Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 26, 2012, Pages 10581-10586

  Jo, Hakryul ^a,b,f   Mondal, Subhanjan ^a,b   Tan, Dewar ^a,b   Nagata, Eiichiro ^c   Takizawa, Shunya ^c   Sharma, Alok K ^d   Hou, Qingming ^e   Shanmugasundaram, Kumaran ^d   Prasad, Amit ^a,b   Tung, Joe K ^a,b   Tejeda, Alexander O ^a,b   Man, Hengye ^e   Rigby, Alan C ^d   Luo, Hongbo R ^a,b  

^a DANA FARBER HARVARD CANCER CENTER   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e Boston University   (United States)

^f YALE UNIVERSITY   (United States)

Author keywords

Cell signaling; Drug discovery

Indexed keywords

MEMBRANE PROTEIN; PROTEIN KINASE B; PROTEIN SC79; SOMATOMEDIN; UNCLASSIFIED DRUG;

ARTICLE; BRAIN EDEMA; BRAIN ISCHEMIA; CELL SURVIVAL; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; EXCITOTOXICITY; FEMALE; GENETIC SCREENING; HELA CELL; HIGH THROUGHPUT SCREENING; HIPPOCAMPUS; HUMAN; HUMAN CELL; INHIBITION KINETICS; NERVE CELL CULTURE; NERVE CELL NECROSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN ISCHEMIA; CELL DEATH; CYTOSOL; ENZYME ACTIVATION; MICE; NEURONS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84862998910     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1202810109     Document Type: Article

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