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Volumn 17, Issue 5, 2011, Pages 343-350

The present and future of peptide vaccines for cancer: Single or multiple, long or short, alone or in combination?

Author keywords

cancer vaccine; immune therapy; melanoma; neoplasm; Peptide; TLR agonists; vaccine

Indexed keywords

CANCER VACCINE; CD40 ANTIGEN; DNA; IMMUNOLOGIC AGENT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MELAN A; PEPTIDE VACCINE; PHOSPHOPEPTIDE; RNA; TOLL LIKE RECEPTOR AGONIST;

EID: 80053343794     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0b013e318233e5b2     Document Type: Review
Times cited : (254)

References (101)
  • 1
    • 0024554410 scopus 로고
    • The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes. Evidence for shared tumor antigens
    • Darrow TL, Slingluff CL Jr, Seigler HF. The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes. Evidence for shared tumor antigens. J Immunol. 1989; 142:3329-3335. (Pubitemid 19129962)
    • (1989) Journal of Immunology , vol.142 , Issue.9 , pp. 3329-3335
    • Darrow, T.L.1    Slingluff Jr., C.L.2    Seigler, H.F.3
  • 3
    • 12944325331 scopus 로고    scopus 로고
    • A listing of human tumor antigens recognized by T cells: March 2004 update
    • DOI 10.1007/s00262-004-0560-6
    • Novellino L, Castelli C, Parmiani G. A listing of human tumor antigens recognized by T cells: March 2004 update. Cancer Immunol Immunother. 2005;54:187-207. (Pubitemid 40174238)
    • (2005) Cancer Immunology, Immunotherapy , vol.54 , Issue.3 , pp. 187-207
    • Novellino, L.1    Castelli, C.2    Parmiani, G.3
  • 8
    • 72549116845 scopus 로고    scopus 로고
    • Effect of GM-CSF on circulating CD8+ and CD4+ T cell responses to a multipeptide melanoma vaccine: Outcome of a multicenter randomized trial
    • Slingluff CL Jr, Petroni GR, Olson WC, et al. Effect of GM-CSF on circulating CD8+ and CD4+ T cell responses to a multipeptide melanoma vaccine: outcome of a multicenter randomized trial. Clin Cancer Res. 2009;15:7036-7044.
    • (2009) Clin Cancer Res , vol.15 , pp. 7036-7044
    • Slingluff Jr., C.L.1    Petroni, G.R.2    Olson, W.C.3
  • 10
    • 34247159208 scopus 로고    scopus 로고
    • CMV pp65 and IE-1 T cell epitopes recognized by healthy subjects
    • Slezak SL, Bettinotti M, Selleri S, et al. CMV pp65 and IE-1 T cell epitopes recognized by healthy subjects. J Transl Med. 2007;5:17.
    • (2007) J Transl Med , vol.5 , pp. 17
    • Slezak, S.L.1    Bettinotti, M.2    Selleri, S.3
  • 14
    • 54449097809 scopus 로고    scopus 로고
    • Helper T cell responses and clinical activity of a melanoma vaccine with multiple peptides from MAGE and melanocytic differentiation antigens
    • Slingluff CL Jr, Petroni GR, OlsonW, et al. Helper T cell responses and clinical activity of a melanoma vaccine with multiple peptides from MAGE and melanocytic differentiation antigens. J Clin Oncol. 2008;26: 4973-4980.
    • (2008) J Clin Oncol , vol.26 , pp. 4973-4980
    • Slingluff Jr., C.L.1    Olsonw, P.G.2
  • 15
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • DOI 10.1038/nm1100
    • Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med. 2004;10:909-915. (Pubitemid 39273730)
    • (2004) Nature Medicine , vol.10 , Issue.9 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 16
    • 5444266058 scopus 로고    scopus 로고
    • E1696: Final analysis of the clinical and immunological results of a multicenter ECOG phase II trial of multi-epitope peptide vaccination for stage IV melanoma with MART-1 (27-35), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) (MGT) +/j IFNa2b and GM-CSF
    • Kirkwood JM, Lee S, Land S, et al. E1696: final analysis of the clinical and immunological results of a multicenter ECOG phase II trial of multi-epitope peptide vaccination for stage IV melanoma with MART-1 (27-35), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) (MGT) +/j IFNa2b and GM-CSF. J Clin Oncol (Meeting Abstracts). 2004;22:7502
    • (2004) J Clin Oncol (Meeting Abstracts) , vol.22 , pp. 7502
    • Kirkwood, J.M.1    Lee, S.2    Land, S.3
  • 19
    • 33846322927 scopus 로고    scopus 로고
    • Alum with interleukin-12 augments immunity to a melanoma peptide vaccine: Correlation with time to relapse in patients with resected high-risk disease
    • DOI 10.1158/1078-0432.CCR-06-1450
    • Hamid O, Solomon JC, Scotland R, et al. Alum with interleukin-12 augments immunity to a melanoma peptide vaccine: correlation with time to relapse in patients with resected high-risk disease. Clin Cancer Res. 2007;13:215-222. (Pubitemid 46121871)
    • (2007) Clinical Cancer Research , vol.13 , Issue.1 , pp. 215-222
    • Hamid, O.1    Solomon, J.C.2    Scotland, R.3    Garcia, M.4    Sian, S.5    Ye, W.6    Groshen, S.L.7    Weber, J.S.8
  • 20
    • 79960706708 scopus 로고    scopus 로고
    • A randomized multicenter trial of the effects of melanoma-associated helper peptides and cyclophosphamide on the immunogenicity of a multipeptide melanoma vaccine
    • Slingluff CL Jr, Petroni GR, Chianese-Bullock KA, et al. A randomized multicenter trial of the effects of melanoma-associated helper peptides and cyclophosphamide on the immunogenicity of a multipeptide melanoma vaccine. J Clin Oncol. 2011;29:2924-2932.
    • (2011) J Clin Oncol , vol.29 , pp. 2924-2932
    • Slingluff Jr., C.L.1    Petroni, G.R.2    Chianese-Bullock, K.A.3
  • 21
    • 60849091328 scopus 로고    scopus 로고
    • Multi-peptide vaccines vialed as peptide mixtures can be stable reagents for use in peptide-based immune therapies
    • Chianese-Bullock KA, Lewis ST, Sherman NE, et al. Multi-peptide vaccines vialed as peptide mixtures can be stable reagents for use in peptide-based immune therapies. Vaccine. 2009;27:1764-1770.
    • (2009) Vaccine , vol.27 , pp. 1764-1770
    • Chianese-Bullock, K.A.1    Lewis, S.T.2    Sherman, N.E.3
  • 22
    • 33644521564 scopus 로고    scopus 로고
    • Ex vivo detectable human CD8 T-cell responses to cancer-testis antigens
    • Baumgaertner P, Rufer N, Devevre E, et al. Ex vivo detectable human CD8 T-cell responses to cancer-testis antigens. Cancer Res. 2006;66: 1912-1916.
    • (2006) Cancer Res , vol.66 , pp. 1912-1916
    • Baumgaertner, P.1    Rufer, N.2    Devevre, E.3
  • 26
    • 0346024187 scopus 로고    scopus 로고
    • + T Lymphocytes in Patients Undergoing Multiple Course Peptide Vaccination
    • DOI 10.1097/00002371-200401000-00004
    • Powell DJ Jr, Rosenberg SA. Phenotypic and functional maturation of tumor antigen-reactive CD8+ T lymphocytes in patients undergoing multiple course peptide vaccination. J Immunother. 2004;27:36-47. (Pubitemid 38076167)
    • (2004) Journal of Immunotherapy , vol.27 , Issue.1 , pp. 36-47
    • Powell Jr., D.J.1    Rosenberg, S.A.2
  • 28
    • 33645775260 scopus 로고    scopus 로고
    • Limited infiltration of exogenous dendritic cells and naive T cells restricts immune responses in peripheral lymph nodes
    • Mullins DW, Engelhard VH. Limited infiltration of exogenous dendritic cells and naive T cells restricts immune responses in peripheral lymph nodes. J Immunol. 2006;176:4535-4542.
    • (2006) J Immunol , vol.176 , pp. 4535-4542
    • Mullins, D.W.1    Engelhard, V.H.2
  • 29
    • 33646779561 scopus 로고    scopus 로고
    • Altered CD8(+) T-cellresponses when immunizing with multiepitope peptide vaccines
    • Rosenberg SA, Sherry RM, Morton KE, et al. Altered CD8(+) T-cellresponses when immunizing with multiepitope peptide vaccines. J Immunother. 2006;29:224-231.
    • (2006) J Immunother , vol.29 , pp. 224-231
    • Rosenberg, S.A.1    Sherry, R.M.2    Morton, K.E.3
  • 30
    • 0025095664 scopus 로고
    • Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response
    • Fearon ER, Pardoll DM, Itaya T, et al. Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell. 1990;60:397-403.
    • (1990) Cell , vol.60 , pp. 397-403
    • Fearon, E.R.1    Pardoll, D.M.2    Itaya, T.3
  • 34
    • 0028960970 scopus 로고
    • Principles for adoptive T cell therapy of human viral diseases
    • Greenberg PD, Riddell SR. Principles for adoptive T cell therapy of human viral diseases. Annu Rev Immunol. 1995;13:545-586.
    • (1995) Annu Rev Immunol , vol.13 , pp. 545-586
    • Greenberg, P.D.1    Riddell, S.R.2
  • 35
    • 0032822960 scopus 로고    scopus 로고
    • Anti-tumour activity against B16-F10 melanoma with a GM-CSF secreting allogeneic tumour cell vaccine
    • DOI 10.1038/sj.gt.3300961
    • Kayaga J, Souberbielle BE, Sheikh N, et al. Anti-tumour activity against B16-F10 melanoma with a GM-CSF secreting allogeneic tumour cell vaccine. Gene Ther. 1999;6:1475-1481 [published erratum appears in Gene Ther. 1999;6:1905]. (Pubitemid 29396736)
    • (1999) Gene Therapy , vol.6 , Issue.8 , pp. 1475-1481
    • Kayaga, J.1    Souberbielle, B.E.2    Sheikh, N.3    Morrow, W.J.W.4    Scott-Taylor, T.5    Vile, R.6    Dalgleish, A.G.7
  • 36
    • 0025761922 scopus 로고
    • CD4+ T cell clones specific for the human p97 melanoma-associated antigen can eradicate pulmonary metastases from a murine tumor expressing the p97 antigen
    • Kahn M, Sugawara H, McGowan P, et al. CD4+ T cell clones specific for the human p97 melanoma-associated antigen can eradicate pulmonary metastases from a murine tumor expressing the p97 antigen. J Immunol. 1991;146:3235-3241.
    • (1991) J Immunol , vol.146 , pp. 3235-3241
    • Kahn, M.1    Sugawara, H.2    McGowan, P.3
  • 41
    • 0031782910 scopus 로고    scopus 로고
    • + T cell responses in antitumor immunity
    • DOI 10.1016/S0952-7915(98)80228-8
    • Pardoll DM, Topalian Sl. The role of CD4+ T cell responses in antitumor immunity. Curr Opin Immunol. 1998;10:588-594. (Pubitemid 28479193)
    • (1998) Current Opinion in Immunology , vol.10 , Issue.5 , pp. 588-594
    • Pardoll, D.M.1    Topalian, S.L.2
  • 43
    • 0028981087 scopus 로고
    • GM2-KLH conjugate vaccine: Increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21
    • Helling F, Zhang S, Shang A, et al. GM2-KLH conjugate vaccine: increased immunogenicity in melanoma patients after administration with immunological adjuvant QS-21. Cancer Res. 1995;55:2783-2788.
    • (1995) Cancer Res , vol.55 , pp. 2783-2788
    • Helling, F.1    Zhang, S.2    Shang, A.3
  • 46
    • 0026703523 scopus 로고
    • Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination
    • Valmori D, Pessi A, Bianchi E, et al. Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination. J Immunol. 1992;149:717-721.
    • (1992) J Immunol , vol.149 , pp. 717-721
    • Valmori, D.1    Pessi, A.2    Bianchi, E.3
  • 53
    • 0033103512 scopus 로고    scopus 로고
    • Identification of MAGE-3 epitopes presented by HLA-DR molecules to CD4(+) T lymphocytes [see comments]
    • Chaux P, Vantomme V, Stroobant V, et al. Identification of MAGE-3 epitopes presented by HLA-DR molecules to CD4(+) T lymphocytes [see comments]. J Exp Med. 1999;189:767-778.
    • (1999) J Exp Med , vol.189 , pp. 767-778
    • Chaux, P.1    Vantomme, V.2    Stroobant, V.3
  • 54
    • 0030802482 scopus 로고    scopus 로고
    • Isolation of novel HLA-DR restricted potential tumor-associated antigens from the melanoma cell line FM3
    • Halder T, Pawelec G, Kirkin AF, et al. Isolation of novel HLA-DR restricted potential tumor-associated antigens from the melanoma cell line FM3. Cancer Res. 1997;57:3238-3244. (Pubitemid 27351741)
    • (1997) Cancer Research , vol.57 , Issue.15 , pp. 3238-3244
    • Halder, T.1    Pawelec, G.2    Kirkin, A.F.3    Zeuthen, J.4    Meyer, H.E.5    Kun, L.6    Kalbacher, H.7
  • 55
    • 0031690656 scopus 로고    scopus 로고
    • Tumour-specific MHC-class-II-restricted responses after in vitro sensitization to synthetic peptides corresponding to gp100 and Annexin II eluted from melanoma cells
    • DOI 10.1007/s002620050501
    • Li K, Adibzadeh M, Halder T, et al. Tumour-specific MHC-class-IIY restricted responses after in vitro sensitization to synthetic peptides corresponding to gp100 and Annexin II eluted from melanoma cells. Cancer Immunol Immunother. 1998;47:32-38. (Pubitemid 28430528)
    • (1998) Cancer Immunology Immunotherapy , vol.47 , Issue.1 , pp. 32-38
    • Li, K.1    Adibzadeh, M.2    Halder, T.3    Kalbacher, H.4    Heinzel, S.5    Muller, C.6    Zeuthen, J.7    Pawelec, G.8
  • 58
    • 4143107936 scopus 로고    scopus 로고
    • Immune responses to a class II helper peptide epitope in patients with stage III/IV resected melanoma
    • DOI 10.1158/1078-0432.CCR-04-0241
    • Wong R, Lau R, Chang J, et al. Immune responses to a class II helper peptide epitope in patients with stage III/IV resected melanoma. Clin Cancer Res. 2004;10:5004-5013. (Pubitemid 39099774)
    • (2004) Clinical Cancer Research , vol.10 , Issue.15 , pp. 5004-5013
    • Wong, R.1    Lau, R.2    Chang, J.3    Kuus-Reichel, T.4    Brichard, V.5    Bruck, C.6    Weber, J.7
  • 61
    • 4143107936 scopus 로고    scopus 로고
    • Immune responses to a class II helper peptide epitope in patients with stage III/IV resected melanoma
    • DOI 10.1158/1078-0432.CCR-04-0241
    • Wong R, Lau R, Chang J, et al. Immune responses to a class II helper peptide epitope in patients with stage III/IV resected melanoma. Clin Cancer Res. 2004;10:5004-5013. (Pubitemid 39099774)
    • (2004) Clinical Cancer Research , vol.10 , Issue.15 , pp. 5004-5013
    • Wong, R.1    Lau, R.2    Chang, J.3    Kuus-Reichel, T.4    Brichard, V.5    Bruck, C.6    Weber, J.7
  • 62
    • 0035113705 scopus 로고    scopus 로고
    • Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients
    • Knutson KL, Schiffman K, Disis Ml. Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients. J Clin Invest. 2001;107:477-484. (Pubitemid 32167994)
    • (2001) Journal of Clinical Investigation , vol.107 , Issue.4 , pp. 477-484
    • Knutson, K.L.1    Schiffman, K.2    Disis, M.L.3
  • 63
    • 79960741390 scopus 로고    scopus 로고
    • First report of a randomized phase II trial of multi-epitope vaccination with melanoma peptides for cytotoxic T cells and helper T cells in patients with metastatic melanoma: An Eastern Cooperative Oncology Group Study (E1602)
    • Abstract 8508
    • Slingluff CL Jr, Lee SJ, Chianese-Bullock KA, et al. First report of a randomized phase II trial of multi-epitope vaccination with melanoma peptides for cytotoxic T cells and helper T cells in patients with metastatic melanoma: An Eastern Cooperative Oncology Group Study (E1602). J Clin Oncol. 2010;28. Abstract 8508.
    • (2010) J Clin Oncol. , pp. 28
    • Slingluff Jr., C.L.1    Lee, S.J.2    Chianese-Bullock, K.A.3
  • 64
    • 54549089744 scopus 로고    scopus 로고
    • Phosphorylationdependent interaction between antigenic peptides and MHC class I: A molecular basis for the presentation of transformed self
    • Mohammed F, Cobbold M, Zarling AL, et al. Phosphorylationdependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self. Nat Immunol. 2008;9:1236-1243.
    • (2008) Nat Immunol , vol.9 , pp. 1236-1243
    • Mohammed, F.1    Cobbold, M.2    Zarling, A.L.3
  • 65
    • 67749145750 scopus 로고    scopus 로고
    • Identification of tumorassociated MHC class-restricted phosphopeptides as targets for immunotherapy
    • Depontieu FR, Qian J, Zarling AL, et al. Identification of tumorassociated, MHC class-restricted phosphopeptides as targets for immunotherapy. Proc Natl Acad Sci U S A. 2009;106:12073-12078.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12073-12078
    • Depontieu, F.R.1    Qian, J.2    Zarling, A.L.3
  • 66
    • 77954762820 scopus 로고    scopus 로고
    • Structural basis for the presentation of tumor-associated MHC class-restricted phosphopeptides to CD4+ T cells
    • Li Y, Depontieu FR, Sidney J, et al. Structural basis for the presentation of tumor-associated MHC class-restricted phosphopeptides to CD4+ T cells. J Mol Biol. 2010;399:596-603.
    • (2010) J Mol Biol , vol.399 , pp. 596-603
    • Li, Y.1    Depontieu, F.R.2    Sidney, J.3
  • 67
    • 77954960118 scopus 로고    scopus 로고
    • Immunogenicity for CD8+ and CD4+ T cells of two formulations of an incomplete Freunds adjuvant for multipeptide melanoma vaccines
    • Slingluff CL Jr, Petroni GR, Smolkin ME, et al. Immunogenicity for CD8+ and CD4+ T cells of two formulations of an incomplete Freunds adjuvant for multipeptide melanoma vaccines. J Immunother. 2010;33: 630-638.
    • (2010) J Immunother , vol.33 , pp. 630-638
    • Slingluff Jr., C.L.1    Petroni, G.R.2    Smolkin, M.E.3
  • 68
    • 77954958313 scopus 로고    scopus 로고
    • Different adjuvanticity of incomplete Freunds adjuvant derived from beef or vegetable components in melanoma patients immunized with a peptide vaccine
    • Rosenberg SA, Yang JC, Kammula US, et al. Different adjuvanticity of incomplete Freunds adjuvant derived from beef or vegetable components in melanoma patients immunized with a peptide vaccine. J Immunother. 2010;33:626-629.
    • (2010) J Immunother , vol.33 , pp. 626-629
    • Rosenberg, S.A.1    Yang, J.C.2    Kammula, U.S.3
  • 69
    • 77956527209 scopus 로고    scopus 로고
    • Dynamic changes in cellular infiltrates with repeated cutaneous vaccination: A histologic and immunophenotypic analysis
    • Schaefer JT, Patterson JW, Deacon DH, et al. Dynamic changes in cellular infiltrates with repeated cutaneous vaccination: a histologic and immunophenotypic analysis. J Transl Med. 2010;8:79.
    • (2010) J Transl Med , vol.8 , pp. 79
    • Schaefer, J.T.1    Patterson, J.W.2    Deacon, D.H.3
  • 70
    • 77954951500 scopus 로고    scopus 로고
    • Peptide/incomplete Freund adjuvant emulsion depots are a graveyard for tumor antigen-specific CD8+ T cells [abstract]
    • Overwijk W, Hailemichael Y, Dai Z, et al. Peptide/incomplete Freund adjuvant emulsion depots are a graveyard for tumor antigen-specific CD8+ T cells [abstract]. J Immunother. 2009;32:971
    • (2009) J Immunother , vol.32 , pp. 971
    • Overwijk, W.1    Hailemichael, Y.2    Dai, Z.3
  • 71
    • 76649093262 scopus 로고    scopus 로고
    • Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice
    • Zhu Q, Egelston C, Gagnon S, et al. Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice. J Clin Invest. 2010;120:607-616.
    • (2010) J Clin Invest , vol.120 , pp. 607-616
    • Zhu, Q.1    Egelston, C.2    Gagnon, S.3
  • 72
    • 65249164025 scopus 로고    scopus 로고
    • Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells
    • Makela SM, Strengell M, Pietila TE, et al. Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells. J Leukoc Biol. 2009;85:664-672.
    • (2009) J Leukoc Biol , vol.85 , pp. 664-672
    • Makela, S.M.1    Strengell, M.2    Pietila, T.E.3
  • 75
    • 34250854079 scopus 로고    scopus 로고
    • The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4
    • DOI 10.1126/science.1138963
    • Mata-Haro V, Cekic C, Martin M, et al. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science. 2007; 316:1628-1632. (Pubitemid 46982038)
    • (2007) Science , vol.316 , Issue.5831 , pp. 1628-1632
    • Mata-Haro, V.1    Cekic, C.2    Martin, M.3    Chilton, P.M.4    Casella, C.R.5    Mitchell, T.C.6
  • 77
    • 77955515616 scopus 로고    scopus 로고
    • Poly-ICLC promotes the infiltration of effector T cells into intracranial gliomas via induction of CXCL10 in IFN-alpha and IFN-gamma dependent manners
    • Zhu X, Fallert-Junecko BA, Fujita M, et al. Poly-ICLC promotes the infiltration of effector T cells into intracranial gliomas via induction of CXCL10 in IFN-alpha and IFN-gamma dependent manners. Cancer Immunol Immunother. 2010;59:1401-1409.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1401-1409
    • Zhu, X.1    Fallert-Junecko, B.A.2    Fujita, M.3
  • 78
    • 77952540334 scopus 로고    scopus 로고
    • Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: Clinical results
    • CluffCW. Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results. Adv Exp Med Biol. 2010;667:111-123.
    • (2010) Adv Exp Med Biol , vol.667 , pp. 111-123
    • Cluff, C.W.1
  • 79
    • 42449147062 scopus 로고    scopus 로고
    • Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines
    • Ahonen CL, Wasiuk A, Fuse S, et al. Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines. Blood. 2008;111:3116-3125.
    • (2008) Blood , vol.111 , pp. 3116-3125
    • Ahonen, C.L.1    Wasiuk, A.2    Fuse, S.3
  • 80
    • 0029935569 scopus 로고    scopus 로고
    • Enhanced tumor outgrowth after peptide vaccination: Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors
    • Toes RE, Blom RJ, Offringa R, et al. Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors. J Immunol. 1996;156:3911-3918. (Pubitemid 26139943)
    • (1996) Journal of Immunology , vol.156 , Issue.10 , pp. 3911-3918
    • Toes, R.E.M.1    Blom, R.J.J.2    Offringa, R.3    Kast, W.M.4    Melief, C.J.M.5
  • 82
    • 0027520754 scopus 로고
    • Peptides of 23 residues or greater are required to stimulate a high affinity class II-restricted T cell response
    • Srinivasan M, Domanico SZ, Kaumaya PT, et al. Peptides of 23 residues or greater are required to stimulate a high affinity class-restricted T cell response. Eur J Immunol. 1993;23:1011-1016. (Pubitemid 23120158)
    • (1993) European Journal of Immunology , vol.23 , Issue.5 , pp. 1011-1016
    • Srinivasan, M.1    Domanico, S.Z.2    Kaumaya, P.T.P.3    Pierce, S.K.4
  • 84
    • 0141832121 scopus 로고    scopus 로고
    • MHC-guided processing: Binding of large antigen fragments
    • Sercarz EE, Maverakis E. MHC-guided processing: binding of large antigen fragments. Nat Rev Immunol. 2003;3:621-629. (Pubitemid 37328665)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.8 , pp. 621-629
    • Sercarz, E.E.1    Maverakis, E.2
  • 85
    • 44849109375 scopus 로고    scopus 로고
    • Superior induction of antitumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation
    • BijkerMS, van den Eeden SJ, FrankenKL, et al. Superior induction of antitumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation. Eur J Immunol. 2008;38:1033-1042.
    • (2008) Eur J Immunol , vol.38 , pp. 1033-1042
    • Bijker, M.S.1    Van Den Eeden, S.J.2    Franken, K.L.3
  • 87
    • 70350772293 scopus 로고    scopus 로고
    • Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia
    • Kenter GG, Welters MJ, Valentijn AR, et al. Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N Engl J Med. 2009;361:1838-1847.
    • (2009) N Engl J Med , vol.361 , pp. 1838-1847
    • Kenter, G.G.1    Welters, M.J.2    Valentijn, A.R.3
  • 88
    • 80053341541 scopus 로고    scopus 로고
    • National Cancer Institute Immunotherapy Agent Workshop. Bethesda, MD. 12 July 2007
    • National Cancer Institute Immunotherapy Agent Workshop. Bethesda, MD. 12 July 2007.
  • 89
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010;28:3167-3175.
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 90
    • 77955917121 scopus 로고    scopus 로고
    • Safety and antitumor activity of biweekly MDX-1106 (Anti-PD-1, BMS-936558/ONO-4538) in patients with advanced refractory malignancies
    • Abstract 2506
    • Sznol M, Powderly JD, Smith DC, et al. Safety and antitumor activity of biweekly MDX-1106 (Anti-PD-1, BMS-936558/ONO-4538) in patients with advanced refractory malignancies. J Clin Oncol. 2010;28. Abstract 2506.
    • (2010) J Clin Oncol , pp. 28
    • Sznol, M.1    Powderly, J.D.2    Smith, D.C.3
  • 91
    • 79251571760 scopus 로고    scopus 로고
    • The role of the PD-1 pathway in autoimmunity and peripheral tolerance
    • Fife BT, Pauken KE. The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Ann N Y Acad Sci. 2011;1217:45-59.
    • (2011) Ann N y Acad Sci , vol.1217 , pp. 45-59
    • Fife, B.T.1    Pauken, K.E.2
  • 94
    • 70350433514 scopus 로고    scopus 로고
    • Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal
    • Fife BT, Pauken KE, Eagar TN, et al. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol. 2009;10:1185-1192.
    • (2009) Nat Immunol , vol.10 , pp. 1185-1192
    • Fife, B.T.1    Pauken, K.E.2    Eagar, T.N.3
  • 95
    • 13544259967 scopus 로고    scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand 1
    • Hirata S, Senju S, Matsuyoshi H, et al. Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand. J Immunol. 2005;174:1888-1897. (Pubitemid 40223928)
    • (2005) Journal of Immunology , vol.174 , Issue.4 , pp. 1888-1897
    • Hirata, S.1    Senju, S.2    Matsuyoshi, H.3    Fukuma, D.4    Uemura, Y.5    Nishimura, Y.6
  • 97
    • 68549135290 scopus 로고    scopus 로고
    • Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with Sipuleucel-T in advanced prostate cancer
    • Higano CS, Schellhammmer PF, Small EJ, et al. Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with Sipuleucel-T in advanced prostate cancer. Cancer. 2009;115:3670-3679.
    • (2009) Cancer , vol.115 , pp. 3670-3679
    • Higano, C.S.1    Schellhammmer, P.F.2    Small, E.J.3
  • 98
    • 70350135349 scopus 로고    scopus 로고
    • A phase III multiinstitutional randomized study of immunization with the gp100: 209-217(210M) peptide followed by high-dose IL-2 compared with high-dose IL-2 alone in patients with metastatic melanoma
    • Abstract CRA9011
    • Schwartzentruber DJ, Lawson D, Richards J, et al. A phase III multiinstitutional randomized study of immunization with the gp100: 209-217(210M) peptide followed by high-dose IL-2 compared with high-dose IL-2 alone in patients with metastatic melanoma. J Clin Oncol. 2009;27. Abstract CRA9011.
    • (2009) J Clin Oncol , pp. 27
    • Schwartzentruber, D.J.1    Lawson, D.2    Richards, J.3
  • 99
    • 79957831345 scopus 로고    scopus 로고
    • Gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma
    • Schwartzentruber DJ, Lawson DH, Richards JM, et al. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med. 2011;364:2119-2127.
    • (2011) N Engl J Med , vol.364 , pp. 2119-2127
    • Schwartzentruber, D.J.1    Lawson, D.H.2    Richards, J.M.3
  • 100
    • 72549086588 scopus 로고    scopus 로고
    • Effect of granulocyte/macrophage colony-stimulating factor on vaccination with an allogeneic whole-cell melanoma vaccine
    • Faries MB, Hsueh EC, Ye X, et al. Effect of granulocyte/macrophage colony-stimulating factor on vaccination with an allogeneic whole-cell melanoma vaccine. Clin Cancer Res. 2009;15:7029-7035.
    • (2009) Clin Cancer Res , vol.15 , pp. 7029-7035
    • Faries, M.B.1    Hsueh, E.C.2    Ye, X.3
  • 101
    • 78449242173 scopus 로고    scopus 로고
    • E4697: Phase III cooperative group study of yeast-derived granulocyte macrophage colony-stimulating factor (GM-CSF) versus placebo as adjuvant treatment of patients with completely resected stage III-IV melanoma
    • Abstract 8504
    • Lawson DH, Lee SJ, Tarhini AA, et al. E4697: phase III cooperative group study of yeast-derived granulocyte macrophage colony-stimulating factor (GM-CSF) versus placebo as adjuvant treatment of patients with completely resected stage III-IV melanoma. J Clin Oncol. 2010;28. Abstract 8504.
    • (2010) J Clin Oncol. , pp. 28
    • Lawson, D.H.1    Lee, S.J.2    Tarhini, A.A.3


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