Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for akt1

Journal of the American Chemical Society

Volumn 133, Issue 45, 2011, Pages 18280-18288

  Millward, Steven W ^a   Henning, Ryan K ^a   Kwong, Gabriel A ^b   Pitram, Suresh ^c   Agnew, Heather D ^c   Deyle, Kaycie M ^a   Nag, Arundhati ^a   Hein, Jason ^d   Lee, Su Seong ^e   Lim, Jaehong ^e   Pfeilsticker, Jessica A ^a   Sharpless, K Barry ^d   Heath, James R ^a  

^a California Institute of Technology   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Integrated Diagnostics   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY LIGANDS; ALLOSTERIC INHIBITOR; BIOCHEMICAL ASSAY; BRANCHED STRUCTURES; CANCER CELLS; CLICK REACTION; IMMUNOPRECIPITATES; IN-SITU; QUANTITATIVE ASSESSMENTS; SMALL MOLECULES;

MONOCLONAL ANTIBODIES; PEPTIDES;

ENZYME INHIBITION;

MONOCLONAL ANTIBODY; PEPTIDE; PROTEIN KINASE B;

ARTICLE; BINDING AFFINITY; BINDING SITE; BIOASSAY; CANCER CELL; CELL LYSATE; CLICK CHEMISTRY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ASSAY; ENZYME INHIBITION; IMMUNOPRECIPITATION; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS;

ALLOSTERIC SITE; CLICK CHEMISTRY; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80755172538     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2064389     Document Type: Article

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