Degradation of Akt using protein-catalyzed capture agents

Journal of Peptide Science

Volumn 22, Issue 4, 2016, Pages 196-200

  Henning, Ryan K ^a   Varghese, Joseph O ^a   Das, Samir ^a   Nag, Arundhati ^a   Tang, Grace ^a   Tang, Kevin ^a   Sutherland, Alexander M ^a   Heath, James R ^a  

^a California Institute of Technology   (United States)

Author keywords

Akt; click chemistry; PROTAC; protein catalyzed capture agents

Indexed keywords

CHIMERIC PROTEIN; EPITOPE; PROTEIN KINASE B; ANTINEOPLASTIC AGENT; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PEPTIDE; TRI-A TRILIGAND;

ALLOSTERISM; ARTICLE; CLICK CHEMISTRY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; LIVER CANCER CELL LINE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; CATALYSIS; CELL PROLIFERATION; DRUG SCREENING; ENZYME ACTIVATION; HUMAN; IC50; METABOLISM; MOLECULARLY TARGETED THERAPY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CATALYSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INHIBITORY CONCENTRATION 50; MOLECULAR TARGETED THERAPY; PEPTIDES; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84959160925     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.2858     Document Type: Article

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