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Angewandte Chemie - International Edition

Volumn 54, Issue 33, 2015, Pages 9659-9662

Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

(12) Gustafson, Jeffrey L a Neklesa, Taavi K a Cox, Carly S a Roth, Anke G a Buckley, Dennis L a Tae, Hyun Seop a Sundberg, Thomas B a Stagg, D Blake b Hines, John a McDonnell, Donald P b Norris, John D b Crews, Craig M a

a YALE UNIVERSITY (United States)

b DUKE UNIVERSITY SCHOOL OF MEDICINE (United States)

Author keywords

antiproliferation; cancer; drug design; hormones; protein degradation

Indexed keywords

CELL CULTURE; CELL PROLIFERATION; DISEASES; HORMONES; HYDROPHOBICITY; TRANSCRIPTION; TUMORS; UROLOGY;

ANDROGEN-DEPENDENT; ANTI-TUMOR CHEMOTHERAPEUTIC; ANTIPROLIFERATION; CANCER; DRUG DESIGN; PROSTATE CANCER CELLS; PROTEIN DEGRADATION; RESISTANCE MECHANISMS;

MOLECULES;

ANDROGEN RECEPTOR; ANDROGEN RECEPTOR ANTAGONIST; ANTINEOPLASTIC AGENT; AR PROTEIN, HUMAN; ENZALUTAMIDE; MOLECULAR LIBRARY; PHENYLTHIOHYDANTOIN;

ANALOGS AND DERIVATIVES; CELL PROLIFERATION; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; HUMAN; MALE; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; POINT MUTATION; PROSTATE; PROSTATIC NEOPLASMS; PROTEIN DEGRADATION; TUMOR CELL LINE;

ANDROGEN RECEPTOR ANTAGONISTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MALE; PHENYLTHIOHYDANTOIN; POINT MUTATION; PROSTATE; PROSTATIC NEOPLASMS; PROTEOLYSIS; RECEPTORS, ANDROGEN; SMALL MOLECULE LIBRARIES;

EID: 84938415968 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201503720 Document Type: Article

Times cited : (154)

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