메뉴 건너뛰기




Volumn 13, Issue 1, 2013, Pages 65-178

Current and experimental antibody-based therapeutics: Insights, breakthroughs, setbacks and future directions

Author keywords

Antibody; Antibody based therapeutics; Antithrombotic agents; Immune response; Monoclonal antibodies

Indexed keywords

ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; FIBRINOLYTIC AGENT; MONOCLONAL ANTIBODY;

EID: 84957942752     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (15)

References (171)
  • 1
    • 33746836894 scopus 로고    scopus 로고
    • Targeted therapy of cancer: New prospects for antibodies and immunoconjugates
    • Sharkey RM, Goldenberg DM. Targeted therapy of cancer: new prospects for antibodies and immunoconjugates. CA Cancer J Clin 2006; 56: 226-43.
    • (2006) CA Cancer J Clin , vol.56 , pp. 226-243
    • Sharkey, R.M.1    Goldenberg, D.M.2
  • 2
    • 16844385150 scopus 로고    scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity. 1975
    • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. 1975. J Immunol 2005; 174: 2453-5.
    • (2005) J Immunol , vol.174 , pp. 2453-2455
    • Kohler, G.1    Milstein, C.2
  • 3
    • 74749097572 scopus 로고    scopus 로고
    • Teillaud JL. [Antibodies: Better knowledge for a better use]
    • Abes R, Dutertre CA, Teillaud JL. [Antibodies: better knowledge for a better use]. Med Sci (Paris) 2009; 25: 1011-9.
    • (2009) Med Sci (Paris) , vol.25
    • Abes, R.1    Dutertre, C.A.2
  • 4
    • 77951586447 scopus 로고    scopus 로고
    • Strategies and challenges for the next generation of therapeutic antibodies
    • Beck A, Wurch T, Bailly C, Corvaia N. Strategies and challenges for the next generation of therapeutic antibodies. Nat Rev Immunol 2010; 10: 345-52.
    • (2010) Nat Rev Immunol , vol.10 , pp. 345-352
    • Beck, A.1    Wurch, T.2    Bailly, C.3    Corvaia, N.4
  • 5
    • 0026880552 scopus 로고
    • Between fact and technique: The beginnings of hybridoma technology
    • Cambrosio A, Keating P. Between fact and technique: the beginnings of hybridoma technology. J Hist Biol 1992; 25: 175-230.
    • (1992) J Hist Biol , vol.25 , pp. 175-230
    • Cambrosio, A.1    Keating, P.2
  • 7
    • 77951529848 scopus 로고    scopus 로고
    • Therapeutic antibodies for autoimmunity and inflammation
    • Chan AC, Carter PJ. Therapeutic antibodies for autoimmunity and inflammation. Nat Rev Immunol 2010; 10: 301-16.
    • (2010) Nat Rev Immunol , vol.10 , pp. 301-316
    • Chan, A.C.1    Carter, P.J.2
  • 8
    • 84857139331 scopus 로고    scopus 로고
    • Monoclonal antibodiesfor the treatment of cancer
    • Shuptrine CW, Surana R, Weiner LM. Monoclonal antibodiesfor the treatment of cancer. Semin Cancer Biol 2012; 22(1): 3-13.
    • (2012) Semin Cancer Biol , vol.22 , Issue.1 , pp. 3-13
    • Shuptrine, C.W.1    Surana, R.2    Weiner, L.M.3
  • 9
    • 0029565168 scopus 로고
    • Side-effects of a monoclonal antibody, muromonab CD3/orthoclone OKT3: Bibliographic review
    • Sgro C. Side-effects of a monoclonal antibody, muromonab CD3/orthoclone OKT3: bibliographic review. Toxicology 1995; 105: 23-9.
    • (1995) Toxicology , vol.105 , pp. 23-29
    • Sgro, C.1
  • 10
    • 0028812791 scopus 로고
    • Mechanisms of action and overview of OKT3
    • Norman DJ. Mechanisms of action and overview of OKT3. Ther Drug Monit 1995; 17: 615-20.
    • (1995) Ther Drug Monit , vol.17 , pp. 615-620
    • Norman, D.J.1
  • 11
    • 74749083620 scopus 로고    scopus 로고
    • [Toxic effects and use of therapeutic monoclonal antibodies]
    • Pallardy M. [Toxic effects and use of therapeutic monoclonal antibodies]. Med Sci (Paris) 2009; 25: 1130-4.
    • (2009) Med Sci (Paris) , vol.25 , pp. 1130-1134
    • Pallardy, M.1
  • 12
    • 79952001750 scopus 로고    scopus 로고
    • Mechanisms of monoclonal antibody-drug interactions
    • Zhou H, Mascelli MA. Mechanisms of monoclonal antibody-drug interactions. Annu Rev Pharmacol Toxicol 2011; 51: 359-72.
    • (2011) Annu Rev Pharmacol Toxicol , vol.51 , pp. 359-372
    • Zhou, H.1    Mascelli, M.A.2
  • 14
    • 0344665785 scopus 로고    scopus 로고
    • Comparative pharmacology of GP IIb/IIIa antagonists
    • Schror K, Weber AA. Comparative pharmacology of GP IIb/IIIa antagonists. J Thromb Thrombolysis 2003; 15: 71-80.
    • (2003) J Thromb Thrombolysis , vol.15 , pp. 71-80
    • Schror, K.1    Weber, A.A.2
  • 15
    • 0034916180 scopus 로고    scopus 로고
    • Platelet aggregation inhibition with glycoprotein IIb--IIIa inhibitors
    • Proimos G. Platelet aggregation inhibition with glycoprotein IIb--IIIa inhibitors. J Thromb Thrombolysis 2001; 11: 99-110.
    • (2001) J Thromb Thrombolysis , vol.11 , pp. 99-110
    • Proimos, G.1
  • 16
    • 0024348697 scopus 로고
    • Generation and characterization of monoclonal antibodies specific for the human neu oncogene product
    • 185
    • McKenzie SJ, Marks PJ, Lam T, Morgan J, Panicali DL, Trimpe KL, Carney WP. Generation and characterization of monoclonal antibodies specific for the human neu oncogene product, p185. Oncogene 1989; 4: 543-8.
    • (1989) Oncogene , vol.4 , pp. 543-548
    • McKenzie, S.J.1    Marks, P.J.2    Lam, T.3    Morgan, J.4    Panicali, D.L.5    Trimpe, K.L.6    Carney, W.P.7
  • 17
    • 77952056212 scopus 로고    scopus 로고
    • Engineering and characterization of a chimeric anti-platelet glycoprotein Ibalpha monoclonal antibody and preparation of its Fab fragment
    • Yang J, Ji S, Dong N, Zhao Y, Ruan C. Engineering and characterization of a chimeric anti-platelet glycoprotein Ibalpha monoclonal antibody and preparation of its Fab fragment. Hybridoma (Larchmt) 2010; 29: 125-32.
    • (2010) Hybridoma (Larchmt) , vol.29 , pp. 125-132
    • Yang, J.1    Ji, S.2    Dong, N.3    Zhao, Y.4    Ruan, C.5
  • 18
    • 0034978577 scopus 로고    scopus 로고
    • Expression and purification of monospecific and bispecific recombinant antibody fragments derived from antibodies that block the CD80/CD86-CD28 costimulatory pathway
    • Dincq S, Bosman F, Buyse MA, et al. Expression and purification of monospecific and bispecific recombinant antibody fragments derived from antibodies that block the CD80/CD86-CD28 costimulatory pathway. Protein Expr Purif 2001; 22: 11-24.
    • (2001) Protein Expr Purif , vol.22 , pp. 11-24
    • Dincq, S.1    Bosman, F.2    Buyse, M.A.3
  • 19
    • 84856226120 scopus 로고    scopus 로고
    • Novel peptideligand with high binding capacity for antibody purification
    • Lund LN, Gustavsson PE, Michael R, et al. Novel peptideligand with high binding capacity for antibody purification. J Chromatogr A 2012; 1225: 158-67.
    • (2012) J Chromatogr A , vol.1225 , pp. 158-167
    • Lund, L.N.1    Gustavsson, P.E.2    Michael, R.3
  • 20
    • 80051941878 scopus 로고    scopus 로고
    • Therapeutic monoclonal antibodies
    • Yamada T. Therapeutic monoclonal antibodies. Keio J Med2011; 60: 37-46.
    • Keio J Med2011 , vol.60 , pp. 37-46
    • Yamada, T.1
  • 21
    • 79952639529 scopus 로고    scopus 로고
    • Hybridoma technologies for antibodyproduction
    • Tomita M, Tsumoto K. Hybridoma technologies for antibodyproduction. Immunotherapy 2011; 3: 371-80.
    • (2011) Immunotherapy , vol.3 , pp. 371-380
    • Tomita, M.1    Tsumoto, K.2
  • 22
    • 80053648778 scopus 로고    scopus 로고
    • Monoclonal antibodiesand antibody fragments: State of the art and future perspectives in the treatment of non-haematological tumors
    • Di Fede G, Bronte G, Rizzo S, et al. Monoclonal antibodiesand antibody fragments: state of the art and future perspectives in the treatment of non-haematological tumors. Expert Opin Biol Ther 2011; 11: 1433-45.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1433-1445
    • Di Fede, G.1    Bronte, G.2    Rizzo, S.3
  • 23
    • 84857435187 scopus 로고    scopus 로고
    • Jones ML.Improved Protein-A separation of V(H)3 Fab from Fc after papain digestion of antibodies
    • Seldon TA, Hughes KE, Munster DJ, Chin DY, Jones ML.Improved Protein-A separation of V(H)3 Fab from Fc after papain digestion of antibodies. J Biomol Tech 2011; 22: 50-2.
    • (2011) J Biomol Tech , vol.22 , pp. 50-52
    • Seldon, T.A.1    Hughes, K.E.2    Munster, D.J.3    Chin, D.Y.4
  • 24
    • 84856528560 scopus 로고    scopus 로고
    • DaphnisE. Blocking glomerular immunoglobulin deposits in a mouse model of lupus nephritis on indirect immunofluorescence with the use of Fab fragments
    • Petrakis I, Mavroeidi V, Stylianou K, Giannakakis K, DaphnisE. Blocking glomerular immunoglobulin deposits in a mouse model of lupus nephritis on indirect immunofluorescence with the use of Fab fragments. J Immunol Methods 2011; 376(1-2): 139-42.
    • (2011) J Immunol Methods , vol.376 , Issue.1-2 , pp. 139-142
    • Petrakis, I.1    Mavroeidi, V.2    Stylianou, K.3    Giannakakis, K.4
  • 25
    • 84858687801 scopus 로고    scopus 로고
    • A humanized GPVImouse model to assess the antithrombotic efficacy of anti- GPVI agents
    • Mangin PH, Tang C, Bourdon C, et al. A humanized GPVImouse model to assess the antithrombotic efficacy of anti- GPVI agents. J Pharmacol Exp Ther 2012; 341(1): 156-63.
    • (2012) J Pharmacol Exp Ther , vol.341 , Issue.1 , pp. 156-163
    • Mangin, P.H.1    Tang, C.2    Bourdon, C.3
  • 26
    • 84969300586 scopus 로고    scopus 로고
    • Effect of intravitreal ranibizumab inthe treatment of peripapillary choroidal neovascularisation
    • 2729
    • Hamoudi H, Sorensen TL. Effect of intravitreal ranibizumab inthe treatment of peripapillary choroidal neovascularisation. J Ophthalmol 2011; 2011: 602729.
    • (2011) J Ophthalmol , vol.2011 , Issue.60
    • Hamoudi, H.1    Sorensen, T.L.2
  • 27
    • 84864403617 scopus 로고    scopus 로고
    • Yoon YH.Ranibizumab in South Korean and Taiwanese patients with age-related macular degeneration: Primary outcome of the EXTEND 3 study
    • [Epub ahead of print]
    • Lee FL, Kwon OW, Chung H, Lai CC, Sheu SJ, Yoon YH.Ranibizumab in South Korean and Taiwanese patients with age-related macular degeneration: primary outcome of the EXTEND 3 study. Acta Ophthalmol 2012; [Epub ahead of print].
    • (2012) Acta Ophthalmol
    • Lee, F.L.1    Kwon, O.W.2    Chung, H.3    Lai, C.C.4    Sheu, S.J.5
  • 28
    • 17844399251 scopus 로고    scopus 로고
    • CDP-870 (Certolizumab) in rheumatoidarthriti
    • Kaushik VV, Moots RJ. CDP-870 (certolizumab) in rheumatoidarthritis. Expert Opin Biol Ther 2005; 5: 601-6.
    • (2005) Expert Opin Biol Ther , vol.5 , pp. 601-606
    • Kaushik, V.V.1    Moots, R.J.2
  • 29
    • 34447523749 scopus 로고    scopus 로고
    • Certolizumabpegol for the treatment of Crohn's disease
    • Sandborn WJ, Feagan BG, Stoinov S, et al. Certolizumabpegol for the treatment of Crohn's disease. N Engl J Med 2007; 357: 228-38.
    • (2007) N Engl J Med , vol.357 , pp. 228-238
    • Sandborn, W.J.1    Feagan, B.G.2    Stoinov, S.3
  • 30
    • 77953660821 scopus 로고    scopus 로고
    • Certolizumab pegol
    • Goel N, Stephens S. Certolizumab pegol. MAbs 2010; 2: 137-47.
    • (2010) Mabs , vol.2 , pp. 137-147
    • Goel, N.1    Stephens, S.2
  • 31
    • 33744947552 scopus 로고    scopus 로고
    • Monoclonal antibody formand function: Manufacturing the right antibodies for treating drug abuse
    • Peterson E, Owens SM, Henry RL. Monoclonal antibody formand function: manufacturing the right antibodies for treating drug abuse. AAPS J 2006; 8: E383-90.
    • (2006) AAPS J , vol.8 , pp. E90-EE383
    • Peterson, E.1    Owens, S.M.2    Henry, R.L.3
  • 32
    • 0036196127 scopus 로고    scopus 로고
    • Effectivesingle chain antibody (ScFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv
    • Arafat WO, Gomez-Navarro J, Buchsbaum DJ, et al. Effectivesingle chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv. Gene Ther 2002; 9: 256-62.
    • (2002) Gene Ther , vol.9 , pp. 256-262
    • Arafat, W.O.1    Gomez-Navarro, J.2    Buchsbaum, D.J.3
  • 33
    • 0032801102 scopus 로고    scopus 로고
    • Di-, tri- andtetrameric single chain Fv antibody fragments against human CD19: Effect of valency on cell binding
    • Le Gall F, Kipriyanov SM, Moldenhauer G, Little M. Di-, tri- andtetrameric single chain Fv antibody fragments against human CD19: effect of valency on cell binding. FEBS Lett 1999; 453: 164-8.
    • (1999) FEBS Lett , vol.453 , pp. 164-168
    • Le Gall, F.1    Kipriyanov, S.M.2    Moldenhauer, G.3    Little, M.4
  • 34
    • 0031942906 scopus 로고    scopus 로고
    • Prolonged in vivotumour retention of a human diabody targeting the extracellular domain of human HER2/neu
    • Adams GP, Schier R, McCall AM, et al. Prolonged in vivotumour retention of a human diabody targeting the extracellular domain of human HER2/neu. Br J Cancer 1998; 77: 1405-12.
    • (1998) Br J Cancer , vol.77 , pp. 1405-1412
    • Adams, G.P.1    Schier, R.2    McCall, A.M.3
  • 35
    • 4744362284 scopus 로고    scopus 로고
    • Preliminary reportof the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery
    • Mathew JP, Shernan SK, White WD, et al. Preliminary reportof the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery. Stroke 2004; 35: 2335-9.
    • (2004) Stroke , vol.35 , pp. 2335-2339
    • Mathew, J.P.1    Shernan, S.K.2    White, W.D.3
  • 36
    • 54149107444 scopus 로고    scopus 로고
    • Pexelizumab inischemic heart disease: A systematic review and meta-analysis on 15,196 patients
    • Testa L, Van Gaal WJ, Bhindi R, et al. Pexelizumab inischemic heart disease: a systematic review and meta-analysis on 15,196 patients. J Thorac Cardiovasc Surg 2008; 136: 884-93.
    • (2008) J Thorac Cardiovasc Surg , vol.136 , pp. 884-893
    • Testa, L.1    Van Gaal, W.J.2    Bhindi, R.3
  • 37
    • 78651387929 scopus 로고    scopus 로고
    • Antibody-based therapeutics to watch in 2011
    • Reichert JM. Antibody-based therapeutics to watch in 2011.MAbs 2011; 3: 76-99.
    • (2011) Mabs , vol.3 , pp. 76-99
    • Reichert, J.M.1
  • 38
    • 0024281428 scopus 로고
    • A novel form ofTNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF
    • Kriegler M, Perez C, DeFay K, Albert I, Lu SD. A novel form ofTNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell 1988; 53: 45-53.
    • (1988) Cell , vol.53 , pp. 45-53
    • Kriegler, M.1    Perez, C.2    Defay, K.3    Albert, I.4    Lu, S.D.5
  • 39
    • 77951573241 scopus 로고    scopus 로고
    • Antibodies to watch in 2010
    • Reichert JM. Antibodies to watch in 2010. MAbs 2010; 2: 84-100.
    • (2010) Mabs , vol.2 , pp. 84-100
    • Reichert, J.M.1
  • 40
    • 77957361348 scopus 로고    scopus 로고
    • Development trends forhuman monoclonal antibody therapeutics
    • Nelson AL, Dhimolea E, Reichert JM. Development trends forhuman monoclonal antibody therapeutics. Nat Rev Drug Discov 2010; 9: 767-74.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 767-774
    • Nelson, A.L.1    Dhimolea, E.2    Reichert, J.M.3
  • 41
    • 80155160475 scopus 로고    scopus 로고
    • Combinationtherapy for pain management in inflammatory arthritis (Rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
    • Ramiro S, Radner H, van der Heijde D, et al. Combinationtherapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis). Cochrane Database Syst Rev 2011;(10): CD008886.
    • (2011) Cochrane Database Syst Rev , vol.10
    • Ramiro, S.1    Radner, H.2    Van Der Heijde, D.3
  • 42
    • 78649657061 scopus 로고    scopus 로고
    • Antibody immunosuppressivetherapy in solid organ transplant
    • Klipa D, Mahmud N, Ahsan N. Antibody immunosuppressivetherapy in solid organ transplant: Part II. MAbs 2010; 2: 607-12.
    • (2010) Mabs , vol.2 , pp. 607-612
    • Klipa, D.1    Mahmud, N.2    Ahsan, N.3
  • 43
    • 7944234122 scopus 로고    scopus 로고
    • Prevention ofopportunistic infections in immunosuppressed patients in the tropical top end of the Northern Territory
    • Davis JS, Currie BJ, Fisher DA, et al. Prevention ofopportunistic infections in immunosuppressed patients in the tropical top end of the Northern Territory. Commun Dis Intell 2003; 27: 526-32.
    • (2003) Commun Dis Intell , vol.27 , pp. 526-532
    • Davis, J.S.1    Currie, B.J.2    Fisher, D.A.3
  • 44
    • 0025899561 scopus 로고
    • A novel IL-1 receptor,cloned from B cells by mammalian expression, is expressed in many cell types
    • McMahan CJ, Slack JL, Mosley B, et al. A novel IL-1 receptor,cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J 1991; 10: 2821-32
    • (1991) EMBO J , vol.10 , pp. 2821-2832
    • McMahan, C.J.1    Slack, J.L.2    Mosley, B.3
  • 45
    • 36048991069 scopus 로고    scopus 로고
    • Recent advances in immunopathophysiology ofinterleukin-6: An innovative therapeutic drug, tocilizumab (recombinant humanized anti-human interleukin-6 receptor antibody), unveils the mysterious etiology of immune-mediated inflammatory diseases
    • Ohsugi Y. Recent advances in immunopathophysiology ofinterleukin-6: an innovative therapeutic drug, tocilizumab (recombinant humanized anti-human interleukin-6 receptor antibody), unveils the mysterious etiology of immune-mediated inflammatory diseases. Biol Pharm Bull 2007; 30: 2001-6.
    • (2007) Biol Pharm Bull , vol.30 , pp. 2001-2006
    • Ohsugi, Y.1
  • 46
    • 73849124607 scopus 로고    scopus 로고
    • Ustekinumab: Lessonslearned from targeting interleukin-12/23p40 in immune-mediated diseases
    • Elliott M, Benson J, Blank M, et al. Ustekinumab: lessonslearned from targeting interleukin-12/23p40 in immune-mediated diseases. Ann NY Acad Sci 2009; 1182: 97-110.
    • (2009) Ann NY Acad Sci , vol.1182 , pp. 97-110
    • Elliott, M.1    Benson, J.2    Blank, M.3
  • 47
    • 0032878696 scopus 로고    scopus 로고
    • A review ofinterleukin-2 receptor antagonists in solid organ transplantation
    • Berard JL, Velez RL, Freeman RB, Tsunoda SM. A review ofinterleukin-2 receptor antagonists in solid organ transplantation. Pharmacotherapy 1999; 19: 1127-37.
    • (1999) Pharmacotherapy , vol.19 , pp. 1127-1137
    • Berard, J.L.1    Velez, R.L.2    Freeman, R.B.3    Tsunoda, S.M.4
  • 48
    • 0029565168 scopus 로고
    • Side-effects of a monoclonal antibody, muromonabCD3/orthoclone OKT3: Bibliographic review
    • Sgro C. Side-effects of a monoclonal antibody, muromonabCD3/orthoclone OKT3: bibliographic review. Toxicology 1995; 105: 23-29.
    • (1995) Toxicology , vol.105 , pp. 23-29
    • Sgro, C.1
  • 49
    • 0029932047 scopus 로고    scopus 로고
    • Muromonab CD3: A reappraisal of itspharmacology and use as prophylaxis of solid organ transplant rejection
    • Wilde MI, Goa KL. Muromonab CD3: a reappraisal of itspharmacology and use as prophylaxis of solid organ transplant rejection. Drugs 1996; 51: 865-94.
    • (1996) Drugs , vol.51 , pp. 865-894
    • Wilde, M.I.1    Goa, K.L.2
  • 50
    • 0033568236 scopus 로고    scopus 로고
    • Phase I trial of a humanized,Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala- Ala) in the treatment of acute renal allograft rejection
    • Woodle ES, Xu D, Zivin RA, et al. Phase I trial of a humanized,Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala- Ala) in the treatment of acute renal allograft rejection. Transplantation 1999; 68: 608-16.
    • (1999) Transplantation , vol.68 , pp. 608-616
    • Woodle, E.S.1    Xu, D.2    Zivin, R.A.3
  • 51
    • 0033392641 scopus 로고    scopus 로고
    • Daclizumab: A review of its use in theprevention of acute rejection in renal transplant recipients
    • Wiseman LR, Faulds D. Daclizumab: a review of its use in theprevention of acute rejection in renal transplant recipients. Drugs 1999; 58: 1029-42.
    • (1999) Drugs , vol.58 , pp. 1029-1042
    • Wiseman, L.R.1    Faulds, D.2
  • 52
    • 69549084441 scopus 로고    scopus 로고
    • [Immunosuppression after liver transplantation]
    • Calmus Y. [Immunosuppression after liver transplantation].Presse Med 2009; 38: 1307-13.
    • (2009) Presse Med , vol.38 , pp. 1307-1313
    • Calmus, Y.1
  • 53
    • 33846175028 scopus 로고    scopus 로고
    • The role of basiliximab inductiontherapy in organ transplantation
    • Ramirez CB, Marino IR. The role of basiliximab inductiontherapy in organ transplantation. Expert Opin Biol Ther 2007; 7: 137-48.
    • (2007) Expert Opin Biol Ther , vol.7 , pp. 137-148
    • Ramirez, C.B.1    Marino, I.R.2
  • 54
    • 75149156618 scopus 로고    scopus 로고
    • Basiliximab: A review of its useas induction therapy in renal transplantation
    • McKeage K, McCormack PL. Basiliximab: a review of its useas induction therapy in renal transplantation. BioDrugs 2010; 24: 55-76.
    • (2010) Biodrugs , vol.24 , pp. 55-76
    • McKeage, K.1    McCormack, P.L.2
  • 55
    • 79953070535 scopus 로고    scopus 로고
    • An overview of the diagnostic andtherapeutic use of monoclonal antibodies in medicine
    • Goldsmith SJ, Signore A. An overview of the diagnostic andtherapeutic use of monoclonal antibodies in medicine. Q J Nucl Med Mol Imaging 2010; 54: 574-81.
    • (2010) Q J Nucl Med Mol Imaging , vol.54 , pp. 574-581
    • Goldsmith, S.J.1    Signore, A.2
  • 57
    • 80052773697 scopus 로고    scopus 로고
    • Role ofT and dendritic cells in mouse islet allografts treated with anti- CD45RB monoclonal antibodies
    • Deng CY, Qi H, Wang XG, Zhou HX, Deng SP, Li FR. Role ofT and dendritic cells in mouse islet allografts treated with anti- CD45RB monoclonal antibodies. Transplant Proc 2011; 43: 2721-7.
    • (2011) Transplant Proc , vol.43 , pp. 2721-2727
    • Deng, C.Y.1    Qi, H.2    Wang, X.G.3    Zhou, H.X.4    Deng, S.P.5    Li, F.R.6
  • 58
    • 83055173312 scopus 로고    scopus 로고
    • Rapamycin combined withanti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation
    • Gagliani N, Gregori S, Jofra T, et al. Rapamycin combined withanti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation. PLoS One 2011; 6: e28434.
    • (2011) Plos One , vol.6
    • Gagliani, N.1    Gregori, S.2    Jofra, T.3
  • 59
    • 79955544000 scopus 로고    scopus 로고
    • LFA-1 antagonisminhibits early infiltration of endogenous memory CD8 T cells into cardiac allografts and donor-reactive T cell priming
    • Setoguchi K, Schenk AD, Ishii D, et al. LFA-1 antagonisminhibits early infiltration of endogenous memory CD8 T cells into cardiac allografts and donor-reactive T cell priming. Am J Transplant 2011; 11: 923-35.
    • (2011) Am J Transplant , vol.11 , pp. 923-935
    • Setoguchi, K.1    Schenk, A.D.2    Ishii, D.3
  • 60
    • 0033231415 scopus 로고    scopus 로고
    • Cerf-Bensussan N, et al. [Role ofcalcineurin-dependent drugs on the immunosuppressive effect induced by the anti-LFA-1 antibody in a fetal intestinal transplantation model in mice]
    • Cretolle-Vastel C, Camby C, Cerf-Bensussan N, et al. [Role ofcalcineurin-dependent drugs on the immunosuppressive effect induced by the anti-LFA-1 antibody in a fetal intestinal transplantation model in mice]. Chirurgie 1999; 124: 503-10.
    • (1999) Chirurgie , vol.124 , pp. 503-510
    • Cretolle-Vastel, C.1    Camby, C.2
  • 61
    • 80053264821 scopus 로고    scopus 로고
    • Dosing done right: A review ofcommon chemotherapy calculations
    • Gaguski ME, Karcheski T. Dosing done right: a review ofcommon chemotherapy calculations. Clin J Oncol Nurs 2011; 15: 471-3.
    • (2011) Clin J Oncol Nurs , vol.15 , pp. 471-473
    • Gaguski, M.E.1    Karcheski, T.2
  • 62
    • 84857139331 scopus 로고    scopus 로고
    • Monoclonal antibodiesfor the treatment of cancer
    • Shuptrine CW, Surana R, Weiner LM. Monoclonal antibodiesfor the treatment of cancer. Semin Cancer Biol 2012; 22(1): 3-13.
    • (2012) Semin Cancer Biol , vol.22 , Issue.1 , pp. 3-13
    • Shuptrine, C.W.1    Surana, R.2    Weiner, L.M.3
  • 63
    • 78049427830 scopus 로고    scopus 로고
    • Tumor antigen-targeted,monoclonal antibody-based immunotherapy: Clinical response, cellular immunity, and immunoescape
    • Ferris RL, Jaffee EM, Ferrone S. Tumor antigen-targeted,monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape. J Clin Oncol 2010; 28: 4390-9.
    • (2010) J Clin Oncol , vol.28 , pp. 4390-4399
    • Ferris, R.L.1    Jaffee, E.M.2    Ferrone, S.3
  • 64
    • 0031957306 scopus 로고    scopus 로고
    • Rituximab: A new therapeutic monoclonal antibodyfor non-Hodgkin's lymphoma
    • Scott SD. Rituximab: a new therapeutic monoclonal antibodyfor non-Hodgkin's lymphoma. Cancer Pract 1998; 6: 195-7.
    • (1998) Cancer Pract , vol.6 , pp. 195-197
    • Scott, S.D.1
  • 65
    • 1842368507 scopus 로고    scopus 로고
    • IDEC-C2B8(Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma
    • Maloney DG, Grillo-Lopez AJ, White CA, et al. IDEC-C2B8(Rituximab) anti-CD20 monoclonal antibody therapy in patients with relapsed low-grade non-Hodgkin's lymphoma. Blood 1997; 90: 2188-95.
    • (1997) Blood , vol.90 , pp. 2188-2195
    • Maloney, D.G.1    Grillo-Lopez, A.J.2    White, C.A.3
  • 66
    • 79957472810 scopus 로고    scopus 로고
    • Rituximab inHodgkin lymphoma: Is the target always a hit?
    • Saini KS, Azim HA Jr, Cocorocchio E, et al. Rituximab inHodgkin lymphoma: is the target always a hit? Cancer Treat Rev 2011; 37: 385-90.
    • (2011) Cancer Treat Rev , vol.37 , pp. 385-390
    • Saini, K.S.1    Azim, H.A.2    Cocorocchio, E.3
  • 67
    • 79955011744 scopus 로고    scopus 로고
    • Molecularmechanisms of the antitumor effects of anti-CD20 antibodies
    • Winiarska M, Glodkowska-Mrowka E, Bil J, Golab J. Molecularmechanisms of the antitumor effects of anti-CD20 antibodies. Front Biosci 2011; 16: 277-306.
    • (2011) Front Biosci , vol.16 , pp. 277-306
    • Winiarska, M.1    Glodkowska-Mrowka, E.2    Bil, J.3    Golab, J.4
  • 68
    • 0022510242 scopus 로고
    • SchlossmanSF. Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes
    • Tedder TF, Forsgren A, Boyd AW, Nadler LM, SchlossmanSF. Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes. Eur J Immunol 1986; 16: 881-7.
    • (1986) Eur J Immunol , vol.16 , pp. 881-887
    • Tedder, T.F.1    Forsgren, A.2    Boyd, A.W.3    Nadler, L.M.4
  • 70
    • 33846657588 scopus 로고    scopus 로고
    • Unique aspects of supportive careusing monoclonal antibodies in cancer treatment
    • Dillman RO, Hendrix CS. Unique aspects of supportive careusing monoclonal antibodies in cancer treatment. Support Cancer Ther 2003; 1: 38-48.
    • (2003) Support Cancer Ther , vol.1 , pp. 38-48
    • Dillman, R.O.1    Hendrix, C.S.2
  • 71
    • 0036179899 scopus 로고    scopus 로고
    • Binding to CD20 byanti-B1 antibody or F(Ab')(2) is sufficient for induction of apoptosis in B-cell lines
    • Cardarelli PM, Quinn M, Buckman D, et al. Binding to CD20 byanti-B1 antibody or F(ab')(2) is sufficient for induction of apoptosis in B-cell lines. Cancer Immunol Immunother 2002; 51: 15-24.
    • (2002) Cancer Immunol Immunother , vol.51 , pp. 15-24
    • Cardarelli, P.M.1    Quinn, M.2    Buckman, D.3
  • 72
    • 48149111997 scopus 로고    scopus 로고
    • Novel humanizedanti-CD20 monoclonal antibodies with unique germline VH and VL gene recruitment and potent effector functions
    • Nishida M, Teshigawara K, Niwa O, et al. Novel humanizedanti-CD20 monoclonal antibodies with unique germline VH and VL gene recruitment and potent effector functions. Int J Oncol 2008; 32: 1263-74.
    • (2008) Int J Oncol , vol.32 , pp. 1263-1274
    • Nishida, M.1    Teshigawara, K.2    Niwa, O.3
  • 73
    • 1942502328 scopus 로고    scopus 로고
    • Characterization of a newhumanized anti-CD20 monoclonal antibody, IMMU-106, and Its use in combination with the humanized anti-CD22 antibody, epratuzumab, for the therapy of non-Hodgkin's lymphoma
    • Stein R, Qu Z, Chen S, et al. Characterization of a newhumanized anti-CD20 monoclonal antibody, IMMU-106, and Its use in combination with the humanized anti-CD22 antibody, epratuzumab, for the therapy of non-Hodgkin's lymphoma. Clin Cancer Res 2004; 10: 2868-78.
    • (2004) Clin Cancer Res , vol.10 , pp. 2868-2878
    • Stein, R.1    Qu, Z.2    Chen, S.3
  • 74
    • 78651376557 scopus 로고    scopus 로고
    • New anti-CD20 monoclonal antibodies forthe treatment of B-cell lymphoid malignancies
    • Robak T, Robak E. New anti-CD20 monoclonal antibodies forthe treatment of B-cell lymphoid malignancies. BioDrugs 2011; 25: 13-25.
    • (2011) Biodrugs , vol.25 , pp. 13-25
    • Robak, T.1    Robak, E.2
  • 75
    • 84865455090 scopus 로고    scopus 로고
    • The future of antibodies as cancerdrugs
    • [Epub ahead of print]
    • Reichert JM, Dhimolea E. The future of antibodies as cancerdrugs. Drug Discov Today 2012; [Epub ahead of print].
    • (2012) Drug Discov Today
    • Reichert, J.M.1    Dhimolea, E.2
  • 76
    • 32844473407 scopus 로고    scopus 로고
    • Monoclonal antibody therapy
    • O'Mahony D, Bishop MR. Monoclonal antibody therapy. FrontBiosci 2006; 11: 1620-35.
    • (2006) Frontbiosci , vol.11 , pp. 1620-1635
    • O'mahony, D.1    Bishop, M.R.2
  • 77
    • 0035165102 scopus 로고    scopus 로고
    • HER2 overexpression and cancertargeting
    • Wang SC, Hung MC. HER2 overexpression and cancertargeting. Semin Oncol 2001; 28: 115-24.
    • (2001) Semin Oncol , vol.28 , pp. 115-124
    • Wang, S.C.1    Hung, M.C.2
  • 78
    • 0035680513 scopus 로고    scopus 로고
    • TargetingHER2: Recent developments and future directions for breast cancer patients
    • Wang SC, Zhang L, Hortobagyi GN, Hung MC. TargetingHER2: recent developments and future directions for breast cancer patients. Semin Oncol 2001; 28: 21-9.
    • (2001) Semin Oncol , vol.28 , pp. 21-29
    • Wang, S.C.1    Zhang, L.2    Hortobagyi, G.N.3    Hung, M.C.4
  • 79
    • 0026783567 scopus 로고
    • Prognosticfactors in human primary breast cancer: Comparison of c-myc and HER2/neu amplification
    • Berns EM, Foekens JA, van Putten WL, et al. Prognosticfactors in human primary breast cancer: comparison of c-myc and HER2/neu amplification. J Steroid Biochem Mol Biol 1992; 43: 13-9.
    • (1992) J Steroid Biochem Mol Biol , vol.43 , pp. 13-19
    • Berns, E.M.1    Foekens, J.A.2    Van Putten, W.L.3
  • 80
    • 0025986825 scopus 로고
    • A monoclonalantibody against the c-erbB-2 protein enhances the cytotoxicity of cis-diamminedichloroplatinum against human breast and ovarian tumor cell lines
    • Hancock MC, Langton BC, Chan T, et al. A monoclonalantibody against the c-erbB-2 protein enhances the cytotoxicity of cis-diamminedichloroplatinum against human breast and ovarian tumor cell lines. Cancer Res 1991; 51: 4575-80.
    • (1991) Cancer Res , vol.51 , pp. 4575-4580
    • Hancock, M.C.1    Langton, B.C.2    Chan, T.3
  • 81
    • 80053977101 scopus 로고    scopus 로고
    • Lapatinib in the treatment ofHER-2 overexpressing breast cancer
    • Vrdoljak E, Boban M, Ban M. Lapatinib in the treatment ofHER-2 overexpressing breast cancer. J BUON 2011; 16: 393-9.
    • (2011) J BUON , vol.16 , pp. 393-399
    • Vrdoljak, E.1    Boban, M.2    Ban, M.3
  • 82
    • 84857236823 scopus 로고    scopus 로고
    • Lapatinib withtrastuzumab for HER2-positive early breast cancer (NeoALTTO): A randomised, open-label, multicentre, phase 3 trial
    • Baselga J, Bradbury I, Eidtmann H, et al. Lapatinib withtrastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial. Lancet 2012; 379(9816): 633-40.
    • (2012) Lancet , vol.379 , Issue.9816 , pp. 633-640
    • Baselga, J.1    Bradbury, I.2    Eidtmann, H.3
  • 83
    • 84856032571 scopus 로고    scopus 로고
    • Cardiotoxic effects of trastuzumab
    • Hysing J, Wist E. Cardiotoxic effects of trastuzumab. TidsskrNor Laegeforen 2011; 131: 2239-41.
    • (2011) Tidsskrnor Laegeforen , vol.131 , pp. 2239-2241
    • Hysing, J.1    Wist, E.2
  • 84
    • 84859409756 scopus 로고    scopus 로고
    • Antitumor activityof a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3
    • McDonagh CF, Huhalov A, Harms BD, et al. Antitumor activityof a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3. Mol Cancer Ther 2012; 11(3): 582-93.
    • (2012) Mol Cancer Ther , vol.11 , Issue.3 , pp. 582-593
    • McDonagh, C.F.1    Huhalov, A.2    Harms, B.D.3
  • 85
    • 55249104916 scopus 로고    scopus 로고
    • Targeting ErbB2 andErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro
    • Robinson MK, Hodge KM, Horak E, et al. Targeting ErbB2 andErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro. Br J Cancer 2008; 99: 1415-25.
    • (2008) Br J Cancer , vol.99 , pp. 1415-1425
    • Robinson, M.K.1    Hodge, K.M.2    Horak, E.3
  • 86
    • 41249097332 scopus 로고    scopus 로고
    • A molecular view of anti-ErbB monoclonal antibodytherapy
    • Leahy DJ. A molecular view of anti-ErbB monoclonal antibodytherapy. Cancer Cell 2008; 13: 291-3.
    • (2008) Cancer Cell , vol.13 , pp. 291-293
    • Leahy, D.J.1
  • 88
    • 84863132749 scopus 로고    scopus 로고
    • New gene-immunotherapy combining TRAIL-lymphocytes and EpCAMxCD3 Bispecific antibody for tumor targeting
    • Groth A, Salnikov AV, Ottinger S, et al. New gene-immunotherapy combining TRAIL-lymphocytes and EpCAMxCD3 Bispecific antibody for tumor targeting. Clin Cancer Res 2012; 18: 1028-38.
    • (2012) Clin Cancer Res , vol.18 , pp. 1028-1038
    • Groth, A.1    Salnikov, A.V.2    Ottinger, S.3
  • 89
    • 79955662260 scopus 로고    scopus 로고
    • Immunomodulatory therapy ofcancer with T cell-engaging BiTE antibody blinatumomab
    • Nagorsen D, Baeuerle PA. Immunomodulatory therapy ofcancer with T cell-engaging BiTE antibody blinatumomab. Exp Cell Res 2011; 317: 1255-60.
    • (2011) Exp Cell Res , vol.317 , pp. 1255-1260
    • Nagorsen, D.1    Baeuerle, P.A.2
  • 90
    • 84858257263 scopus 로고    scopus 로고
    • Dual targeting strategies with bispecificantibodies
    • [Epub ahead of print]
    • Kontermann R. Dual targeting strategies with bispecificantibodies. MAbs 2012; 4: [Epub ahead of print].
    • (2012) Mabs , vol.4
    • Kontermann, R.1
  • 91
    • 84863177511 scopus 로고    scopus 로고
    • Plummer JB, et al.Immunotherapeutic Potential of Anti-Human EndogenousCurrent and Experimental Antibody-Based TherapeuticsRetrovirus-K Envelope Protein Antibodies in Targeting Breast Tumors
    • Wang-Johanning F, Rycaj K, Plummer JB, et al.Immunotherapeutic Potential of Anti-Human EndogenousCurrent and Experimental Antibody-Based TherapeuticsRetrovirus-K Envelope Protein Antibodies in Targeting Breast Tumors. J Natl Cancer Inst 2012; 104(3): 189-210.
    • (2012) J Natl Cancer Inst , vol.104 , Issue.3 , pp. 189-210
    • Wang-Johanning, F.1    Rycaj, K.2
  • 92
    • 0031081790 scopus 로고    scopus 로고
    • TGF-beta receptors and signal transduction
    • Miyazono K. TGF-beta receptors and signal transduction. Int JHematol 1997; 65: 97-104.
    • (1997) Int Jhematol , vol.65 , pp. 97-104
    • Miyazono, K.1
  • 93
    • 84958021834 scopus 로고    scopus 로고
    • 89Zr-Desferrioxamine-anti-CD105 TRC105 chimericmonoclonal antibody
    • Bethesda MD
    • Leung K. 89Zr-Desferrioxamine-anti-CD105 TRC105 chimericmonoclonal antibody. In: ed. ^Eds. Molecular Imaging and Contrast Agent Database (MICAD): Bethesda MD 2004.
    • (2004) Molecular Imaging and Contrast Agent Database (MICAD)
    • Leung, K.1
  • 94
    • 3242686833 scopus 로고    scopus 로고
    • The price tag on progress--chemotherapy forcolorectal cancer
    • Schrag D. The price tag on progress--chemotherapy forcolorectal cancer. N Engl J Med 2004; 351: 317-9.
    • (2004) N Engl J Med , vol.351 , pp. 317-319
    • Schrag, D.1
  • 95
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil,leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A, et al. Fluorouracil,leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009; 27: 663-71.
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 97
    • 84857148173 scopus 로고    scopus 로고
    • Mizunuma N. [Administration-limiting factor of bevacizumab for patient with metastatic colorectal cancer]
    • Kawazoe Y, Hatake K, Suenaga M, Mizunuma N. [Administration-limiting factor of bevacizumab for patient with metastatic colorectal cancer]. Nihon Rinsho 2011; 69 Suppl 3: 472-6.
    • Nihon Rinsho 2011; 69 Suppl , vol.3 , pp. 472-476
    • Kawazoe, Y.1    Hatake, K.2    Suenaga, M.3
  • 98
    • 84860740352 scopus 로고    scopus 로고
    • Effectiveness of LiverMetastasectomies in Patients With Metastatic Colorectal Cancer Treated With FIr-B/FOx Triplet Chemotherapy Plus Bevacizumab
    • Bruera G, Cannita K, Giuliante F, et al. Effectiveness of LiverMetastasectomies in Patients With Metastatic Colorectal Cancer Treated With FIr-B/FOx Triplet Chemotherapy Plus Bevacizumab. Clin Colorectal Cancer 2011; 11(2): 119-26.
    • (2011) Clin Colorectal Cancer , vol.11 , Issue.2 , pp. 119-126
    • Bruera, G.1    Cannita, K.2    Giuliante, F.3
  • 99
    • 84856253589 scopus 로고    scopus 로고
    • Bevacizumab added toneoadjuvant chemotherapy for breast cancer
    • Bear HD, Tang G, Rastogi P, et al. Bevacizumab added toneoadjuvant chemotherapy for breast cancer. N Engl J Med 2012; 366: 310-20.
    • (2012) N Engl J Med , vol.366 , pp. 310-320
    • Bear, H.D.1    Tang, G.2    Rastogi, P.3
  • 100
    • 84856291930 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer
    • von Minckwitz G, Eidtmann H, Rezai M, et al. Neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer. N Engl J Med 2012; 366: 299-309.
    • (2012) N Engl J Med , vol.366 , pp. 299-309
    • Von Minckwitz, G.1    Eidtmann, H.2    Rezai, M.3
  • 101
    • 80155159962 scopus 로고    scopus 로고
    • Bevacizumab: A review of its use in combination with paclitaxel or capecitabine as first-line therapy for HER2-negative metastatic breast cancer
    • Croom KF, Dhillon S. Bevacizumab: a review of its use in combination with paclitaxel or capecitabine as first-line therapy for HER2-negative metastatic breast cancer. Drugs 2011; 71: 2213-29.
    • (2011) Drugs , vol.71 , pp. 2213-2229
    • Croom, K.F.1    Dhillon, S.2
  • 103
    • 0029838529 scopus 로고    scopus 로고
    • Antiplatelet therapy
    • Schafer AI. Antiplatelet therapy. Am J Med 1996; 101: 199-209.
    • (1996) Am J Med , vol.101 , pp. 199-209
    • Schafer, A.I.1
  • 105
    • 18744423567 scopus 로고
    • An in vivo model of experimental arterial stenosis, intimal damage, and periodic thrombosis
    • Folts J. An in vivo model of experimental arterial stenosis, intimal damage, and periodic thrombosis. Circulation 1991; 83: 143-144.
    • (1991) Circulation , vol.83 , pp. 143-144
    • Folts, J.1
  • 106
    • 0024425993 scopus 로고
    • Aspirin and human platelets: From clinical trials to acetylation of cyclooxygenase and back
    • Patrono C. Aspirin and human platelets: from clinical trials to acetylation of cyclooxygenase and back. Trends Pharmacol Sci 1989; 10: 453-8.
    • (1989) Trends Pharmacol Sci , vol.10 , pp. 453-458
    • Patrono, C.1
  • 107
    • 79952541090 scopus 로고    scopus 로고
    • The impact and management of acquired platelet dysfunction
    • Scharf RE, Rahman MM, Seidel H. The impact and management of acquired platelet dysfunction. Hamostaseologie 2011; 31: 28-40.
    • (2011) Hamostaseologie , vol.31 , pp. 28-40
    • Scharf, R.E.1    Rahman, M.M.2    Seidel, H.3
  • 108
    • 66049107647 scopus 로고    scopus 로고
    • Platelet receptors and signaling in the dynamics of thrombus formation
    • Rivera J, Lozano ML, Navarro-Nunez L, Vicente V. Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica 2009; 94: 700-11.
    • (2009) Haematologica , vol.94 , pp. 700-711
    • Rivera, J.1    Lozano, M.L.2    Navarro-Nunez, L.3    Vicente, V.4
  • 110
    • 84857781525 scopus 로고    scopus 로고
    • Correction of Murine Bernard-Soulier Syndrome by Lentivirus-mediated Gene Therapy
    • Kanaji S, Kuether EL, Fahs SA, et al. Correction of Murine Bernard-Soulier Syndrome by Lentivirus-mediated Gene Therapy. Mol Ther 2011; 20(3): 625-32.
    • (2011) Mol Ther , vol.20 , Issue.3 , pp. 625-632
    • Kanaji, S.1    Kuether, E.L.2    Fahs, S.A.3
  • 111
    • 82855163998 scopus 로고    scopus 로고
    • A A386G biallelic GPIbalpha gene mutation with anomalous behavior: A new mechanism suggested for Bernard-Soulier syndrome pathogenesis
    • Vettore S, Tezza F, Malara A, et al. A A386G biallelic GPIbalpha gene mutation with anomalous behavior: a new mechanism suggested for Bernard-Soulier syndrome pathogenesis. Haematologica 2011; 96: 1878-82.
    • (2011) Haematologica , vol.96 , pp. 1878-1882
    • Vettore, S.1    Tezza, F.2    Malara, A.3
  • 112
    • 84868625269 scopus 로고    scopus 로고
    • The in vivo effect of fibrinogen and factor XIII on clot formation and fibrinolysis in Glanzmann's thrombasthenia
    • [Epub ahead of print]
    • Shenkman B, Livnat T, Misgav M, Budnik I, Einav Y, Martinowitz U. The in vivo effect of fibrinogen and factor XIII on clot formation and fibrinolysis in Glanzmann's thrombasthenia. Platelets 2012; [Epub ahead of print].
    • (2012) Platelets
    • Shenkman, B.1    Livnat, T.2    Misgav, M.3    Budnik, I.4    Einav, Y.5    Martinowitz, U.6
  • 113
    • 84862688177 scopus 로고    scopus 로고
    • A novel ELISA for diagnosis of Glanzmann's thrombasthenia and the heterozygote carriers
    • Lobo V, Shetty S, Kulkarni B, Ghosh K. A novel ELISA for diagnosis of Glanzmann's thrombasthenia and the heterozygote carriers. Ann Hematol 2011; 91(6): 917-21.
    • (2011) Ann Hematol , vol.91 , Issue.6 , pp. 917-921
    • Lobo, V.1    Shetty, S.2    Kulkarni, B.3    Ghosh, K.4
  • 117
    • 81055149626 scopus 로고    scopus 로고
    • Aborted myocardial infarction in intracoronary compared with standard intravenous abciximab administration in patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction
    • Eitel I, Desch S, Schindler K, Fuernau G, Schuler G, Thiele H. Aborted myocardial infarction in intracoronary compared with standard intravenous abciximab administration in patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction. Int J Cardiol 2011; 153: 21-5.
    • (2011) Int J Cardiol , vol.153 , pp. 21-25
    • Eitel, I.1    Desch, S.2    Schindler, K.3    Fuernau, G.4    Schuler, G.5    Thiele, H.6
  • 118
    • 0027464742 scopus 로고
    • Uses and limitations of monoclonal antibodies (MoAbs) in the treatment of malignant disease: A review
    • Kemshead JT, Hopkins K. Uses and limitations of monoclonal antibodies (MoAbs) in the treatment of malignant disease: a review. J R Soc Med 1993; 86: 219-24.
    • (1993) J R Soc Med , vol.86 , pp. 219-224
    • Kemshead, J.T.1    Hopkins, K.2
  • 119
    • 0033597341 scopus 로고    scopus 로고
    • Activation of the GP 2b-3a complex induced by platelet adhesion to collagen is mediated by both alpha(2)beta(1) integrin and GP VI
    • Nakamura T, Kambayashi J, Okuma M, Tandon NN. Activation of the GP 2b-3a complex induced by platelet adhesion to collagen is mediated by both alpha(2)beta(1) integrin and GP VI. J Biol Chem 1999; 274: 11897-903.
    • (1999) J Biol Chem , vol.274 , pp. 11897-11903
    • Nakamura, T.1    Kambayashi, J.2    Okuma, M.3    Tandon, N.N.4
  • 120
    • 0027221024 scopus 로고
    • Autoantibodies against the platelet glycoproteins (GP) IIb/IIIa, Ia/IIa, and IV and partial deficiency in GPIV in a patient with a bleeding disorder and a defective platelet collagen interaction
    • Beer JH, Rabaglio M, Berchtold P, et al. Autoantibodies against the platelet glycoproteins (GP) IIb/IIIa, Ia/IIa, and IV and partial deficiency in GPIV in a patient with a bleeding disorder and a defective platelet collagen interaction. Blood 1993; 82: 820-9.
    • (1993) Blood , vol.82 , pp. 820-829
    • Beer, J.H.1    Rabaglio, M.2    Berchtold, P.3
  • 121
    • 33746590241 scopus 로고    scopus 로고
    • Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: Development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti- human platelet agents
    • Boylan B, Berndt MC, Kahn ML, Newman PJ. Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti- human platelet agents. Blood 2006; 108: 908-14.
    • (2006) Blood , vol.108 , pp. 908-914
    • Boylan, B.1    Berndt, M.C.2    Kahn, M.L.3    Newman, P.J.4
  • 122
    • 0034109756 scopus 로고    scopus 로고
    • Evidence against a direct role of the integrin alpha2beta1 in collagen-induced tyrosine phosphorylation in human platelets
    • Hers I, Berlanga O, Tiekstra MJ, Kamiguti AS, Theakston RD, Watson SP. Evidence against a direct role of the integrin alpha2beta1 in collagen-induced tyrosine phosphorylation in human platelets. Eur J Biochem 2000; 267: 2088-97.
    • (2000) Eur J Biochem , vol.267 , pp. 2088-2097
    • Hers, I.1    Berlanga, O.2    Tiekstra, M.J.3    Kamiguti, A.S.4    Theakston, R.D.5    Watson, S.P.6
  • 123
    • 1542755135 scopus 로고    scopus 로고
    • Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments
    • Lecut C, Feeney LA, Kingsbury G, et al. Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments. J Thromb Haemost 2003; 1: 2653-62.
    • (2003) J Thromb Haemost , vol.1 , pp. 2653-2662
    • Lecut, C.1    Feeney, L.A.2    Kingsbury, G.3
  • 124
    • 43749099001 scopus 로고    scopus 로고
    • Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression
    • Ohlmann P, Hechler B, Ravanat C, et al. Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression. J Thromb Haemost 2008; 6: 1003-11.
    • (2008) J Thromb Haemost , vol.6 , pp. 1003-1011
    • Ohlmann, P.1    Hechler, B.2    Ravanat, C.3
  • 125
    • 34247398257 scopus 로고    scopus 로고
    • The Fab fragment of a novel anti-GPVI monoclonal antibody, OM4, reduces in vivo thrombosis without bleeding risk in rats
    • Li H, Lockyer S, Concepcion A, et al. The Fab fragment of a novel anti-GPVI monoclonal antibody, OM4, reduces in vivo thrombosis without bleeding risk in rats. Arterioscler Thromb Vasc Biol 2007; 27: 1199-205.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1199-1205
    • Li, H.1    Lockyer, S.2    Concepcion, A.3
  • 126
    • 65349125946 scopus 로고    scopus 로고
    • Deficiency of von Willebrand factor protects mice from ischemic stroke
    • Kleinschnitz C, De Meyer SF, Schwarz T, et al. Deficiency of von Willebrand factor protects mice from ischemic stroke. Blood 2009; 113: 3600-3603.
    • (2009) Blood , vol.113 , pp. 3600-3603
    • Kleinschnitz, C.1    De Meyer, S.F.2    Schwarz, T.3
  • 127
    • 34547862097 scopus 로고    scopus 로고
    • The von Willebrand factor antagonist (GPG-290) prevents coronary thrombosis without prolongation of bleeding time
    • Wadanoli M, Sako D, Shaw GD, et al. The von Willebrand factor antagonist (GPG-290) prevents coronary thrombosis without prolongation of bleeding time. Thromb Haemost 2007; 98: 397-405.
    • (2007) Thromb Haemost , vol.98 , pp. 397-405
    • Wadanoli, M.1    Sako, D.2    Shaw, G.D.3
  • 128
    • 0035279906 scopus 로고    scopus 로고
    • Anti-human vWF monoclonal antibody, AJvW-2 Fab, inhibits repetitive coronary artery thrombosis without bleeding time prolongation in dogs
    • Kageyama S, Yamamoto H, Nakazawa H, Yoshimoto R. Anti-human vWF monoclonal antibody, AJvW-2 Fab, inhibits repetitive coronary artery thrombosis without bleeding time prolongation in dogs. Thromb Res 2001; 101: 395-404.
    • (2001) Thromb Res , vol.101 , pp. 395-404
    • Kageyama, S.1    Yamamoto, H.2    Nakazawa, H.3    Yoshimoto, R.4
  • 129
    • 0037123856 scopus 로고    scopus 로고
    • Effect of a humanized monoclonal antibody to von Willebrand factor in a canine model of coronary arterial thrombosis
    • Kageyama S, Matsushita J, Yamamoto H. Effect of a humanized monoclonal antibody to von Willebrand factor in a canine model of coronary arterial thrombosis. Eur J Pharmacol 2002; 443: 143-9.
    • (2002) Eur J Pharmacol , vol.443 , pp. 143-149
    • Kageyama, S.1    Matsushita, J.2    Yamamoto, H.3
  • 130
    • 0037093219 scopus 로고    scopus 로고
    • Inhibition of the von Willebrand (VWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons
    • Wu D, Vanhoorelbeke K, Cauwenberghs N, et al. Inhibition of the von Willebrand (VWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons. Blood 2002; 99: 3623-8.
    • (2002) Blood , vol.99 , pp. 3623-3628
    • Wu, D.1    Vanhoorelbeke, K.2    Cauwenberghs, N.3
  • 131
    • 0037464822 scopus 로고    scopus 로고
    • Generation and characterization ofrecombinant single chain Fv antibody that recognizes platelet glycoprotein Ibalpha
    • Dai K, Zhu H, Ruan C. Generation and characterization ofrecombinant single chain Fv antibody that recognizes platelet glycoprotein Ibalpha. Thromb Res 2003; 109: 137-44.
    • (2003) Thromb Res , vol.109 , pp. 137-144
    • Dai, K.1    Zhu, H.2    Ruan, C.3
  • 132
    • 58949099543 scopus 로고    scopus 로고
    • Villalon CM. 5-hydroxytryptamine andcardiovascular regulation
    • Ramage AG, Villalon CM. 5-hydroxytryptamine andcardiovascular regulation. Trends Pharmacol Sci 2008; 29: 472-81.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 472-481
    • Ramage, A.G.1
  • 133
    • 79956122627 scopus 로고    scopus 로고
    • Platelet-derivedserotonin links vascular disease and tissue fibrosis
    • Dees C, Akhmetshina A, Zerr P, et al. Platelet-derivedserotonin links vascular disease and tissue fibrosis. J Exp Med 2011; 208: 961-72.
    • (2011) J Exp Med , vol.208 , pp. 961-972
    • Dees, C.1    Akhmetshina, A.2    Zerr, P.3
  • 134
    • 0030332149 scopus 로고    scopus 로고
    • Immunogenic andantigenic analysis of the extracellular loops of the serotoninergic 5-HT1A receptor
    • Verdot L, Ferrer-di-Martino M, Hoebeke J. Immunogenic andantigenic analysis of the extracellular loops of the serotoninergic 5-HT1A receptor. Blood Press Suppl 1996; 3: 8-10.
    • (1996) Blood Press Suppl , vol.3 , pp. 8-10
    • Verdot, L.1    Ferrer-Di-Martino, M.2    Hoebeke, J.3
  • 135
    • 0029070345 scopus 로고
    • Hoebeke J.Characterization of pharmacologically active anti-peptide antibodies directed against the first and second extracellular loops of the serotonin 5-HT1A receptor
    • Verdot L, Bertin B, Guilloteau D, Strosberg AD, Hoebeke J.Characterization of pharmacologically active anti-peptide antibodies directed against the first and second extracellular loops of the serotonin 5-HT1A receptor. J Neurochem 1995; 65: 319-28.
    • (1995) J Neurochem , vol.65 , pp. 319-328
    • Verdot, L.1    Bertin, B.2    Guilloteau, D.3    Strosberg, A.D.4
  • 136
    • 0026079843 scopus 로고
    • Nieuwenhuis HK.Biochemical characterization of PECAM-1 (CD31 antigen) on human platelets
    • Metzelaar MJ, Korteweg J, Sixma JJ, Nieuwenhuis HK.Biochemical characterization of PECAM-1 (CD31 antigen) on human platelets. Thromb Haemost 1991; 66: 700-7.
    • (1991) Thromb Haemost , vol.66 , pp. 700-707
    • Metzelaar, M.J.1    Korteweg, J.2    Sixma, J.J.3
  • 137
    • 0027242126 scopus 로고
    • Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans
    • DeLisser HM, Yan HC, Newman PJ, Muller WA, Buck CA, Albelda SM. Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans. J Biol Chem 1993; 268: 16037-46.
    • (1993) J Biol Chem , vol.268 , pp. 16037-16046
    • Delisser, H.M.1    Yan, H.C.2    Newman, P.J.3    Muller, W.A.4    Buck, C.A.5    Albelda, S.M.6
  • 139
    • 0028201028 scopus 로고
    • The role of PECAM-1 in vascular cell biology
    • Newman PJ. The role of PECAM-1 in vascular cell biology.Ann NY Acad Sci 1994; 714: 165-74.
    • (1994) Ann NY Acad Sci , vol.714 , pp. 165-174
    • Newman, P.J.1
  • 140
    • 0027431090 scopus 로고
    • Murine platelet endothelial cell adhesion molecule (PECAM-1)/CD31 modulates beta 2 integrins on lymphokine activated killer cells
    • Piali L, Albelda SM, Baldwin HS, Hammel P, Gisler RH, Imhof BA. Murine platelet endothelial cell adhesion molecule (PECAM-1)/CD31 modulates beta 2 integrins on lymphokine activated killer cells. Eur J Immunol 1993; 23: 2464-71.
    • (1993) Eur J Immunol , vol.23 , pp. 2464-2471
    • Piali, L.1    Albelda, S.M.2    Baldwin, H.S.3    Hammel, P.4    Gisler, R.H.5    Imhof, B.A.6
  • 141
    • 84863639324 scopus 로고    scopus 로고
    • Regulation of plateletbiology by platelet endothelial cell adhesion molecule-1
    • Jones CI, Moraes LA, Gibbins JM. Regulation of plateletbiology by platelet endothelial cell adhesion molecule-1. Platelets 2011;23(5): 331-5.
    • (2011) Platelets , vol.23 , Issue.5 , pp. 331-335
    • Jones, C.I.1    Moraes, L.A.2    Gibbins, J.M.3
  • 142
    • 78651244331 scopus 로고    scopus 로고
    • Monoclonal antibody to CD31 (PECAM-1) inhibits tubular regeneration after ischemia reperfusion injury in the rat
    • Valentini X, Gossiaux A, Caron N, Nonclercq D, Legrand A, Toubeau G. Monoclonal antibody to CD31 (PECAM-1) inhibits tubular regeneration after ischemia reperfusion injury in the rat. Nephron Exp Nephrol 2011; 118: e60-8.
    • (2011) Nephron Exp Nephrol , vol.118 , pp. e8-ee60
    • Valentini, X.1    Gossiaux, A.2    Caron, N.3    Nonclercq, D.4    Legrand, A.5    Toubeau, G.6
  • 143
    • 67650759561 scopus 로고    scopus 로고
    • Aspirin "resistance" and its impacton cardiovascular morbidity and mortality: It is real, clinically relevant and should be measured
    • Brister SJ, Buchanan MR. Aspirin "resistance" and its impacton cardiovascular morbidity and mortality: it is real, clinically relevant and should be measured. Heart 2009; 95: 1223-4.
    • (2009) Heart , vol.95 , pp. 1223-1224
    • Brister, S.J.1    Buchanan, M.R.2
  • 144
    • 0021366670 scopus 로고
    • Arachidonic acid-induced platelet aggregation is mediated by a thromboxane A2/prostaglandin H2 receptor interaction
    • Parise LV, Venton DL, Le Breton GC. Arachidonic acid-induced platelet aggregation is mediated by a thromboxane A2/prostaglandin H2 receptor interaction. J Pharmacol Exp Ther 1984; 228: 240-4.
    • (1984) J Pharmacol Exp Ther , vol.228 , pp. 240-244
    • Parise, L.V.1    Venton, D.L.2    Le Breton, G.C.3
  • 145
    • 0020002304 scopus 로고
    • ThromboxaneA2/prostaglandin H2 directly stimulates platelet shape change independent of secreted ADP
    • Parise LV, Venton DL, Le Breton GC. ThromboxaneA2/prostaglandin H2 directly stimulates platelet shape change independent of secreted ADP. J Pharmacol Exp Ther 1982; 222: 276-81.
    • (1982) J Pharmacol Exp Ther , vol.222 , pp. 276-281
    • Parise, L.V.1    Venton, D.L.2    Le Breton, G.C.3
  • 146
    • 0021323077 scopus 로고
    • MacIntyreDE. Thromboxane-induced phosphatidate formation in human platelets. Relationship to receptor occupancy and to changes in cytosolic free calcium
    • Pollock WK, Armstrong RA, Brydon LJ, Jones RL, MacIntyreDE. Thromboxane-induced phosphatidate formation in human platelets. Relationship to receptor occupancy and to changes in cytosolic free calcium. Biochem J 1984; 219: 833-42.
    • (1984) Biochem J , vol.219 , pp. 833-842
    • Pollock, W.K.1    Armstrong, R.A.2    Brydon, L.J.3    Jones, R.L.4
  • 147
    • 0021817884 scopus 로고
    • Reversal of thromboxaneA2/prostaglandin H2 and ADP-induced calcium release in intact platelets
    • Brace LD, Venton DL, Le Breton GC. Reversal of thromboxaneA2/prostaglandin H2 and ADP-induced calcium release in intact platelets. Am J Physiol 1985; 249: H8-13.
    • (1985) Am J Physiol , vol.249 , pp. H8-H13
    • Brace, L.D.1    Venton, D.L.2    Le Breton, G.C.3
  • 148
    • 0039826513 scopus 로고
    • ThromboxaneA2/prostaglandin H2 mobilizes calcium in human blood platelets
    • Brace LD, Venton DL, Le Breton GC. ThromboxaneA2/prostaglandin H2 mobilizes calcium in human blood platelets. Am J Physiol 1985; 249: H1-7.
    • (1985) Am J Physiol , vol.249 , pp. H1-H7
    • Brace, L.D.1    Venton, D.L.2    Le Breton, G.C.3
  • 150
    • 81855176161 scopus 로고    scopus 로고
    • The C-terminal segment of the second extracellular loop of the thromboxane A2 receptor plays an important role in platelet aggregation
    • Murad JP, Espinosa EV, Ting HJ, Khasawneh FT. The C-terminal segment of the second extracellular loop of the thromboxane A2 receptor plays an important role in platelet aggregation. Biochem Pharmacol 2012; 83: 88-96.
    • (2012) Biochem Pharmacol , vol.83 , pp. 88-96
    • Murad, J.P.1    Espinosa, E.V.2    Ting, H.J.3    Khasawneh, F.T.4
  • 151
    • 84865148939 scopus 로고    scopus 로고
    • Khasawneh FT.Characterization of the in vivo antiplatelet activity of the antihypertensive agent losartan
    • Murad JP, Espinosa EV, Ting HJ, Khasawneh FT.Characterization of the in vivo antiplatelet activity of the antihypertensive agent losartan. J Cardiovasc Pharmacol Ther 2012; 17: 308-14.
    • (2012) J Cardiovasc Pharmacol Ther , vol.17 , pp. 308-314
    • Murad, J.P.1    Espinosa, E.V.2    Ting, H.J.3
  • 152
    • 0034900174 scopus 로고    scopus 로고
    • Approval summary:Gemtuzumab ozogamicin in relapsed acute myeloid leukemia
    • Bross PF, Beitz J, Chen G, et al. Approval summary:gemtuzumab ozogamicin in relapsed acute myeloid leukemia. Clin Cancer Res 2001; 7: 1490-6.
    • (2001) Clin Cancer Res , vol.7 , pp. 1490-1496
    • Bross, P.F.1    Beitz, J.2    Chen, G.3
  • 153
    • 0036007596 scopus 로고    scopus 로고
    • Gemtuzumabozogamicin, a potent and selective anti-CD33 antibody calicheamicin conjugate for treatment of acute myeloid leukemia
    • Hamann PR, Hinman LM, Hollander I, et al. Gemtuzumabozogamicin, a potent and selective anti-CD33 antibody calicheamicin conjugate for treatment of acute myeloid leukemia. Bioconjug Chem 2002; 13: 47-58.
    • (2002) Bioconjug Chem , vol.13 , pp. 47-58
    • Hamann, P.R.1    Hinman, L.M.2    Hollander, I.3
  • 154
    • 0035878068 scopus 로고    scopus 로고
    • Mylotarg(Gemtuzumab ozogamicin) therapy is associated with hepatic venoocclusive disease in patients who have not received stem cell transplantation
    • Giles FJ, Kantarjian HM, Kornblau SM, et al. Mylotarg(gemtuzumab ozogamicin) therapy is associated with hepatic venoocclusive disease in patients who have not received stem cell transplantation. Cancer 2001; 92: 406-13.
    • (2001) Cancer , vol.92 , pp. 406-413
    • Giles, F.J.1    Kantarjian, H.M.2    Kornblau, S.M.3
  • 155
    • 0042442407 scopus 로고    scopus 로고
    • Priorgemtuzumab ozogamicin exposure significantly increases the risk of veno-occlusive disease in patients who undergo myeloablative allogeneic stem cell transplantation
    • Wadleigh M, Richardson PG, Zahrieh D, et al. Priorgemtuzumab ozogamicin exposure significantly increases the risk of veno-occlusive disease in patients who undergo myeloablative allogeneic stem cell transplantation. Blood 2003; 102: 1578-82.
    • (2003) Blood , vol.102 , pp. 1578-1582
    • Wadleigh, M.1    Richardson, P.G.2    Zahrieh, D.3
  • 156
    • 84862690092 scopus 로고    scopus 로고
    • Antibody-drug conjugates: Basic concepts,examples and future perspectives
    • Casi G, Neri D. Antibody-drug conjugates: Basic concepts,examples and future perspectives. J Control Release 2012; 161(2): 422-8.
    • (2012) J Control Release , vol.161 , Issue.2 , pp. 422-428
    • Casi, G.1    Neri, D.2
  • 157
    • 80054092983 scopus 로고    scopus 로고
    • Sliwkowski MX.Trastuzumab emtansine: A unique antibody-drug conjugate in development for human epidermal growth factor receptor 2 positive cancer
    • LoRusso PM, Weiss D, Guardino E, Girish S, Sliwkowski MX.Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2 positive cancer. Clin Cancer Res 2011; 17: 6437-47.
    • (2011) Clin Cancer Res , vol.17 , pp. 6437-6447
    • Lorusso, P.M.1    Weiss, D.2    Guardino, E.3    Girish, S.4
  • 158
    • 84861166159 scopus 로고    scopus 로고
    • New therapies inHER2-positive breast cancer: A major step towards a cure of the disease?
    • Awada A, Bozovic-Spasojevic I, Chow L. New therapies inHER2-positive breast cancer: A major step towards a cure of the disease? Cancer Treat Rev 2012; 38(5): 494-504.
    • (2012) Cancer Treat Rev , vol.38 , Issue.5 , pp. 494-504
    • Awada, A.1    Bozovic-Spasojevic, I.2    Chow, L.3
  • 159
    • 84855789037 scopus 로고    scopus 로고
    • Brentuximab Vedotin (SGN-35), an antibody-drugconjugate for the treatment of CD30-positive malignancies
    • Gualberto A. Brentuximab Vedotin (SGN-35), an antibody-drugconjugate for the treatment of CD30-positive malignancies. Expert Opin Investig Drugs 2012; 21: 205-16.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 205-216
    • Gualberto, A.1
  • 160
    • 84856998215 scopus 로고    scopus 로고
    • Emerging Pharmacotherapy for Relapsedor Refractory Hodgkin's Lymphoma: Focus on Brentuximab Vedotin
    • Furtado M, Rule S. Emerging Pharmacotherapy for Relapsedor Refractory Hodgkin's Lymphoma: Focus on Brentuximab Vedotin. Clin Med Insights Oncol 2012; 6: 31-9.
    • (2012) Clin Med Insights Oncol , vol.6 , pp. 31-39
    • Furtado, M.1    Rule, S.2
  • 162
    • 80052960859 scopus 로고    scopus 로고
    • Conatumumab (AMG655) coated nanoparticles for targeted pro-apoptotic drug delivery
    • Fay F, McLaughlin KM, Small DM, et al. Conatumumab (AMG655) coated nanoparticles for targeted pro-apoptotic drug delivery. Biomaterials 2011; 32: 8645-53.
    • (2011) Biomaterials , vol.32 , pp. 8645-8653
    • Fay, F.1    McLaughlin, K.M.2    Small, D.M.3
  • 165
    • 80155127321 scopus 로고    scopus 로고
    • Prospects for TIM3-TargetedAntitumor Immunotherapy
    • Ngiow SF, Teng MW, Smyth MJ. Prospects for TIM3-TargetedAntitumor Immunotherapy. Cancer Res 2011; 71: 6567-71.
    • (2011) Cancer Res , vol.71 , pp. 6567-6571
    • Ngiow, S.F.1    Teng, M.W.2    Smyth, M.J.3
  • 166
    • 79956103042 scopus 로고    scopus 로고
    • Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors
    • Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ. Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors. Cancer Res 2011; 71: 3540-51.
    • (2011) Cancer Res , vol.71 , pp. 3540-3551
    • Ngiow, S.F.1    Von Scheidt, B.2    Akiba, H.3    Yagita, H.4    Teng, M.W.5    Smyth, M.J.6
  • 167
    • 78449243489 scopus 로고    scopus 로고
    • Immune checkpoint proteins: A new the rapeuticparadigm for cancer-preclinical background: CTLA-4 and PD-1 blockade
    • Weber J. Immune checkpoint proteins: a new the rapeuticparadigm for cancer-preclinical background: CTLA-4 and PD-1 blockade. Semin Oncol 2010; 37: 430-9.
    • (2010) Semin Oncol , vol.37 , pp. 430-439
    • Weber, J.1
  • 168
    • 77950862827 scopus 로고    scopus 로고
    • A molecular model for cocainebinding by the immunotherapeutic human/mouse chimeric monoclonal antibody 2E2
    • Lape M, Paula S, Ball WJ, Jr. A molecular model for cocainebinding by the immunotherapeutic human/mouse chimeric monoclonal antibody 2E2. Eur J Med Chem 2010; 45: 2291-8.
    • (2010) Eur J Med Chem , vol.45 , pp. 2291-2298
    • Lape, M.1    Paula, S.2    Ball, W.J.3
  • 169
    • 0034844734 scopus 로고    scopus 로고
    • Alternative routes ofadministration as an approach to improve insulin therapy: Update on dermal, oral, nasal and pulmonary insulin delivery
    • Heinemann L, Pfutzner A, Heise T. Alternative routes ofadministration as an approach to improve insulin therapy: update on dermal, oral, nasal and pulmonary insulin delivery. Curr Pharm Des 2001; 7: 1327-51.
    • (2001) Curr Pharm Des , vol.7 , pp. 1327-1351
    • Heinemann, L.1    Pfutzner, A.2    Heise, T.3
  • 170
    • 78649657055 scopus 로고    scopus 로고
    • Inhaled insulin: A model forpulmonary systemic absorption?
    • Becquemin MH, Chaumuzeau JP. Inhaled insulin: a model forpulmonary systemic absorption? Rev Mal Respir 2010; 27: e54-65.
    • (2010) Rev Mal Respir , vol.27 , pp. e54-e65
    • Becquemin, M.H.1    Chaumuzeau, J.P.2
  • 171
    • 83055163304 scopus 로고    scopus 로고
    • [Insulin therapy in 2011]
    • Perusiova J. [Insulin therapy in 2011]. Vnitr Lek 2011; 57: 930-6.
    • (2011) Vnitr Lek , vol.57 , pp. 930-936
    • Perusiova, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.