Cell-permeable cyclic peptides from synthetic libraries inspired by natural products

Journal of the American Chemical Society

Volumn 137, Issue 2, 2015, Pages 715-721

  Hewitt, William M ^a   Leung, Siegfried S F ^b,d   Pye, Cameron R ^a   Ponkey, Alexandra R ^a   Bednarek, Maria ^c   Jacobson, Matthew P ^b   Lokey, R Scott ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MEDIMMUNE   (United States)

^d Circle Pharma Inc ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIBRARIES; MOLECULES; PEPTIDES; PROTEINS;

CHEMICAL EQUATIONS; COMBINATORIAL LIBRARY; COMPUTATIONAL APPROACH; MEMBRANE DIFFUSION; MEMBRANE-PERMEABLE; PROTEIN-PROTEIN INTERACTIONS; SMALL-MOLECULE DRUGS; THERAPEUTIC TARGETS;

SCAFFOLDS (BIOLOGY);

BACERIDIN; CYCLOPEPTIDE; GUANGOMIDE A; HEXAPEPTIDE; MOLECULAR SCAFFOLD; NATURAL PRODUCT; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT;

ARTICLE; CELL MEMBRANE PERMEABILITY; COMBINATORIAL LIBRARY; CONSENSUS SEQUENCE; DIASTEREOISOMER; HYDROGEN BOND; LIPOPHILICITY; STEREOCHEMISTRY; STEREOISOMERISM; BIOMIMETICS; CACO 2 CELL LINE; CHEMICAL STRUCTURE; COMBINATORIAL CHEMISTRY; HUMAN; METABOLISM; PROTEIN CONFORMATION;

BIOLOGICAL PRODUCTS; BIOMIMETICS; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; MODELS, MOLECULAR; PEPTIDES, CYCLIC; PROTEIN CONFORMATION;

EID: 84921484823     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja508766b     Document Type: Article

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