-
1
-
-
77949967131
-
Targeting metabolic transformation for cancer therapy
-
PMID:20300106
-
Tennant DA, Durán RV, Gottlieb E. Targeting metabolic transformation for cancer therapy. Nat Rev Cancer 2010; 10:267-77; PMID:20300106; http://dx.doi.org/10.1038/nrc2817.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 267-277
-
-
Tennant, D.A.1
Durán, R.V.2
Gottlieb, E.3
-
2
-
-
0031795905
-
Adaptive alterations in cellular metabolism with malignant transformation
-
discussion 634-6; PMID:9605654
-
Fischer CP, Bode BP, Souba WW. Adaptive alterations in cellular metabolism with malignant transformation. Ann Surg 1998; 227:627-34, discussion 634-6; PMID:9605654; http://dx.doi.org/10.1097/00000658-199805000-00003.
-
(1998)
Ann Surg
, vol.227
, pp. 627-634
-
-
Fischer, C.P.1
Bode, B.P.2
Souba, W.W.3
-
3
-
-
79959588949
-
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells
-
PMID:21692052
-
Sandulache VC, Ow TJ, Pickering CR, Frederick MJ, Zhou G, Fokt I, et al. Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. Cancer 2011; 117:2926-38; PMID:21692052; http://dx.doi.org/10.1002/cncr.25868.
-
(2011)
Cancer
, vol.117
, pp. 2926-2938
-
-
Sandulache, V.C.1
Ow, T.J.2
Pickering, C.R.3
Frederick, M.J.4
Zhou, G.5
Fokt, I.6
-
4
-
-
75149148563
-
Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer
-
PMID:19881548
-
DeBerardinis RJ, Cheng T. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010; 29:313-24; PMID:19881548; http://dx.doi.org/10.1038/onc.2009.358.
-
(2010)
Oncogene
, vol.29
, pp. 313-324
-
-
DeBerardinis, R.J.1
Cheng, T.2
-
5
-
-
77958478353
-
Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells
-
PMID:20935507
-
Meng M, Chen S, Lao T, Liang D, Sang N. Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells. Cell Cycle 2010; 9:3921-32; PMID:20935507; http://dx.doi.org/10.4161/cc.9.19.13139.
-
(2010)
Cell Cycle
, vol.9
, pp. 3921-3932
-
-
Meng, M.1
Chen, S.2
Lao, T.3
Liang, D.4
Sang, N.5
-
6
-
-
0036130362
-
Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death
-
PMID:11906817
-
Matés JM, Pérez-Gómez C, Núñez de Castro I, Asenjo M, Márquez J. Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death. Int J Biochem Cell Biol 2002; 34:439-58; PMID:11906817; http://dx.doi.org/10.1016/ S1357-2725(01)00143-1.
-
(2002)
Int J Biochem Cell Biol
, vol.34
, pp. 439-458
-
-
Matés, J.M.1
Pérez-Gómez, C.2
Núñez De Castro, I.3
Asenjo, M.4
Márquez, J.5
-
8
-
-
0033620972
-
Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing
-
PMID:11015561
-
Elgadi KM, Meguid RA, Qian M, Souba WW, Abcouwer SF. Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing. Physiol Genomics 1999; 1:51-62; PMID:11015561.
-
(1999)
Physiol Genomics
, vol.1
, pp. 51-62
-
-
Elgadi, K.M.1
Meguid, R.A.2
Qian, M.3
Souba, W.W.4
Abcouwer, S.F.5
-
9
-
-
0025080859
-
Biosynthesis and processing of renal mitochondrial glutaminase in cultured proximal tubular epithelial cells and in isolated mitochondria
-
PMID:2211660
-
Perera SY, Chen TC, Curthoys NP. Biosynthesis and processing of renal mitochondrial glutaminase in cultured proximal tubular epithelial cells and in isolated mitochondria. J Biol Chem 1990; 265:17764-70; PMID:2211660.
-
(1990)
J Biol Chem
, vol.265
, pp. 17764-17770
-
-
Perera, S.Y.1
Chen, T.C.2
Curthoys, N.P.3
-
10
-
-
64749116346
-
C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
PMID:19219026
-
Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009; 458:762-5; PMID:19219026; http://dx.doi.org/10.1038/nature07823.
-
(2009)
Nature
, vol.458
, pp. 762-765
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.C.3
Lee, Y.S.4
Kita, K.5
Ochi, T.6
-
11
-
-
57749088701
-
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
-
PMID:19033189
-
Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A 2008; 105:18782-7; PMID:19033189; http://dx.doi.org/10.1073/pnas.0810199105.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 18782-18787
-
-
Wise, D.R.1
DeBerardinis, R.J.2
Mancuso, A.3
Sayed, N.4
Zhang, X.Y.5
Pfeiffer, H.K.6
-
12
-
-
77952737658
-
Mitochondrial metabolism and ROS generation are essential for Krasmediated tumorigenicity
-
PMID:20421486
-
Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, et al. Mitochondrial metabolism and ROS generation are essential for Krasmediated tumorigenicity. Proc Natl Acad Sci U S A 2010; 107:8788-93; PMID:20421486; http://dx.doi.org/10.1073/pnas.1003428107.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 8788-8793
-
-
Weinberg, F.1
Hamanaka, R.2
Wheaton, W.W.3
Weinberg, S.4
Joseph, J.5
Lopez, M.6
-
13
-
-
77956497712
-
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation
-
PMID:20832749
-
Wang JB, Erickson JW, Fuji R, Ramachandran S, Gao P, Dinavahi R, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 2010; 18:207-19; PMID:20832749; http://dx.doi.org/10.1016/j.ccr. 2010.08.009.
-
(2010)
Cancer Cell
, vol.18
, pp. 207-219
-
-
Wang, J.B.1
Erickson, J.W.2
Fuji, R.3
Ramachandran, S.4
Gao, P.5
Dinavahi, R.6
-
14
-
-
78549283855
-
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1
-
PMID:21045145
-
Seltzer MJ, Bennett BD, Joshi AD, Gao P, Thomas AG, Ferraris DV, et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res 2010; 70:8981-7; PMID:21045145; http://dx.doi.org/10. 1158/0008-5472.CAN-10-1666.
-
(2010)
Cancer Res
, vol.70
, pp. 8981-8987
-
-
Seltzer, M.J.1
Bennett, B.D.2
Joshi, A.D.3
Gao, P.4
Thomas, A.G.5
Ferraris, D.V.6
-
15
-
-
0034212427
-
Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells
-
PMID:10816417
-
Lobo C, Ruiz-Bellido MA, Aledo JC, Márquez J, Núñez De Castro I, Alonso FJ. Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells. Biochem J 2000; 348:257-61; PMID:10816417; http://dx.doi.org/10.1042/0264-6021:3480257.
-
(2000)
Biochem J
, vol.348
, pp. 257-261
-
-
Lobo, C.1
Ruiz-Bellido, M.A.2
Aledo, J.C.3
Márquez, J.4
Núñez De Castro, I.5
Alonso, F.J.6
-
16
-
-
8644279503
-
Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells
-
PMID:15511236
-
Lora J, Alonso FJ, Segura JA, Lobo C, Márquez J, Matés JM. Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells. Eur J Biochem 2004; 271:4298-306; PMID:15511236; http://dx.doi.org/10.1111/j.1432-1033.2004.04370.x.
-
(2004)
Eur J Biochem
, vol.271
, pp. 4298-4306
-
-
Lora, J.1
Alonso, F.J.2
Segura, J.A.3
Lobo, C.4
Márquez, J.5
Matés, J.M.6
-
17
-
-
67650874081
-
Cancer statistics, 2009
-
PMID:19474385
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009; 59:225-49; PMID:19474385; http://dx.doi.org/10.3322/ caac.20006.
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Thun, M.J.6
-
18
-
-
77951717316
-
Molecular target class is predictive of in vitro response profile
-
PMID:20406975
-
Greshock J, Bachman KE, Degenhardt YY, Jing J, Wen YH, Eastman S, et al. Molecular target class is predictive of in vitro response profile. Cancer Res 2010; 70:3677-86; PMID:20406975; http://dx.doi.org/10.1158/0008-5472.CAN-09- 3788.
-
(2010)
Cancer Res
, vol.70
, pp. 3677-3686
-
-
Greshock, J.1
Bachman, K.E.2
Degenhardt, Y.Y.3
Jing, J.4
Wen, Y.H.5
Eastman, S.6
-
19
-
-
79961102335
-
Gene expression profiling reveals novel biomarkers in nonsmall cell lung cancer
-
PMID:20878980
-
Sanchez-Palencia A, Gomez-Morales M, Gomez-Capilla JA, Pedraza V, Boyero L, Rosell R, et al. Gene expression profiling reveals novel biomarkers in nonsmall cell lung cancer. Int J Cancer 2011; 129:355-64; PMID:20878980; http://dx.doi.org/10.1002/ijc.25704.
-
(2011)
Int J Cancer
, vol.129
, pp. 355-364
-
-
Sanchez-Palencia, A.1
Gomez-Morales, M.2
Gomez-Capilla, J.A.3
Pedraza, V.4
Boyero, L.5
Rosell, R.6
-
20
-
-
0017324665
-
Glutamine binding sites
-
PMID:909432
-
Pinkus LM. Glutamine binding sites. Methods Enzymol 1977; 46:414-27; PMID:909432; http://dx.doi.org/10.1016/S0076-6879(77)46049-X.
-
(1977)
Methods Enzymol
, vol.46
, pp. 414-427
-
-
Pinkus, L.M.1
-
21
-
-
34548789512
-
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl) ethyl sulfide (BPTES)
-
PMID:17581113
-
Robinson MM, McBryant SJ, Tsukamoto T, Rojas C, Ferraris DV, Hamilton SK, et al. Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl) ethyl sulfide (BPTES). Biochem J 2007; 406:407-14; PMID:17581113; http://dx.doi.org/10.1042/BJ20070039.
-
(2007)
Biochem J
, vol.406
, pp. 407-414
-
-
Robinson, M.M.1
McBryant, S.J.2
Tsukamoto, T.3
Rojas, C.4
Ferraris, D.V.5
Hamilton, S.K.6
-
22
-
-
77953229896
-
Kinetics of a novel isoform of phosphate activated glutaminase (PAG) in SH-SY5Y neuroblastoma cells
-
PMID:19894115
-
Roberg BA, Torgner IA, Kvamme E. Kinetics of a novel isoform of phosphate activated glutaminase (PAG) in SH-SY5Y neuroblastoma cells. Neurochem Res 2010; 35:875-80; PMID:19894115; http://dx.doi.org/10.1007/s11064-009-0077-7.
-
(2010)
Neurochem Res
, vol.35
, pp. 875-880
-
-
Roberg, B.A.1
Torgner, I.A.2
Kvamme, E.3
-
23
-
-
64949087598
-
Glutamine in neoplastic cells: Focus on the expression and roles of glutaminases
-
PMID:19428809
-
Szeliga M, Obara-Michlewska M. Glutamine in neoplastic cells: focus on the expression and roles of glutaminases. Neurochem Int 2009; 55:71-5; PMID:19428809; http://dx.doi.org/10.1016/j.neuint.2009.01.008.
-
(2009)
Neurochem Int
, vol.55
, pp. 71-75
-
-
Szeliga, M.1
Obara-Michlewska, M.2
-
24
-
-
41049090828
-
Relative expression of mRNAS coding for glutaminase isoforms in CNS tissues and CNS tumors
-
PMID:17940881
-
Szeliga M, Matyja E, Obara M, Grajkowska W, Czernicki T, Albrecht J. Relative expression of mRNAS coding for glutaminase isoforms in CNS tissues and CNS tumors. Neurochem Res 2008; 33:808-13; PMID:17940881; http://dx.doi.org/10. 1007/s11064-007-9507-6.
-
(2008)
Neurochem Res
, vol.33
, pp. 808-813
-
-
Szeliga, M.1
Matyja, E.2
Obara, M.3
Grajkowska, W.4
Czernicki, T.5
Albrecht, J.6
-
25
-
-
0347370301
-
Complexity and species variation of the kidney-type glutaminase gene
-
PMID:12045296
-
Porter LD, Ibrahim H, Taylor L, Curthoys NP. Complexity and species variation of the kidney-type glutaminase gene. Physiol Genomics 2002; 9:157-66; PMID:12045296.
-
(2002)
Physiol Genomics
, vol.9
, pp. 157-166
-
-
Porter, L.D.1
Ibrahim, H.2
Taylor, L.3
Curthoys, N.P.4
-
26
-
-
84856374900
-
Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism
-
PMID:22228304
-
Cassago A, Ferreira AP, Ferreira IM, Fornezari C, Gomes ER, Greene KS, et al. Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. Proc Natl Acad Sci U S A 2012; 109:1092-7; PMID:22228304; http://dx.doi.org/10.1073/pnas. 1112495109.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 1092-1097
-
-
Cassago, A.1
Ferreira, A.P.2
Ferreira, I.M.3
Fornezari, C.4
Gomes, E.R.5
Greene, K.S.6
-
27
-
-
79958103961
-
Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
-
PMID:20156581
-
Mazurek S. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol 2011; 43:969-80; PMID:20156581; http://dx.doi.org/10.1016/j.biocel.2010.02.005.
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 969-980
-
-
Mazurek, S.1
-
28
-
-
0026701297
-
Glutamine antagonist with diet deficient in glutamine and aspartate reduce tumor growth
-
PMID:1412455
-
Yoshioka K, Takehara H, Okada A, Komi N. Glutamine antagonist with diet deficient in glutamine and aspartate reduce tumor growth. Tokushima J Exp Med 1992; 39:69-76; PMID:1412455.
-
(1992)
Tokushima J Exp Med
, vol.39
, pp. 69-76
-
-
Yoshioka, K.1
Takehara, H.2
Okada, A.3
Komi, N.4
-
29
-
-
46749104479
-
Premature senescence of human endothelial cells induced by inhibition of glutaminase
-
PMID:18317946
-
Unterluggauer H, Mazurek S, Lener B, Hütter E, Eigenbrodt E, Zwerschke W, et al. Premature senescence of human endothelial cells induced by inhibition of glutaminase. Biogerontology 2008; 9:247-59; PMID:18317946; http://dx.doi.org/10.1007/s10522-008-9134-x.
-
(2008)
Biogerontology
, vol.9
, pp. 247-259
-
-
Unterluggauer, H.1
Mazurek, S.2
Lener, B.3
Hütter, E.4
Eigenbrodt, E.5
Zwerschke, W.6
-
30
-
-
0033166518
-
A mechanism behind the antitumour effect of 6-diazo-5-oxo-L-norleucine (DON): Disruption of mitochondria
-
PMID:10533463
-
Wu F, Lukinius A, Bergström M, Eriksson B, Watanabe Y, Långström B. A mechanism behind the antitumour effect of 6-diazo-5-oxo-L-norleucine (DON): disruption of mitochondria. Eur J Cancer 1999; 35:1155-61; PMID:10533463; http://dx.doi.org/10.1016/S0959-8049(99)00099-4.
-
(1999)
Eur J Cancer
, vol.35
, pp. 1155-1161
-
-
Wu, F.1
Lukinius, A.2
Bergström, M.3
Eriksson, B.4
Watanabe, Y.5
Långström, B.6
|