Potential prognostic biomarker CD73 regulates epidermal growth factor receptor expression in human breast cancer

IUBMB Life

Volumn 64, Issue 11, 2012, Pages 911-920

  Zhi, Xiuling ^a   Wang, Yingjian ^b   Yu, Jerry ^a,c   Yu, Jiangang ^a   Zhang, Liying ^d   Yin, Lianhua ^a   Zhou, Ping ^a  

^a FUDAN UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

^c UNIVERSITY OF LOUISVILLE   (United States)

^d Central Hospital of Jinzhou Liaoning   (China)

Author keywords

breast cancer; CD73; EGFR; PPAR ; prognostic biomarker

Indexed keywords

5' NUCLEOTIDASE; ADENOSINE A2 RECEPTOR AGONIST; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE P60; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; TUMOR MARKER;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER PROGNOSIS; CANCER SURVIVAL; CELL ADHESION; CELL INVASION; CELL MIGRATION; COMPUTER MODEL; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECURRENCE FREE SURVIVAL; TISSUE MICROARRAY; VALIDATION PROCESS; WESTERN BLOTTING;

5'-NUCLEOTIDASE; ADENOCARCINOMA, MUCINOUS; ADENOSINE DIPHOSPHATE; ADULT; AGED; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CARCINOMA, LOBULAR; CARCINOMA, MEDULLARY; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; GPI-LINKED PROTEINS; HUMANS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PHOSPHORYLATION; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 84867832930     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1086     Document Type: Article

References (40)

1. Mathers, C. D., Boerma, T., and, Ma Fat, D., (2009) Global and regional causes of death. Br. Med. Bull. 92, 7-32.
2. Mills, J. H., Thompson, L. F., Mueller, C., Waickman, A. T., Jalkanen, S., et al. (2008) CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 105, 9325-9330.
3. Thompson, L. F., Eltzschig, H. K., Ibla, J. C., Van De Wiele, C. J., Resta, R., et al. (2004) Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J. Exp. Med. 200, 1395-1405.
4. Peng, Z., Fernandez, P., Wilder, T., Yee, H., Chiriboga, L., et al. (2008) Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis. FASEB J. 22, 2263-2272.
5. Castrop, H., Huang, Y., Hashimoto, S., Mizel, D., Hansen, P., et al. (2004) Impairment of tubuloglomerular feedback regulation of GFR in ecto-5'-nucleotidase/CD73-deficient mice. J. Clin. Invest. 114, 634-642.
6. Eckle, T., Krahn, T., Grenz, A., Kohler, D., Mittelbronn, M., et al. (2007) Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation 115, 1581-1590.
7. Koszalka, P., Ozuyaman, B., Huo, Y., Zernecke, A., Flogel, U., et al. (2004) Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ. Res. 95, 814-821.
8. Wang, L., Fan, J., Thompson, L. F., Zhang, Y., Shin, T., et al. (2011) CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice. J. Clin. Invest. 121, 2371-2382.
9. Canbolat, O., Durak, I., Cetin, R., Kavutcu, M., Demirci, S., et al. (1996) Activities of adenosine deaminase, 5'-nucleotidase, guanase, and cytidine deaminase enzymes in cancerous and non-cancerous human breast tissues. Breast Cancer Res. Treat. 37, 189-193.
10. Durak, I., Cetin, R., Canbolat, O., Cetin, D., Yurtarslani, Z., et al. (1994) Adenosine deaminase, 5'-nucleotidase, guanase and cytidine deaminase activities in gastric tissues from patients with gastric cancer. Cancer Lett. 84, 199-202.
11. Flocke, K., and, Mannherz, H. G., (1991) Isolation and characterization of 5'-nucleotidase of a human pancreatic tumor cell line. Biochim. Biophys. Acta 1076, 273-281.
12. Kondo, T., Nakazawa, T., Murata, S. I., and, Katoh, R., (2006) Expression of CD73 and its ecto-5'-nucleotidase activity are elevated in papillary thyroid carcinomas. Histopathology 48, 612-614.
13. Gutensohn, W., Thiel, E., and, Emmerich, B., (1983) Evaluation of 5'-nucleotidase as biochemical marker in leukemias and lymphomas. Klin. Wochenschr. 61, 57-62.
14. Fukunaga, Y., Evans, S. S., Yamamoto, M., Ueda, Y., Tamura, K., et al. (1989) Increased density of ecto 5' nucleotidase antigen on leukemic T cells from patients with cutaneous T-cell lymphoma and adult T-cell leukemia/lymphoma. Blood 74, 2486-2492.
15. Fenoglio, C., Necchi, D., Civallero, M., Ceroni, M., and, Nano, R., (1997) Cytochemical demonstration of nitric oxide synthase and 5' nucleotidase in human glioblastoma. Anticancer Res. 17, 2507-2511.
16. Stagg, J., Divisekera, U., McLaughlin, N., Sharkey, J., Pommey, S., et al. (2010) Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc. Natl. Acad. Sci. USA 107, 1547-1552.
17. Spychala, J., Lazarowski, E., Ostapkowicz, A., Ayscue, L. H., Jin, A., et al. (2004) Role of estrogen receptor in the regulation of ecto-5'-nucleotidase and adenosine in breast cancer. Clin. Cancer Res. 10, 708-717.
18. Spychala, J., (2000) Tumor-promoting functions of adenosine. Pharmacol. Ther. 87, 161-173.
19. Stagg, J., Beavis, P. A., Divisekera, U., Liu, M. C., Moller, A., et al. (2012) CD73-deficient mice are resistant to carcinogenesis. Cancer Res. 72, 2190-2196.
20. Stagg, J., Divisekera, U., Duret, H., Sparwasser, T., Teng, M. W., et al. (2011) CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis. Cancer Res. 71, 2892-2900.
21. Mikhailov, A., Sokolovskaya, A., Yegutkin, G. G., Amdahl, H., West, A., et al. (2008) CD73 participates in cellular multiresistance program and protects against TRAIL-induced apoptosis. J. Immunol. 181, 464-475.
22. Supernat, A., Markiewicz, A., Welnicka-Jaskiewicz, M., Seroczynska, B., Skokowski, J., et al. (2012) CD73 expression as a potential marker of good prognosis in breast carcinoma. Appl. Immunohistochem. Mol. Morphol. 20, 103-107.
23. Zajchowski, D. A., Bartholdi, M. F., Gong, Y., Webster, L., Liu, H. L., et al. (2001) Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells. Cancer Res. 61, 5168-5178.
24. Monaghan-Benson, E., and, McKeown-Longo, P. J., (2006) Urokinase-type plasminogen activator receptor regulates a novel pathway of fibronectin matrix assembly requiring Src-dependent transactivation of epidermal growth factor receptor. J. Biol. Chem. 281, 9450-9459.
25. Zhi, X., Chen, S., Zhou, P., Shao, Z., Wang, L., et al. (2007) RNA interference of ecto-5'-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion. Clin. Exp. Metastasis 24, 439-448.
26. Zhi, X., Wang, Y., Zhou, X., Yu, J., Jian, R., et al. (2010) RNAi-mediated CD73 suppression induces apoptosis and cell-cycle arrest in human breast cancer cells. Cancer Sci. 101, 2561-2569.
27. Jin, D., Fan, J., Wang, L., Thompson, L. F., Liu, A., et al. (2010) CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res. 70, 2245-2255.
28. Fischer, O. M., Hart, S., Gschwind, A., and, Ullrich, A., (2003) EGFR signal transactivation in cancer cells. Biochem. Soc. Trans. 31, 1203-1208.
29. Williams-Pritchard, G., Knight, M., Hoe, L. S., Headrick, J. P., and, Peart, J. N., (2011) Essential role of EGFR in cardioprotection and signaling responses to A1 adenosine receptors and ischemic preconditioning. Am. J. Physiol. Heart Circ. Physiol. 300, H2161-H2168.
30. Chen, A., and, Xu, J., (2005) Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G447-G456.
31. Wakabayashi, K., Kambe, F., Nagaya, T., Kato, M., Saito, K., et al. (2002) Effect of PPARα ligand on TNFα-dependent expression of EGF receptor in human glioma cell line. Environ. Med. 46, 33-35.
32. Biscardi, J. S., Maa, M. C., Tice, D. A., Cox, M. E., Leu, T. H., et al. (1999) c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J. Biol. Chem. 274, 8335-8343.
33. Airas, L., Niemela, J., Salmi, M., Puurunen, T., Smith, D. J., et al. (1997) Differential regulation and function of CD73, a glycosyl- phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells. J. Cell Biol. 136, 421-431.
34. Xie, K. Q., Zhang, L. M., Cao, Y., Zhu, J., Feng, L. Y., (2009) Adenosine A(1) receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro. Acta Pharmacol. Sin. 30, 889-898.
35. Kamath, L., Meydani, A., Foss, F., and, Kuliopulos, A., (2001) Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells. Cancer Res. 61, 5933-5940.
36. Bloomer, C. W., Kenyon, L., Hammond, E., Hyslop, T., Andrews, D. W., et al. (2003) Cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) expression in human pituitary macroadenomas. Am. J. Clin. Oncol. 26, S75-S80.
37. Bartsch, J. E., Staren, E. D., and, Appert, H. E., (2003) Adhesion and migration of extracellular matrix-stimulated breast cancer. J. Surg. Res. 110, 287-294.
38. Lau, G. T., Huang, H., Lin, S. M., and, Leung, L. K., (2010) Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells. Eur. J. Pharmacol. 648, 24-30.
39. McShane, L. M., Altman, D. G., Sauerbrei, W., Taube, S. E., Gion, M., et al. (2005) Reporting recommendations for tumour MARKer prognostic studies (REMARK). Br. J. Cancer 93, 387-391.
40. Gyorffy, B., Lanczky, A., Eklund, A. C., Denkert, C., Budczies, J., et al. (2010) An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res. Treat. 123, 725-731.