Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 22, 2013, Pages 8942-8947

  Hines, John ^a   Gough, Jonathan D ^a   Corson, Timothy W ^a   Crews, Craig M ^a,b,c  

^a Office of Cellular Tissues and Gene Therapies   (United States)

^b Department of Chemistry ^*  (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Protein degradation; SH2 domain; Signal transduction

Indexed keywords

CHIMERIC PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; FIBROBLAST GROWTH FACTOR RECEPTOR 2; NERVE GROWTH FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; SUPPRESSOR OF CYTOKINE SIGNALING 3; TROPOMYOSIN; TROPOMYOSIN RECEPTOR KINASE A; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; AUTOPHOSPHORYLATION; BINDING SITE; CELL MEMBRANE PERMEABILITY; CHIMERA; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; UBIQUITINATION;

PROTEIN DEGRADATION; SH2 DOMAIN; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME ACTIVATION; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOBLOTTING; MCF-7 CELLS; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, ERBB-3; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RECEPTOR, TRKA; SIGNAL TRANSDUCTION; STREPTAVIDIN; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84878429220     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217206110     Document Type: Article

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