fraaije, W.A. Kamps, and E.S. de Bont The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia Crit Rev Oncol Hematol 50 2 2004 87 100
7. F. Mbeunkui, and D.J. Johann Cancer and the tumor microenvironment: a review of an essential relationship Cancer Chemother Pharmacol 63 4 2009 571 582
8. C. Cuvier, A. Jang, and R.P. Hill Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion Clin Exp Metastasis 15 1 1997 19 25
9. C. Liu, S. Gao, and L. Zhang Tumor microenvironment: hypoxia and buffer capacity for immunotherapy Med Hypotheses 69 3 2007 590 595
10. M.C. Brahimi-Horn, and J. Pouyssegur Oxygen, a source of life and stress FEBS Lett 581 19 2007 3582 3591
11. M.C. Brahimi-Horn, G. Bellot, and J. Pouyssegur Hypoxia and energetic tumour metabolism Curr Opin Genet Dev 21 1 2011 67 72
12. T.I. Goonewardene, H.M. Sowter, and A.L. Harris Hypoxia-induced pathways in breast cancer Microsc Res Tech 59 1 2002 41 48
13. K. Ryu, C. Park, and Y. Lee Hypoxia-inducible factor 1 alpha represses the transcription of the estrogen receptor alpha gene in human breast cancer cells Biochem Biophys Res Commun 407 4 2011 831 836
14. H. Bando, M. Toi, K. Kitada, and M. Koike Genes commonly upregulated by hypoxia in human breast cancer cells MCF-7 and MDA-MB-231 Biomed Pharmacother 57 8 2003 333 340
15. L.M. Postovit, D.E. Abbott, S.L. Payne, W.W. Wheaton, N.V. Margaryan, and R. Sullivan Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration J Cell Biochem 103 5 2008 1369 1378
16. R.S. Bindra, and P.M. Glazer Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis Mutat Res 569 1-2 2005 75 85
17. T.Y. Reynolds, S. Rockwell, and P.M. Glazer Genetic instability induced by the tumor microenvironment Cancer Res 56 24 1996 5754 5757
18. C.L. Chang, G. Marra, D.P. Chauhan, H.T. Ha, K. Chang, and L. Ricciardiella Oxidative stress inactivates the human DNA mismatch repair system Am J Physiol Cell Physiol 283 1 2002 C148 C154
19. R. Sager Expression genetics in cancer: shifting the focus from DNA to RNA Proc Natl Acad Sci USA 94 3 1997 952 955
20. S. Boyault, Y. Drouet, C. Navarro, T. Bachelot, C. Lasset, and I. Treilleux Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes Breast Cancer Res Treat 2011
21. L.A. Liotta, and E.C. Kohn The microenvironment of the tumour-host interface Nature 411 6835 2001 375 379
22. K. Rasanen, and A. Vaheri Activation of fibroblasts in cancer stroma Exp Cell Res 316 17 2010 2713 2722
23. O.E. Franco, A.K. Shaw, D.W. Strand, and S.W. Hayward Cancer associated fibroblasts in cancer pathogenesis Semin Cell Dev Biol 21 1 2010 33 39
24. N.A. Bhowmick, E.G. Neilson, and H.L. Moses Stromal fibroblasts in cancer initiation and progression Nature 432 7015 2004 332 337
25. J.A. Wallace, F. Li, G. Leone, and M.C. Ostrowski Pten in the breast tumor microenvironment: modeling tumor-stroma coevolution Cancer Res 71 4 2011 1203 1207
26. A.J. Trimboli, C.Z. Cantemir-Stone, F. Li, J.A. Wallace, A. Merchant, and N. Creasap Pten in stromal fibroblasts suppresses mammary epithelial tumours Nature 461 7267 2009 1084 1091
27. R.J. Akhurst, and R. Derynck TGF-beta signaling in cancer-a double-edged sword Trends Cell Biol 11 11 2001 S44 S51
28. R. Kalluri, and R.A. Weinberg The basics of epithelial-mesenchymal transition J Clin Invest 119 6 2009 1420 1428
29. B. Bierie, and H.L. Moses Transforming growth factor beta (TGF-beta) and inflammation in cancer Cytokine Growth Factor Rev 21 1 2010 49 59
30. J. Ho, H. Chen, and J.J. Lebrun Novel dominant negative Smad antagonists to TGFbeta signaling Cell Signal 19 7 2007 1565 1574
31. J.M. English, and M.H. Cobb Pharmacological inhibitors of MAPK pathways Trends Pharmacol Sci 23 1 2002 40 45
32. N.J. Laping, E. Grygielko, A. Mathur, J. Bomberger, C. Tweed, and W. Martin Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542 Mol Pharmacol 62 1 2002 58 64
33. J.G. Parvani, M.A. Taylor, and W.P. Schiemann Noncanonical TGF-beta signaling during mammary tumorigenesis J Mammary Gland Biol Neoplasia 16 2 2011 127 146
34. M.A. Taylor, J.G. Parvani, and W.P. Schiemann The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells J Mammary Gland Biol Neoplasia 15 2 2010 169 190
35. M.K. Asiedu, J.N. Ingle, M.D. Behrens, D.C. Radisky, and K.L. Knutson TGF{beta}/TNF{alpha}-Mediated epithelial-mesenchymal transition generates breast cancer stem cells with a Claudin-low phenotype Cancer Res 2011
36. G. Lorusso, and C. Ruegg The tumor microenvironment and its contribution to tumor evolution toward metastasis Histochem Cell Biol 130 6 2008 1091 1103
37. A. Mantovani, P. Allavena, A. Sica, and F. Balkwill Cancer-related inflammation Nature 454 7203 2008 436 444
38. Y.I. Cha, and R.N. DuBois NSAIDs and cancer prevention: targets downstream of COX-2 Annu Rev Med 58 2007 239 252
39. B.C. Zhang, J. Gao, J. Wang, Z.G. Rao, C. Wang, and J.F. Gao Tumor-associated macrophages infiltration is associated with peritumoral lymphangiogenesis and poor prognosis in lung adenocarcinoma Med Oncol 2010
40. W. Zhang, L. Wang, D. Zhou, Q. Cui, D. Zhao, and Y. Wu Expression of tumor-associated macrophages and vascular endothelial growth factor correlates with poor prognosis of peripheral T-cell lymphoma, not otherwise specified Leuk Lymphoma 52 1 2011 46 52
41. A. Mantovani, T. Schioppa, C. Porta, P. Allavena, and A. Sica Role of tumor-associated macrophages in tumor progression and invasion Cancer Metastasis Rev 25 3 2006 315 322
42. R.D. Leek, and A.L. Harris Tumor-associated macrophages in breast cancer J Mammary Gland Biol Neoplasia 7 2 2002 177 189
43. M.H. Barcellos-Hoff, and S.A. Ravani Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells Cancer Res 60 5 2000 1254 1260
44. F. Moinfar, Y.G. Man, L. Arnould, G.L. Bratthauer, M. Ratschek, and F.A. Tavassoli Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis Cancer Res 60 9 2000 2562 2566
45. K. Kurose, K. Gilley, S. Matsumoto, P.H. Watson, X.P. Zhou, and C. Eng Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas Nat Genet 32 3 2002 355 357
46. D. Ribatti, and A. Vacca The role of microenvironment in tumor angiogenesis Genes Nutr 3 1 2008 29 34
47. R.D. Leek, R.J. Landers, A.L. Harris, and C.E. Lewis Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast Br J Cancer 79 5-6 1999 991 995
48. M. Relf, S. LeJeune, P.A. Scott, S. Fox, K. Smith, and R. Leek Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis Cancer Res 57 5 1997 963 969
49. J. Rykala, K. Przybylowskia, I. Majsterek, G. Pasz-Walczak, A. Sygut, and A. Dziki Angiogenesis markers quantification in breast cancer and their correlation with clinicopathological prognostic variables Pathol Oncol Res 2011
50. A. Kohrmann, U. Kammerer, M. Kapp, J. Dietl, and J. Anacker Expression of matrix metalloproteinases (MMPs) in primary human breast cancer and breast cancer cell lines: new findings and review of the literature BMC Cancer 9 2009 188
51. S. Patel, G. Sumitra, B.C. Koner, and A. Saxena Role of serum matrix metalloproteinase-2 and -9 to predict breast cancer progression Clin Biochem 44 10-11 2011 869 872
52. J.M. Pellikainen, K.M. Ropponen, V.V. Kataja, J.K. Kellokoski, M.J. Eskelinen, and V.M. Kosma Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis Clin Cancer Res 10 22 2004 7621 7628
53. A.R. Anderson, A.M. Weaver, P.T. Cummings, and V. Quaranta Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment Cell 127 5 2006 905 915
54. A. Alphonso, and S.K. Alahari Stromal cells and integrins: conforming to the needs of the tumor microenvironment Neoplasia 11 12 2009 1264 1271
55. D.E. White, and W.J. Muller Multifaceted roles of integrins in breast cancer metastasis J Mammary Gland Biol Neoplasia 12 2-3 2007 135 142
56. J. Jenab-Wolcott, and B.J. Giantonio Bevacizumab: current indications and future development for management of solid tumors Expert Opin Biol Ther 9 4 2009 507 517
57. J.C. Yang, L. Haworth, R.M. Sherry, P. Hwu, D.J. Schwartzentruber, and S.L. Topalian A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer N Engl J Med 349 5 2003 427 434
58. L. Gianni, W. Eiermann, V. Semiglazov, A. Manikhas, A. Lluch, and S. Tjulandin Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort Lancet 375 9712 2010 377 384